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1. 发明授权

US5589932A Spectrophotometric method and apparatus for the characterization of blood and blood types 失效
标题翻译：用于表征血液和血液类型的分光光度法和仪器
公开(公告)号：US5589932A
公开(公告)日：1996-12-31
申请号：US385717
申请日：1995-02-08
申请人： Luis H. Garcia-Rubio , Manuel Bayona , Robert Potter , German Leparc
发明人： Luis H. Garcia-Rubio , Manuel Bayona , Robert Potter , German Leparc
IPC分类号： G01N21/31 , G01N21/49 , G01N33/80 , G01N33/48 , A61B5/00 , G06F15/00
CPC分类号： G01N33/80 , G01N21/31 , G01N21/49
摘要： A method and apparatus for determining the type of a blood sample are provided wherein a turbidity spectrum of the blood sample is collected over a predetermined wavelength range, from which is calculated an extinction spectrum. This extinction spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. A further method is provided for for detecting the presence of a substance in a bodily fluid sample, the substance having a size in the range of generally 0.5 to 20 .mu.m. Exemplary substances that could be of interest to detect include, but are not limited to, hemoglobin, bilirubin, red blood cell antigens, microorganisms, and viruses. This embodiment includes the additional step of deconvoluting the extinction spectrum to obtain a particle size distribution for comparison with a database of control samples.
摘要翻译：提供了一种用于确定血液样本类型的方法和装置，其中在预定波长范围内收集血液样本的浊度谱，由此计算消光谱。然后将该消光谱与从具有已知血型的对照血液样品收集的一组对照光谱进行比较，从该血液样品中可以确定血液样品的类型。提供了一种用于检测物质在体液样品中的存在的另一种方法，该物质的大小通常在0.5至20μm的范围内。可能感兴趣的检测的示例性物质包括但不限于血红蛋白，胆红素，红细胞抗原，微生物和病毒。该实施方案包括解卷积消光谱以获得粒度分布的附加步骤，用于与对照样品的数据库进行比较。

2. 发明授权

US06330058B1 Spectrophotometric method and apparatus for blood typing 有权
标题翻译：分光光度法和血液分型装置
公开(公告)号：US06330058B1
公开(公告)日：2001-12-11
申请号：US09548569
申请日：2000-04-13
申请人： Luis Humberto Garcia-Rubio , Smita Narayanan , German Leparc , Robert Potter , Sharyn Orton
发明人： Luis Humberto Garcia-Rubio , Smita Narayanan , German Leparc , Robert Potter , Sharyn Orton
IPC分类号： G01N3348
CPC分类号： G01N33/80 , G01N21/31
摘要： A method and apparatus for characterizing the type of a blood sample are provided wherein an optical density spectrum of the sample is collected over a predetermined wavelength range. A reference optical density spectrum is collected over a predetermined wavelength range for a portion of the blood sample diluted in saline. Another portion of the blood sample is then mixed with an antibody corresponding to a known blood type (e.g., anti-A, anti-B, anti-D antibody). The optical density spectrum is then collected over a predetermined wavelength range for blood diluted with saline and each antibody in saline. The slopes are then calculated over a predetermined wavelength range for each spectrum. A numerical indicator of agglutination is then calculated by dividing the slope of each antibody-treated sample by the slope of the sample in saline. The resulting number is multiplied by 100. The agglutination index (AI) is arrived at by subtracting this number from 100 so that the magnitude of the AI is a reflection of the degree of agglutination of the sample. A high index value indicates large agglutination (i.e., strong interaction with antibody). Blood type is determined by comparing the AI to a predetermined empirical cutoff value. Typically cutoff values greater than 17 indicate type-specific interaction (type AB samples yield AI values over 17 with both anti-A and anti-B antibodies, while type O samples yield AI values less than 17 with both anti-A and anti-B antibodies).
摘要翻译：提供了用于表征血液样本的类型的方法和装置，其中在预定波长范围内收集样品的光密度谱。对于在盐水中稀释的部分血液样品，在预定波长范围内收集参考光密度光谱。然后将另一部分血液样品与对应于已知血型（例如抗A，抗B，抗-D抗体）的抗体混合。然后在预定波长范围内收集用盐水稀释的血液和盐水中的每种抗体的光密度谱。然后在每个频谱的预定波长范围内计算斜率。然后通过将每个抗体处理的样品的斜率除以盐水中样品的斜率来计算凝集数值指标。结果数乘以100.通过从100减去该数值得到凝集指数（AI），使得AI的大小反映样品的凝集程度。高指数值表示大的凝集（即与抗体的强相互作用）。通过将AI与预定经验截断值进行比较来确定血型。通常，大于17的截止值表示类型特异性相互作用（AB型样品产生具有抗A和抗B抗体的17个以上的AI值，而O型样品在抗A和抗B两者中产生小于17的AI值抗体）。

