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1. 发明授权

US6039727A Channel forming device with penetration limiter 失效
标题翻译：具有穿透限制器的通道形成装置
公开(公告)号：US6039727A
公开(公告)日：2000-03-21
申请号：US584957
申请日：1996-01-11
申请人： Manuel A. Javier, Jr. , Stephen B. Pearce , Randy J. Kesten , Sam G. Payne , Kevin Gertner
发明人： Manuel A. Javier, Jr. , Stephen B. Pearce , Randy J. Kesten , Sam G. Payne , Kevin Gertner
IPC分类号： A61B18/20 , A61B17/00 , A61B18/22 , A61B19/00 , A61N5/06
CPC分类号： A61B18/22 , A61B2017/00247 , A61B2017/0046 , A61B2018/00392 , A61B2090/036
摘要： An laser device for forming channels within an outer wall of a patient's heart which has an elongated optical fiber, a lens or probe tip secured to the distal end of the optical fiber and means to limit the penetration of the probe tip or lens. Preferably, an outer support sleeve is secured to the proximal portion of the probe tip and a distal portion of the optical fiber proximal to the probe tip. In one preferred embodiment of the invention, a helical coil is disposed between the distal portion of the optical fiber and the proximal portion of the probe tip to ensure a better bond therebetween, particularly when the optical fiber has a lubricous fluoropolymer coating.
摘要翻译：一种用于在患者心脏的外壁内形成通道的激光装置，其具有细长的光纤，固定到光纤的远端的透镜或探针尖端，以及限制探针尖端或透镜的穿透的装置。优选地，外部支撑套筒固定到探针尖端的近端部分，并且光纤的远端部分靠近探针尖端。在本发明的一个优选实施例中，螺旋线圈设置在光纤的远端部分和探针尖端的近端部分之间，以确保其间的更好的粘合，特别是当光纤具有润滑的含氟聚合物涂层时。

2. 发明授权

US06322548B1 Delivery catheter system for heart chamber 失效
标题翻译：心室输送导管系统
公开(公告)号：US06322548B1
公开(公告)日：2001-11-27
申请号：US09052971
申请日：1998-03-31
申请人： Sam G. Payne , Randy J. Kesten , Michael Aita , Stewart Kume , Stephen B. Pearce , Manuel A. Javier, Jr. , Michael H. Rosenthal
发明人： Sam G. Payne , Randy J. Kesten , Michael Aita , Stewart Kume , Stephen B. Pearce , Manuel A. Javier, Jr. , Michael H. Rosenthal
IPC分类号： A61M3100
CPC分类号： A61B18/24 , A61B17/0218 , A61B17/32002 , A61B17/3203 , A61B17/3478 , A61B18/12 , A61B90/39 , A61B2017/00243 , A61B2017/00247 , A61B2017/003 , A61B2017/22082 , A61B2017/2905 , A61B2017/2927 , A61B2017/320004 , A61B2017/3488 , A61B2018/00392 , A61B2090/036 , A61M25/0041 , A61M25/0084 , A61M25/0662 , A61M2025/0089 , A61M2210/125
摘要： A delivery catheter system for delivering a substance delivery member into a patient's left ventricle which includes a first delivery catheter with a shaped distal extremity configured to be aligned with or parallel to a longitudinal axis or long dimension of the patient's left ventricle and a second delivery catheter slidably and rotatably disposed within an inner lumen of the first delivery catheter which has a shaped distal shaft section and an inner lumen configured to slidably receive a substance delivery member such as an elongated cannula slidably disposed within a polymer sheath. The shaped distal section of the first delivery catheter is shaped or is shapeable within the patient's heart chamber. The second delivery catheter is advanced out of the inner lumen of the first delivery catheter until the distal end extends out of the port in the distal end of the first delivery catheter and provides a passageway for substance delivery member to engage the endocardial surface at a perpendicular or near perpendicular orientation.
摘要翻译：一种输送导管系统，用于将物质递送部件输送到患者的左心室中，该输送导管系统包括具有成形远端的第一输送导管，该第一输送导管被构造为与患者的左心室的纵向轴线或长度尺寸对准或平行，可滑动地和可旋转地设置在第一输送导管的内腔内，该第一输送导管具有成形的远端轴部分和内腔，其构造成可滑动地容纳诸如可滑动地设置在聚合物护套内的细长插管的物质输送构件。第一输送导管的形状的远端部分在患者的心室内成形或可成形。第二输送导管从第一输送导管的内腔推出，直到远端从第一输送导管的远端中的端口延伸出来，并且提供用于物质输送构件在垂直方向上接合心内膜表面的通道或近垂直取向。

