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1. 发明授权

US09278193B2 Systems and methods for providing a convection-enhanced delivery device 有权
标题翻译：用于提供对流增强输送装置的系统和方法
公开(公告)号：US09278193B2
公开(公告)日：2016-03-08
申请号：US13143535
申请日：2010-01-11
申请人： M. Ishaq Haider , Frank Martin , Richard Klug
发明人： M. Ishaq Haider , Frank Martin , Richard Klug
IPC分类号： A61M25/02
CPC分类号： A61M25/02 , A61M2025/024
摘要： A delivery device system is provided for assisting a patient and physician in maintaining a depth and position of an inserted catheter within a target tissue. The delivery device includes a base member that is secured to an external surface of the patient. The base member includes an aperture through which a catheter is inserted to access the target tissue. The base member further includes a hinged clip that selectively locks into a closed position to secure the catheter within the delivery device and maintain a desired insertion depth of the catheter within the target tissue. The base member further includes a receiving channel for compatibly and adjustably securing an adapter portion of the catheter in a horizontal orientation.
摘要翻译：提供递送装置系统，用于帮助患者和医生保持插入的导管在目标组织内的深度和位置。输送装置包括固定到患者的外表面的基部构件。基部构件包括孔，插入导管以进入目标组织。基部构件还包括铰接夹，其选择性地锁定到关闭位置以将导管固定在输送装置内并且保持导管在目标组织内的期望的插入深度。基部构件还包括用于将导管的适配器部分以水平取向相容且可调节地固定的接收通道。

2. 发明申请

US20110306934A1 SYSTEMS AND METHODS FOR PROVIDING A CONVECTION-ENHANCED DELIVERY DEVICE 有权
标题翻译：用于提供对流增强传送装置的系统和方法
公开(公告)号：US20110306934A1
公开(公告)日：2011-12-15
申请号：US13143535
申请日：2010-01-11
申请人： M. Ishaq Haider , Frank Martin , Richard Klug
发明人： M. Ishaq Haider , Frank Martin , Richard Klug
IPC分类号： A61M25/02
CPC分类号： A61M25/02 , A61M2025/024
摘要： A delivery device system is provided for assisting a patient and physician in maintaining a depth and position of an inserted catheter within a target tissue. The delivery device includes a base member that is secured to an external surface of the patient. The base member includes an aperture through which a catheter is inserted to access the target tissue. The base member further includes a hinged clip that selectively locks into a closed position to secure the catheter within the delivery device and maintain a desired insertion depth of the catheter within the target tissue. The base member further includes a receiving channel for compatibly and adjustably securing an adapter portion of the catheter in a horizontal orientation.
摘要翻译：提供递送装置系统，用于帮助患者和医生保持插入的导管在目标组织内的深度和位置。输送装置包括固定到患者的外表面的基部构件。基部构件包括孔，插入导管以进入目标组织。基部构件还包括铰接夹，其选择性地锁定到关闭位置以将导管固定在输送装置内并且保持导管在目标组织内的期望的插入深度。基部构件还包括用于将导管的适配器部分以水平取向相容且可调节地固定的接收通道。

3. 发明授权

US09775956B2 Needle assembly for mixing of substances 有权
公开(公告)号：US09775956B2
公开(公告)日：2017-10-03
申请号：US13810675
申请日：2010-07-22
申请人： Frank Martin , Richard J. Klug , M. Ishaq Haider
发明人： Frank Martin , Richard J. Klug , M. Ishaq Haider
IPC分类号： A61M37/00 , A61M5/32 , A61M5/24 , A61M5/34
CPC分类号： A61M5/3294 , A61M5/2448 , A61M5/346 , A61M5/347 , A61M2005/2474
摘要： In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.

4. 发明申请

US20080103434A1 Microprotrusion Arrays and Methods for Using Same to Deliver Substances into Tissue 审中-公开
标题翻译：微量滴定阵列和使用相同方法将物质输送到组织中的方法
公开(公告)号：US20080103434A1
公开(公告)日：2008-05-01
申请号：US11942138
申请日：2007-11-19
申请人： Alexander Lastovich , Jason Alarcon , John Dekker , M. Ishaq Haider , John Mikszta , Frank Martin , Scott O'Connor
发明人： Alexander Lastovich , Jason Alarcon , John Dekker , M. Ishaq Haider , John Mikszta , Frank Martin , Scott O'Connor
IPC分类号： A61M37/00 , B29C41/46
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.
摘要翻译：具有流体保持或引导图案的改进的微冲击磨损装置，以及用于将物质输送到皮肤中的具体设计参数和方法。公开了这样的装置的各种构造，包括圆顶形，沟道状，图案化和阶梯状。

