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1. 发明授权

US08119248B2 Organic-inorganic hybrid free standing film, and its production method 有权
标题翻译：有机 - 无机杂化自立膜及其制备方法
公开(公告)号：US08119248B2
公开(公告)日：2012-02-21
申请号：US12433512
申请日：2009-04-30
申请人： Makoto Sawada , Taisei Nishimi , Jiro Tsukahara , Shuuji Kanayama , Ritsuko Morita
发明人： Makoto Sawada , Taisei Nishimi , Jiro Tsukahara , Shuuji Kanayama , Ritsuko Morita
IPC分类号： B05D3/00
CPC分类号： B01D67/0079 , Y10T428/31855
摘要： A free standing film having excellent mechanical strength and flexibility as well as sufficient area is provided. The organic-inorganic hybrid free standing film includes an organic polymer having a constitutional repeating unit derived from a monomer represented by general formula (1) and a hydrolytic condensate of a metal alkoxide.
摘要翻译：提供了具有优异的机械强度和柔韧性以及足够面积的自立式膜。有机 - 无机混合自立膜包括具有来自由通式（1）表示的单体的构成重复单元和金属醇盐的水解缩合物的有机聚合物。

2. 发明申请

US20090274842A1 ORGANIC-INORGANIC HYBRID FREE STANDING FILM, AND ITS PRODUCTION METHOD 有权
标题翻译：有机 - 无机杂交免费立式电影及其制作方法
公开(公告)号：US20090274842A1
公开(公告)日：2009-11-05
申请号：US12433512
申请日：2009-04-30
申请人： Makoto SAWADA , Taisei Nishimi , Jiro Tsukahara , Shuuji Kanayama , Ritsuko Morita
发明人： Makoto SAWADA , Taisei Nishimi , Jiro Tsukahara , Shuuji Kanayama , Ritsuko Morita
IPC分类号： B05D3/00 , C08K3/10
CPC分类号： B01D67/0079 , Y10T428/31855
摘要： A free standing film having excellent mechanical strength and flexibility as well as sufficient area is provided. The organic-inorganic hybrid free standing film includes an organic polymer having a constitutional repeating unit derived from a monomer represented by general formula (1) and a hydrolytic condensate of a metal alkoxide.
摘要翻译：提供了具有优异的机械强度和柔韧性以及足够面积的自立式膜。有机 - 无机混合自立膜包括具有来自由通式（1）表示的单体的构成重复单元和金属醇盐的水解缩合物的有机聚合物。

3. 发明授权

US08574904B2 Method for production of mesenchymal cell, method for production of tooth, and mesenchymal cell for formation of tooth 失效
标题翻译：生产间充质细胞的方法，牙齿生产方法和牙髓形成间充质细胞
公开(公告)号：US08574904B2
公开(公告)日：2013-11-05
申请号：US12523918
申请日：2008-01-18
申请人： Takashi Tsuji , Ritsuko Morita
发明人： Takashi Tsuji , Ritsuko Morita
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0654 , A61K6/02 , A61K35/12 , C12N2500/30 , C12N2500/62 , C12N2501/385 , C12N2506/02
摘要： The present invention provides a method for producing mesenchymal cells for production of mesenchymal cells for formation of a tooth, the method comprising: culturing totipotent stem cells in the presence of a differentiation inducer to produce a cell population after differentiation induction treatment, the cell population containing CD44-positive and CD29-positive cells or CD44-positive and CD106-positive cells; and selecting, from the cell population after the differentiation induction treatment, the CD44-positive and CD29-positive cells or CD44-positive and CD106-positive cells as the mesenchymal cells for the formation of the tooth. The present invention also provides a method for producing a tooth comprising: positioning, in a support carrier capable of retaining cells in a state of contacting therewith, a first cell mass substantially consisting of only either one of mesenchymal cells and epithelial cells and a second cell mass substantially consisting of only the other one of the mesenchymal cells and epithelial cells, the first and second cell masses being not mixed with each other but made to closely contact with each other; and culturing the first and second cell masses; wherein the mesenchymal cells comprise the mesenchymal cells for the formation of the tooth.
摘要翻译：本发明提供了一种生产用于形成牙齿的间充质细胞的间充质细胞的方法，所述方法包括：在分化诱导剂存在下培养全能干细胞，以在分化诱导处理后产生细胞群，所述细胞群含有 CD44阳性和CD29阳性细胞或CD44阳性和CD106阳性细胞; 并从分化诱导治疗后的细胞群中选择CD44阳性和CD29阳性细胞或CD44阳性和CD106阳性细胞作为形成牙齿的间充质细胞。本发明还提供了一种牙齿的制造方法，包括：将能够保持与其接触的细胞的支撑载体定位为基本上由间充质细胞和上皮细胞中的任一种组成的第一细胞团和第二细胞质量基本上仅由间充质细胞和上皮细胞中的另一个组成，第一和第二细胞团彼此不混合但彼此紧密接触; 培养第一和第二细胞团; 其中间质细胞包含用于形成牙齿的间充质细胞。