3. 发明授权

US06036677A Catheter with flexible intermediate section 失效
公开(公告)号：US06036677A
公开(公告)日：2000-03-14
申请号：US123880
申请日：1998-07-28
申请人： Manuel A. Javier, Jr. , Stephen B. Pearce , Sam G. Payne , Randy J. Kesten
发明人： Manuel A. Javier, Jr. , Stephen B. Pearce , Sam G. Payne , Randy J. Kesten
IPC分类号： A61B17/00 , A61M25/00 , A61M25/06 , A61M5/00
CPC分类号： A61M25/0662 , A61M25/0054 , A61B2017/00247 , A61B2018/00392
摘要： An intraluminal catheter with an elongated tubular shaft with proximal, intermediate, and distal shaft sections for positioning a therapeutic or diagnostic device within a patient's body region such as a heart chamber. The intermediate shaft section has greater flexibility than the proximal or distal shaft sections, and is preferably of sufficient flexibility to easily assume the curvature of the patient's aortic arch, and reduce the force of contact between the catheter distal end and tissue defining the patient's body region to thereby reduce restriction on the rotation of the catheter. The flexible intermediate shaft section is preferably of a length to occupy a significant portion of the aortic arch, and the catheter overall length is preferably sufficient to have a catheter proximal extremity extending out of the patient and a distal extremity extending at least into an aortic passageway adjacent the patient's left ventricle.

4. 发明授权

US5951567A Introducer for channel forming device 失效
标题翻译：通道成型装置的引导者
公开(公告)号：US5951567A
公开(公告)日：1999-09-14
申请号：US900208
申请日：1997-07-24
申请人： Manuel A. Javier, Jr. , Stephen B. Pearce , Randy J. Kesten , Sam G. Payne
发明人： Manuel A. Javier, Jr. , Stephen B. Pearce , Randy J. Kesten , Sam G. Payne
IPC分类号： A61B17/00 , A61B19/00 , A61M23/00 , A61M25/06 , A61F11/00
CPC分类号： A61B17/00 , A61B2017/00247 , A61B2018/00392 , A61B2090/033 , A61M25/0662
摘要： The invention is directed to an introducer which is formed of a relatively rigid tubular member having an inner lumen and an elongated slot in the distal portion of the introducer. The introducer is particularly suitable for introducing an elongated channel forming device having radially extending arms for limiting the depth of penetration into a guiding or delivery catheter. By pulling the channel forming member into the inner lumen of the introducer, the radially extending arms are bent or folded forwardly into the inner lumen and they remain in this position until they extend out the distal end of the guiding or delivery catheter.
摘要翻译：本发明涉及一种导引器，其由相对刚性的管状构件形成，该管状构件具有内腔和导引器的远端部分中的细长狭槽。导引器特别适用于引入具有径向延伸臂的细长通道形成装置，用于限制穿透深度进入导向或输送导管。通过将通道形成构件拉入导引器的内腔中，径向延伸的臂向前弯曲或折叠到内腔中，并且它们保持在该位置，直到它们延伸出引导或输送导管的远端。

