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1. 发明申请

US20060142222A1 Novel gene relating to fibrotic conditions 审中-公开
标题翻译：与纤维化病症有关的新基因
公开(公告)号：US20060142222A1
公开(公告)日：2006-06-29
申请号：US10547710
申请日：2004-03-03
申请人： Makoto Ogino , Tomohiro Hirose , Kazumi Hayashi , Tomonobu Koizumi , Toshihide Yokoyama
发明人： Makoto Ogino , Tomohiro Hirose , Kazumi Hayashi , Tomonobu Koizumi , Toshihide Yokoyama
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/04 , A61K38/54 , C12N9/99
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4712 , G01N2500/10
摘要： This discloses a novel human or rat polypeptide useful in improving and/or preventing organ fibrosis and a polynucleotide encoding the aforementioned polypeptide, an expression vector containing the aforementioned polynucleotide, and a cell transfected with the aforementioned expression vector. The aforementioned polynucleotide shows a remarkable decrease in the expression dose in the kidney of a chronic renal insufficiency model rat and in the bladder of a rat suffering from the induction of fibrotic conditions in the bladder, compared with a normal individual. Also, the production of extracellular matrix is suppressed by overexpression of the aforementioned polypeptide. Also disclosed are the promoter region of the aforementioned polypeptide, a method for screening a remedy for fibrotic conditions, and a process for producing a medicinal composition for improving fibrotic conditions which contains a substance obtained by the aforementioned screening method as the active ingredient.
摘要翻译：这公开了可用于改善和/或预防器官纤维化的新型人或大鼠多肽和编码上述多肽的多核苷酸，含有上述多核苷酸的表达载体和用上述表达载体转染的细胞。与正常个体相比，上述多核苷酸表现出慢性肾功能不全模型大鼠肾脏和膀胱中诱导纤维化病症的大鼠膀胱中的表达剂量显着降低。此外，通过上述多肽的过表达来抑制细胞外基质的产生。还公开了上述多肽的启动子区域，筛选纤维化病症的治疗方法，以及生产用于改善纤维化病症的药物组合物的方法，其含有通过上述筛选方法获得的物质作为活性成分。

2. 发明授权

US4437192A Implants of biologically active glass or glass ceramic containing titania 失效
标题翻译：含有二氧化钛的生物活性玻璃或玻璃陶瓷植入物
公开(公告)号：US4437192A
公开(公告)日：1984-03-20
申请号：US476041
申请日：1983-03-16
申请人： Takamitsu Fujiu , Makoto Ogino , Michio Kariya , Takeo Ichimura
发明人： Takamitsu Fujiu , Makoto Ogino , Michio Kariya , Takeo Ichimura
IPC分类号： C03C3/062 , A61F2/00 , A61L27/00 , A61L27/10 , A61L27/12 , C03C3/064 , C03C3/089 , C03C3/095 , C03C3/115 , C03C4/00 , C03C8/02 , C03C10/00 , C03C10/04 , A61F1/00 , A61F1/24
CPC分类号： C03C3/089 , A61L27/10 , A61L27/12 , C03C10/0009 , C03C10/0054 , C03C4/0007 , A61F2310/00293
摘要： A biologically active glass and class-ceramic composition useful for making surgical and dental implants comprising, by mol %,:______________________________________ SiO.sub.2 35.about.60 B.sub.2 O.sub.3 5.about.15 Na.sub.2 O 10.about. 30 CaO 5.about. 40 TiO.sub.2 0.5.about. 10 P.sub.2 O.sub.5 0.about. 15 K.sub.2 O 0.about. 20 Li.sub.2 O 0.about. 10 MgO 0.about. 5 Al.sub.2 O.sub.3 + ZrO.sub.2 + Nb.sub.2 O.sub.5 0.about. 8 La.sub.2 O.sub.3 + Ta.sub.2 O.sub.5 + Y.sub.2 O.sub.3 0.about.8 and F.sub.2 0.about.15. ______________________________________
摘要翻译：一种生物活性玻璃和类陶瓷组合物，可用于制造手术和牙科植入物，其中包含：摩尔％：-SiO2 35差异60 -B2O3 5差异15 -Na2O 10差异30 -CaO 5差异40 -TiO 2 0.5差异10 -P2O5 0差异15-K2O 0差异20 -Li2O 0差异10 -MgO 0差异5-Al2O3 + ZrO2 + Nb2O5 0差异8 -La2O3 + Ta2O5 + Y2O3 0差异8和-F2 0差异15. -

