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1. 发明授权

US08338552B2 Co-polymer films for sensors 有权
标题翻译：用于传感器的共聚合膜
公开(公告)号：US08338552B2
公开(公告)日：2012-12-25
申请号：US12947598
申请日：2010-11-16
申请人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
发明人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
IPC分类号： C08F26/06 , C08F126/06
CPC分类号： C08F26/06 , C08F212/08
摘要： Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed.
摘要翻译：实施方案包括包含共聚物的传感器，所述共聚物包含第一单体和第二单体。对于一些实施方案，第一单体是聚-4-乙烯基吡啶，第二单体是聚-4-乙烯基吡啶鎓丙胺氯化物。对于一些实施方案，第一单体是聚苯乙烯，第二单体是聚-2-乙烯基吡啶鎓丙胺氯化物。对于一些实施方案，第一单体是聚-4-乙烯基吡啶，第二单体是聚-4-乙烯基吡啶鎓苄胺氯化物。描述和要求保护其他实施例。

2. 发明申请

US20100022731A1 Co-polymer films for sensors 有权
标题翻译：用于传感器的共聚合膜
公开(公告)号：US20100022731A1
公开(公告)日：2010-01-28
申请号：US11820472
申请日：2007-06-19
申请人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
发明人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
IPC分类号： C08F26/06
CPC分类号： C08F26/06 , C08F212/08
摘要： Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed.
摘要翻译：实施方案包括包含共聚物的传感器，所述共聚物包含第一单体和第二单体。对于一些实施方案，第一单体是聚-4-乙烯基吡啶，第二单体是聚-4-乙烯基吡啶鎓丙胺氯化物。对于一些实施方案，第一单体是聚苯乙烯，第二单体是聚-2-乙烯基吡啶鎓丙胺氯化物。对于一些实施方案，第一单体是聚-4-乙烯基吡啶，第二单体是聚-4-乙烯基吡啶鎓苄胺氯化物。描述和要求保护其他实施例。

3. 发明授权

US07858720B2 Co-polymer films for sensors 有权
公开(公告)号：US07858720B2
公开(公告)日：2010-12-28
申请号：US11820472
申请日：2007-06-19
申请人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
发明人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
IPC分类号： C08F126/06
CPC分类号： C08F26/06 , C08F212/08
摘要： Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed.

4. 发明申请

US20110060114A1 Co-Polymer Films for Sensors 有权
标题翻译：传感器用共聚合膜
公开(公告)号：US20110060114A1
公开(公告)日：2011-03-10
申请号：US12947598
申请日：2010-11-16
申请人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
发明人： Margaret A. Ryan , Margie L. Homer , Shiao-Pin S. Yen , Adam Kisor , April D. Jewell , Abhijit V. Shevade , Kenneth S. Manatt , Charles Taylor , Mario Blanco , William A. Goddard
IPC分类号： C08F226/06
CPC分类号： C08F26/06 , C08F212/08
摘要： Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed.
摘要翻译：实施方案包括包含共聚物的传感器，所述共聚物包含第一单体和第二单体。对于一些实施方案，第一单体是聚-4-乙烯基吡啶，第二单体是聚-4-乙烯基吡啶鎓丙胺氯化物。对于一些实施方案，第一单体是聚苯乙烯，第二单体是聚-2-乙烯基吡啶鎓丙胺氯化物。对于一些实施方案，第一单体是聚-4-乙烯基吡啶，第二单体是聚-4-乙烯基吡啶鎓苄胺氯化物。描述和要求保护其他实施例。

