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1. 发明申请

US20060210591A1 Immunization of an individual against carcinomas and the preliminary stages thereof 有权
公开(公告)号：US20060210591A1
公开(公告)日：2006-09-21
申请号：US11433386
申请日：2006-05-15
申请人： Magnus Doeberitz , Michael Linnebacher , Wolfgang Rudy
发明人： Magnus Doeberitz , Michael Linnebacher , Wolfgang Rudy
IPC分类号： A61K48/00 , A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53
摘要： The present invention relates to a pharmaceutical composition, comprising a cell cycle regulatory protein and/or an expressible nucleic acid coding for this in an amount suitable for immunization of an individual against carcinomas and the preliminary stages thereof and common auxiliary agents and/or to the use of a cell cycle regulatory protein and/or an expressible nucleic acid coding for this to immunize an individual against carcinomas and the preliminary stages thereof.

2. 发明授权

US07569538B2 Immunization of an individual against carcinomas and the preliminary stages thereof 有权
标题翻译：免疫个体对癌症及其初步阶段
公开(公告)号：US07569538B2
公开(公告)日：2009-08-04
申请号：US11433386
申请日：2006-05-15
申请人： Magnus Von Knebel Doeberitz , Michael Linnebacher , Wolfgang Rudy
发明人： Magnus Von Knebel Doeberitz , Michael Linnebacher , Wolfgang Rudy
IPC分类号： A61K38/00 , A61K35/12
CPC分类号： A61K39/0011 , A61K2039/53
摘要： The present invention relates to a pharmaceutical composition, comprising a cell cycle regulatory protein and/or an expressible nucleic acid coding for this in an amount suitable for immunization of an individual against carcinomas and the preliminary stages thereof and common auxiliary agents and/or to the use of a cell cycle regulatory protein and/or an expressible nucleic acid coding for this to immunize an individual against carcinomas and the preliminary stages thereof.
摘要翻译：本发明涉及一种药物组合物，其包含细胞周期调节蛋白和/或编码该细胞周期调节蛋白和/或可表达核酸的量，其适合个体免疫个体对癌症及其初级阶段和普通助剂和/或使用细胞周期调节蛋白和/或编码该细胞周期调控蛋白的可表达核酸来免疫个体免受癌症及其初步阶段的侵害。

3. 发明授权

US08946171B2 Immunization of an individual against carcinomas and the preliminary stages thereof 有权
公开(公告)号：US08946171B2
公开(公告)日：2015-02-03
申请号：US12500458
申请日：2009-07-09
申请人： Magnus Von Knebel Doeberitz , Michael Linnebacher , Wolfgang Rudy
发明人： Magnus Von Knebel Doeberitz , Michael Linnebacher , Wolfgang Rudy
IPC分类号： A61K48/00 , A61K38/08 , A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53
摘要： The present invention relates to a pharmaceutical composition, comprising a cell cycle regulatory protein and/or an expressible nucleic acid coding for this in an amount suitable for immunization of an individual against carcinomas and the preliminary stages thereof and common auxiliary agents and/or to the use of a cell cycle regulatory protein and/or an expressible nucleic acid coding for this to immunize an individual against carcinomas and the preliminary stages thereof.

4. 发明申请

US20110064770A1 Immunization of an Individual Against Carcinomas and the Preliminary Stages Thereof 有权
标题翻译：免疫个体抗癌及其初步阶段
公开(公告)号：US20110064770A1
公开(公告)日：2011-03-17
申请号：US12500458
申请日：2009-07-09
申请人： Magnus Von Knebel Doeberitz , Michael Linnebacher , Wolfgang Rudy
发明人： Magnus Von Knebel Doeberitz , Michael Linnebacher , Wolfgang Rudy
IPC分类号： A61K39/00 , A61K35/00
CPC分类号： A61K39/0011 , A61K2039/53
摘要： The present invention relates to a pharmaceutical composition, comprising a cell cycle regulatory protein and/or an expressible nucleic acid coding for this in an amount suitable for immunization of an individual against carcinomas and the preliminary stages thereof and common auxiliary agents and/or to the use of a cell cycle regulatory protein and/or an expressible nucleic acid coding for this to immunize an individual against carcinomas and the preliminary stages thereof.
摘要翻译：本发明涉及一种药物组合物，其包含细胞周期调节蛋白和/或编码该细胞周期调节蛋白和/或可表达核酸的量，其适合个体免疫个体对癌症及其初级阶段和普通助剂和/或使用细胞周期调节蛋白和/或编码该细胞周期调控蛋白的可表达核酸来免疫个体免受癌症及其初步阶段的侵害。

