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1. 发明授权

US08632801B2 Stable therapeutic formulations 有权
标题翻译：稳定的治疗剂型
公开(公告)号：US08632801B2
公开(公告)日：2014-01-21
申请号：US11617639
申请日：2006-12-28
申请人： Mahmoud Ameri , Michel J. N. Cormier , Scott Sellers , Yuh-Fun Maa
发明人： Mahmoud Ameri , Michel J. N. Cormier , Scott Sellers , Yuh-Fun Maa
IPC分类号： A61F13/00 , A61K9/70 , A61K39/02 , A61K45/00 , A61K38/29 , C07K14/635 , A61K31/715
CPC分类号： A61K9/0021 , A61K9/703 , A61K31/716 , A61K38/2242 , A61K38/29 , A61K48/00 , A61K2039/54 , A61M37/0015 , A61M2037/0023 , B65B7/02 , B65B31/00 , B65B51/10 , B65B55/00 , B65D81/20 , B65D81/266 , Y02A50/471 , Y02A50/478
摘要： Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.
摘要翻译：用于配制和递送具有增强的物理稳定性的生物活性剂制剂的组合物和方法，并且其中由氧和/或水的存在引起的劣化被最小化和/或控制，以产生稳定的制剂。用于配制和递送本发明的生物活性剂的组合物和方法进一步促进它们掺入生物相容性涂层中，所述生物相容性涂层可用于涂覆角质层刺穿的微喷射体，或多个角质层刺穿的输送装置的微突出物，用于通过受试者的皮肤递送生物相容性涂层，从而提供递送生物活性剂的有效手段。

2. 发明申请

US20070184096A1 Stable Therapeutic Formulations 有权
标题翻译：稳定的治疗配方
公开(公告)号：US20070184096A1
公开(公告)日：2007-08-09
申请号：US11617639
申请日：2006-12-28
申请人： Mahmoud Ameri , Michel Cormier , Scott Sellers , Yuh-Fun Maa
发明人： Mahmoud Ameri , Michel Cormier , Scott Sellers , Yuh-Fun Maa
IPC分类号： A61K48/00 , A61K9/70 , A61K31/716
CPC分类号： A61K9/0021 , A61K9/703 , A61K31/716 , A61K38/2242 , A61K38/29 , A61K48/00 , A61K2039/54 , A61M37/0015 , A61M2037/0023 , B65B7/02 , B65B31/00 , B65B51/10 , B65B55/00 , B65D81/20 , B65D81/266 , Y02A50/471 , Y02A50/478
摘要： Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.
摘要翻译：用于配制和递送具有增强的物理稳定性的生物活性剂制剂的组合物和方法，并且其中由氧和/或水的存在引起的劣化被最小化和/或控制，以产生稳定的制剂。用于配制和递送本发明的生物活性剂的组合物和方法进一步促进它们掺入生物相容性涂层中，所述生物相容性涂层可用于涂覆角质层刺穿的微喷射体，或多个角质层刺穿的输送装置的微突出物，用于通过受试者的皮肤递送生物相容性涂层，从而提供递送生物活性剂的有效手段。

3. 发明申请

US20050266011A1 Method and formulation for transdermal delivery of immunologically active agents 审中-公开
标题翻译：用于透皮递送免疫活性剂的方法和制剂
公开(公告)号：US20050266011A1
公开(公告)日：2005-12-01
申请号：US11112311
申请日：2005-04-21
申请人： Yuh-Fun Maa , Mahmoud Ameri , Scott Sellers
发明人： Yuh-Fun Maa , Mahmoud Ameri , Scott Sellers
IPC分类号： A61K39/00 , A61K39/02 , A61K39/145 , H04N7/18
CPC分类号： A61K39/02 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/54 , C12N2760/16134
摘要： A method for formulating an immunologically active agent and an apparatus for delivery same, the method comprising the steps of providing a bulk immunologically active agent, subjecting the bulk immunologically active agent to tangential-flow filtration to provide an immunologically active agent solution, adding at least one excipient to the agent solution and spray-drying the agent solution to form an immunologically active agent product; the apparatus comprising a microprojection member that includes a plurality of microprojections having a biocompatible coating disposed thereon that includes a spray-dried immunologically active agent. In a preferred embodiment, the immunologically active agent comprises an influenza vaccine, more preferably, a split-varion influenza vaccine.
摘要翻译：用于配制免疫活性剂的方法和用于递送免疫活性剂的装置，所述方法包括以下步骤：提供本体免疫活性剂，使本体免疫活性剂经受切向流过滤以提供免疫活性剂溶液，至少加入将一种赋形剂加入到试剂溶液中并喷雾干燥试剂溶液以形成免疫活性剂产品; 所述装置包括微突出物构件，所述微突出物构件包括多个具有布置在其上的生物相容性涂层的微喷射体，其包括喷雾干燥的免疫活性剂。在优选的实施方案中，免疫活性剂包含流感疫苗，更优选分裂型流感疫苗。