5. 发明授权

US07843565B2 Optical gas monitor 有权
标题翻译：光学气体监测仪
公开(公告)号：US07843565B2
公开(公告)日：2010-11-30
申请号：US11807538
申请日：2007-05-29
申请人： Sheng Wu , Andrei Deev , Steve L. Palm , Yongchun Tang , William A. Goddard
发明人： Sheng Wu , Andrei Deev , Steve L. Palm , Yongchun Tang , William A. Goddard
IPC分类号： G01N21/25
CPC分类号： G01N21/39 , G01N2021/1795 , G01N2021/399 , G01N2201/0691
摘要： A frequency modulated spectroscopy system, including a photo-detector, a band-pass filter to filter the output of the photo-detector, and a rectifier to demodulate. The band-pass filter has a relatively high Q factor. With the high Q factor band-pass filter and rectifier, a reference sinusoid is not required for demodulation, resulting in phase-insensitive spectroscopy. Other embodiments are described and claimed.
摘要翻译：一种频率调制光谱系统，包括光电检测器，用于滤波光检测器输出的带通滤波器，以及整流器进行解调。带通滤波器具有较高的Q因子。对于高Q因子带通滤波器和整流器，解调不需要参考正弦波，导致相位不敏感的谱。描述和要求保护其他实施例。

6. 发明授权

US10253084B2 Methods for predicting three-dimensional structures for alpha helical membrane proteins and their use in design of selective ligands 有权
公开(公告)号：US10253084B2
公开(公告)日：2019-04-09
申请号：US12142707
申请日：2008-06-19
申请人： Ravinder Abrol , William A. Goddard , Adam R. Griffith , Victor Wai Tak Kam
发明人： Ravinder Abrol , William A. Goddard , Adam R. Griffith , Victor Wai Tak Kam
IPC分类号： G06F19/00 , G01N33/68 , C07K14/705
摘要： A method for practical prediction of the three-dimensional structure of α-helical membrane proteins (HMPs) is described. The method allows one to predict the binding site and structure for strongly bound ligands. The method combines a protocol of computational methods enabling a complete ensemble of packings to be sampled and systematically reducing this ensemble to progressively more accurate structures until at the end there remain a few that might be functionally relevant and likely to play a role in all binding and activation processes. This method is well suited to automatic operation making it practical to obtain, for example, the ensemble of important structures for all human GPCRs. With this ensemble of all active GPCR structures in the human body, an infimum method is presented to maximize efficacy toward the selected target while minimizing binding to all other GPCRs to eliminate toxicity arising from cross-reacting with other GPCRs (a most common source of drug failure). This infimum method is broadly applicable to any set of proteins where a ligand is desired to be able to modulate the function of one protein while not affecting the function of other proteins.

7. 发明授权

US08370074B2 System and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors 有权
标题翻译：用于预测膜蛋白中跨膜结构域的系统和方法，并开采用于识别G蛋白偶联受体的基因组
公开(公告)号：US08370074B2
公开(公告)日：2013-02-05
申请号：US12606605
申请日：2009-10-27
申请人： Rene J. Trabanino , Nagarajan Vaidehi , Spencer E. Hall , William A. Goddard , Wely Floriano
发明人： Rene J. Trabanino , Nagarajan Vaidehi , Spencer E. Hall , William A. Goddard , Wely Floriano
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58 , G06F7/60
CPC分类号： G06F19/16 , G06F19/22
摘要： The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the presence of transmembrane regions in proteins, such as G-Protein Coupled Receptors (GPCR), and protein structural models generated according to the protocol. The protocol features a coarse grain sampling method, such as hydrophobicity analysis, to provide a fast and accurate procedure for predicting transmembrane regions. Methods and apparatus of the invention are useful to screen protein or polynucleotide databases for encoded proteins with transmembrane regions, such as GPCRs.
摘要翻译：本发明提供计算机实现的方法和装置，其使用多尺度分子动力学和分子模拟方法实现分层协议，以预测蛋白质中的跨膜区域的存在，例如G-蛋白质偶联受体（GPCR），以及根据协议。该方案采用粗粒度采样方法，如疏水性分析，为预测跨膜区域提供快速准确的程序。本发明的方法和装置可用于筛选具有跨膜区的编码蛋白质的蛋白质或多核苷酸数据库，例如GPCR。