5. 发明授权

US06723082B1 Delivery catheter system for heart chamber 失效
标题翻译：心室输送导管系统
公开(公告)号：US06723082B1
公开(公告)日：2004-04-20
申请号：US09405937
申请日：1999-09-27
申请人： Sam G. Payne , Randy J. Kesten , Michael Aita , Stewart M. Kume , Stephen B. Pearce , Manuel A. Javier, Jr.
发明人： Sam G. Payne , Randy J. Kesten , Michael Aita , Stewart M. Kume , Stephen B. Pearce , Manuel A. Javier, Jr.
IPC分类号： A61M2501
CPC分类号： A61M25/0084 , A61B17/0218 , A61B17/32002 , A61B17/3203 , A61B17/3478 , A61B18/12 , A61B18/24 , A61B90/39 , A61B2017/00243 , A61B2017/00247 , A61B2017/003 , A61B2017/00703 , A61B2017/22082 , A61B2017/2905 , A61B2017/2927 , A61B2017/320004 , A61B2017/3488 , A61B2018/00392 , A61B2090/036 , A61M25/0041 , A61M25/0662 , A61M2025/0089 , A61M2025/0096 , A61M2210/125
摘要： Apparatus and methods for delivering an angiogenic agent to a site within the heart. Either using a percutaneous, intraoperative or minimally invasive approach, an elongated member containing an angiogenic agent is guided to a heart wall and the agent is dispensed into heart tissue. Additional fluids or substances can be dispensed in combination with the angiogenic agent to provide visualization and site mapping. In certain embodiments, the angiogenic agent is delivered adjunctively with the administration of energy, such as laser energy or RF energy which disturbs the heart tissue sufficiently to enhance the effects of the angiogenic agent. A delivery catheter system for delivering a substance delivery member into a patient's left ventricle which includes a first delivery catheter with a shaped distal extremity configured to be aligned with or parallel to a longitudinal axis or long dimension of the patient's left ventricle and a second delivery catheter slidably and rotatably disposed within an inner lumen of the first delivery catheter which has a shaped distal shaft section and an inner lumen configured to slidably receive a substance delivery member such as an elongated cannula slidably disposed within a polymer sheath.
摘要翻译：用于将血管生成剂递送到心脏内的部位的装置和方法。使用经皮，术中或微创方法，将含有血管生成剂的细长构件引导至心脏壁，并将试剂分配到心脏组织中。额外的流体或物质可以与血管生成剂组合分配，以提供可视化和位点作图。在某些实施方案中，血管生成剂通过施加能量（例如激光能量或RF能量）辅助递送，其能够充分地干扰心脏组织以增强血管发生剂的作用。一种输送导管系统，用于将物质递送部件输送到患者的左心室中，该输送导管系统包括具有成形远端的第一输送导管，该第一输送导管被构造为与患者的左心室的纵向轴线或长度尺寸对准或平行，可滑动地和可旋转地设置在第一输送导管的内腔内，该第一输送导管具有成形的远端轴部分和内腔，其构造成可滑动地容纳诸如可滑动地设置在聚合物护套内的细长插管的物质输送构件。

6. 发明授权

US06285903B1 Intracorporeal device with radiopaque marker 失效
标题翻译：具有不透射线标记的体内器械
公开(公告)号：US06285903B1
公开(公告)日：2001-09-04
申请号：US09107843
申请日：1998-06-30
申请人： Michael H. Rosenthal , Manuel A. Javier, Jr. , Sam G. Payne , Stephen B. Pearce , Randy J. Kesten
发明人： Michael H. Rosenthal , Manuel A. Javier, Jr. , Sam G. Payne , Stephen B. Pearce , Randy J. Kesten
IPC分类号： A61B505
CPC分类号： A61M25/0108 , A61B6/12 , A61B90/39
摘要： An intracorporeal device generally having an elongate shaft with an asymmetric radiopaque marker disposed upon or within the distal end thereof. The radiopaque marker member enables the user to determine the orientation of the distal end of the device under fluoroscopic and similar imaging techniques. In certain embodiments the device is configured as a delivery catheter system having multiple delivery catheters, some or all of which may have radiopaque marker members disposed upon or within their distal ends. The delivery catheter system is configured in some embodiments to deliver an elongated diagnostic or therapeutic device to a desired location within a patient's heart.
摘要翻译：体内装置通常具有设置在其远端上或其远端内的具有不对称不透射线标记的细长轴。不透射线的标记构件使得用户能够在荧光镜和类似成像技术下确定装置的远端的取向。在某些实施例中，该装置被配置为具有多个输送导管的递送导管系统，其中一些或全部可具有设置在其远端上或其远端内的不透射线的标记构件。输送导管系统在一些实施例中被配置以将细长的诊断或治疗装置递送到患者心脏内的期望位置。