4. 发明申请

US20060280645A1 Method for terminal sterilization of transdermal delivery devices 审中-公开
标题翻译：透皮给药装置终末灭菌方法
公开(公告)号：US20060280645A1
公开(公告)日：2006-12-14
申请号：US11446531
申请日：2006-06-01
申请人： Scott Sellers , Yuh-Fun Maa
发明人： Scott Sellers , Yuh-Fun Maa
IPC分类号： A61F13/02 , A61L2/00
CPC分类号： A61L2/081 , A61K9/0021 , A61K38/2242 , A61L2/08 , A61L2/087 , A61M37/0015 , A61M2037/0061
摘要： A method and system for providing a terminally sterilized transdermal natriuretic peptide delivery device. A microprojection member having a plurality of stratum corneum-piercing microprojections is coated with a natriuretic peptide- formulation an exposed to sufficient radiation to sterilize the microprojection member while retaining sufficient activity of the natriuretic peptide. Preferably, the microprojection member is sealed in packing with an inert atmosphere and reduced moisture. The sterilizing radiation can be gamma radiation or e-beam, preferably delivered in a dose in the range of approximately 14-21 kGy. Also preferably, the irradiation is performed at −78.5-25° C. In preferred embodiments, the radiation is delivered at a rate greater than 3.0 kGy/hr.
摘要翻译：一种用于提供终末灭菌的透皮利钠肽递送装置的方法和系统。具有多个角质层穿刺微突出物的微突出物构件涂覆有暴露于足够辐射的利尿钠肽制剂，以在保留足够的利尿钠肽活性的同时对微突出物构件进行灭菌。优选地，微喷射构件以惰性气氛密封在包装中并减少水分。灭菌辐射可以是γ辐射或电子束，优选以约14-21kGy的剂量递送。还优选地，在-78.5-25℃下进行照射。在优选的实施方案中，以大于3.0kGy / hr的速率递送辐射。

5. 发明申请

US20060067943A1 Stabilization of alum-adjuvanted immunologically active agents 审中-公开
标题翻译：明矾佐剂免疫活性剂的稳定化
公开(公告)号：US20060067943A1
公开(公告)日：2006-03-30
申请号：US11237200
申请日：2005-09-27
申请人： Yuh-Fun Maa , Scott Sellers
发明人： Yuh-Fun Maa , Scott Sellers
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12 , A61K39/02 , A61K31/715 , A61K31/7012
CPC分类号： A61K39/292 , A61K9/1652 , A61K9/70 , A61K39/12 , A61K39/39 , A61K2039/54 , A61K2039/55505 , A61M37/00 , A61M37/0015 , A61M2037/0046 , C12N2730/10134
摘要： A composition and method for formulating and delivering an adjuvanted immunological active agent, especially a vaccine, wherein adjuvant coagulation and concomitant loss of vaccine efficacy enhancement is mitigated or avoided. The adjuvanted, immunologically-active agent can be subjected to freezing, drying, freeze-drying, or lyophilization, and when reconstituted, retains a high level of potency. The present invention further provides for a composition and method for formulating and delivering a stable, adjuvanted, immunologically-active agent capable of being deposited on a transdermal delivery device or microprojection or array thereof.
摘要翻译：用于配制和递送佐剂的免疫活性剂，特别是疫苗的组合物和方法，其中减轻或避免了辅助凝血和伴随的疫苗功效增强丧失。佐剂化的免疫活性剂可以进行冷冻，干燥，冷冻干燥或冻干，当重构时保持高水平的效力。本发明还提供了一种用于配制和递送能够沉积在透皮递送装置或微突出物或其阵列上的稳定的佐剂化免疫活性剂的组合物和方法。

