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1. 发明申请

US20110152661A1 Method and apparatus for identifying the viability of ischemic myocardium of a patient 审中-公开
标题翻译：用于鉴定患者缺血心肌的存活力的方法和装置
公开(公告)号：US20110152661A1
公开(公告)日：2011-06-23
申请号：US12924195
申请日：2010-09-22
申请人： Marc D. Feldman , Anil Tharian George Kottam , John Pearce , Jonathan Valvano , John Porterfield
发明人： Marc D. Feldman , Anil Tharian George Kottam , John Pearce , Jonathan Valvano , John Porterfield
IPC分类号： A61B5/0408 , A61B5/0402
CPC分类号： A61B5/0538 , A61B5/02 , A61B5/416 , A61B5/6883
摘要： A method for identifying the viability of ischemic myocardium of a patient. The method includes the steps of measuring in real-time the ischemic myocardium of a beating or non-beating heart. There is the step of determining in real-time whether the ischemic myocardium of the beating or non-beating heart is stunned or is nonviable. An apparatus for identifying the viability of ischemic myocardium of a patient's heart. The apparatus includes an electrode array having at least four electrodes for electrical communication with the heart which produces an array signal. The apparatus includes a processor portion in communication with the array which receives the array signal and determines in real-time whether the ischemic myocardium of the heart is stunned or is nonviable. An apparatus for analyzing living tissue. The apparatus includes an electrode array having at least four electrodes for electrical communication with the tissue which produces an array signal. The apparatus includes an admittance magnitude and phase detection circuit in communication with the array which receives the array signal from the array and produces a detection circuit signal corresponding to phase angle and magnitude of the array and signal. The apparatus includes a processor in communication with the detection circuit which receives the detection circuit signal and determines permittivity and conductivity of the tissue in real-time. A method for analyzing living tissue.
摘要翻译：用于鉴定患者缺血心肌的存活力的方法。该方法包括实时测量跳动或不跳动心脏的缺血心肌的步骤。实时确定殴打或非跳动心脏的缺血性心肌是否震惊或不可行的步骤。用于鉴定患者心脏缺血心肌的存活力的装置。该装置包括具有至少四个用于与心脏电连通的电极的电极阵列，其产生阵列信号。该装置包括与阵列通信的处理器部分，其接收阵列信号并实时确定心脏的缺血心肌是否震惊或不可行。一种用于分析活体组织的装置。该装置包括具有至少四个电极的电极阵列，用于与组织电连通，产生阵列信号。该装置包括与阵列通信的导纳幅度和相位检测电路，其接收来自阵列的阵列信号，并产生对应于阵列和信号的相位角和幅度的检测电路信号。该装置包括与检测电路通信的处理器，其接收检测电路信号并实时确定组织的介电常数和电导率。一种分析活体组织的方法。

2. 发明授权

US10076669B2 Admittance measurement for tuning bi-ventricular pacemakers 有权
公开(公告)号：US10076669B2
公开(公告)日：2018-09-18
申请号：US13373850
申请日：2011-12-02
申请人： Marc D. Feldman , John Porterfield , Erik Larson , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Erik Larson , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/365 , A61B5/053 , A61N1/368
CPC分类号： A61N1/36571 , A61B5/0538 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： An apparatus for treating a heart of a patient includes a first lead and at least a second lead for pacing the heart adapted to be in electrical communication with the heart. The apparatus includes a microcontroller in communication with the first and second leads which triggers the first lead at either different times or the same time from when the microcontroller triggers the second lead. Alternatively, the apparatus includes a microcontroller in communication with the first and second leads that determines heart volume, including stroke volume, end-systolic volume, and calculated values including ejection fraction, from admittance from signals from the first and second leads and uses the admittance as feedback to control heart volume ejected, as measured by stroke volume, calculated values such as ejection fraction, and control end-systolic volume, with respect to the first and second leads. A method for treating the heart of a patient.

3. 发明申请

US20230038471A1 Method and Apparatus for Monitoring a Patient 有权
公开(公告)号：US20230038471A1
公开(公告)日：2023-02-09
申请号：US17962451
申请日：2022-10-07
申请人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
发明人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/0538 , A61B5/00 , A61N1/362 , G16H40/63 , A61N1/05
摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

4. 发明申请

US20190298997A1 Method and Apparatus for Monitoring a Patient 审中-公开
公开(公告)号：US20190298997A1
公开(公告)日：2019-10-03
申请号：US16316548
申请日：2017-07-12
申请人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
发明人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/053 , A61B5/00 , A61N1/05 , A61N1/362 , G16H40/63
摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

