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1. 发明申请

US20080299153A1 B. ANTHRACIS PREVENTION AND TREATMENT: MUTANT B. ANTHRACIS LACKING LUXS ACTIVITY AND FURANONE INHIBITION OF GROWTH, AI-2 QUORUM SENSING, AND TOXIN PRODUCTION 有权
标题翻译： B.安全性预防和治疗：突变B.安慰剂缺乏激素活性和呋喃酮抑制生长，AI-2次感测和毒素生产
公开(公告)号：US20080299153A1
公开(公告)日：2008-12-04
申请号：US12044135
申请日：2008-03-07
申请人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
IPC分类号： A61K39/07 , C07H21/04 , C07K14/32 , C07K16/12 , A61K31/34 , A01N43/08 , A61P31/04 , C12N1/21
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

2. 发明申请

US20120157522A1 B. Anthracis Prevention and Treatment: Mutant B. Anthracis Lacking Luxs Activity and Furanone Inhibition of Growth, AI-2 Quorum Sensing, and Toxin Production 审中-公开
标题翻译： B.炭疽预防与治疗：突变体B.炭疽菌缺乏活性和呋喃酮抑制生长，AI-2法定感应和毒素生产
公开(公告)号：US20120157522A1
公开(公告)日：2012-06-21
申请号：US13091999
申请日：2011-04-21
申请人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
IPC分类号： A61K31/365 , A61P31/04
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽芽孢杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

3. 发明授权

US07955596B2 B. anthracis prevention and treatment: mutant B. anthracis lacking luxs activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production 有权
标题翻译： B.炭疽预防和治疗：突变体B.炭疽菌缺乏勒克斯活性和呋喃酮抑制生长，AI-2群体感应和毒素生产
公开(公告)号：US07955596B2
公开(公告)日：2011-06-07
申请号：US12044135
申请日：2008-03-07
申请人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
IPC分类号： A01N63/00 , A61K39/00 , A61K39/02 , C12N1/12 , C12N15/74 , C12N15/75
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽芽孢杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

4. 发明授权

US07365184B2 B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production 失效
标题翻译： B.炭疽预防和治疗：突变体B.蒽醌缺乏luxS活性和呋喃酮抑制生长，AI-2群体感应和毒素生产
公开(公告)号：US07365184B2
公开(公告)日：2008-04-29
申请号：US10823396
申请日：2004-04-12
申请人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus B. Jones , Martin J. Blaser , Thomas Wood , Dacheng Ren
IPC分类号： C07H21/04 , C12N15/00 , C12N21/02 , C12P21/04 , C12P21/06
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽芽孢杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

5. 发明申请

US20050042634A1 B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production 失效
标题翻译： B.炭疽预防和治疗：突变体B.蒽醌缺乏luxS活性和呋喃酮抑制生长，AI-2群体感应和毒素生产
公开(公告)号：US20050042634A1
公开(公告)日：2005-02-24
申请号：US10823396
申请日：2004-04-12
申请人： Marcus Jones , Martin Blaser , Thomas Wood , Dacheng Ren
发明人： Marcus Jones , Martin Blaser , Thomas Wood , Dacheng Ren
IPC分类号： C07H21/04 , C07K14/32 , C12N20060101 , C12N5/06 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/74 , C12P21/04 , C12Q1/68
CPC分类号： C07K14/32
摘要： The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B. anthracis infection, or enhance an immune response to B. anthracis infection, by administering a vaccine comprising a B. anthracis cell in which the luxS gene is mutated.
摘要翻译：本发明涉及炭疽芽孢杆菌具有编码功能性LuxS多肽的luxS基因的发现，并且炭疽杆菌合成功能性的AI-2群体感应分子。本发明提供了与野生型炭疽芽孢杆菌相比，不产生功能性AI-2分子并具有生长缺陷的缺乏luxS基因功能的突变体B.炭疽杆菌。本发明还涉及通过抑制炭疽芽孢杆菌LuxS多肽的活性或通过将炭疽杆菌暴露于呋喃酮而抑制炭疽芽孢杆菌生长或预防或治疗炭疽杆菌感染的方法。特别地，本发明涉及使用呋喃酮（一种抑制AI-2介导的群体感应的化合物）来抑制炭疽芽孢杆菌的生长，抑制炭疽杆菌毒素生产，特别是保护性抗原的产生，并防止或治疗炭疽杆菌感染。本发明还提供了通过施用包含luxS基因突变的炭疽杆菌细胞的疫苗来预防炭疽杆菌感染或增强对炭疽杆菌感染的免疫应答的方法。

6. 发明授权

US12071602B2 Inductively coupled capacitor wireless sensor system for rapid antimicrobial susceptibility testing 有权
公开(公告)号：US12071602B2
公开(公告)日：2024-08-27
申请号：US17972618
申请日：2022-10-25
申请人： Dacheng Ren , Yikang Xu
发明人： Dacheng Ren , Yikang Xu
IPC分类号： G01N35/02 , C12M1/34 , C12Q1/18
CPC分类号： C12M1/3407 , C12M1/34 , C12Q1/18 , G01N35/028
摘要： An electrochemical biosensor based on magnetically coupled LC sensors for the rapid detection of microbial growth and sensitivity to microbials. The engineered LC sensors can be placed in 96 well plates and communicate the reading remotely with a receiver coil for signal analysis. The sensors were validated by testing the growth of Escherichia. coli, Staphylococcus. aureus, and Pseudomonas aeruginosa in the presence and absence of different antibiotics. Drug-resistant strains were used as controls. Bacterial growth was detected within 30 mins of culture inoculation, allowing rapid determination of antibiotic susceptibility at the phenotypic level. The pattern shown in the LC sensor AST is consistent with results collected with traditional optical density (OD) 600 nm measurement, additional validation was also performed with lysogeny broth (LB) dosed with fetal bovine serum (FBS). With the compatibility with 96-well plates, this rapid AST may be used for low-cost, point-of-care applications.