8. 发明申请

US20090035836A1 MODULATING PH-SENSITIVE BINDING USING NON-NATURAL AMINO ACIDS 审中-公开
标题翻译：使用非天然氨基酸调节敏感性结合
公开(公告)号：US20090035836A1
公开(公告)日：2009-02-05
申请号：US12147379
申请日：2008-06-26
申请人： Deepshikha Datta , William A. Goddard , David Tirrell , Joyce Yaochun Peng
发明人： Deepshikha Datta , William A. Goddard , David Tirrell , Joyce Yaochun Peng
IPC分类号： C12N7/00 , C07K2/00 , C07K16/00
CPC分类号： C07K16/32
摘要： The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional fragment, derivative, etc.). The invention also relates to specific uses in regulating pH-sensitive binding of antibodies to tumor site, by conferring enhanced tumor-specificity/selectivity. In that embodiment, the non-natural amino acids preferably have desirable side-chain pKa's, such that at below physiological pH (e.g. about pH 6.3-6.5) the non-natural amino acid confer enhanced binding to tumor antigens in acidic environments. Such non-natural amino acids can be incorporated by any suitable means, such as by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs (e.g. the degenerate codon orthogonal system.
摘要翻译：本发明提供了通过将非天然氨基酸掺入蛋白质（例如抗体或其功能片段，衍生物等）来调节pH敏感蛋白质相互作用的方法，系统和试剂。本发明还涉及通过赋予增强的肿瘤特异性/选择性来调节抗体对肿瘤部位的pH敏感结合的具体用途。在该实施方案中，非天然氨基酸优选具有所需的侧链pKa，使得在低于生理pH（例如约pH 6.3-6.5）下，非天然氨基酸在酸性环境中赋予增强的与肿瘤抗原的结合。这样的非天然氨基酸可以通过任何合适的方式并入，例如通过利用修饰的氨酰-tRNA合成酶将非标准氨基酸装入修饰的tRNA，其与通常形成的密码子形成严格的沃森 - 克里克碱基配对与天然tRNA的摆动碱基配对（如简并密码子正交系统）。

9. 发明授权

US09209375B2 Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires 有权
标题翻译：用于控制半导体纳米线的热导率和热电功率的方法和装置
公开(公告)号：US09209375B2
公开(公告)日：2015-12-08
申请号：US12175027
申请日：2008-07-17
申请人： Akram Boukai , Yuri Bunimovich , William A. Goddard , James R. Heath , Jamil Tahir-Kheli
发明人： Akram Boukai , Yuri Bunimovich , William A. Goddard , James R. Heath , Jamil Tahir-Kheli
IPC分类号： H01L35/12 , H01L35/26 , H01L35/32 , H01L35/34
CPC分类号： H01L35/26 , H01L35/32 , H01L35/34 , H01L2924/0002 , H01L2924/00
摘要： Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires are described. The thermal conductivity and the thermoelectric power are controlled substantially independently of the electrical conductivity of the nanowires by controlling dimensions and doping, respectively, of the nanowires. A thermoelectric device comprising p-doped and n-doped semiconductor nanowire thermocouples is also shown, together with a method to fabricate alternately p-doped and n-doped arrays of silicon nanowires.
摘要翻译：描述了用于控制半导体纳米线的热导率和热电功率的方法和装置。通过分别控制纳米线的尺寸和掺杂，热导率和热电功率基本上独立于纳米线的电导率来控制。还示出了包括p掺杂和n掺杂半导体纳米线热电偶的热电器件，以及交替地制造硅纳米线的p掺杂和n掺杂阵列的方法。

10. 发明授权

US08481421B2 Functional anchors connecting graphene-like carbon to metal 有权
标题翻译：将石墨烯碳与金属连接的功能锚
公开(公告)号：US08481421B2
公开(公告)日：2013-07-09
申请号：US12179345
申请日：2008-07-24
申请人： William A. Goddard , Weiqiao Deng , Yuki Matsuda
发明人： William A. Goddard , Weiqiao Deng , Yuki Matsuda
IPC分类号： H01L21/4763
CPC分类号： H01M4/92 , B82B1/00 , B82Y30/00 , H01M4/923 , H01M8/1004
摘要： Functional linkers or anchors interconnecting graphene-like carbon, such as nanotubes or graphite sheets, with a conducting material such as a metal, are shown, together with related structures, devices, methods and systems.
摘要翻译：示出了将诸如纳米管或石墨片之类的石墨烯碳与导电材料如金属相互连接的功能连接器或锚，以及相关结构，装置，方法和系统。

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