3. 发明申请

US20050244829A1 Method of screening insulin resistance inproving drug 审中-公开
标题翻译：筛查胰岛素抵抗药物的方法
公开(公告)号：US20050244829A1
公开(公告)日：2005-11-03
申请号：US10519447
申请日：2003-07-01
申请人： Makoto Ogino , Hideki Endoh
发明人： Makoto Ogino , Hideki Endoh
IPC分类号： A61P3/08 , C07K14/47 , G01N33/50 , C12Q1/68 , C12N1/18 , C12Q1/66
CPC分类号： G01N33/5023 , C07K14/4702 , C07K2319/71 , C07K2319/80 , G01N33/5008
摘要： A method for identifying and screening a novel substance promoting the transcription induction activity of PPARγ and improving insulin resistance by promoting the interaction between PPAR promoting the transcription induction activity of PPARγ and p68 RNA helicase and/or promoting the expression of p68RNA helicase is disclosed. The method is a new type method for screening an agent for improving insulin resistance by promoting the transcription induction activity of PPARγ which is different from the conventional PPAR agonist. Furthermore, the method for producing a pharmaceutical composition for improving insulin resistance which comprises the substance obtainable by the above method for screening as an active ingredient is disclosed.
摘要翻译：公开了通过促进PPARγ和p68 RNA解旋酶的转录诱导活性和/或促进p68RNA解旋酶表达的PPAR之间的相互作用来鉴定和筛选促进PPARγ的转录诱导活性的新物质并提高胰岛素抵抗的方法。该方法是通过促进与常规PPAR激动剂不同的PPARγ的转录诱导活性来筛选改善胰岛素抵抗的药剂的新型方法。此外，公开了包含通过上述筛选方法获得的物质作为活性成分的用于改善胰岛素抵抗的药物组合物的制备方法。

4. 发明授权

US4411624A Dental implant 失效
标题翻译：牙种植体
公开(公告)号：US4411624A
公开(公告)日：1983-10-25
申请号：US309513
申请日：1981-10-07
申请人： Makoto Ogino , Takamitsu Fujiu , Michio Kariya , Takeo Ichimura
发明人： Makoto Ogino , Takamitsu Fujiu , Michio Kariya , Takeo Ichimura
IPC分类号： A61C8/00 , A61C13/08
CPC分类号： A61C8/0018 , A61C8/0012 , A61C8/0013
摘要： A dental implant is disclosed which comprises a dental root part to be embedded in a jaw bone alone or in combination with a dental crown part or a dental crown support part. At least a major portion of the surface of the dental root part to be in contact with the jaw bone is formed of a biologically active material. The contour of the surface of the dental root part is rotationally symmetrical with its diameter being constant or decreased monotonously from its one end, that is, the collum dentis portion to the other end, that is, the root end portion. The root end portion is smoothly closed.
摘要翻译：公开了一种牙科植入物，其包括单独嵌入颚骨或与牙冠部或牙冠支撑部组合的牙根部。牙根部的与颚骨接触的表面的至少大部分由生物活性物质形成。牙根部的表面的轮廓是旋转对称的，其直径是恒定的或从其一端单一地减少，即，将小齿龈部分到另一端，即根部端部。根部端部平滑地封闭。