5. 发明授权

US07517662B2 Method for solution based diagnosis 有权
标题翻译：基于解决方案的诊断方法
公开(公告)号：US07517662B2
公开(公告)日：2009-04-14
申请号：US10633484
申请日：2003-07-31
申请人： Rüdiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
发明人： Rüdiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
IPC分类号： G01N33/574
CPC分类号： G01N33/57411 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N2333/82
摘要： This invention provides methods for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.
摘要翻译：本发明提供了通过在测试样品溶液中进行的基于溶液的生物化学测试程序来改进医学相关条件诊断的方法。本发明提供了一种通过从溶液获得的分子信息替代包含在测试样品的细胞学和/或组织学数据内的基于细胞的形态信息的方法，其中原始测试样品被溶解，因此能够准确和可重复地评估医学上的溶解试样的相关诊断。根据本发明的方法包括以下步骤：确定与待诊断的病症相关的一种或多种疾病标志物的水平，确定适合于替代与样品的形态学方面有关的信息的一种或多种标准化标记的水平，比较和/或组合疾病和归一化标记的数据，以及评估医学上相关的病症的诊断。

6. 发明申请

US20080305098A1 Recombinant Polypeptides and Methods for Detecting and/or Quantifying Autoantibodies Against Tsh Receptor 审中-公开
标题翻译：重组多肽和用于检测和/或定量针对Tsh受体的自身抗体的方法
公开(公告)号：US20080305098A1
公开(公告)日：2008-12-11
申请号：US12094533
申请日：2006-11-21
申请人： Steve Fenning , Xiaoping Yang , Andreas Dreusch , Wolfgang Rudy
发明人： Steve Fenning , Xiaoping Yang , Andreas Dreusch , Wolfgang Rudy
IPC分类号： A61K38/43 , C07K16/18 , C12N9/10 , C12N9/24 , C12N15/11 , A61P43/00 , C12N15/00 , C12N1/20 , G01N33/53
CPC分类号： C07K14/723 , C07K2319/23 , C07K2319/24 , C07K2319/60 , G01N33/564 , G01N2333/72
摘要： The present invention relates to unglycosylated isolated and purified recombinant polypeptides comprising a fusion protein able to bind to autoantibodies produced in response to an autoimmune disease associated with an immune reaction to a TSH-receptor (TSHR). Also disclosed are methods of detecting and/or quantifying such autoantibodies using the isolated and purified recombinant polypeptides and respective kits.
摘要翻译：本发明涉及非糖基化的分离和纯化的重组多肽，其包含能够结合针对与TSH受体（TSHR）的免疫反应相关的自身免疫疾病产生的自身抗体的融合蛋白。还公开了使用分离和纯化的重组多肽和相应试剂盒来检测和/或定量这种自身抗体的方法。

7. 发明申请

US20090181406A1 KITS FOR DETECTING CERVICAL DYSPLASIA 审中-公开
标题翻译：用于检测血清斑块的试剂盒
公开(公告)号：US20090181406A1
公开(公告)日：2009-07-16
申请号：US12400629
申请日：2009-03-09
申请人： Rudiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
发明人： Rudiger Ridder , Wolfgang Rudy , Matthias Herkert , Marcus Trunk-Gehmacher , Anja Reichert , Magnus Von Knebel Doeberitz
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/57411 , G01N33/5076 , G01N33/5091 , G01N33/574 , G01N2333/82
摘要： This invention provides methods and kits for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.
摘要翻译：本发明提供用于通过在测试样品溶液中进行的基于溶液的生物化学测试程序来改善医学相关条件的诊断的方法和试剂盒。本发明提供了一种通过从溶液获得的分子信息替代包含在测试样品的细胞学和/或组织学数据内的基于细胞的形态信息的方法，其中原始测试样品被溶解，因此能够准确和可重复地评估医学上的溶解试样的相关诊断。根据本发明的方法包括以下步骤：确定与待诊断的病症相关的一种或多种疾病标志物的水平，确定适合于替代与样品的形态学方面有关的信息的一种或多种标准化标记的水平，比较和/或组合疾病和归一化标记的数据，以及评估医学相关病症的诊断。

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