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1. 发明申请

US20190216784A1 PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF 审中-公开
公开(公告)号：US20190216784A1
公开(公告)日：2019-07-18
申请号：US16247359
申请日：2019-01-14
申请人： MERIAL, INC.
发明人： Mark D. Soll , Joseph K. Rosentel, JR. , James Pate , Natalya Shub , Monica Tejwani-Motwani , Carol Belansky
IPC分类号： A61K31/42 , A61K38/15 , A61K45/06 , A61K31/4745 , A61K31/4402 , A61K31/44 , A61K31/415 , A61K31/366 , A61K31/231 , A61K31/22 , A61K31/215 , A61K9/06 , A61K9/00 , A01N49/00 , A01N43/80 , A01N43/40 , A61K47/26 , A61K47/22 , A61K47/14 , A61K47/10 , A61K47/08 , A61K31/7048
摘要： This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

2. 发明申请

US20160051519A1 PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF 有权
公开(公告)号：US20160051519A1
公开(公告)日：2016-02-25
申请号：US14930690
申请日：2015-11-03
申请人： MERIAL, INC.
发明人： Mark D. Soll , Joseph K. Rosentel, JR. , James Pate , Natalya Shub , Monica Tejwani-Motwani , Carol Belansky
IPC分类号： A61K31/42 , A61K31/4402 , A61K45/06 , A61K31/215 , A61K31/415 , A61K38/15 , A61K31/22 , A61K31/44
CPC分类号： A61K31/42 , A01N43/40 , A01N43/80 , A01N49/00 , A61K9/0017 , A61K9/06 , A61K31/215 , A61K31/22 , A61K31/231 , A61K31/366 , A61K31/415 , A61K31/44 , A61K31/4402 , A61K31/4745 , A61K31/7048 , A61K38/15 , A61K45/06 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

3. 发明申请

US20170333397A1 PARASITICIDAL COMPOSITIONS COMPRISING FIPRONIL AT HIGH CONCENTRATIONS 审中-公开
公开(公告)号：US20170333397A1
公开(公告)日：2017-11-23
申请号：US15522647
申请日：2015-10-30
申请人： MERIAL INC.
发明人： James Pate , Natalya Shub
IPC分类号： A61K31/415 , A61K9/00 , A01N47/02 , A61K31/215 , A01N43/40
CPC分类号： A61K31/415 , A01N43/40 , A01N47/02 , A01N49/00 , A61K9/0017 , A61K31/215
摘要： The invention provides for spot-on formulations comprising fipronil in a high concentration for the treatment or prophylaxis of parasites of mammals and birds, and in particular, cats, dogs, horses, chickens, sheep and cattle with the aim of ridding these animals of all the parasites commonly encountered by birds and mammals. The invention also provides for effective and lasting destruction of ectoparasites, such as fleas, ticks, itch mites and lice, and of endoparasites, nematodes, such as filariae, and roundworms of the digestive tract of animals and humans.

4. 发明授权

US09756852B2 Topical delivery formulation 有权
公开(公告)号：US09756852B2
公开(公告)日：2017-09-12
申请号：US14600651
申请日：2015-01-20
申请人： MERIAL INC.
发明人： James Pate , Natalya Shub
IPC分类号： A01N25/34 , A01N25/10 , A01N43/56 , A01N53/00 , A61K9/00
CPC分类号： A01N25/10 , A01N43/56 , A01N53/00 , A61K9/0014
摘要： The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.

5. 发明申请

US20150201611A1 TOPICAL DELIVERY FORMULATION 有权
标题翻译：主题交付配方
公开(公告)号：US20150201611A1
公开(公告)日：2015-07-23
申请号：US14600651
申请日：2015-01-20
申请人： MERIAL INC.
发明人： James Pate , Natalya Shub
IPC分类号： A01N25/10 , A01N53/00 , A01N43/56
CPC分类号： A01N25/10 , A01N43/56 , A01N53/00 , A61K9/0014
摘要： The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.
摘要翻译：本发明是具有优异防水性能的浇注抗寄生虫制剂。倾注配方使用一种或多种聚合物（水溶性或不含水溶性）在约5至约40％w / w的范围内，一种或多种在约50至约94％w / w范围内的溶剂，含或不含有约5至约30％w / w范围内的添加剂（例如异丙醇或乙醇），以及任选的增塑剂在约0.5至约25％w / w范围内。灌注抗寄生虫制剂在施用于动物（牛，绵羊，狗等）时具有有限的扩散。浇注抗寄生虫制剂进一步部分蒸发，留下将至少一种活性成分扩散至动物皮肤的防水聚合物基质。

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