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1. 发明授权

US07001420B2 Coil reinforced multilayered inner tubular member for a balloon catheter 失效
标题翻译：用于球囊导管的线圈加强多层内管状构件
公开(公告)号：US07001420B2
公开(公告)日：2006-02-21
申请号：US10279648
申请日：2002-10-24
申请人： Marc L. Speck , Sharon Wong , Jeong S. Lee , Matthew Chludzinski
发明人： Marc L. Speck , Sharon Wong , Jeong S. Lee , Matthew Chludzinski
IPC分类号： A61F2/06
CPC分类号： A61M25/005 , A61M25/104
摘要： A catheter having an elongated shaft formed of a polymeric tubular member with at least a section having a lubricious inner layer defining the guidewire lumen, a coiled support member at least partially embedded in the lubricious inner layer, and an outer layer on an outer surface of at least a distal portion of the lubricious inner layer. In a presently preferred embodiment, the coil supported polymeric tubular member forms an inner tubular member of a balloon catheter.
摘要翻译：一种导管，其具有由聚合物管状构件形成的细长轴，所述细长轴至少具有限定所述导丝管腔的润滑内层的部分，至少部分地嵌入所述光滑内层中的螺旋支撑构件，以及外侧表面上的外层至少光滑内层的远端部分。在当前优选的实施例中，线圈支撑的聚合物管状构件形成气囊导管的内部管状构件。

2. 发明申请

US20130283147A1 WEB-BASED COLLABORATIVE DOCUMENT REVIEW SYSTEM 审中-公开
标题翻译：基于WEB的协同文件审查系统
公开(公告)号：US20130283147A1
公开(公告)日：2013-10-24
申请号：US13450908
申请日：2012-04-19
申请人： Sharon Wong , Brian Wong , Jacob Mouka
发明人： Sharon Wong , Brian Wong , Jacob Mouka
IPC分类号： G06F17/00
CPC分类号： G06F17/21 , G06Q10/10
摘要： A method of collaboratively editing a document includes converting an originating document to a web document comprising segmented files in a markup language; storing the web document on a server; retrieving the web document to generate edits thereto from a first participant; transmitting the first participant edits to the server and associating the first edits with the web document; retrieving the web document including first participant edits to generate additional edits thereto from a second participant; transmitting the second participant edits to the server and associating the second participant edits with the web document and the first participant edits; reviewing edits from all participants by a document administrator, accepting or rejecting edits, including conflicting edits, until desired changes are made to the web document; and converting the web document including first and second participant edits into an edited document into a proprietary format.
摘要翻译：一种协同编辑文档的方法包括：将起始文档转换成包括标记语言的分段文件的web文档; 将所述Web文档存储在服务器上; 检索所述网络文档以从第一参与者生成编辑; 将所述第一参与者编辑发送到所述服务器并将所述第一编辑与所述web文档相关联; 检索所述网络文档包括第一参与者编辑以从第二参与者产生附加的编辑; 将所述第二参与者编辑发送到所述服务器并将所述第二参与者编辑与所述web文档和所述第一参与者编辑相关联; 审查文档管理员的所有参与者的修改，接受或拒绝编辑，包括冲突的编辑，直到对Web文档进行所需的更改; 以及将包括第一和第二参与者编辑的web文档转换为专有格式的编辑文档。