5. 发明申请

US20120150252A1 Admittance measurement for tuning bi-ventricular pacemakers 审中-公开
标题翻译：调整双心室起搏器的导纳测量
公开(公告)号：US20120150252A1
公开(公告)日：2012-06-14
申请号：US13373850
申请日：2011-12-02
申请人： Marc D. Feldman , John Porterfield , Erik Larson , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Erik Larson , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/36571 , A61B5/0538 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： An apparatus for treating a heart of a patient includes a first lead and at least a second lead for pacing the heart adapted to be in electrical communication with the heart. The apparatus includes a microcontroller in communication with the first and second leads which triggers the first lead at either different times or the same time from when the microcontroller triggers the second lead. Alternatively, the apparatus includes a microcontroller in communication with the first and second leads that determines heart volume, including stroke volume, end-systolic volume, and calculated values including ejection fraction, from admittance from signals from the first and second leads and uses the admittance as feedback to control heart volume ejected, as measured by stroke volume, calculated values such as ejection fraction, and control end-systolic volume, with respect to the first and second leads. A method for treating the heart of a patient.
摘要翻译：一种用于治疗患者心脏的装置包括第一引线和至少第二引线，用于起搏适于与心脏电连通的心脏。该装置包括与第一和第二引线通信的微控制器，其在微控制器触发第二引线的不同时间或同时触发第一引线。或者，该装置包括与第一和第二引线通信的微控制器，其从来自第一和第二引线的信号的导纳确定心脏体积，包括笔画体积，收缩末期容积以及包括射血分数的计算值，并使用导纳作为反馈以控制排出的心脏体积，如通过卒中体积测量的计算值，例如相对于第一和第二引线的射血分数和控制收缩末容积。一种治疗患者心脏的方法。

6. 发明授权

US11478646B2 Method and apparatus for monitoring a patient 有权
公开(公告)号：US11478646B2
公开(公告)日：2022-10-25
申请号：US16316548
申请日：2017-07-12
申请人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
发明人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
IPC分类号： A61N1/36 , A61N1/365 , G16H40/63 , A61B5/0205 , A61B5/0538 , A61B5/00 , A61N1/05 , A61N1/362 , A61B5/029 , A61B5/08
摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

7. 发明申请

US20180078169A1 Method and Apparatus for Monitoring an Organ of a Patient 审中-公开
公开(公告)号：US20180078169A1
公开(公告)日：2018-03-22
申请号：US15816067
申请日：2017-11-17
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61B5/053 , A61B5/00 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/20 , A61B5/107 , A61B5/08 , A61B5/0488 , A61B5/0215 , A61N1/365 , A61N1/39 , A61N1/368
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ. The apparatus includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ. A method for monitoring an organ of a patient includes the steps of detecting with a detector the admittance of the organ. There is the step of transmitting with a transmitter in communication with the detector a wireless signal indicative of admittance of the organ.

8. 发明授权

US11589767B2 Low power apparatus and method to measure complex electrical admittance or impedance 有权
公开(公告)号：US11589767B2
公开(公告)日：2023-02-28
申请号：US16536146
申请日：2019-08-08
申请人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
发明人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
IPC分类号： A61B5/0538 , A61N1/05 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/0215 , A61B5/029
摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

9. 发明授权

US10420952B2 Method and apparatus for treating a patient's heart using hemodynamics 有权
公开(公告)号：US10420952B2
公开(公告)日：2019-09-24
申请号：US13648725
申请日：2012-10-10
申请人： Marc D. Feldman , Erik R. Larson , John A. Pearce , Jonathan W. Valvano , John Porterfield
发明人： Marc D. Feldman , Erik R. Larson , John A. Pearce , Jonathan W. Valvano , John Porterfield
IPC分类号： A61N1/39 , A61B5/02 , A61B5/00
摘要： An apparatus for treating a patient's heart includes a sensor for measuring hemodynamics of the heart. The apparatus includes a processing unit which receives the hemodynamics from the sensor and uses the hemodynamics to determine whether to shock the heart. A method for treating a patient's heart. The method includes the steps of measuring hemodynamics of the heart with a sensor. There is the step of receiving the hemodynamics from the sensor at a processing unit which uses the hemodynamics to determine whether to shock the heart.

10. 发明授权

US09820673B2 Method and apparatus for monitoring an organ of a patient 有权
公开(公告)号：US09820673B2
公开(公告)日：2017-11-21
申请号：US14213473
申请日：2014-03-14
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/05 , A61B5/053 , A61B5/107 , A61B5/20 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/08 , A61B5/029 , A61B5/0295 , A61B5/00 , A61B5/0215 , A61N1/365 , A61N1/368 , A61N1/39
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An implanted device for an organ of a patient including a housing. The device includes a detector having electrodes that have a varying distance over time between them which produces a detector signal based on electrical signals derived from the organ. The device includes a signal processor disposed in the housing in communication with the detector which determines admittance from the detector signal based on the varying distance over time between the electrodes. The device includes a drive circuit disposed in the housing to cause the electrodes to generate emitted electrical signals. A method for monitoring a patient's organ.

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