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1. 发明授权

US08808359B2 Catheter system for stenting bifurcated vessels 有权
标题翻译：用于支架分娩血管的导管系统
公开(公告)号：US08808359B2
公开(公告)日：2014-08-19
申请号：US12651972
申请日：2010-01-04
申请人： Pierre Hilaire , James J. Leary , Machiel Van Der Leest
发明人： Pierre Hilaire , James J. Leary , Machiel Van Der Leest
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2/97 , A61F2002/065 , A61F2002/067 , A61F2250/006
摘要： A catheter system and method are described for stenting a vessel at a bifurcation or sidebranch of the vessel. The catheter system includes a first balloon catheter, a second balloon catheter and a releasable linking device for holding the first and second balloon catheters arranged in a side-by-side configuration and aligned with one another along a longitudinal axis. The linking device allows the catheter system to be advanced as a unit and helps prevent premature or inadvertent dislodgement of the stent from the catheters, yet is releasable so that one or both of the balloon catheters can be released from the linking device and maneuvered separately from the rest of the catheter system when desired. The method utilizes the described catheter system for stenting bifurcated vessels using a modified “kissing balloons” technique.
摘要翻译：描述了用于在血管的分叉或侧分支处支架血管的导管系统和方法。导管系统包括第一气囊导管，第二球囊导管和可释放连接装置，用于保持以并排构造布置并沿着纵向轴线彼此对准的第一和第二气囊导管。连接装置允许导管系统作为一个单元前进，并且有助于防止支架从导管中过早或无意地移出，但是可释放，使得气囊导管中的一个或两个可以从连接装置释放并与导管系统的其余部分。该方法利用所描述的导管系统用于使用改进的“接吻气球”技术支架分叉血管。

2. 发明授权

US07713296B2 Catheter system for stenting bifurcated vessels 有权
标题翻译：用于支架分叉血管的导管系统
公开(公告)号：US07713296B2
公开(公告)日：2010-05-11
申请号：US11319767
申请日：2005-12-27
申请人： Pierre Hilaire , Machiel Van Der Leest
发明人： Pierre Hilaire , Machiel Van Der Leest
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61B1/041 , A61F2/856 , A61F2/915 , A61F2/954 , A61F2002/065 , A61F2002/826 , A61F2002/91558 , A61F2230/001 , A61F2250/0036 , A61F2250/0039
摘要： A stenting system includes a stent delivery catheter having a catheter shaft with a step balloon mounted thereon. The step balloon has a proximal portion and a distal portion, wherein the proximal portion is inflatable to a larger expanded diameter than the distal portion. A two-part stent has a proximal part that is mounted on the proximal portion of the step balloon and a distal part that is mounted on the distal portion of the step balloon and a non-link zone between the proximal part and the distal part of the two-part stent. The proximal part and the distal part of the two-part stent are each configured with stent struts that extend like interdigitating fingers into the non-link zone to provide improved strut coverage in the carina region of the bifurcated vessel. The non-link zone effectively eliminates any difficulties in alignment of the two parts relative to one another during placement of the two-part stent in a bifurcated vessel.
摘要翻译：支架系统包括具有安装在其上的阶梯式气囊的导管轴的支架输送导管。台阶气球具有近端部分和远端部分，其中近端部分可膨胀至比远侧部分更大的扩张直径。两部分支架具有安装在台阶球囊的近端部分上的近端部分，以及安装在台阶球囊的远端部分上的远端部分和位于步骤球囊的近端部分和远端部分之间的非连接区域两部分支架。两部分支架的近端部分和远端部分各自配置有支架支柱，支架支柱如同指状指状物延伸到非连接区域，以提供分叉血管的耳状区域中改善的支柱覆盖。在将两部分支架放置在分叉的容器中时，非连接区有效地消除了两个部件相对于彼此对准的任何困难。

