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1. 发明授权

US08329396B1 Cloned DNA sequences hybridizable with genomic RNA of lymphadenopathy associated virus (LAV) 失效
标题翻译：与淋巴结病相关病毒（LAV）的基因组RNA杂交的克隆DNA序列
公开(公告)号：US08329396B1
公开(公告)日：2012-12-11
申请号：US08052728
申请日：1993-04-27
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses with cloned DNA sequences which are hybridizable to genomic RNA and DNA of lymphadenopathy associated virus. It further relates to the cloned DNA sequences and a process for their preparation.
摘要翻译：本发明在淋巴结病毒病毒领域。本发明涉及用克隆的DNA序列检测淋巴结病毒相关病毒或相关病毒或DNA前病毒的诊断方法和方法，其可与基因组RNA和淋巴结病病毒相关病毒的DNA杂交。它还涉及克隆的DNA序列及其制备方法。

2. 发明授权

US08507196B1 Nucleic acid probe of human immunodeficiency virus type 1 (HIV-1), and a method and kit employing this probe for detecting the presence of nucleic acid of HIV-1 失效
标题翻译：人类免疫缺陷病毒1型（HIV-1）的核酸探针，以及采用该探针检测HIV-1核酸存在的方法和试剂盒
公开(公告)号：US08507196B1
公开(公告)日：2013-08-13
申请号：US08051226
申请日：1993-04-23
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA, or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them, and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

3. 发明授权

US07626013B1 HIV-1 DNA fragments that hybridize to genomic HIV-1DNA 失效
标题翻译：与基因组HIV-1DNA杂交的HIV-1 DNA片段
公开(公告)号：US07626013B1
公开(公告)日：2009-12-01
申请号：US08466921
申请日：1995-06-06
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
IPC分类号： C07H21/04 , A61K39/21 , C12N5/00
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： The inventors have isolated cloned cDNA encoding the RNA genome of Human Immunodeficiency Virus type 1 (HIV-1). Various clones are described, which encode different regions of the genome, including those regions encoding viral antigens or proteins. Hybridization results indicate the difference between the HIV-1 clones and those of HTLV-I and HTLV-II. The inventors have also produced a restriction map of the entire cloned genomic sequence in order to facilitate further subcloning and using the restriction fragments in other hybridization tests and in methods to express encoded sequences.
摘要翻译：发明人分离了编码人类免疫缺陷病毒1型（HIV-1）的RNA基因组的克隆cDNA。描述了编码基因组的不同区域的各种克隆，包括编码病毒抗原或蛋白质的那些区域。杂交结果表明HIV-1克隆与HTLV-I和HTLV-II的克隆之间的差异。本发明人还制备了克隆的整个克隆基因组序列的限制图谱，以促进进一步的亚克隆，并在其它杂交试验和表达编码序列的方法中使用限制性片段。

4. 发明授权

US07585619B1 Method for detecting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity 失效
标题翻译：检测人类免疫缺陷病毒1型（HIV-1）逆转录酶（RT）活性的方法
公开(公告)号：US07585619B1
公开(公告)日：2009-09-08
申请号：US08384248
申请日：1995-02-06
申请人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
发明人： Marc Alizon , Francoise Barre Sinoussi , Pierre Sonigo , Pierre Tiollais , Jean-Claude Chermann , Luc Montagnier , Simon Wain-Hobson
IPC分类号： C12Q1/70 , A61K39/21
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses with cloned DNA sequences which are hybridizable to genomic RNA and DNA of lymphadenopathy associated virus. It further relates to the cloned DNA sequences and a process for their preparation.
摘要翻译：本发明在淋巴结病毒病毒领域。本发明涉及用克隆的DNA序列检测淋巴结病毒相关病毒或相关病毒或DNA前病毒的诊断方法和方法，其可与基因组RNA和淋巴结病病毒相关病毒的DNA杂交。它还涉及克隆的DNA序列及其制备方法。

5. 发明授权

US5843638A Nucleic acids and pepties of human immunodeficiency virus type-1 (HIV-1). 失效
标题翻译：人类免疫缺陷病毒1型（HIV-1）的核酸和肽。
公开(公告)号：US5843638A
公开(公告)日：1998-12-01
申请号：US468387
申请日：1995-06-06
申请人： Luc Montagnier , Bernard Krust , Solange Chamaret , Fran.cedilla.ois Clavel , Jean-Claude Chermann , Fran.cedilla.oise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
发明人： Luc Montagnier , Bernard Krust , Solange Chamaret , Fran.cedilla.ois Clavel , Jean-Claude Chermann , Fran.cedilla.oise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
IPC分类号： C07H21/04 , C12N15/49 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , C12Q1/703 , C12N2740/16122 , C12N2740/16222
摘要： This invention is directed to nucleic acids derived from the pol region of the genome of human immunodeficiency virus type 1 (HIV-1). The nucleic acids are useful as probes for the detection of HIV-1. More particularly, this invention is directed to nucleic acids encoding a pol region of HIV-1 extending from about nucleotide 1856 to about 1906 and extending from about nucleotide 2048 to about nucleotide 2797.
摘要翻译：本发明涉及从人类免疫缺陷病毒1型（HIV-1）的基因组的pol区衍生的核酸。核酸可用作检测HIV-1的探针。更具体地，本发明涉及编码HIV-1的pol区的核酸，其延伸自约核苷酸1856至约1906并从约核苷酸2048延伸至约核苷酸2797。

