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1. 发明授权

US07960402B2 Carbamoyl-substituted spiro derivative 有权
标题翻译：氨基甲酰取代的螺衍生物
公开(公告)号：US07960402B2
公开(公告)日：2011-06-14
申请号：US11662102
申请日：2005-09-06
申请人： Makoto Jitsuoka , Norikazu Ohtake , Nagaaki Sato , Shigeru Tokita , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Norikazu Ohtake , Nagaaki Sato , Shigeru Tokita , Daisuke Tsukahara
IPC分类号： A61K31/44 , A61K31/34 , A61K31/335 , C07D401/00 , C07D307/00
CPC分类号： C07D307/94 , C07D209/96 , C07D401/12 , C07D405/08 , C07D405/12 , C07D405/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D493/10
摘要： A compound represented by, e.g. the formula (I): [wherein X, Y, Z, and W each independently represent optionally substituted methine; A, B, and D each independently represent —C(O)—, etc.; Q represents a methine or a nitrogen; and R represents the formula (II-1), optionally substituted with lower alkyl, etc.; (wherein R6 represents a lower alkyl, etc; and R7 and R8 each independently represents a lower alkyl, etc.)] or a pharmaceutically acceptable salt of the compound. The compounds and salt have antagonistic activity against a histamine H3 receptor or inverse agonistic activity against a histamine H3 receptor. They are useful in the prevention or treatment of metabolic diseases, circulatory diseases, or neurotic diseases.
摘要翻译：化合物。式（I）：[其中X，Y，Z和W各自独立地表示任选取代的次甲基; A，B和D各自独立地表示-C（O） - 等; Q表示次甲基或氮; 并且R代表式（II-1），任选被低级烷基取代等; （其中R6表示低级烷基等; R7和R8各自独立地表示低级烷基等）]或化合物的药学上可接受的盐。化合物和盐对组胺H3受体具有拮抗作用或对组胺H3受体具有反向激动作用。它们可用于预防或治疗代谢疾病，循环系统疾病或神经病。

2. 发明申请

US20080171753A1 Carbamoyl-Substituted Spiro Derivative 有权
标题翻译：氨基甲酰取代的螺衍生物
公开(公告)号：US20080171753A1
公开(公告)日：2008-07-17
申请号：US11662102
申请日：2005-09-06
申请人： Makoto Jitsuoka , Norikazu Ohtake , Nagaaki Sato , Shigeru Tokita , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Norikazu Ohtake , Nagaaki Sato , Shigeru Tokita , Daisuke Tsukahara
IPC分类号： A61K31/497
CPC分类号： C07D307/94 , C07D209/96 , C07D401/12 , C07D405/08 , C07D405/12 , C07D405/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D493/10
摘要： A compound represented by, e.g. the formula (I): [wherein X, Y, Z, and W each independently represent optionally substituted methine; A, B, and D each independently represent —C(O)—, etc.; Q represents a methine or a nitrogen; and R represents the formula (II-1), optionally substituted with lower alkyl, etc.; (wherein R6 represents a lower alkyl, etc; and R7 and R8 each independently represents a lower alkyl, etc.)] or a pharmaceutically acceptable salt of the compound. The compounds and salt have antagonistic activity against a histamine H3 receptor or inverse agonistic activity against a histamine H3 receptor. They are useful in the prevention or treatment of metabolic diseases, circulatory diseases, or neurotic diseases.
摘要翻译：化合物。式（I）：[其中X，Y，Z和W各自独立地表示任选取代的次甲基; A，B和D各自独立地表示-C（O） - 等; Q表示次甲基或氮; 并且R代表式（II-1），任选被低级烷基取代等; （其中R 6表示低级烷基等; R 7和R 8各自独立地表示低级烷基等）]或化合物的药学上可接受的盐。化合物和盐对组胺H3受体具有拮抗作用或对组胺H3受体具有反向激动作用。它们可用于预防或治疗代谢疾病，循环系统疾病或神经病。