3. 发明申请

US20090157160A1 APPARATUS AND METHODS FOR PROTECTED ANGIOPLASTY AND STENTING AT A CAROTID BIFURCATION 审中-公开
标题翻译：保护性放射治疗的装置和方法
公开(公告)号：US20090157160A1
公开(公告)日：2009-06-18
申请号：US12067142
申请日：2006-09-19
申请人： Machiel Van Der Leest , Pierre Hilaire , Philippe Moulin , James Leary
发明人： Machiel Van Der Leest , Pierre Hilaire , Philippe Moulin , James Leary
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/958 , A61M25/104 , A61M2025/0183
摘要： Apparatus and methods are described for performing protected angioplasty and stenting of a patient's carotid bifurcation. An integrated catheter system can be configured in a rapid-exchange version or in an over-the-wire version. The catheter system includes a self-expanding stent, a stent delivery sheath, a combination angioplasty balloon catheter and stent pusher catheter, an embolic protection device and, in the rapid-exchange version, an auto-releasing sheath. The method includes: inserting a guiding catheter to the carotid bifurcation; inserting the catheter system through the guiding catheter; advancing the embolic protection device beyond the lesion; positioning the stent and balloon segment of the catheter system at the lesion; releasing the self-expanding stent; pulling the stent delivery sheath back into the guiding catheter; positioning and deploying the protection member; advancing the combination angioplasty balloon catheter and stent pusher catheter and inflating the angioplasty balloon within the lesion; deflating the angioplasty balloon and withdrawing the combination angioplasty balloon catheter and stent pusher catheter and stent delivery sheath together; and aspirating potential emboli through the guiding catheter.
摘要翻译：描述了用于执行患者颈动脉分叉的保护性血管成形术和支架置入的装置和方法。集成导管系统可以以快速交换版本或线上版本配置。导管系统包括自扩张支架，支架输送护套，组合血管成形术球囊导管和支架推进导管，栓塞保护装置，并且在快速更换版本中具有自动释放护套。该方法包括：将引导导管插入颈动脉分叉; 通过引导导管插入导管系统; 推进栓塞保护装置超过病变; 将导管系统的支架和气囊段定位在病变处; 释放自扩张支架; 将支架输送护套拉回导引导管; 定位和部署保护构件; 推进组合血管成形术球囊导管和支架推动导管，并使病变内的血管成形术气囊膨胀; 将血管成形术气囊放气并将组合血管成形术球囊导管和支架推进导管和支架输送护套并入; 并通过引导导管抽吸潜在的栓塞。

4. 发明申请

US20100174352A1 Catheter system for angioplasty and stenting with embolic protection 审中-公开
标题翻译：用于血管成形术和支架置入的导管系统具有栓塞保护
公开(公告)号：US20100174352A1
公开(公告)日：2010-07-08
申请号：US12079472
申请日：2008-03-27
申请人： Machiel Van Der Leest , Pierre Hilaire
发明人： Machiel Van Der Leest , Pierre Hilaire
IPC分类号： A61F2/84 , A61M29/00 , A61F2/01
CPC分类号： A61B17/12136 , A61B2017/22067 , A61F2/013 , A61F2/958 , A61F2/97 , A61F2230/0006
摘要： Apparatus and methods are described for performing angioplasty and stenting with embolic protection. A catheter system includes an angioplasty balloon catheter, a balloon-expandable stent, an embolic protection device and a linking device. The catheter system has an undeployed configuration in which the balloon-expandable stent is mounted on the inflatable angioplasty balloon in an uninflated condition, the embolic protection member is positioned distally to the balloon-expandable stent and the angioplasty balloon, and the linking device is mounted on the catheter shaft of the angioplasty balloon catheter and the device shaft of the embolic protection device. The linking device prevents any relative longitudinal motion of the angioplasty balloon catheter and the embolic protection device, which might lead to accidental dislodgement of the balloon-expandable stent.
摘要翻译：描述了用于执行栓塞保护的血管成形术和支架置入的装置和方法。导管系统包括血管成形术球囊导管，球囊扩张支架，栓塞保护装置和连接装置。导管系统具有未部署的构造，其中气球可扩张支架处于未膨胀状态下安装在可充气血管成形术球囊上，栓塞保护构件位于球囊扩张支架和血管成形术球囊的远侧，并且连接装置被安装在血管成形术球囊导管的导管轴上和栓塞保护装置的装置轴上。连接装置防止血管成形术球囊导管和栓塞保护装置的任何相对纵向运动，这可能导致球囊可扩张支架的意外移动。