5. 发明申请

US20130116617A1 NEEDLE ASSEMBLY FOR MIXING OF SUBSTANCES 有权
标题翻译：用于混合物质的针头组件
公开(公告)号：US20130116617A1
公开(公告)日：2013-05-09
申请号：US13810675
申请日：2010-07-22
申请人： Frank Martin , Richard J. Klug , M. Ishaq Haider
发明人： Frank Martin , Richard J. Klug , M. Ishaq Haider
IPC分类号： A61M5/32
CPC分类号： A61M5/3294 , A61M5/2448 , A61M5/346 , A61M5/347 , A61M2005/2474
摘要： In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.
摘要翻译：在本发明的一个方面，提供一种针组件，其包括：主体，其具有近端，远端和位于其间的通道，所述主体被配置为安装到注射器; 所述针固定到所述主体，所述针具有近端和远端，所述远端从所述主体的远端向远侧延伸并且被形成为用于插入到患者体内，所述针的近端与所述通道连通; 以及设置在针的近端的近侧的通道中的过滤器。有利地，提供针组件，其允许混合至少两种物质以准备注射，而不改变相关联的注射器。

6. 发明申请

US20120041394A1 OPTIMIZED INTRACRANIAL CATHETERS FOR CONVECTION-ENHANCED DELIVERY OF THERAPEUTICS 有权
标题翻译：优化的治疗加速输血管内导管
公开(公告)号：US20120041394A1
公开(公告)日：2012-02-16
申请号：US13143536
申请日：2010-01-11
申请人： M. Ishaq Haider , Frank Martin , Bruce Clyde Roberts , Jason B. Alarcon
发明人： M. Ishaq Haider , Frank Martin , Bruce Clyde Roberts , Jason B. Alarcon
IPC分类号： A61B17/34
CPC分类号： A61M25/0068 , A61M25/007 , A61M25/0606
摘要： A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.
摘要翻译：一种可引导导管，其包括由套管针线内部支撑的热反应性粘弹性材料。可引导导管还包括多个倒角的尖端和插入在导管的内表面和套管针的外表面之间的间隙，使得启动流体被允许流过导管并且清除被捕获在套管针和套管针之间的空气导管的内表面。在插入导管之后，套管针被去除并且通过导管输注治疗剂。

7. 发明授权

US09402974B2 Optimized intracranial catheters for convection-enhanced delivery of therapeutics 有权
标题翻译：优化的颅内导管用于对流增强治疗的递送
公开(公告)号：US09402974B2
公开(公告)日：2016-08-02
申请号：US13143536
申请日：2010-01-11
申请人： M. Ishaq Haider , Frank Martin , Bruce Clyde Roberts , Jason B. Alarcon
发明人： M. Ishaq Haider , Frank Martin , Bruce Clyde Roberts , Jason B. Alarcon
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61M25/0068 , A61M25/007 , A61M25/0606
摘要： A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.
摘要翻译：一种可引导导管，其包括由套管针线内部支撑的热反应性粘弹性材料。可引导导管还包括多个倒角的尖端和插入在导管的内表面和套管针的外表面之间的间隙，使得启动流体被允许流过导管并且清除被捕获在套管针和套管针之间的空气导管的内表面。在插入导管之后，套管针被去除并且通过导管输注治疗剂。

