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1. 发明授权

US5646179A .gamma.-pyrones, .gamma.-pyridones, and .gamma.-thiopyrones, their use as medicaments and process for preparing same 失效
标题翻译： γ-吡喃酮和γ-硫吡喃酮，它们作为药物的用途及其制备方法
公开(公告)号：US5646179A
公开(公告)日：1997-07-08
申请号：US571027
申请日：1995-12-12
申请人： Lutz Muller-Kuhrt , Andreas Immelmann
发明人： Lutz Muller-Kuhrt , Andreas Immelmann
IPC分类号： C07D309/38 , A61K31/35
CPC分类号： C07D309/38
摘要： The invention relates to novel .gamma.-pyrones, .gamma.-pyridones and .gamma.-thiopyrones and their use as medicaments against viral diseases, preferably for the treatment of retroviral diseases, comprising compounds of the formula (I), in which R.sub.1 and R.sub.2 stand for hydrogen, a branched-chain or unbranched-chain C.sub.1 to C.sub.26, preferably C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.26 alkenyl or C.sub.1 to C.sub.26 alkinyl group or combinations thereof; R.sub.3 stands for a branched-chain or unbranched-chain C.sub.1 to C.sub.26 alkyl group; and R.sub.4 stands for a C.sub.3 to C.sub.26 cycloalkyl, branched-chain or unbranched-chain alkyl, alkenyl or alkinyl group. The hydrogen atoms of the methylenic group in R.sub.1, R.sub.2 and R.sub.4 may be substituted by O alkyl (C.sub.1 to C.sub.6), O acyl, O aryl, O aralkyl and alkyl (C.sub.1 to C.sub.6) groups, and in R.sub.4 also by halogenated groups, oxo groups and hydroxylic groups with double links. The elements represented by Z are independently from each other O, S or NH. ##STR1##
摘要翻译：本发明涉及新颖的γ-吡蚜酮，γ-吡咯烷酮和γ-硫代吡喃酮及其作为抗病毒疾病的药物的用途，优选用于治疗逆转录病毒疾病，包括式（I）化合物，其中R1和R2代表氢，支链或非支链C1至C26，优选C1至C6烷基，C1至C26烯基或C1至C26炔基或其组合; R3代表支链或非支链C1至C26烷基; R4代表C3至C26环烷基，支链或非支链烷基，烯基或炔基。 R 1，R 2和R 4中的亚甲基基团的氢原子可以被O（C 1 -C 6），O酰基，O芳基，O芳烷基和（C 1 -C 6）烷基取代，R 4也可被卤代基取代，氧代基和具有双链接的羟基。由Z表示的元素彼此独立地为O，S或NH。（一）

2. 发明授权

US5637455A HIV-2 virus variants 失效
标题翻译： HIV-2病毒变体
公开(公告)号：US5637455A
公开(公告)日：1997-06-10
申请号：US358575
申请日：1994-12-14
申请人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
发明人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
IPC分类号： G01N33/569 , A61K38/00 , A61K39/21 , A61K39/395 , C07K14/005 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/00 , C12N5/10 , C12N7/00 , C12N15/48 , C12N15/49 , C12R1/92 , G01N33/577 , G01N33/53
CPC分类号： C12N7/00 , C07K14/005 , C07K16/1045 , A61K38/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S530/81 , Y10S530/815 , Y10S530/826
摘要： HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.
摘要翻译：可以从相应的病毒分离物HIV D194（ECACC V 87122303）或感染的细胞系HUT 194（ECACC V 87122306）或来自病毒分离物HIV的HIV病毒变体，即病毒HIV D194和病毒HIV D205克隆 D205（ECACC V87122304）及其RNA或RNA片段以及从其衍生的DNA和DNA片段和/或蛋白质及其用于诊断和治疗的用途。

3. 发明授权

US5677147A HIV-2 virus variants 失效
公开(公告)号：US5677147A
公开(公告)日：1997-10-14
申请号：US684682
申请日：1996-07-22
申请人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
发明人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
IPC分类号： G01N33/569 , A61K38/00 , A61K39/21 , A61K39/395 , C07K14/005 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/00 , C12N5/10 , C12N7/00 , C12N15/48 , C12N15/49 , C12R1/92 , G01N33/577
CPC分类号： C12N7/00 , C07K14/005 , C07K16/1045 , A61K38/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S530/81 , Y10S530/815 , Y10S530/826
摘要： HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.

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