3. 发明申请

US20120149703A1 AZA-SUBSTITUTED SPIRO DERIVATIVES 审中-公开
标题翻译： AZA替代的SPIRO衍生物
公开(公告)号：US20120149703A1
公开(公告)日：2012-06-14
申请号：US13396887
申请日：2012-02-15
申请人： Makoto Jitsuoka , Nagaaki Sato , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Nagaaki Sato , Daisuke Tsukahara
IPC分类号： A61K31/5377 , A61K31/439 , C07D491/107 , A61P3/06 , A61P9/00 , A61P3/00 , A61P9/10 , A61P9/12 , A61P25/20 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/08 , A61P25/30 , A61P25/32 , A61P3/10 , A61P3/04 , A61K31/506
CPC分类号： C07D491/10
摘要： A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided: [wherein X, Y, Z and W each independently represent a methine group or a nitrogen atom, provided that a case where all of X, Y, Z and W are methine group; A represents —O— or the like, B represents —C(O)— or the like, D represent —(CH2)m2-, —O— or the like, and m2 represents 0 or 1; Q represents a methine group or a nitrogen atom; and R represents a group represented by the following formula (II-1) (wherein R6, R7 and R8 independently represent a lower alkyl group or the like].
摘要翻译：提供下式（I）的化合物或其药学上可接受的盐：[其中X，Y，Z和W各自独立地表示次甲基或氮原子，条件是X，Y，Z全部为 W是次甲基; A表示-O-等，B表示-C（O） - 等，D表示 - （CH2）m2-，-O-等，m2表示0或1; Q表示次甲基或氮原子; 并且R表示由下式（II-1）表示的基团（其中R 6，R 7和R 8独立地表示低级烷基等）。

4. 发明申请

US20110009622A1 LONG-CHAIN FATTY ACYL ELONGASE INHIBITOR COMPRISING ARYLSULFONYL DERIVATIVE AS ACTIVE INGREDIENT 有权
标题翻译：包含ARYLSULFONYL衍生物作为活性成分的长链脂肪ACYL ELONGASE抑制剂
公开(公告)号：US20110009622A1
公开(公告)日：2011-01-13
申请号：US12933444
申请日：2009-04-17
申请人： Makoto Jitsuoka , Tsuyoshi Nagase , Nagaaki Sato , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Tsuyoshi Nagase , Nagaaki Sato , Daisuke Tsukahara
IPC分类号： C07D223/06 , C07D413/12 , C07D265/30 , C07D239/38 , C07D487/08 , C07D241/18 , C07D221/22 , C07D498/04 , C07D471/04 , C07D413/04 , C07D401/04 , C07D401/12 , C07D211/96 , C07D211/54 , C07D213/56 , C07D249/12 , C07D235/14 , C07D403/12 , C07D231/18 , C07D207/48 , C07C311/16 , C07C237/20 , C07D413/14
CPC分类号： C07D211/96 , C07C311/16 , C07C311/19 , C07C311/20 , C07C317/44 , C07C2601/02 , C07C2601/14 , C07D207/48 , C07D213/70 , C07D213/75 , C07D231/40 , C07D231/52 , C07D239/38 , C07D249/12 , C07D265/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D453/06 , C07D471/04 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/08
摘要： [Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I): [wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].
摘要翻译： [问题]提供可用作循环系统疾病，神经系统疾病，代谢紊乱，繁殖系统疾病，消化系统疾病，肿瘤，感染性疾病等的预防药物或补救剂的化合物或作为除草剂。 [解决方案]长链脂肪酰基延伸酶抑制剂，其包含作为其活性成分的式（I）的化合物或其药物活性盐：[其中W表示氢原子，C 1-6烷基等等 X表示芳基，杂芳基等; n表示0或1; Z表示氢原子，C1-6烷基等; A1，A2，A3和A4各自独立地表示CH或N]。

5. 发明申请

US20090258871A1 Aza-Substituted Spiro Derivatives 有权
标题翻译：氮杂取代的螺衍生物
公开(公告)号：US20090258871A1
公开(公告)日：2009-10-15
申请号：US12084817
申请日：2006-11-10
申请人： Makoto Jitsuoka , Nagaaki Sato , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Nagaaki Sato , Daisuke Tsukahara
IPC分类号： A61K31/5377 , C07D221/20 , A61K31/438 , C07D295/00 , C07D239/24 , A61K31/506 , A61P3/00 , A61P25/00
CPC分类号： C07D491/10
摘要： A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided: [wherein X, Y, Z and W each independently represent a methine group or a nitrogen atom, provided that a case where all of X, Y, Z and W are methine group; A represents —O— or the like, B represents —C(O)— or the like, D represent —(CH2)m2-, —O— or the like, and m2 represents 0 or 1; Q represents a methine group or a nitrogen atom; and R represents a group represented by the following formula (II-1) (wherein R6, R7 and R8 independently represent a lower alkyl group or the like].
摘要翻译：提供下式（I）的化合物或其药学上可接受的盐：[其中X，Y，Z和W各自独立地表示次甲基或氮原子，条件是X，Y，Z全部为 W是次甲基; A表示-O-等，B表示-C（O） - 等，D表示 - （CH2）m2-，-O-等，m2表示0或1; Q表示次甲基或氮原子; 并且R表示由下式（II-1）表示的基团（其中R 6，R 7和R 8独立地表示低级烷基等）。