8. 发明授权

US08556848B2 Valve for mixing of substances 有权
标题翻译：用于混合物质的阀
公开(公告)号：US08556848B2
公开(公告)日：2013-10-15
申请号：US12863456
申请日：2009-01-12
申请人： Richard J. Klug , M. Ishaq Haider , Frank Martin
发明人： Richard J. Klug , M. Ishaq Haider , Frank Martin
IPC分类号： A61M37/00
CPC分类号： A61M5/31596
摘要： A valve is provided herein for permitting mixing of at least two components, the valve including a body configured for slidable liquid tight engagement with an injector or drug cartridge barrel. The body includes a proximal end, a distal end, and a channel extending therebetween, the channel having a proximal portion and a distal portion. A poppet is sealingly and slidably disposed in the channel to selectively move between first and second positions. The poppet includes a proximal end, a distal end, and a fluid channel, the fluid channel being defined in the poppet and extending from an outlet opening located distally of the distal end of the body. With the poppet being in the first position, the poppet defines a liquid tight seal in the channel such that liquid flow through the channel is prevented. With the poppet being in the second position, the fluid channel is in communication with the proximal portion of the channel so as to define a liquid flow path from the proximal portion of the channel to the outlet opening. Advantageously, with the subject invention, a valve is provided which permits controlled separation and mixing of substances in a standard injector or drug cartridge barrel, without any modification required thereto.
摘要翻译：本文提供了一种用于允许混合至少两个部件的阀，所述阀包括构造成用于与注射器或药物盒筒可滑动地液密接合的主体。主体包括近端，远端和在其间延伸的通道，通道具有近端部分和远端部分。提升阀被密封地和可滑动地设置在通道中以选择性地在第一和第二位置之间移动。提升阀包括近端，远端和流体通道，流体通道限定在提升阀中并且从位于主体远端的出口开口延伸。当提升阀处于第一位置时，提升阀在通道中限定液体密封，使得液体流过通道被阻止。当提升阀处于第二位置时，流体通道与通道的近端部分连通，从而限定从通道的近端部分到出口的液体流动路径。有利地，在本发明中，提供了一种阀，其允许在标准注射器或药物盒筒中的物质的受控分离和混合，而不需要任何修改。

9. 发明申请

US20100286605A1 VALVE FOR MIXING OF SUBSTANCES 有权
标题翻译：用于混合物质的阀
公开(公告)号：US20100286605A1
公开(公告)日：2010-11-11
申请号：US12863456
申请日：2009-01-12
申请人： Richard J. Klug , M. Ishaq Haider , Frank Martin
发明人： Richard J. Klug , M. Ishaq Haider , Frank Martin
IPC分类号： A61M37/00 , F16K1/00
CPC分类号： A61M5/31596
摘要： A valve is provided herein for permitting mixing of at least two components, the valve including a body configured for slidable liquid tight engagement with an injector or drug cartridge barrel. The body includes a proximal end, a distal end, and a channel extending therebetween, the channel having a proximal portion and a distal portion. A poppet is sealingly and slidably disposed in the channel to selectively move between first and second positions. The poppet includes a proximal end, a distal end, and a fluid channel, the fluid channel being defined in the poppet and extending from an outlet opening located distally of the distal end of the body. With the poppet being in the first position, the poppet defines a liquid tight seal in the channel such that liquid flow through the channel is prevented. With the poppet being in the second position, the fluid channel is in communication with the proximal portion of the channel so as to define a liquid flow path from the proximal portion of the channel to the outlet opening. Advantageously, with the subject invention, a valve is provided which permits controlled separation and mixing of substances in a standard injector or drug cartridge barrel, without any modification required thereto.
摘要翻译：本文提供了一种用于允许混合至少两个部件的阀，所述阀包括构造成用于与注射器或药物盒筒可滑动地液密接合的主体。主体包括近端，远端和在其间延伸的通道，通道具有近端部分和远端部分。提升阀被密封地和可滑动地设置在通道中以选择性地在第一和第二位置之间移动。提升阀包括近端，远端和流体通道，流体通道限定在提升阀中并且从位于主体远端的出口开口延伸。当提升阀处于第一位置时，提升阀在通道中限定液体密封，使得液体流过通道被阻止。当提升阀处于第二位置时，流体通道与通道的近端部分连通，从而限定从通道的近端部分到出口的液体流动路径。有利地，在本发明中，提供了一种阀，其允许在标准注射器或药物盒筒中的物质的受控分离和混合，而不需要任何修改。

10. 发明授权

US08075826B2 Microprotrusion arrays and methods for using same to deliver substances into tissue 有权
标题翻译：微量滴定阵列及其使用方法将物质输送到组织中
公开(公告)号：US08075826B2
公开(公告)日：2011-12-13
申请号：US12487374
申请日：2009-06-18
申请人： Alexander G. Lastovich , Jason B. Alarcon , John P. Dekker, III , M. Ishaq Haider , John A. Mikszta , Frank E. Martin , Scott A. O'Connor
发明人： Alexander G. Lastovich , Jason B. Alarcon , John P. Dekker, III , M. Ishaq Haider , John A. Mikszta , Frank E. Martin , Scott A. O'Connor
IPC分类号： B29C59/02
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.
摘要翻译：具有流体保持或引导图案的改进的微冲击磨损装置，以及用于将物质输送到皮肤中的具体设计参数和方法。公开了这样的装置的各种构造，包括圆顶形，沟道状，图案化和阶梯状。

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