5. 发明授权

US07641684B2 Catheter system for stenting bifurcated vessels 有权
标题翻译：用于支架分叉血管的导管系统
公开(公告)号：US07641684B2
公开(公告)日：2010-01-05
申请号：US10833494
申请日：2004-04-27
申请人： Pierre Hilaire , James J. Leary , Machiel Van Der Leest
发明人： Pierre Hilaire , James J. Leary , Machiel Van Der Leest
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2/97 , A61F2002/065 , A61F2002/067 , A61F2250/006
摘要： A catheter system and method are described for stenting a vessel at a bifurcation or sidebranch of the vessel. The catheter system includes a first balloon catheter, a second balloon catheter and a releasable linking device for holding the first and second balloon catheters arranged in a side-by-side configuration and aligned with one another along a longitudinal axis. The linking device allows the catheter system to be advanced as a unit and helps prevent premature or inadvertent dislodgement of the stent from the catheters, yet is releasable so that one or both of the balloon catheters can be released from the linking device and maneuvered separately from the rest of the catheter system when desired. The method utilizes the described catheter system for stenting bifurcated vessels using a modified “kissing balloons” technique.
摘要翻译：描述了用于在血管的分叉或侧分支处支架血管的导管系统和方法。导管系统包括第一气囊导管，第二球囊导管和可释放连接装置，用于保持以并排构造布置并沿着纵向轴线彼此对准的第一和第二气囊导管。连接装置允许导管系统作为一个单元前进，并且有助于防止支架从导管中过早或无意地移出，但是可释放，使得气囊导管中的一个或两个可以从连接装置释放并与导管系统的其余部分。该方法利用所描述的导管系统用于使用改进的“接吻气球”技术支架分叉血管。

6. 发明申请

US20060271152A1 Catheter system for stenting bifurcated vessels 有权
标题翻译：用于支架分叉血管的导管系统
公开(公告)号：US20060271152A1
公开(公告)日：2006-11-30
申请号：US11319767
申请日：2005-12-27
申请人： Pierre Hilaire , Machiel Van Der Leest
发明人： Pierre Hilaire , Machiel Van Der Leest
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61B1/041 , A61F2/856 , A61F2/915 , A61F2/954 , A61F2002/065 , A61F2002/826 , A61F2002/91558 , A61F2230/001 , A61F2250/0036 , A61F2250/0039
摘要： A stenting system includes a stent delivery catheter having a catheter shaft with a step balloon mounted thereon. The step balloon has a proximal portion and a distal portion, wherein the proximal portion is inflatable to a larger expanded diameter than the distal portion. A two-part stent has a proximal part that is mounted on the proximal portion of the step balloon and a distal part that is mounted on the distal portion of the step balloon and a non-link zone between the proximal part and the distal part of the two-part stent. The proximal part and the distal part of the two-part stent are each configured with stent struts that extend like interdigitating fingers into the non-link zone to provide improved strut coverage in the carina region of the bifurcated vessel. The non-link zone effectively eliminates any difficulties in alignment of the two parts relative to one another during placement of the two-part stent in a bifurcated vessel.
摘要翻译：支架系统包括具有安装在其上的阶梯式气囊的导管轴的支架输送导管。台阶气球具有近端部分和远端部分，其中近端部分可膨胀至比远侧部分更大的扩张直径。两部分支架具有安装在台阶球囊的近端部分上的近端部分，以及安装在台阶球囊的远端部分上的远端部分和位于步骤球囊的近端部分和远端部分之间的非连接区域两部分支架。两部分支架的近端部分和远端部分各自配置有支架支柱，支架支柱如同指状指状物延伸到非连接区域，以提供分叉血管的耳状区域中改善的支柱覆盖。在将两部分支架放置在分叉的容器中时，非连接区有效地消除了两个部件相对于彼此对准的任何困难。