6. 发明申请

US20060034903A1 Apparatus and method for transdermal delivery of natriuretic peptides 审中-公开
标题翻译：利尿钠肽经皮递送的装置和方法
公开(公告)号：US20060034903A1
公开(公告)日：2006-02-16
申请号：US11201625
申请日：2005-08-10
申请人： Yuh-Fun Maa , Scott Sellers , Peter Daddona , Marika Kamberi , Vidhya Gopalakrishnan , B. Silber , Frank Stonebanks
发明人： Yuh-Fun Maa , Scott Sellers , Peter Daddona , Marika Kamberi , Vidhya Gopalakrishnan , B. Silber , Frank Stonebanks
IPC分类号： A61K38/17 , A61M31/00 , A61F13/02
CPC分类号： A61K9/0021 , A61K9/19 , A61K38/2242 , A61K47/26 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus and method for transdermally delivering a natriuretic peptide comprising a delivery system having a microprojection member that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the natriuretic peptide is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a natriuretic peptide-containing hydrogel formulation. In an alternative embodiment, the natriuretic peptide is contained in both the coating and the hydrogel formulation. In yet another embodiment, the natriuretic peptide is contained in a solid state formulation.
摘要翻译：一种用于经皮递送利尿钠肽的装置和方法，包括具有微突出物构件的递送系统，所述微突出物构件包括多个微突出物（或其阵列），所述微突出物适合于将角质层刺入下面的表皮层或表皮层和真皮层中。在一个实施方案中，利尿钠肽包含在应用于微喷射构件的生物相容性涂层中。在另一个实施方案中，递送系统包括含利尿钠肽的水凝胶制剂。在替代实施方案中，利尿钠肽包含在包衣和水凝胶制剂中。在另一个实施方案中，利尿钠肽包含在固态制剂中。

7. 发明申请

US20060280644A1 Method for terminal sterilization of transdermal delivery devices 审中-公开
标题翻译：透皮给药装置终末灭菌方法
公开(公告)号：US20060280644A1
公开(公告)日：2006-12-14
申请号：US11446530
申请日：2006-06-01
申请人： Scott Sellers , Yuh-Fun Maa
发明人： Scott Sellers , Yuh-Fun Maa
IPC分类号： A61L2/00
CPC分类号： A61K9/0021 , A61K41/0019 , A61L2/081 , A61L2/087 , A61L2/206 , A61M37/00 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： A method and system for providing a terminally sterilized transdermal influenza vaccine delivery device. A microprojection member having a plurality of stratum corneum-piercing microprojections is coated with an influenza vaccine-formulation and exposed to sufficient radiation to sterilize the microprojection member while retaining sufficient potency of the influenza vaccine. Preferably, the microprojection member is sealed in packaging, such as a foil pouch. Also preferably, a retainer ring and adhesive are included within the packaging. The sterilizing radiation can be gamma radiation or e-beam, preferably delivered in a dose in the range of approximately 7-21 kGy. Also preferably, the irradiation is performed from −78.5-25° C. In preferred embodiments, the radiation is delivered at a rate greater than 3.0 kGy/hr.
摘要翻译：一种用于提供终末灭菌的经皮流感疫苗递送装置的方法和系统。具有多个角质层穿孔微突出物的微突出物构件涂覆有流感疫苗制剂并且暴露于足够的辐射以在保持足够的流感疫苗的效力的同时对微突出物构件进行灭菌。优选地，微喷射构件被密封在包装中，例如箔袋。还优选地，保持环和粘合剂包括在包装内。灭菌辐射可以是γ辐射或电子束，优选以约7-21kGy的剂量递送。还优选地，照射从-78.5-25℃进行。在优选的实施方案中，以大于3.0kGy / hr的速率递送辐射。