3. 发明授权

US07691642B1 Spectrophotometric method and apparatus for the cross-matching of platelets 有权
标题翻译：用于血小板交叉匹配的分光光度法和装置
公开(公告)号：US07691642B1
公开(公告)日：2010-04-06
申请号：US11164466
申请日：2005-11-23
申请人： Luis Humberto Garcia-Rubio , Robert Potter , German Leparc , Sharyn Orton , Yvette Mattley , Christina Bacon
发明人： Luis Humberto Garcia-Rubio , Robert Potter , German Leparc , Sharyn Orton , Yvette Mattley , Christina Bacon
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , G01N21/49 , G01N33/80 , Y10T436/101666 , Y10T436/106664 , Y10T436/110833 , Y10T436/112499 , Y10T436/115831 , Y10T436/12 , Y10T436/25125
摘要： A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined wavelength range. For blood typing, this spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. Further methods and apparatus are provided for determining the viability of and for cross matching a platelet unit Additional method and apparatus permit analysis of the sample for the presence of a contaminant, Particles can also be counted in the sample, even when present in low concentrations, including white blood cell.
摘要翻译：提供了用于表征血液样本的类型和各种血液成分的方法和装置，其中在预定波长范围上收集样品的透射光谱。对于血型分析，然后将该光谱与从已知血型对照血液样品收集的一组对照光谱进行比较，从该血液样品中可以确定血液样品的类型。提供了进一步的方法和装置，用于确定血小板单元的生存力和交叉匹配附加方法和装置允许样品分析污染物的存在，即使以低浓度存在，也可以将样品中的颗粒计数，包括白细胞。

4. 发明授权

US06984526B2 Spectrophotometric method for determining the viability of a sample containing platelets 有权
标题翻译：用于测定含有血小板的样品的活力的分光光度法
公开(公告)号：US06984526B2
公开(公告)日：2006-01-10
申请号：US09861781
申请日：2001-05-21
申请人： Luis Humberto Garcia-Rubio , Robert Potter , German Leparc , Sharyn Orton , Yvette Mattley , Christina Bacon
发明人： Luis Humberto Garcia-Rubio , Robert Potter , German Leparc , Sharyn Orton , Yvette Mattley , Christina Bacon
IPC分类号： G01N21/62
CPC分类号： G01N21/31 , G01N21/49 , G01N33/80 , Y10T436/101666 , Y10T436/106664 , Y10T436/110833 , Y10T436/112499 , Y10T436/115831 , Y10T436/12 , Y10T436/25125
摘要： A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined wavelength range. For blood typing, this spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. Further methods and apparatus are provided for determining the viability of and for cross matching a platelet unit. Additional method and apparatus permit analysis of the sample for the presence of a contaminant. Particles can also be counted in the sample, even when present in low concentrations, including white blood cell.
摘要翻译：提供了用于表征血液样本的类型和各种血液成分的方法和装置，其中在预定波长范围上收集样品的透射光谱。对于血型分析，然后将该光谱与从已知血型对照血液样品收集的一组对照光谱进行比较，从该血液样品中可以确定血液样品的类型。提供了进一步的方法和装置，用于确定血小板单元的活力和交叉匹配。附加的方法和装置允许对样品的污染物的存在进行分析。即使以低浓度存在，包括白细胞，也可以在样品中计数颗粒。

5. 发明授权

US08753845B2 Thermostable reverse transcriptases and uses thereof 有权
标题翻译：热稳定逆转录酶及其用途
公开(公告)号：US08753845B2
公开(公告)日：2014-06-17
申请号：US12979899
申请日：2010-12-28
申请人： Gulshan Dhariwal , Gary Gerard , Jun Lee , Robert Potter , Kim Rosenthal , Michael D. Smith
发明人： Gulshan Dhariwal , Gary Gerard , Jun Lee , Robert Potter , Kim Rosenthal , Michael D. Smith
IPC分类号： C12P19/34 , C12N9/12
CPC分类号： C12N9/1276 , C12P19/34 , C12Y207/07049
摘要： The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to increase thermostability, decrease terminal deoxynucleotidyl transferase activity, and/or increase fidelity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA molecules) using these reverse transcriptase enzymes or compositions. The invention also relates to nucleic acid molecules produced by these methods and to the use of such nucleic acid molecules to produce desired polypeptides. The invention also concerns kits comprising such enzymes or compositions.
摘要翻译：本发明涉及分子和细胞生物学领域。本发明通常涉及逆转录酶和逆转录核酸分子，特别是信使RNA分子的方法。具体地，本发明涉及已被突变或修饰以增加热稳定性，降低末端脱氧核苷酸转移酶活性和/或增加保真度的逆转录酶，以及使用这些方法来产生，扩增或测序核酸分子（特别是cDNA分子）的方法逆转录酶或组合物。本发明还涉及通过这些方法产生的核酸分子以及这种核酸分子用于产生所需多肽的用途。本发明还涉及包含这些酶或组合物的试剂盒。