4. 发明申请

US20100119997A1 METHOD FOR PRODUCTION OF MESENCHYMAL CELL, METHOD FOR PRODUCTION OF TOOTH, AND MESENCHYMAL CELL FOR FORMATION OF TOOTH 失效
标题翻译：用于生产细胞的方法，用于生产牙齿的方法和用于形成牙齿的中胚层细胞
公开(公告)号：US20100119997A1
公开(公告)日：2010-05-13
申请号：US12523918
申请日：2008-01-18
申请人： Takashi Tsuji , Ritsuko Morita
发明人： Takashi Tsuji , Ritsuko Morita
IPC分类号： A61C13/00 , C12N5/077
CPC分类号： C12N5/0654 , A61K6/02 , A61K35/12 , C12N2500/30 , C12N2500/62 , C12N2501/385 , C12N2506/02
摘要： The present invention provides a method for producing mesenchymal cells for production of mesenchymal cells for formation of a tooth, the method comprising: culturing totipotent stem cells in the presence of a differentiation inducer to produce a cell population after differentiation induction treatment, the cell population containing CD44-positive and CD29-positive cells or CD44-positive and CD 106-positive cells; and selecting, from the cell population after the differentiation induction treatment, the CD44-positive and CD29-positive cells or CD44-positive and CD 106-positive cells as the mesenchymal cells for the formation of the tooth. The present invention also provides a method for producing a tooth comprising: positioning, in a support carrier capable of retaining cells in a state of contacting therewith, a first cell mass substantially consisting of only either one of mesenchymal cells and epithelial cells and a second cell mass substantially consisting of only the other one of the mesenchymal cells and epithelial cells, the first and second cell masses being not mixed with each other but made to closely contact with each other; and culturing the first and second cell masses; wherein the mesenchymal cells comprise the mesenchymal cells for the formation of the tooth.
摘要翻译：本发明提供了一种生产用于形成牙齿的间充质细胞的间充质细胞的方法，所述方法包括：在分化诱导剂存在下培养全能干细胞，以在分化诱导处理后产生细胞群，所述细胞群含有 CD44阳性和CD29阳性细胞或CD44阳性和CD106阳性细胞; 并从分化诱导处理后的细胞群中选择CD44阳性和CD29阳性细胞或CD44阳性和CD106阳性细胞作为形成牙齿的间充质细胞。本发明还提供了一种牙齿的制造方法，包括：将能够保持与其接触的细胞的支撑载体定位为基本上由间充质细胞和上皮细胞中的任一种组成的第一细胞团和第二细胞质量基本上仅由间充质细胞和上皮细胞中的另一个组成，第一和第二细胞团彼此不混合但彼此紧密接触; 培养第一和第二细胞团; 其中间质细胞包含用于形成牙齿的间充质细胞。

5. 发明授权

US08258146B2 Minoxidil aqueous composition containing bile acid 有权
标题翻译：含有胆汁酸的米诺地尔含水组合物
公开(公告)号：US08258146B2
公开(公告)日：2012-09-04
申请号：US12728915
申请日：2010-03-22
申请人： Ritsuko Morita , Katsuhiko Kanazawa
发明人： Ritsuko Morita , Katsuhiko Kanazawa
IPC分类号： A61K31/506 , C07J9/00
CPC分类号： A61K8/4953 , A61K8/63 , A61K9/0014 , A61K9/10 , A61K31/506 , A61K31/575 , A61K45/06 , A61Q5/02 , A61Q7/00 , A61K2300/00
摘要： An object of the present invention is to provide a liquid composition wherein minoxidil can be dissolved at a relatively high concentration (the saturating amount or above), stimulation of skin and stickiness is suppressed without containing an organic solvent, and excellent effects of percutaneous absorption is achieved. The present invention provides a liquid composition comprising (i) minoxidil, (ii) bile acid or a salt thereof, and (iii) an aqueous medium in an amount of 30% by weight or more of the weight of the composition.
摘要翻译：本发明的目的是提供一种液体组合物，其中米诺地尔可以以相对高的浓度（饱和量或以上）溶解，抑制皮肤刺激和粘性，而不含有机溶剂，并且经皮吸收的优异作用是实现了本发明提供一种液体组合物，其包含（i）米诺地尔，（ii）胆汁酸或其盐，和（iii）含量为组合物重量的30重量％以上的水性介质。

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