6. 发明授权

US08420823B2 Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient 有权
标题翻译：包含芳基磺酰基衍生物作为活性成分的长链脂肪酰基延伸酶抑制剂
公开(公告)号：US08420823B2
公开(公告)日：2013-04-16
申请号：US12933444
申请日：2009-04-17
申请人： Makoto Jitsuoka , Tsuyoshi Nagase , Nagaaki Sato , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Tsuyoshi Nagase , Nagaaki Sato , Daisuke Tsukahara
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/4453 , C07D401/10
CPC分类号： C07D211/96 , C07C311/16 , C07C311/19 , C07C311/20 , C07C317/44 , C07C2601/02 , C07C2601/14 , C07D207/48 , C07D213/70 , C07D213/75 , C07D231/40 , C07D231/52 , C07D239/38 , C07D249/12 , C07D265/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D453/06 , C07D471/04 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/08
摘要： [Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I): [wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].
摘要翻译： [问题]提供可用作循环系统疾病，神经系统疾病，代谢紊乱，繁殖系统疾病，消化系统疾病，肿瘤，感染性疾病等的预防药物或补救剂的化合物或作为除草剂。 [解决方案]长链脂肪酰基延伸酶抑制剂，其包含作为其活性成分的式（I）的化合物或其药物活性盐：[其中W表示氢原子，C 1-6烷基等等 X表示芳基，杂芳基等; n表示0或1; Z表示氢原子，C1-6烷基等; A1，A2，A3和A4各自独立地表示CH或N]。

7. 发明授权

US08158791B2 Aza-substituted spiro derivatives 有权
标题翻译：氮杂取代的螺衍生物
公开(公告)号：US08158791B2
公开(公告)日：2012-04-17
申请号：US12084817
申请日：2006-11-10
申请人： Makoto Jitsuoka , Nagaaki Sato , Daisuke Tsukahara
发明人： Makoto Jitsuoka , Nagaaki Sato , Daisuke Tsukahara
IPC分类号： A61K31/44 , A61K31/34 , A61K31/335 , C07D221/00
CPC分类号： C07D491/10
摘要： A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided: [wherein X, Y, Z and W each independently represent a methine group or a nitrogen atom, provided that a case where all of X, Y, Z and W are methine group; A represents —O— or the like, B represents —C(O)— or the like, D represent —(CH2)m2-, —O— or the like, and m2 represents 0 or 1; Q represents a methine group or a nitrogen atom; and R represents a group represented by the following formula (II-1) (wherein R6, R7 and R8 independently represent a lower alkyl group or the like].
摘要翻译：提供下式（I）的化合物或其药学上可接受的盐：[其中X，Y，Z和W各自独立地表示次甲基或氮原子，条件是X，Y，Z全部为 W是次甲基; A表示-O-等，B表示-C（O） - 等，D表示 - （CH2）m2-，-O-等，m2表示0或1; Q表示次甲基或氮原子; 并且R表示由下式（II-1）表示的基团（其中R 6，R 7和R 8独立地表示低级烷基等）。

8. 发明申请

US20130048209A1 METHOD FOR PRODUCING LIGHT EMITTING DIODE DEVICE 有权
标题翻译：用于生产发光二极管器件的方法
公开(公告)号：US20130048209A1
公开(公告)日：2013-02-28
申请号：US13597341
申请日：2012-08-29
申请人： Yasunari OOYABU , Hiroyuki Katayama , Daisuke Tsukahara , Munehisa Mitani
发明人： Yasunari OOYABU , Hiroyuki Katayama , Daisuke Tsukahara , Munehisa Mitani
IPC分类号： H01L33/00
CPC分类号： H01L33/52 , H01L2933/005
摘要： A method for producing a light emitting diode device includes the steps of preparing a laminate including, in order, a supporting layer, a constraining layer and an encapsulating resin layer, each formed in a thickness direction; cutting the encapsulating resin layer and the constraining layer in the laminate into a pattern corresponding to the light emitting diode element; removing a portion which does not correspond to the light emitting diode element in the encapsulating resin layer and the constraining layer that are cut into the pattern; allowing the encapsulating resin layer corresponding to the light emitting diode element to be opposed to the light emitting diode element to be pressed in the direction where they come close to each other so as to encapsulate the light emitting diode element by the encapsulating resin layer; and removing the supporting layer and the constraining layer from the laminate.
摘要翻译：一种发光二极管器件的制造方法，其特征在于，具有如下工序：在厚度方向上形成有依次层叠的支撑层，约束层和密封树脂层。将层压体中的封装树脂层和约束层切割成对应于发光二极管元件的图案; 去除与切割成图案的封装树脂层和约束层中的发光二极管元件不对应的部分; 使与发光二极管元件相对应的封装树脂层与发光二极管元件相对，以使它们彼此靠近的方向被按压，以便通过封装树脂层封装发光二极管元件; 并从层叠体上除去支撑层和约束层。