7. 发明授权

US08569027B2 System and method for controlling bacterial persister cells with weak electric currents 有权
标题翻译：用弱电流控制细菌细胞的系统和方法
公开(公告)号：US08569027B2
公开(公告)日：2013-10-29
申请号：US12853697
申请日：2010-08-10
申请人： Dacheng Ren , Mi Zhang , Tagbo Niepa , Jeremy Gilbert
发明人： Dacheng Ren , Mi Zhang , Tagbo Niepa , Jeremy Gilbert
IPC分类号： C12N13/00
CPC分类号： C12N13/00
摘要： A system and method for treating persister cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate persister cells and the efficacy can be further improved through synergistic effects with antibiotics. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has a broad spectrum applications in treating chronic and drug resistant infections, such as those caused by Pseudomonas aeruginosa, Mycobacterium tuberculosis and methicillin resistant Staphylococcus aureus, and may also be used for decontamination of medical devices.
摘要翻译：用电化学方法治疗持续细胞的系统和方法，单独或与抗生素组合。弱电流用于有效消除持续细胞，并通过与抗生素的协同作用进一步提高功效。该方法可适用于慢性感染的新疗法和控制持续性生物污损的策略。该系统在治疗慢性和耐药性感染例如由绿脓假单胞菌，结核分枝杆菌和耐甲氧西林金黄色葡萄球菌引起的感染中具有广泛的应用，并且还可用于医疗器械的去污。

8. 发明申请

US20110034406A1 System And Method For Controlling Bacterial Persister Cells With Weak Electric Currents 有权
标题翻译：用弱电流控制细菌持久细胞的系统和方法
公开(公告)号：US20110034406A1
公开(公告)日：2011-02-10
申请号：US12853697
申请日：2010-08-10
申请人： Dacheng Ren , Mi Zhang , Tagbo Niepa , Jeremy Gilbert
发明人： Dacheng Ren , Mi Zhang , Tagbo Niepa , Jeremy Gilbert
IPC分类号： C12N13/00 , C12M1/42 , A01N43/58 , A01P15/00 , A01N43/08
CPC分类号： C12N13/00
摘要： A system and method for treating persister cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate persister cells and the efficacy can be further improved through synergistic effects with antibiotics. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has a broad spectrum applications in treating chronic and drug resistant infections, such as those caused by Pseudomonas aeruginosa, Mycobacterium tuberculosis and methicillin resistant Staphylococcus aureus, and may also be used for decontamination of medical devices.
摘要翻译：用电化学方法治疗持续细胞的系统和方法，单独或与抗生素组合。弱电流用于有效消除持续细胞，并通过与抗生素的协同作用进一步提高功效。该方法可适用于慢性感染的新疗法和控制持续性生物污损的策略。该系统在治疗慢性和耐药性感染例如由绿脓假单胞菌，结核分枝杆菌和耐甲氧西林金黄色葡萄球菌引起的感染中具有广泛的应用，并且还可用于医疗器械的去污。

9. 发明公开

US20240360325A1 SURFACE TOPOGRAPHY WITH FERROMAGNETIC POLYMER PILLARS CAPABLE OF MOVEMENT IN RESPONSE TO MAGNETIC FIELDS 审中-公开
公开(公告)号：US20240360325A1
公开(公告)日：2024-10-31
申请号：US18140075
申请日：2023-04-27
申请人： Dacheng Ren , Huan Gu
发明人： Dacheng Ren , Huan Gu
IPC分类号： C09D5/16 , C09D7/40 , C09D7/61
CPC分类号： C09D5/1687 , C09D5/1675 , C09D5/1681 , C09D7/61 , C09D7/66
摘要： An anti-fouling surface having micron scale pillars embedded with Fe3O4 nanoparticles is designed. The pillars may be repeatedly induced to move according to a predetermined frequency, such as one that mimic that of the beating movement of natural cilia, through the application of a magnetic field. When square-shaped pillars with a height of 10 μm, width of 2 μm, and inter-pattern distance of 5 μm actuated for three minutes, more than 99.9 percent of biofilm cells were detached and via gentle rinsing from the surface having the pillars. The anti-fouling surface enables effective prevention of biofilm formation and removal of established biofilms, and can be applied to a broad spectrum of polymers.

10. 发明授权

US08663914B2 System and method for controlling bacterial cells with weak electric currents 有权
标题翻译：用弱电流控制细菌细胞的系统和方法
公开(公告)号：US08663914B2
公开(公告)日：2014-03-04
申请号：US13030793
申请日：2011-02-18
申请人： Dacheng Ren , Mi Zhang , Tagbo Niepa , Jeremy Gilbert
发明人： Dacheng Ren , Mi Zhang , Tagbo Niepa , Jeremy Gilbert
IPC分类号： C12Q1/70
CPC分类号： C12N13/00 , A01N59/00
摘要： A system and method for treating bacterial cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate bacterial cells. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has broad spectrum applications in treating chronic and drug resistant infections, such as those caused by Pseudomonas aeruginosa, Mycobacterium tuberculosis and methicillin resistant Staphylococcus aureus, and may also be used for decontamination of medical devices.
摘要翻译：一种用电化学方法处理细菌细胞的方法，其单独或与抗生素组合。弱电流用于有效消除细菌细胞。该方法可适用于慢性感染的新疗法和控制持续性生物污损的策略。该系统在广泛应用于治疗慢性和耐药性感染，例如由绿脓假单胞菌，结核分枝杆菌和耐甲氧西林金黄色葡萄球菌引起的感染，也可用于医疗器械的去污。

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