8. 发明申请

US20050220854A1 Apparatus and method for transdermal delivery of influenza vaccine 审中-公开
标题翻译：用于流感疫苗透皮递送的装置和方法
公开(公告)号：US20050220854A1
公开(公告)日：2005-10-06
申请号：US11084631
申请日：2005-03-18
申请人： Yuh-Fun Maa , Scott Sellers , James Matriano , Asha Ramdas
发明人： Yuh-Fun Maa , Scott Sellers , James Matriano , Asha Ramdas
IPC分类号： A61K9/19 , A61K9/70 , A61K39/02 , A61K39/12 , A61K39/145 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/26 , A61M31/00 , A61M37/00 , C12Q1/70
CPC分类号： A61K39/12 , A61K9/0021 , A61K9/19 , A61K39/145 , A61K47/10 , A61K47/186 , A61K47/20 , A61K47/26 , A61K2039/54 , A61K2039/545 , A61K2039/55511 , A61K2039/55583 , A61K2039/70 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection member having a biocompatible coating disposed thereon that includes the immunologically active agent. Preferably, the biocompatible coating is formed from a vaccine coating formulation.
摘要翻译：一种用于透皮递送免疫活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括适于穿透角质层进入下面的表皮层的多个微突出物（或阵列），或表皮和真皮层，所述微突出物构件具有设置在其上的包含免疫活性剂的生物相容性涂层。优选地，生物相容性涂层由疫苗涂层制剂形成。

9. 发明授权

US08990501B1 Multiple cluster processor 有权
标题翻译：多集群处理器
公开(公告)号：US08990501B1
公开(公告)日：2015-03-24
申请号：US11250149
申请日：2005-10-12
申请人： Scott Sellers , Gil Tene
发明人： Scott Sellers , Gil Tene
IPC分类号： G06F12/08
CPC分类号： G06F12/0811 , G06F12/0815 , G06F12/0888
摘要： A multiple processor system is disclosed. The processor system includes a first cluster including a first plurality of processors is associated with a first cluster cache, a second cluster including a second plurality of processors associated with a second cluster cache, and a cluster communication network between the first cluster and the second cluster for sharing data between the first cluster and the second cluster. The first cluster includes a first unshared connection to the cluster communication network and the second cluster includes a second unshared connection to the cluster communication network.
摘要翻译：公开了一种多处理器系统。处理器系统包括第一集群，其包括与第一集群高速缓存相关联的第一多个处理器，包括与第二集群高速缓存相关联的第二多个处理器的第二集群以及第一集群和第二集群之间的集群通信网络用于在第一个集群和第二个集群之间共享数据。第一集群包括到集群通信网络的第一非共享连接，第二集群包括到集群通信网络的第二非共享连接。

10. 发明授权

US07577801B1 Array access 有权
标题翻译：阵列访问
公开(公告)号：US07577801B1
公开(公告)日：2009-08-18
申请号：US11296191
申请日：2005-12-06
申请人： Gil Tene , Jack H. Choquette , Scott Sellers , Cliff N. Click, Jr.
发明人： Gil Tene , Jack H. Choquette , Scott Sellers , Cliff N. Click, Jr.
IPC分类号： G06F12/02
CPC分类号： G06F12/0223 , G06F9/30043 , G06F9/345
摘要： Accessing memory in an array includes performing a first instruction, including by determining whether an index used by the first instruction is within a valid range and in the event that the index is within a valid range, determining a memory address related to an array element that corresponds to the index. Accessing memory in the array further includes, in the event that the index is within a valid range, performing a second instruction to access the array element, the access being based at least in part on the memory address determined by the first instruction.
摘要翻译：访问阵列中的存储器包括执行第一指令，包括通过确定第一指令使用的索引是否在有效范围内，以及在索引在有效范围内的情况下，确定与阵列元素有关的存储器地址，对应于索引。如果索引在有效范围内，执行第二指令来访问数组元素，访问存储器还包括至少部分地基于由第一指令确定的存储器地址的访问。

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