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1. 发明申请

US20210082680A1 QUADRUPOLE DEVICES 有权
公开(公告)号：US20210082680A1
公开(公告)日：2021-03-18
申请号：US16970252
申请日：2019-02-15
申请人： Micromass UK Limited
发明人： Gordon David , David Langridge , Martin Raymond Green , Richard Moulds , Daniel J. Kenny , Kenneth Worthington
IPC分类号： H01J49/42
摘要： A method of operating a quadrupole device is disclosed. The method comprises operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device, and operating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device. In the first mode of operation, the quadrupole device is operated in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or in a first X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. In the second mode of operation, the quadrupole device is operated in a second X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device.

2. 发明授权

US10453667B2 Mass filter having extended operational lifetime 有权
公开(公告)号：US10453667B2
公开(公告)日：2019-10-22
申请号：US15578053
申请日：2016-05-31
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
IPC分类号： H01J49/42 , H01J49/06
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.

3. 发明授权

US10354848B2 Method of mass analysis using ion filtering 有权
公开(公告)号：US10354848B2
公开(公告)日：2019-07-16
申请号：US15576980
申请日：2016-05-31
申请人： MICROMASS UK LIMITED
发明人： Richard Moulds
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42 , H01J49/36
摘要： A method of mass spectrometry is disclosed comprising detecting the ions transmitted by a mass filter (4) with a detector (6); changing the RF and/or DC voltage applied to the mass filter (4) during a voltage transition period so as to change the mass to charge ratio capable of being transmitted by the mass filter (4); preventing ions from reaching the detector during the voltage transition period; and allowing ions to be transmitted to the detector (6) after the voltage transition period.

4. 发明申请

US20200075308A1 MASS FILTER HAVING EXTENDED OPERATIONAL LIFETIME 审中-公开
公开(公告)号：US20200075308A1
公开(公告)日：2020-03-05
申请号：US16563203
申请日：2019-09-06
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
IPC分类号： H01J49/42 , H01J49/06
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.

5. 发明授权

US10325766B2 Method of optimising spectral data 有权
公开(公告)号：US10325766B2
公开(公告)日：2019-06-18
申请号：US15301172
申请日：2015-04-01
申请人： Micromass UK Limited
发明人： Richard Moulds , Keith Richardson , Jason Lee Wildgoose , Martin Raymond Green
IPC分类号： H01J49/26 , H01J49/00 , G01N27/62 , H01J49/40
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analyzing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, while discarding less optimal data.

6. 发明申请

US20180174817A1 MASS FILTER HAVING EXTENDED OPERATIONAL LIFETIME 审中-公开
公开(公告)号：US20180174817A1
公开(公告)日：2018-06-21
申请号：US15578053
申请日：2016-05-31
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
IPC分类号： H01J49/42 , H01J49/06
CPC分类号： H01J49/4215 , H01J49/063 , H01J49/067 , H01J49/4255
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.

7. 发明公开

US20230326733A1 SYSTEM FOR DETERMINING THE CLEANLINESS OF MASS SPECTROMETER ION OPTICS 审中-公开
公开(公告)号：US20230326733A1
公开(公告)日：2023-10-12
申请号：US18042956
申请日：2021-08-26
申请人： Micromass UK Limited
发明人： David Gordon , Nicola Lumley , Alastair Booth , Richard Moulds
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/06 , H01J49/0036
摘要： A mass spectrometer is disclosed comprising: an ion detector; ion optics for guiding ions to the ion detector; one or more voltage supply for supplying voltages to said ion optics; control circuitry for controlling the one or more voltage supply so as to switch the ion optics between operating in a first mode in which the ion optics are unable to transmit ions having a first mass to charge ratio or first polarity to the ion detector and a second mode in which the ion optics are able to transmit ions having said first mass to charge ratio or first polarity to the ion detector for a time period; and to repeatedly switch between the first and second modes a plurality of times; and a processor and circuitry configured to: (i) determine the intensity of an ion signal detected by the detector at a first time in each of the time periods that the ion optics are in the second mode; and (ii) determine the intensity of the ion signal detected by the detector at a second, later time in each of the time periods that the ion optics are in the second mode.

8. 发明授权

US10832900B2 Mass filter having extended operational lifetime 有权
公开(公告)号：US10832900B2
公开(公告)日：2020-11-10
申请号：US16563203
申请日：2019-09-06
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
IPC分类号： H01J49/42 , H01J49/06
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.

9. 发明申请

US20170011899A1 Method of Optimising Spectral Data 审中-公开
标题翻译：优化光谱数据的方法
公开(公告)号：US20170011899A1
公开(公告)日：2017-01-12
申请号：US15301172
申请日：2015-04-01
申请人： Micromass UK Limited
发明人： Richard Moulds , Keith Richardson , Jason Lee Wildgoose , Martin Raymond Green
IPC分类号： H01J49/00 , G01N27/62 , H01J49/40
CPC分类号： H01J49/0036 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/40
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, whilst discarding less optimal data.
摘要翻译：公开了一种质谱法或离子迁移光谱法。该方法包括：提供多种离子; 在多个顺序采集周期期间分析离子，以便获得与离子有关的光谱数据; 改变光谱仪的操作参数的值，使得其在不同采集周期期间具有不同的值，其中为给定离子获得的光谱数据根据操作参数的值而变化; 分别存储在不同采集周期期间获得的光谱数据; 选择目标离子; 然后询问光谱数据，以便识别包括对应于所述目标离子的数据的一组第一采集周期。从第一采集周期的子集中选择光谱数据允许选择目标离子的最佳光谱数据，同时丢弃较不优化的数据。

10. 发明授权

US11361958B2 Quadrupole devices 有权
公开(公告)号：US11361958B2
公开(公告)日：2022-06-14
申请号：US16970252
申请日：2019-02-15
申请人： Micromass UK Limited
发明人： David Gordon , David Langridge , Martin Raymond Green , Richard Moulds , Daniel J. Kenny , Kenneth Worthington
IPC分类号： H01J49/42 , H01J49/00
摘要： A method of operating a quadrupole device is disclosed. The method comprises operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device, and operating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device. In the first mode of operation, the quadrupole device is operated in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or in a first X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. In the second mode of operation, the quadrupole device is operated in a second X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device.

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