5. 发明授权

US4708652A Apatite composite ceramics 失效
标题翻译：磷灰石复合陶瓷
公开(公告)号：US4708652A
公开(公告)日：1987-11-24
申请号：US810604
申请日：1985-12-19
申请人： Takamitsu Fujiu , Masaaki Mochida , Makoto Ogino
发明人： Takamitsu Fujiu , Masaaki Mochida , Makoto Ogino
IPC分类号： A61C8/00 , A61C13/08 , A61C13/083 , A61F2/00 , A61L27/00 , A61L27/12 , C03C10/16 , C04B35/447
CPC分类号： A61C13/08 , A61C8/0012 , A61K6/0044 , A61K6/0215 , A61K6/0235 , A61K6/024 , A61K6/025 , A61K6/0255 , A61K6/0273 , A61K6/033 , A61L27/12 , C03C10/16 , C04B35/447 , A61F2310/00293 , Y10S623/924
摘要： This invention provides a novel apatite composite ceramic useful for implants such as artificial dental root, artificial bone or the like. The apatite composite ceramic comprises an interconnected structure of fluorapatite phase and an at least partially crystallized biologically active glass phase, which ceramic is obtained by reaction-sintering at a sintering temperature of 700.degree.-1100.degree. C. at a pressure of at least atmospheric pressure a powder mixture of a synthetic hydroxyapatite (A) and a biologically active glass (B) containing fluoride ions and having a crystallization temperature below the sintering temperature in a weight ratio of A/B ranging from 60/40 to 30/70. The reaction-sintered material has excellent biological affinity and high mechanical strength.
摘要翻译：本发明提供了一种新颖的磷灰石复合陶瓷，可用于人造牙根，人造骨等植入物。磷灰石复合陶瓷包括氟磷灰石相和至少部分结晶的生物活性玻璃相的互连结构，该陶瓷通过在至少大气压的压力下在700℃-1100℃的烧结温度下进行反应烧结而获得合成羟基磷灰石（A）和含有氟离子的生物活性玻璃（B）的粉末混合物，其结晶温度低于烧结温度，重量比为A / B为60/40至30/70。反应烧结材料具有优异的生物亲和力和高机械强度。

6. 发明授权

US4497629A Dental implant and method of making same 失效
标题翻译：牙种植体及其制作方法
公开(公告)号：US4497629A
公开(公告)日：1985-02-05
申请号：US449426
申请日：1982-12-13
申请人： Makoto Ogino , Toshihiko Futami , Michio Kariya , Takeo Ichimura , Takamitsu Fujiu
发明人： Makoto Ogino , Toshihiko Futami , Michio Kariya , Takeo Ichimura , Takamitsu Fujiu
IPC分类号： A61C8/00 , A61K6/02 , A61K6/06 , C03C3/062 , C03C3/076 , C03C4/00 , C03C27/02
CPC分类号： A61C8/0012 , A61C8/0013 , C03C27/02 , C03C3/062 , C03C3/076 , C03C4/0007
摘要： A dental implant and a method of making same are disclosed. The dental implant comprises a biocompatible metal core and a multi-layer bioglass coating applied on the core. The outer layer of the multi-layer coating is formed of a bioglass whose chemical composition is selected from within the range of composition particularly defined by the present invention and which has substantially the same thermal expansion coefficient as the core. The inner layer is formed of a bioglass whose chemical composition is substantially the same as the glass of the outer layer with the exception that the content of TiO.sub.2 is increased within a particularly determined range.
摘要翻译：公开了牙科植入物及其制造方法。牙科植入物包括生物相容的金属芯和应用在芯上的多层生物玻璃涂层。多层涂层的外层由生物玻璃形成，该生物玻璃的化学组成选自本发明特别限定的组成范围内，并具有与芯基本上相同的热膨胀系数。内层由生物玻璃形成，其生物玻璃的化学组成基本上与外层玻璃相同，不同之处在于TiO2的含量在特别确定的范围内增加。

7. 发明授权

US4424037A Dental implant 失效
标题翻译：牙种植体
公开(公告)号：US4424037A
公开(公告)日：1984-01-03
申请号：US343833
申请日：1982-01-29
申请人： Makoto Ogino , Takamitsu Fujiu , Toshihiko Futami , Michio Kariya , Takeo Ichimura
发明人： Makoto Ogino , Takamitsu Fujiu , Toshihiko Futami , Michio Kariya , Takeo Ichimura
IPC分类号： A61C8/00
CPC分类号： A61C8/0018 , A61C8/0012 , A61C8/0013
摘要： Dental implant is composed of a core and a coating layer of a biologically active glass or glass-ceramic material covering at least a part of the core to be embedded in the jawbone. The glass or glass-ceramic layer comprises at least two separated portions spaced from each other.
摘要翻译：牙科植入物由覆盖待嵌入颚骨中的芯的至少一部分的生物活性玻璃或玻璃 - 陶瓷材料的芯和涂层组成。玻璃或玻璃陶瓷层包括彼此间隔开的至少两个分离部分。

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