9. 发明授权

US07501711B2 Epoxy resin composition for semiconductor encapsulation and semiconductor device using the same 有权
标题翻译：用于半导体封装的环氧树脂组合物和使用其的半导体器件
公开(公告)号：US07501711B2
公开(公告)日：2009-03-10
申请号：US11665967
申请日：2005-10-18
申请人： Takuya Eto , Kazuhiro Ikemura , Eiji Toyoda , Katsuyuki Nakabayashi , Daisuke Tsukahara
发明人： Takuya Eto , Kazuhiro Ikemura , Eiji Toyoda , Katsuyuki Nakabayashi , Daisuke Tsukahara
IPC分类号： H01L23/28
CPC分类号： C08G59/621 , C08L63/00 , H01L23/295 , H01L2924/0002 , Y10T428/31511 , C08L2666/16 , H01L2924/00
摘要： An epoxy resin composition for semiconductor encapsulation which does not contain conductive foreign metallic particles having such a size that they cannot be detected and eliminated by the conventional method for eliminating conductive foreign metallic particles. The epoxy resin composition for semiconductor encapsulation comprises the following components (A) to (D). Conductive foreign metallic particles having a size of 20 μm or more are substantially not contained in the aforementioned epoxy resin composition. (A) An epoxy resin. (B) A phenol resin. (C) A hardening accelerator. (D) An inorganic filler.
摘要翻译：一种用于半导体封装的环氧树脂组合物，其不含有通过用于消除导电性异质金属颗粒的传统方法不能检测和消除的尺寸的导电异物金属颗粒。用于半导体封装的环氧树脂组合物包括以下组分（A）至（D）。在上述环氧树脂组合物中基本上不含有尺寸为20μm以上的导电性异质金属粒子。（A）环氧树脂。（B）酚醛树脂。（C）硬化促进剂。（D）无机填料。

10. 发明申请

US20080136048A1 Epoxy Resin Composition for Semiconductor Encapsulation and Semiconductor Device Using the Same 有权
标题翻译：用于半导体封装的环氧树脂组合物和使用其的半导体器件
公开(公告)号：US20080136048A1
公开(公告)日：2008-06-12
申请号：US11665967
申请日：2005-10-18
申请人： Takuya Eto , Kazuhiro Ikemura , Eiji Toyoda , Katsuyuki Nakabayashi , Daisuke Tsukahara
发明人： Takuya Eto , Kazuhiro Ikemura , Eiji Toyoda , Katsuyuki Nakabayashi , Daisuke Tsukahara
IPC分类号： H01L23/29 , C08G67/00 , C09K3/00
CPC分类号： C08G59/621 , C08L63/00 , H01L23/295 , H01L2924/0002 , Y10T428/31511 , C08L2666/16 , H01L2924/00
摘要： An epoxy resin composition for semiconductor encapsulation which does not contain conductive foreign metallic particles having such a size that they cannot be detected and eliminated by the conventional method for eliminating conductive foreign metallic particles. The epoxy resin composition for semiconductor encapsulation comprises the following components (A) to (D). Conductive foreign metallic particles having a size of 20 μM or more are substantially not contained in the aforementioned epoxy resin composition.(A) An epoxy resin.(B) A phenol resin.(C) A hardening accelerator.(D) An inorganic filler.
摘要翻译：一种用于半导体封装的环氧树脂组合物，其不含有通过用于消除导电性异质金属颗粒的传统方法不能检测和消除的尺寸的导电异物金属颗粒。用于半导体封装的环氧树脂组合物包括以下组分（A）至（D）。在上述环氧树脂组合物中基本上不含有尺寸为20μm以上的导电性异质金属粒子。（A）环氧树脂。（B）酚醛树脂。（C）硬化促进剂。（D）无机填料。

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