6. 发明申请

US20080093125A1 Method and System for Forming a Non-Circular Borehole 审中-公开
标题翻译：形成非圆形井眼的方法和系统
公开(公告)号：US20080093125A1
公开(公告)日：2008-04-24
申请号：US11691445
申请日：2007-03-26
申请人： Jared Potter , Robert Potter , James Basler , Thomas Wideman
发明人： Jared Potter , Robert Potter , James Basler , Thomas Wideman
IPC分类号： E21B7/18
CPC分类号： E21B7/001 , F03G7/04 , F24T10/15 , F24T2010/53 , Y02E10/125
摘要： System and methods for creating shaped, non-circular boreholes in rocks especially for use with geothermal heat pump applications and for increasing wellbore support in applications such as horizontal oil and gas drilling are described. The systems and methods when applied to geothermal heat pumps create an elliptical shaped hole that is optimized for placing heat transfer tubes with a minimum of grout used. The significantly reduced cross-sectional area of the elliptical borehole also increases the overall drilling rate in rock and especially in hard rocks. In horizontal hard-rock drilling, creation of a horizontal non-circular borehole or modification of a circular borehole to a non-circular geometry is used to stabilize the borehole prior to casing insertion, and may also allow the use of lower mud pressures improving drilling rates. The system uses a non-contacting drilling system which in one embodiment uses a supersonic flame jet drilling system with a movable nozzle that swings between pivot points. In a second embodiment the elliptical shaped hole is created by an abrasive fluid or particle bearing-fluid or air jet drill that moves between pivot points. In another embodiment a non-contacting drill can use dual parallel nutating nozzles that create a pair of overlapping circular holes. The non-circular shaped hole is created by either the high temperature flame or water-particle jet or chemically active fluid jet as it removes rock material by erosion, dissolution and or thermal spalling. Modifications of circular boreholes to a generally elliptical shape can also be done using milling or jetting techniques.
摘要翻译：描述了用于在岩石中形成特殊用于地热热泵应用的成形非圆形钻孔并用于在诸如水平油气钻井的应用中增加井筒支撑的系统和方法。当应用于地热热泵时，系统和方法产生一个椭圆形孔，其优化用于放置最少使用的灌浆的传热管。椭圆孔的横截面积显着减小也增加了岩石，特别是硬岩中的总体钻井速度。在水平硬岩钻井中，在套管插入之前，使用水平非圆形钻孔或圆形钻孔修正为非圆形几何形状来稳定钻孔，并且也可允许使用较低的泥浆压力来改善钻井价格。该系统使用非接触钻井系统，其在一个实施例中使用具有在枢转点之间摆动的可移动喷嘴的超音速火焰喷射钻井系统。在第二实施例中，椭圆形孔由在枢轴点之间移动的研磨流体或颗粒轴承 - 流体或空气喷射钻头产生。在另一个实施例中，非接触钻头可以使用形成一对重叠圆形孔的双平行马蹄形喷嘴。非圆形孔通过高温火焰或水粒子喷射或化学活性流体射流产生，因为它通过侵蚀，溶解和/或热剥落来除去岩石材料。通常使用铣削或喷射技术也可以将圆形钻孔修改成大致椭圆形状。