3. 发明授权

US5834193A Methods for measuring telomere length 失效
标题翻译：测定端粒长度的方法
公开(公告)号：US5834193A
公开(公告)日：1998-11-10
申请号：US660402
申请日：1996-06-07
申请人： Michael R. Kozlowski , Karen R. Prowse , Sy-Shi Wang , Sharon Wong , Nam Woo Kim , Richard Allsopp
发明人： Michael R. Kozlowski , Karen R. Prowse , Sy-Shi Wang , Sharon Wong , Nam Woo Kim , Richard Allsopp
IPC分类号： G01N27/447 , C12N15/09 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6816
摘要： Methods and compositions for the measurement of telomere length have application in medical diagnostic, prognostic, and therapeutic procedures. The methods for measuring telomere length include primer extension-based methods and probe-based methods. The primer extension methods involve elongation of telomeric, linker, and/or subtelomeric based primers under conditions such that the telomere serves as a template for primer extension and that the resultant primer extension products can be compared to standards of known length to provide a measure of telomere length. The probe based methods allow for telomere length measurements using DNA from lysed or whole cells and involve hybridizing an excess of probe to all telomeric repeat sequences in the telomere, measuring the amount of bound probe, and correlating the amount of bound probe measured with telomere length.
摘要翻译：用于测量端粒长度的方法和组合物可用于医学诊断，预后和治疗程序。测量端粒长度的方法包括基于引物延伸的方法和基于探针的方法。引物延伸方法涉及在使得端粒作为引物延伸的模板的条件下延伸端粒末端，接头和/或亚端粒基引物，并且所得到的引物延伸产物可以与已知长度的标准物进行比较，端粒长度基于探针的方法允许使用来自裂解的全细胞的DNA进行端粒长度测量，并且包括将过量的探针与端粒中的所有端粒重复序列杂交，测量结合的探针的量，并将测量的结合的探针的量与端粒长度相关联。

4. 发明授权

US5741677A Methods for measuring telomere length 失效
标题翻译：测定端粒长度的方法
公开(公告)号：US5741677A
公开(公告)日：1998-04-21
申请号：US479916
申请日：1995-06-07
申请人： Michael R. Kozlowski , Karen R. Prowse , Sy-shi Wang , Sharon Wong , Nam Woo Kim , Richard Allsop
发明人： Michael R. Kozlowski , Karen R. Prowse , Sy-shi Wang , Sharon Wong , Nam Woo Kim , Richard Allsop
IPC分类号： G01N27/447 , C12N15/09 , C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6816
摘要： Methods are provided for the determination of telomere length. These methods can be used for diagnosis of cancer and the staging of cancer, and diagnosis of senecesence in cells. Also, the instant methods can be used to determine stages of diseases such as atherosclerosis or HIV infection, and can be used to diagnose infertility.
摘要翻译：提供了测定端粒长度的方法。这些方法可用于诊断癌症和癌症分期，以及诊断细胞中的猝死。此外，本方法可用于确定疾病如动脉粥样硬化或HIV感染的阶段，并且可用于诊断不育症。

5. 发明授权

US08100837B1 Superelastic guidewire with locally altered properties 有权
标题翻译：具有局部改变特性的超弹性导丝
公开(公告)号：US08100837B1
公开(公告)日：2012-01-24
申请号：US09746144
申请日：2000-12-21
申请人： Wayne E. Cornish , Sharon Wong
发明人： Wayne E. Cornish , Sharon Wong
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09108 , A61M2025/09141 , A61M2025/0915 , A61M2025/09175
摘要： A guidewire formed at least in part of a superelastic member with a section having one or more altered properties including physical and mechanical properties. Preferably, the section of altered property has reduced superelasticity with respect to the remainder of the superelastic member. The invention also comprises method of manufacturing such guidewires wherein a section of the superelastic member is isolated and treated to change one or more of the properties. The treatment may be alloying with a diffusable element or isolating one or more sections to work and heat treat to decrease superelasticity relative to the rest of the member. The section having one or more altered properties is preferably a distal portion of the member, for example about the most distal 3 cm.
摘要翻译：至少部分由超弹性构件形成的导丝，其具有包括物理和机械性质的一个或多个改变的特性的区段。优选地，改变的性质的部分相对于超弹性构件的其余部分具有降低的超弹性。本发明还包括制造这种导丝的方法，其中超弹性构件的一部分被分离和处理以改变一种或多种性质。处理可以是与可扩散元件合金化或隔离一个或多个部分以进行加工和热处理以降低相对于其余部件的超弹性。具有一个或多个改变的性质的区段优选地是构件的远侧部分，例如约3cm的最远端。

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