7. 发明授权

US09278015B2 Catheter system for stenting and drug treatment of bifurcated vessels 有权
标题翻译：导管系统用于分支血管的支架和药物治疗
公开(公告)号：US09278015B2
公开(公告)日：2016-03-08
申请号：US11789001
申请日：2007-04-23
申请人： Pierre Hilaire , Machiel Van Der Leest
发明人： Pierre Hilaire , Machiel Van Der Leest
IPC分类号： A61F2/06 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/067 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/001
摘要： A catheter system and method are described for stenting a vessel at a bifurcation or sidebranch of the vessel. The catheter system includes a first balloon catheter, a second balloon catheter and a releasable linking device for holding the first and second balloon catheters arranged in a side-by-side configuration and aligned with one another along a longitudinal axis so that the catheter system can be advanced as a unit. The catheter system is combined with drug eluting technology to prevent restenosis, inflammation and/or thrombosis and/or to promote reendothelialization in the vessel bifurcation. The main vessel stent and/or the sidebranch stent may be coated or impregnated with one or more drugs or bioactive substances. Alternatively or in addition, the first balloon and/or the second balloon may be coated with or include a mechanism for delivering one or more drugs or bioactive substances to the vessel wall.
摘要翻译：描述了用于在血管的分叉或侧分支处支架血管的导管系统和方法。导管系统包括第一气囊导管，第二球囊导管和可释放连接装置，用于保持沿并排构造布置并沿着纵向轴线彼此对准的第一和第二气囊导管，使得导管系统可以作为一个单位进步。导管系统与药物洗脱技术结合，以防止再狭窄，炎症和/或血栓形成和/或促进血管分叉中的再内皮化。主血管支架和/或侧支支架可以用一种或多种药物或生物活性物质进行包衣或浸渍。或者或另外，第一球囊和/或第二球囊可以涂覆或包括用于将一种或多种药物或生物活性物质递送到血管壁的机构。

8. 发明申请

US20100087908A1 APPARATUS AND METHODS FOR STENT DELIVERY WITH EMBOLIC PROTECTION 有权
标题翻译：用于手术保护的手术和方法
公开(公告)号：US20100087908A1
公开(公告)日：2010-04-08
申请号：US12532141
申请日：2008-03-20
申请人： Pierre Hilaire , Machiel Van Der Leest
发明人： Pierre Hilaire , Machiel Van Der Leest
IPC分类号： A61F2/84 , A61B17/22
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61F2230/0093
摘要： The present invention relates to a catheter system of the type comprising: a stent delivery catheter (2) having a proximal end and a distal end and an interior lumen extending between the proximal end and the distal end; a stent (1) having a proximal end and a distal end and a stent lumen extending between the proximal end and the distal end, the stent having an expanded state and an unexpanded state; and an embolic protection filter (3) having an expanded state and an unexpanded state; the catheter system having a deployed position and an undeployed position. According to the invention the catheter system is characterised in that when the catheter system is in the undeployed position, the stent (1) is in its unexpanded state and positioned within the interior lumen of the stent delivery catheter (2) and the embolic protection filter (3) is in its unexpanded state and positioned within the stent lumen of the stent.
摘要翻译：本发明涉及一种导管系统，其包括：支架输送导管（2），其具有近端和远端以及在近端和远端之间延伸的内腔; 具有近端和远端的支架（1）和在近端和远端之间延伸的支架腔，所述支架具有膨胀状态和未膨胀状态; 和具有膨胀状态和未膨胀状态的栓塞保护过滤器（3）; 导管系统具有展开位置和未部署位置。根据本发明，导管系统的特征在于，当导管系统处于未部署位置时，支架（1）处于其未展开状态并且位于支架输送导管（2）的内腔内并且栓塞保护过滤器（3）处于其未展开状态并且位于支架的支架内腔内。