6. 发明授权

US06440657B1 Nucleic acids and peptides of human immunodeficiency virus type (HIV-1) 失效
标题翻译：人类免疫缺陷病毒型（HIV-1）的核酸和肽
公开(公告)号：US06440657B1
公开(公告)日：2002-08-27
申请号：US09478492
申请日：2000-01-06
申请人： Luc Montangnier , Bernard Krust , Solange Chamaret , François Clavel , Jean-Claude Chermann , Françoise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
发明人： Luc Montangnier , Bernard Krust , Solange Chamaret , François Clavel , Jean-Claude Chermann , Françoise Barre-Sinoussi , Marc Alizon , Pierre Sonigo , Stewart Cole , Olivier Danos , Simon Wain-Hobson
IPC分类号： C12Q170
CPC分类号： C07K14/005 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： The molecular cloning and characterization of a novel human retrovirus, designated lymphadenopathy-associated virus, or LAV, is disclosed. LAV was originally isolated from a patient with acquired immune deficiency syndrome (AIDS). A cloned LAV complementary DNA (cDNA) was used to screen a library of recombinant phages constructed from the genomic DNA of LAV-infected T lymphocytes. The nucleotide sequence of an insert obtained from the recombinant phage clone &lgr;J19 was ascertained through M13 shotgun cloning and the dideoxy chain termination sequencing method. The env coding region was identified and various hydrophilic peptides obtained therefrom. These peptides correspond to amino acids 551-577, 594-603, 621-630, 657-679, and 719-758 of the LAV envelope glycoprotein. These peptides should provide suitable diagnostic reagents for the detection LAV-specific antibodies and for the generation of LAV-specific immunological reagents.
摘要翻译：公开了一种新型人类逆转录病毒（称为淋巴结病相关病毒）或LAV的分子克隆和表征。 LAV最初与获得性免疫缺陷综合征（AIDS）的患者分离。使用克隆的LAV互补DNA（cDNA）筛选由LAV感染的T淋巴细胞的基因组DNA构建的重组噬菌体文库。通过M13霰弹枪克隆和双脱氧链终止测序方法确定从重组噬菌体克隆lambdJ19获得的插入物的核苷酸序列。鉴定了env编码区，并由其获得各种亲水性肽。这些肽对应于LAV包膜糖蛋白的氨基酸551-577,594-603,621-630,657-679和719-758。这些肽应为检测LAV特异性抗体和产生LAV特异性免疫试剂提供合适的诊断试剂。

7. 发明授权

US5747242A Diagnostic kits and methods for detecting antibodies to LAV viruses 失效
标题翻译：用于检测LAV病毒抗体的诊断试剂盒和方法
公开(公告)号：US5747242A
公开(公告)日：1998-05-05
申请号：US466907
申请日：1995-06-06
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： A61K39/00 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/16 , G01N33/569 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C12N2740/16021 , C12N2740/16022 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： A variant of a LAV virus, designated LAV.sub.ELI and cable of causing AIDS. The cDNA and antigens of the LAV.sub.ELI virus can be used for the diagnosis of AIDS an pre-AIDS.
摘要翻译： LAV病毒的一个变体，指定为LAVELI，并导致艾滋病的电缆。 LAVELI病毒的cDNA和抗原可用于艾滋病前期的艾滋病诊断。

8. 发明授权

US06730304B2 Variant of LAV viruses 失效
标题翻译： LAV病毒的变体
公开(公告)号：US06730304B2
公开(公告)日：2004-05-04
申请号：US10017580
申请日：2001-12-18
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： A61K3921
CPC分类号： C12Q1/702 , A61K38/00 , C12N7/00 , C12N2740/16021 , C12N2740/16051 , C12Q1/703 , G01N33/56988
摘要： A variant of a LAV virus, designated LAVMAL and capable of causing AIDS. The cDNA and antigens of the LAVMAL virus can be used for the diagnosis of AIDS and pre-AIDS.
摘要翻译： LAV病毒的一种变体，被指定为LAVMAL并能够引起艾滋病。 LAVMAL病毒的cDNA和抗原可用于艾滋病和艾滋病前期的诊断。

