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1. 发明申请

US20140179707A1 NOVEL ERGOLINE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：新颖的胆固醇衍生物及其用途
公开(公告)号：US20140179707A1
公开(公告)日：2014-06-26
申请号：US14134127
申请日：2013-12-19
申请人： MAP PHARMACEUTICALS, INC.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： A61K31/4985 , A61M15/00
CPC分类号： A61K31/4985
摘要： Provided herein are 8′-Hydroxy-2-CF3-dihydroergotamine (8′OH-2-CF3-DHE) compounds, compositions, and dosage forms containing such compositions. Also provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供了含有这种组合物的8'-羟基-2- CF 3 - 二氢麦角胺（8'OH-2-CF3-DHE）化合物，组合物和剂型。本文还提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

2. 发明申请

US20150238487A1 NOVEL ERGOLINE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：新颖的胆固醇衍生物及其用途
公开(公告)号：US20150238487A1
公开(公告)日：2015-08-27
申请号：US14697906
申请日：2015-04-28
申请人： MAP Pharmaceuticals, Inc.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985
摘要： Provided herein are 8′-Hydroxy-2-CF3-dihydroergotamine (8′OH-2-CF3-DHE) compounds, compositions, and dosage forms containing such compositions. Also provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供了含有这种组合物的8'-羟基-2- CF 3 - 二氢麦角胺（8'OH-2-CF3-DHE）化合物，组合物和剂型。本文还提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

3. 发明申请

US20170231976A1 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS 审中-公开
公开(公告)号：US20170231976A1
公开(公告)日：2017-08-17
申请号：US15585925
申请日：2017-05-03
申请人： MAP Pharmaceuticals, Inc.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： A61K31/48 , A61K9/00
CPC分类号： A61K31/48 , A61K9/008 , A61K31/4985 , C07D498/04
摘要： 8′-Hydroxy-Dihydroergotamine (8′-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or disorders selected from amyotrophic lateral sclerosis (ALS), Parkinson's disease, stress/anxiety, nausea, emesis, aggression, pain, neuropathic pain, sleeplessness, insomnia, restless leg syndrome and depression using the compounds, compositions, dosage forms and administration techniques disclosed herein.

4. 发明申请

US20150133456A1 FLUOROERGOLINE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：氟代醇衍生物及其用途
公开(公告)号：US20150133456A1
公开(公告)日：2015-05-14
申请号：US14593792
申请日：2015-01-09
申请人： MAP PHARMACEUTICALS, INC.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： A61K31/4985 , A61M11/02 , A61M15/00 , A61M11/00
CPC分类号： A61K31/4985 , A61K9/0043 , A61K9/0075 , A61K9/008 , A61K47/24 , A61K47/38 , A61M11/003 , A61M11/02 , A61M15/0051 , A61M15/0068 , A61M15/0086 , A61M15/009 , A61M2202/064 , C07D457/02
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供新的氟麦角灵衍生物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

5. 发明申请

US20150306096A1 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS 审中-公开
标题翻译： 8'-羟基二羟基甲酰胺化合物和组合物
公开(公告)号：US20150306096A1
公开(公告)日：2015-10-29
申请号：US14699675
申请日：2015-04-29
申请人： MAP Pharmaceuticals, Inc.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： A61K31/4985
CPC分类号： A61K31/48 , A61K9/008 , A61K31/4985 , C07D498/04
摘要： 8′-Hydroxy-Dihydroergotamine (8′-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or disorders selected from amyotrophic lateral sclerosis (ALS), Parkinson's disease, stress/anxiety, nausea, emesis, aggression, pain, neuropathic pain, sleeplessness, insomnia, restless leg syndrome and depression using the compounds, compositions, dosage forms and administration techniques disclosed herein.
摘要翻译：提供8'-羟基 - 二氢麦角胺（8'-OH DHE）药物化合物，组合物和含有这些组合物的剂型。本文还提供了治疗，预防或改善选自肌萎缩性侧索硬化（ALS），帕金森病，压力/焦虑，恶心，呕吐，侵略，疼痛，神经性疼痛，失眠，失眠，不安的疾病，病症或障碍的方法使用本文公开的化合物，组合物，剂型和给药技术来治疗腿部综合征和抑郁症。

6. 发明申请

US20140179706A1 FLUOROERGOLINE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：氟代醇衍生物及其用途
公开(公告)号：US20140179706A1
公开(公告)日：2014-06-26
申请号：US14134120
申请日：2013-12-19
申请人： MAP PHARMACEUTICALS, INC.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： C07D457/02 , A61K9/00
CPC分类号： A61K31/4985 , A61K9/0043 , A61K9/0075 , A61K9/008 , A61K47/24 , A61K47/38 , A61M11/003 , A61M11/02 , A61M15/0051 , A61M15/0068 , A61M15/0086 , A61M15/009 , A61M2202/064 , C07D457/02
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供新的氟麦角灵衍生物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

7. 发明申请

US20140179705A1 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS 审中-公开
标题翻译： 8'-羟基二羟基甲酰胺化合物和组合物
公开(公告)号：US20140179705A1
公开(公告)日：2014-06-26
申请号：US14134105
申请日：2013-12-19
申请人： MAP PHARMACEUTICALS, INC.
发明人： Thomas Armer , Shashidhar Kori , Libo Wu
IPC分类号： C07D498/04 , A61M15/00
CPC分类号： A61K31/48 , A61K9/008 , A61K31/4985 , C07D498/04
摘要： 8′-Hydroxy-Dihydroergotamine (8′-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or disorders selected from amyotrophic lateral sclerosis (ALS), Parkinson's disease, stress/anxiety, nausea, emesis, aggression, pain, neuropathic pain, sleeplessness, insomnia, restless leg syndrome and depression using the compounds, compositions, dosage forms and administration techniques disclosed herein.
摘要翻译：提供8'-羟基 - 二氢麦角胺（8'-OH DHE）药物化合物，组合物和含有这些组合物的剂型。本文还提供了治疗，预防或改善选自肌萎缩性侧索硬化（ALS），帕金森病，压力/焦虑，恶心，呕吐，侵略，疼痛，神经性疼痛，失眠，失眠，不安的疾病，病症或障碍的方法使用本文公开的化合物，组合物，剂型和给药技术来治疗腿部综合征和抑郁症。

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