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    • 7. 发明申请
    • Reagentless Ceria-Based Colorimetric Sensor
    • 无基于Ceria的比色传感器
    • US20140220608A1
    • 2014-08-07
    • US14244437
    • 2014-04-03
    • Emanuela Silvana AndreescuMaryna OrnatskaCristina R. IspasDaniel Andreescu
    • Emanuela Silvana AndreescuMaryna OrnatskaCristina R. IspasDaniel Andreescu
    • C12Q1/60C12Q1/54C12Q1/26
    • C12Q1/60C12Q1/26C12Q1/54G01N21/78G01N21/8483G01N31/228G01N33/587Y10T436/206664
    • A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
    • 纳米颗粒,复合纳米颗粒和纳米颗粒涂层形式的比色试剂,包括使用方法,制备方法,相关设备的沉积和组装以及具体应用。 比色试剂包括氧化铈纳米颗粒,其用于溶液中或固定在固体支持物上,单独或与氧化酶结合,形成与分析物反应形成有色复合物的活性比色组分。 颜色变化率和颜色强度与样品中存在的分析物的量成比例。 还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。 进一步描述了所公开技术的各种相关应用,包括临床诊断,体内可植入装置,食品安全和发酵控制。
    • 8. 发明申请
    • Reagentless Ceria-Based Colorimetric Sensor
    • 无基于Ceria的比色传感器
    • US20120315659A1
    • 2012-12-13
    • US13156755
    • 2011-06-09
    • Emanuela Silvana AndreescuMaryna OrnatskaCristina R. IspasDaniel Andreescu
    • Emanuela Silvana AndreescuMaryna OrnatskaCristina R. IspasDaniel Andreescu
    • C12Q1/26G01N21/00G01N33/00
    • C12Q1/60C12Q1/26C12Q1/54G01N21/78G01N21/8483G01N31/228G01N33/587Y10T436/206664
    • A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
    • 纳米颗粒,复合纳米颗粒和纳米颗粒涂层形式的比色试剂,包括使用方法,制备方法,相关设备的沉积和组装以及具体应用。 比色试剂包括氧化铈纳米颗粒,其用于溶液中或固定在固体支持物上,单独或与氧化酶结合,形成与分析物反应形成有色复合物的活性比色组分。 颜色变化率和颜色强度与样品中存在的分析物的量成比例。 还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。 进一步描述了所公开技术的各种相关应用,包括临床诊断,体内可植入装置,食品安全和发酵控制。
    • 9. 发明授权
    • Reagentless ceria-based colorimetric sensor
    • 无试剂二氧化铈基比色传感器
    • US08691520B2
    • 2014-04-08
    • US13156755
    • 2011-06-09
    • Emanuela Silvana AndreescuMaryna OrnatskaCristina R. IspasDaniel Andreescu
    • Emanuela Silvana AndreescuMaryna OrnatskaCristina R. IspasDaniel Andreescu
    • C12Q1/48
    • C12Q1/60C12Q1/26C12Q1/54G01N21/78G01N21/8483G01N31/228G01N33/587Y10T436/206664
    • A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
    • 纳米颗粒,复合纳米颗粒和纳米颗粒涂层形式的比色试剂,包括使用方法,制备方法,相关设备的沉积和组装以及具体应用。 比色试剂包括氧化铈纳米颗粒,其用于溶液中或固定在固体支持物上,单独或与氧化酶结合,形成与分析物反应形成有色复合物的活性比色组分。 颜色变化率和颜色强度与样品中存在的分析物的量成比例。 还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。 进一步描述了所公开技术的各种相关应用,包括临床诊断,体内可植入装置,食品安全和发酵控制。