9. 发明申请

US20070250001A1 Guidewire Separator Device and Method of Use 审中-公开
标题翻译：导丝分离装置及其使用方法
公开(公告)号：US20070250001A1
公开(公告)日：2007-10-25
申请号：US11597339
申请日：2005-05-21
申请人： Pierre Hilaire , Machiel Van Der Leest , Thierry Royer
发明人： Pierre Hilaire , Machiel Van Der Leest , Thierry Royer
IPC分类号： A61M31/00
CPC分类号： A61M25/0029 , A61B2017/22038 , A61F2/856 , A61F2/954 , A61M25/0068 , A61M25/0071 , A61M25/008 , A61M2025/0034 , A61M2025/0037 , A61M2025/004 , A61M2025/0063 , A61M2025/018 , A61M2025/0188 , A61M2025/1045
摘要： A guidewire separator device and methods are described for resolving guidewire entanglement and for introducing guidewires into branch vessels when performing angioplasty or stenting of a bifurcated artery. The device has an elongate tubular distal portion joined to an elongate proximal portion. A first lumen extends through the tubular distal portion of the device, with a first distal guidewire port located near a distal end of the distal portion and a first proximal guidewire port located near a proximal end of the distal portion. A second lumen extends through the tubular distal portion of the device, with a second distal guidewire port located near a distal end of the distal portion and a second proximal guidewire port located near a proximal end of the second lumen. One or both of the lumens may continue through the proximal portion of the device. Optionally, the device includes one or more longitudinal slits to externalize the guidewires from the lumens during withdrawal of device.
摘要翻译：描述了一种导线分离装置和方法，用于解决导线缠结并且当执行分叉动脉的血管成形术或支架置入时将引导线引入分支血管。该装置具有连接到细长近端部分的细长管状远端部分。第一腔延伸穿过装置的管状远端部分，第一远端导丝端口位于远侧部分的远端附近，第一近端导丝端口位于远端部分的近端附近。第二腔延伸穿过装置的管状远端部分，第二远端导丝端口位于远端部分的远端附近，第二近端导丝端口位于第二内腔的近端附近。腔中的一个或两个可以继续穿过装置的近侧部分。可选地，该装置包括一个或多个纵向狭缝，以在装置取出期间使来自腔的导线外化。

10. 发明申请

US20100106238A1 CATHETER SYSTEM FOR STENTING BIFURCATED VESSELS 有权
标题翻译：用于控制分支船的导管系统
公开(公告)号：US20100106238A1
公开(公告)日：2010-04-29
申请号：US12651972
申请日：2010-01-04
申请人： Pierre Hilaire , James J. Leary , Machiel Van Der Leest
发明人： Pierre Hilaire , James J. Leary , Machiel Van Der Leest
IPC分类号： A61F2/82 , A61M29/00
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2/97 , A61F2002/065 , A61F2002/067 , A61F2250/006
摘要： A catheter system and method are described for stenting a vessel at a bifurcation or sidebranch of the vessel. The catheter system includes a first balloon catheter, a second balloon catheter and a releasable linking device for holding the first and second balloon catheters arranged in a side-by-side configuration and aligned with one another along a longitudinal axis. The linking device allows the catheter system to be advanced as a unit and helps prevent premature or inadvertent dislodgement of the stent from the catheters, yet is releasable so that one or both of the balloon catheters can be released from the linking device and maneuvered separately from the rest of the catheter system when desired. The method utilizes the described catheter system for stenting bifurcated vessels using a modified “kissing balloons” technique.
摘要翻译：描述了用于在血管的分叉或侧分支处支架血管的导管系统和方法。导管系统包括第一气囊导管，第二球囊导管和可释放连接装置，用于保持以并排构造布置并沿着纵向轴线彼此对准的第一和第二气囊导管。连接装置允许导管系统作为一个单元前进，并且有助于防止支架从导管中过早或无意地移出，但是可释放，使得气囊导管中的一个或两个可以从连接装置释放并与导管系统的其余部分。该方法利用所描述的导管系统用于使用改进的“接吻气球”技术支架分叉血管。

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