7. 发明授权

US6093177A Catheter with flexible intermediate section 失效
公开(公告)号：US6093177A
公开(公告)日：2000-07-25
申请号：US813503
申请日：1997-03-07
申请人： Manuel A. Javier, Jr. , Stephen B. Pearce , Sam G. Payne , Randy J. Kesten
发明人： Manuel A. Javier, Jr. , Stephen B. Pearce , Sam G. Payne , Randy J. Kesten
IPC分类号： A61B17/00 , A61M25/00 , A61M25/06
CPC分类号： A61M25/0662 , A61M25/0054 , A61B2017/00247 , A61B2018/00392
摘要： An intraluminal catheter with an elongated tubular shaft with proximal, intermediate, and distal shaft sections for positioning a therapeutic or diagnostic device within a patient's body region such as a heart chamber. The intermediate shaft section has greater flexibility than the proximal or distal shaft sections, and is preferably of sufficient flexibility to easily assume the curvature of the patient's aortic arch, and reduce the force of contact between the catheter distal end and tissue defining the patient's body region to thereby reduce restriction on the rotation of the catheter. The flexible intermediate shaft section is preferably of a length to occupy a significant portion of the aortic arch, and the catheter overall length is preferably sufficient to have a catheter proximal extremity extending out of the patient and a distal extremity extending at least into an aortic passageway adjacent the patient's left ventricle.

8. 发明授权

US06830568B1 Guiding catheter system for ablating heart tissue 失效
标题翻译：引导导管系统用于消融心脏组织
公开(公告)号：US06830568B1
公开(公告)日：2004-12-14
申请号：US09655162
申请日：2000-09-05
申请人： Randy J. Kesten , Manuel A. Javier, Jr.
发明人： Randy J. Kesten , Manuel A. Javier, Jr.
IPC分类号： A61B1818
CPC分类号： A61M25/0041 , A61B17/0218 , A61B17/32002 , A61B17/3203 , A61B17/3478 , A61B18/12 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/003 , A61B2017/22082 , A61B2017/2905 , A61B2017/2927 , A61B2017/320004 , A61B2017/3488 , A61B2018/00392 , A61M25/0662 , A61M2210/125
摘要： A guiding catheter system for delivering an elongated therapeutic or diagnostic device into a patient's left ventricle which includes a first guiding catheter with a shaped distal extremity configured to be aligned with or parallel to a longitudinal axis or long dimension of the patient's left ventricle and a second guiding catheter slidably and rotatably disposed within an inner lumen of the first guiding catheter which has a shaped distal shaft section and an inner lumen configured to slidably receive an elongated therapeutic or diagnostic device such as a tissue ablation device, e.g. an optical fiber connected to a laser source, an ultrasonic energy emitting device or a radio frequency energy emitting device. The shaped distal section of the first guiding catheter is shaped or is shapable within the patient's heart chamber. The second guiding catheter is advanced out of the inner lumen of the first guiding catheter until the distal end extends out of the port in the distal end of the first guiding catheter and provides a passageway for the therapeutic or diagnostic device to engage the endocardium surface at a perpendicular or near perpendicular orientation.
摘要翻译：一种用于将细长的治疗或诊断装置输送到患者的左心室中的引导导管系统，其包括具有成形的远端末端的第一引导导管，其被配置为与患者的左心室的纵向轴线或长度尺寸对准或平行，引导导管可滑动地和可旋转地设置在第一引导导管的内腔内，该内腔具有成形的远端轴部分和内腔，其构造成可滑动地容纳细长的治疗或诊断装置，例如组织消融装置，连接到激光源的光纤，超声能量发射装置或射频能量发射装置。第一引导导管的形状的远端部分成形或可在患者的心脏腔室内成形。第二引导导管从第一引导导管的内腔推出，直到远端延伸出第一引导导管的远端中的端口为止，并且为治疗或诊断装置提供通道，以使内心膜表面垂直或近垂直取向。