7. 发明申请

US20070137368A1 TWO-POSITION LOCKING DEVICE FOR A SUPPORT FIXTURE 审中-公开
标题翻译：用于支撑装置的两个位置锁定装置
公开(公告)号：US20070137368A1
公开(公告)日：2007-06-21
申请号：US11562696
申请日：2006-11-22
申请人： Joseph DeVille , Robert Potter
发明人： Joseph DeVille , Robert Potter
IPC分类号： G05G11/00
CPC分类号： B65D19/44 , B65D2585/6887 , Y10T74/2025
摘要： A support fixture supports a plurality of components on a shipping rack. The support fixture includes a frame, a plurality of fingers and a locking device. Each finger is pivotally coupled to the frame for movement about a pivot between a support position and a released position. Each finger has a front end and a back end extending from substantially opposite sides of a pivot wherein the front end is presented for supporting one of the components in the support position. The fingers are arranged in a stack with a first finger being disposed at an end of the stack. Each of the fingers has a boss that extends outwardly therefrom to hold an adjacent finger in the support position. The locking device has a pin that is axially movable between an extended position disposed along the back end of the first finger to hold the first finger in the support position and a retracted position spaced apart spaced apart from the first finger to allow pivotal movement of the first finger between the support and released positions. The locking device also has a button operatively coupled to the pin to cause alternating actuation of the pin between the extended and retracted positions with each push of the button toward the pin.
摘要翻译：支撑夹具支撑运输架上的多个部件。支撑夹具包括框架，多个指状物和锁定装置。每个手指枢转地联接到框架，用于围绕支撑位置和释放位置之间的枢轴运动。每个手指具有从枢轴的基本相对的侧面延伸的前端和后端，其中呈现前端以支撑支撑位置中的一个部件。手指被布置成堆叠，其中第一指状物设置在堆叠的端部。每个指状物具有从其向外延伸的凸起，以将相邻的手指保持在支撑位置。锁定装置具有销，该销可在沿着第一手指的后端设置的延伸位置之间轴向移动以将第一手指保持在支撑位置，并且与第一手指间隔开的缩回位置允许枢轴运动第一手指在支撑位置和释放位置之间。锁定装置还具有可操作地联接到销的按钮，以使销在推动位置和缩回位置之间的交替致动，同时按钮朝向销。

8. 发明申请

US20070059713A1 SSB-DNA polymerase fusion proteins 审中-公开
标题翻译： SSB-DNA聚合酶融合蛋白
公开(公告)号：US20070059713A1
公开(公告)日：2007-03-15
申请号：US11222029
申请日：2005-09-09
申请人： Jun Lee , Robert Potter , David Mandelman
发明人： Jun Lee , Robert Potter , David Mandelman
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/22 , C12N15/74
CPC分类号： C12Q1/6806 , C12N9/1252 , C12N9/1276 , C12N15/62 , C12Q1/6848 , C12Q2522/101
摘要： Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).
摘要翻译：包含单链DNA结合蛋白和核酸聚合酶（例如DNA聚合酶或逆转录酶）的融合蛋白。这些高保真蛋白质适用于核酸扩增方法，包括聚合酶链反应（PCR）。

9. 发明申请

US20060292578A1 DNA polymerase blends and mutant DNA polymerases 审中-公开
标题翻译： DNA聚合酶共混物和突变型DNA聚合酶
公开(公告)号：US20060292578A1
公开(公告)日：2006-12-28
申请号：US11170762
申请日：2005-06-28
申请人： Weidong Zheng , Jun Lee , Robert Potter , David Mandelman
发明人： Weidong Zheng , Jun Lee , Robert Potter , David Mandelman
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12P19/34 , C12N9/22 , C12N15/74 , C12N1/21
CPC分类号： C12N9/1252 , C12N9/1276 , C12P19/34 , C12Q1/6806 , C12Q1/686 , C12Y207/07007 , Y02P20/52 , C12Q2561/101 , C12Q2527/149 , C12Q2521/101
摘要： A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5′-exonuclease activity and one of which has 5′-exonuclease activity. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis,
摘要翻译：一种热稳定DNA聚合酶组合物，其包含至少两种DNA聚合酶，其中之一基本上降低了5'-核酸外切酶活性，其中一种具有5'-核酸外切酶活性。该聚合酶可用于包括但不限于核酸合成，DNA测序，核酸扩增和cDNA合成的方法，

10. 发明申请

US20060275792A1 Enhancement of nucleic acid amplification using double-stranded DNA binding proteins 审中-公开
标题翻译：使用双链DNA结合蛋白增强核酸扩增
公开(公告)号：US20060275792A1
公开(公告)日：2006-12-07
申请号：US11365383
申请日：2006-02-28
申请人： Jun Lee , Robert Potter , Sandrine Javorschi-Miller
发明人： Jun Lee , Robert Potter , Sandrine Javorschi-Miller
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , C12Q1/6848 , C12Q2563/107 , C12Q2535/125 , C12Q2525/15
摘要： Disclosed are methods and materials for enhancing the efficiency, specificity and/or specificity of nucleic acid amplification reactions (e.g., PCR amplification reactions). The disclosed inventions involve the use of nonspecific double-stranded DNA binding proteins in amplification reactions. The methods described herein are useful in a wide variety of molecular biology applications including allele specific PCR.
摘要翻译：公开了用于增强核酸扩增反应的效率，特异性和/或特异性的方法和材料（例如，PCR扩增反应）。所公开的发明涉及在扩增反应中使用非特异性双链DNA结合蛋白。本文描述的方法可用于各种分子生物学应用，包括等位基因特异性PCR。

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