9. 发明授权

US06426073B1 Variant of LAV viruses 失效
标题翻译： LAV病毒的变体
公开(公告)号：US06426073B1
公开(公告)日：2002-07-30
申请号：US09328438
申请日：1999-06-09
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： A61K3921
CPC分类号： C12Q1/702 , A61K38/00 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12N2740/16021 , C12N2740/16051 , C12Q1/703 , G01N33/56988
摘要： The present invention relates to a novel human immunodeficiency virus (HIV) capable of inducing lymphadenopathies (LAS) and acquired immune deficiency syndromes (AIDS) in patients which has been designated the lymphadenopathy associated virus strain MAL (LAVMAL). Although the overall genomic organization of LAVMAL is similar to other known HIV-1 isolates such as LAVBRU and HTLV-III, nevertheless, this virus also displays considerable genotypic and phenotypic diversity as compared to these isolates. A proviral molecular clone of the virus was obtained and characterized. The complete nucleotide sequence of this clone was ascertained and putative regulatory regions (e.g., U3, R, U5,), regulatory elements (e.g., the TATA box, AATAAA polyadenylation signal, primer binding site), and open reading frames (e.g., Gag, Pol, Env, Vif, Vpr, Tat, Rev, Nef) identified. Of particular interest are unique polypeptides derived from the viral envelope. The claimed invention is directed toward isolated LAVMAL Env polypeptides consisting of 5-150 amino acids wherein said peptides contain a LAVMAL-specific epitope. These peptides will prove useful, inter alia, as diagnostic reagents and in the generation of immunological reagents for the detection of the virus.
摘要翻译：本发明涉及能够诱导淋巴结病变（LAS）和获得性免疫缺陷综合征（AIDS）的新型人类免疫缺陷病毒（HIV），其已被称为淋巴结病病毒相关病毒株MAL（LAVMAL）。尽管LAVMAL的整体基因组组织与其他已知的HIV-1分离株如LAVBRU和HTLV-III相似，但是与这些分离株相比，该病毒也显示出相当大的基因型和表型多样性。获得病毒的前病毒分子克隆并进行表征。确定了该克隆的完整核苷酸序列，并推定了调控区（如U3，R，U5），调控元件（如TATA盒，AATAAA多聚腺苷酸化信号，引物结合位点）和开放阅读框（如Gag ，Pol，Env，Vif，Vpr，Tat，Rev，Nef）。特别感兴趣的是衍生自病毒包膜的独特多肽。所要求保护的发明涉及由5-150个氨基酸组成的分离的LAVMAL Env多肽，其中所述肽含有LAVMAL特异性表位。这些肽尤其可用作诊断试剂和产生用于检测病毒的免疫试剂。

10. 发明授权

US5773602A DNA fragments obtained from a novel human immunodeficiency virus designated LAV.sub.MAL 失效
标题翻译：从称为LAVMAL的新型人类免疫缺陷病毒获得的DNA片段
公开(公告)号：US5773602A
公开(公告)日：1998-06-30
申请号：US154397
申请日：1993-11-18
申请人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
发明人： Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Luc Montagnier
IPC分类号： G01N33/569 , A61K38/00 , A61K39/12 , A61K39/21 , C07H21/04 , C07K5/00 , C07K7/00 , C07K14/00 , C07K14/16 , C07K14/705 , C07K16/00 , C07K16/10 , C07K17/00 , C12G1/00 , C12N1/00 , C12N5/00 , C12N5/02 , C12N5/06 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N9/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , F16L58/08 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/577 , C07H21/02
CPC分类号： C12Q1/702 , C12N7/00 , C12Q1/703 , G01N33/56988 , A61K38/00 , C12N2740/10021 , C12N2740/10022 , C12N2740/16021 , C12N2740/16051
摘要： A novel human immunodeficiency virus type 1 (HIV-1) isolate, designated lymphadenopathy-associated virus strain MAL, or LAV.sub.MAL, was molecularly cloned and characterized. Nucleotide sequence analysis demonstrated that the viral genome of LAV.sub.MAL is 9229 nucleotides long. This retrovirus contains the canonical gag, pol, and env genes, as well as ancillary genes encoding Vif (or Q), Vpr (or R), Tat (or S), and Nef (or F). This virus differs significantly, at both the nucleotide and amino acid sequence levels, from prototypical HIV isolates (e.g., HTLV-III, LAV.sub.BRU, and ARV). DNA fragments corresponding to the various gene products and regulatory regions are disclosed. These fragments are useful, inter alia, as probes in diagnostic assays and for the generation of recombinant proteins.
摘要翻译：分子克隆和表征了一种新型人类免疫缺陷病毒1型（HIV-1）分离物，称为淋巴结病相关病毒株MAL或LAVMAL。核苷酸序列分析表明，LAVMAL的病毒基因组长度为9229个核苷酸。该逆转录病毒包含标准gag，pol和env基因，以及编码Vif（或Q），Vpr（或R），Tat（或S）和Nef（或F）的辅助基因。来自原型HIV分离株（例如，HTLV-III，LAVBRU和ARV）的核苷酸和氨基酸序列水平的这种病毒显着不同。公开了对应于各种基因产物和调节区的DNA片段。这些片段尤其可用作诊断测定中的探针和重组蛋白的产生。

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