9. 发明授权

US06251104B1 Guiding catheter system for ablating heart tissue 失效
标题翻译：引导导管系统用于消融心脏组织
公开(公告)号：US06251104B1
公开(公告)日：2001-06-26
申请号：US08962530
申请日：1997-10-31
申请人： Randy J. Kesten , Manuel A. Javier, Jr.
发明人： Randy J. Kesten , Manuel A. Javier, Jr.
IPC分类号： A61N506
CPC分类号： A61B18/24 , A61B17/0218 , A61B17/32002 , A61B17/3203 , A61B17/3478 , A61B18/12 , A61B2017/00243 , A61B2017/00247 , A61B2017/003 , A61B2017/22082 , A61B2017/2905 , A61B2017/2927 , A61B2017/320004 , A61B2017/3488 , A61B2018/00392 , A61M25/0041 , A61M25/0662 , A61M2210/125
摘要： A guiding catheter system for delivering an elongated therapeutic or diagnostic device into a patient's left ventricle which includes a first guiding catheter with a shaped distal extremity configured to be aligned with or parallel to a longitudinal axis or long dimension of the patient's left ventricle and a second guiding catheter slidably and rotatably disposed within an inner lumen of the first guiding catheter which has a shaped distal shaft section and an inner lumen configured to slidably receive an elongated therapeutic or diagnostic device such as a tissue ablation device, e.g. an optical fiber connected to a laser source, an ultrasonic energy emitting device or a radio frequency energy emitting device. The shaped distal section of the first guiding catheter is shaped or is shapable within the patient's heart chamber. The second guiding catheter is advanced out of the inner lumen of the first guiding catheter until the distal end extends out of the port in the distal end of the first guiding catheter and provides a passageway for the therapeutic or diagnostic device to engage the endocardium surface at a perpendicular or near perpendicular orientation.
摘要翻译：一种用于将细长的治疗或诊断装置输送到患者的左心室中的引导导管系统，其包括具有成形的远端末端的第一引导导管，其被配置为与患者的左心室的纵向轴线或长度尺寸对准或平行，引导导管可滑动地和可旋转地设置在第一引导导管的内腔内，该内腔具有成形的远端轴部分和内腔，其构造成可滑动地容纳细长的治疗或诊断装置，例如组织消融装置，连接到激光源的光纤，超声能量发射装置或射频能量发射装置。第一引导导管的形状的远端部分成形或可在患者的心脏腔室内成形。第二引导导管从第一引导导管的内腔推出，直到远端延伸出第一引导导管的远端中的端口为止，并且为治疗或诊断装置提供通道，以使内心膜表面垂直或近垂直取向。

10. 发明授权

US06592575B1 Guiding catheter system for ablating heart tissue 失效
标题翻译：引导导管系统用于消融心脏组织
公开(公告)号：US06592575B1
公开(公告)日：2003-07-15
申请号：US09654723
申请日：2000-09-05
申请人： Randy J. Kesten , Manuel A. Javier, Jr.
发明人： Randy J. Kesten , Manuel A. Javier, Jr.
IPC分类号： A61B1818
CPC分类号： A61B18/24 , A61B17/0218 , A61B17/32002 , A61B17/3203 , A61B17/3478 , A61B18/12 , A61B2017/00243 , A61B2017/00247 , A61B2017/003 , A61B2017/22082 , A61B2017/2905 , A61B2017/2927 , A61B2017/320004 , A61B2017/3488 , A61B2018/00392 , A61M25/0041 , A61M25/0662 , A61M2210/125
摘要： A guiding catheter system for delivering an elongated therapeutic or diagnostic device into a patient's left ventricle which includes a first guiding catheter with a shaped distal extremity configured to be aligned with or parallel to a longitudinal axis or long dimension of the patient's left ventricle and a second guiding catheter slidably and rotatably disposed within an inner lumen of the first guiding catheter which has a shaped distal shaft section and an inner lumen configured to slidably receive an elongated therapeutic or diagnostic device such as a tissue ablation device, e.g. an optical fiber connected to a laser source, an ultrasonic energy emitting device or a radio frequency energy emitting device. The shaped distal section of the first guiding catheter is shaped or is shapable within the patient's heart chamber. The second guiding catheter is advanced out of the inner lumen of the first guiding catheter until the distal end extends out, of the port in the distal end of the first guiding catheter and provides a passageway for the therapeutic or diagnostic device to engage the endocardium surface at a perpendicular or near perpendicular orientation.
摘要翻译：一种用于将细长的治疗或诊断装置输送到患者的左心室中的引导导管系统，其包括具有成形的远端末端的第一引导导管，其被配置为与患者的左心室的纵向轴线或长度尺寸对准或平行，引导导管可滑动地和可旋转地设置在第一引导导管的内腔内，该内腔具有成形的远端轴部分和内腔，其构造成可滑动地容纳细长的治疗或诊断装置，例如组织消融装置，连接到激光源的光纤，超声能量发射装置或射频能量发射装置。第一引导导管的形状的远端部分成形或可在患者的心脏腔室内成形。第二引导导管从第一引导导管的内腔推出直到远端延伸出第一引导导管的远端中的端口，并且提供用于治疗或诊断装置接合心内膜表面的通道在垂直或接近垂直取向。

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