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1. 发明申请

US20070148181A1 Ganglioside based vaccine compositions for subcutaneous administration 有权
标题翻译：用于皮下给药的神经节苷脂基疫苗组合物
公开(公告)号：US20070148181A1
公开(公告)日：2007-06-28
申请号：US10547164
申请日：2004-02-27
申请人： Luis Enrique Molina , Circe Mesa Pardillo
发明人： Luis Enrique Molina , Circe Mesa Pardillo
IPC分类号： A61K39/00 , A61K31/739
CPC分类号： A61K39/0011 , A61K9/0019 , A61K39/095 , A61K39/39 , A61K2039/54 , A61K2039/55555
摘要： Vaccine compositions in which gangliosides and the OMP of N. meningitidis were combined to form very small size proteoliposomes (VSSP) to be administered subcutaneously are described, these compositions do not require the use of any additional adjuvant. The described compositions allow the immunological treatments with gangliosides, particularly N-AcGM3/VSSP and N-GcGM3/VSSP, showing advantages due to the less aggressive reaction in the site of injection and can be used in a simpler way and better for the patients.
摘要翻译：描述了其中神经节苷脂和脑膜炎奈瑟氏球菌的OMP组合以形成皮下施用的非常小尺寸的脂蛋白脂质体（VSSP）的疫苗组合物，这些组合物不需要使用任何额外的佐剂。所描述的组合物允许用神经节苷脂，特别是N-AcGM3 / VSSP和N-GcGM3 / VSSP进行免疫治疗，由于注射部位的较小侵蚀性反应而显示出优点，并且可以以更简单的方式使用并且对于患者更好。

2. 发明授权

US08591917B2 Ganglioside based vaccine compositions for subcutaneous administration 有权
标题翻译：用于皮下给药的神经节苷脂基疫苗组合物
公开(公告)号：US08591917B2
公开(公告)日：2013-11-26
申请号：US10547164
申请日：2004-02-27
申请人： Luis Enrique Fernández Molina , Circe Mesa Pardillo
发明人： Luis Enrique Fernández Molina , Circe Mesa Pardillo
IPC分类号： A61K39/02 , A61K39/095 , C12Q1/70
CPC分类号： A61K39/0011 , A61K9/0019 , A61K39/095 , A61K39/39 , A61K2039/54 , A61K2039/55555
摘要： Vaccine compositions in which gangliosides and the OMP of N. meningitidis were combined to form very small size proteoliposomes (VSSP) to be administered subcutaneously are described, these compositions do not require the use of any additional adjuvant.The described compositions allow the immunological treatments with gangliosides, particularly N-AcGM3/VSSP and N-GcGM3/VSSP, showing advantages due to the less aggressive reaction in the site of injection and can be used in a simpler way and better for the patients.
摘要翻译：描述了其中神经节苷脂和脑膜炎奈瑟氏球菌的OMP组合以形成皮下施用的非常小尺寸的脂蛋白脂质体（VSSP）的疫苗组合物，这些组合物不需要使用任何额外的佐剂。所描述的组合物允许用神经节苷脂，特别是N-AcGM3 / VSSP和N-GcGM3 / VSSP进行免疫治疗，由于注射部位的较小侵蚀性反应而显示出优点，并且可以以更简单的方式使用并且对于患者更好。

3. 发明授权

US08697093B2 Vaccine composition based on sticholysin encapsulated into liposomes 有权
标题翻译：基于脂质体包裹的脂溶素的疫苗组合物
公开(公告)号：US08697093B2
公开(公告)日：2014-04-15
申请号：US13808276
申请日：2011-07-05
申请人： Maria Eliana Lanio Ruiz , Luis Enrique Fernández Molina , Rady Judith Laboroe Quintana , Yoelys Cruz Leal , Maria del Carmen Luzardo Lorenzo , Circe Mesa Pardillo , Carlos Manuel Alvarez Valcárcel , Isabel Fabiola Pazos Santos , Mayra Tejuca Martínez , Aisel Valle Garay , Maria Eugenia Alonso Biosca , Liem Canet Santos
发明人： Maria Eliana Lanio Ruiz , Luis Enrique Fernández Molina , Rady Judith Laboroe Quintana , Yoelys Cruz Leal , Maria del Carmen Luzardo Lorenzo , Circe Mesa Pardillo , Carlos Manuel Alvarez Valcárcel , Isabel Fabiola Pazos Santos , Mayra Tejuca Martínez , Aisel Valle Garay , Maria Eugenia Alonso Biosca , Liem Canet Santos
IPC分类号： A61K9/00
CPC分类号： A61K39/39 , A61K9/127 , A61K2039/55516 , A61K2039/55555
摘要： The present invention relates to the field of biotechnology applied to human health. The invention describes a vaccine vehicle which toxins from eukaryotic organisms are encapsulated in liposomes with multiple lipid layers, obtained by means of the process of dehydration/rehydration, the lipid composition of which is dipalmitoylphosphatidylcholine:cholesterol in a molar ration of 1:1, which are designed for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The compositions described allow modulation of the specific CTL immune response to one or more antigens co-encapsulated in the liposomes that containing the toxin. The vaccine vehicle of the present invention presents advantages as compared with others described in the prior art owning to the robust and functional nature of the immune response induced and also the immunomodulating properties thereof.
摘要翻译：本发明涉及应用于人类健康的生物技术领域。本发明描述了一种疫苗载体，其将来自真核生物的毒素包封在具有多个脂质层的脂质体中，其通过脱水/再水化过程获得，其脂质组合物是二棕榈酰磷脂酰胆碱：摩尔比1:1的胆固醇，其中设计用于皮下或肌内给药。这些组合物不需要使用其它佐剂。所描述的组合物允许调节对包含毒素的脂质体中共同包封的一种或多种抗原的特异性CTL免疫应答。本发明的疫苗载体与现有技术中描述的具有与诱导的免疫应答的鲁棒和功能性质以及其免疫调节特性相比具有优势。

4. 发明申请

US20130149376A1 VACCINE COMPOSITION BASED ON STICHOLYSIN ENCAPSULATED INTO LIPOSOMES 有权
标题翻译：基于胶质细胞浸润到脂质体的疫苗组合物
公开(公告)号：US20130149376A1
公开(公告)日：2013-06-13
申请号：US13808276
申请日：2011-07-05
申请人： Maria Eliana Lanio Ruiz , Luis Enrique Fernández Molina , Rady Judith Laboroe Quintana , Yoelys Cruz Leal , Maria del Carmen Luzardo Lorenzo , Circe Mesa Pardillo , Carlos Manuel Alvarez Valcàrcel , Isabel Fabiola Pazos Santos , Mayra Tejuca Martínez , Aisel Valle Garay , María Eugenia Alonso Biosca , Liem Canet Santos
发明人： Maria Eliana Lanio Ruiz , Luis Enrique Fernández Molina , Rady Judith Laboroe Quintana , Yoelys Cruz Leal , Maria del Carmen Luzardo Lorenzo , Circe Mesa Pardillo , Carlos Manuel Alvarez Valcàrcel , Isabel Fabiola Pazos Santos , Mayra Tejuca Martínez , Aisel Valle Garay , María Eugenia Alonso Biosca , Liem Canet Santos
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K9/127 , A61K2039/55516 , A61K2039/55555
摘要： The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine:cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants.The disclosed compositions allow modulation of CTL-specific immune response against one or several antigens co-encapsulated into toxin-containing liposomes. The vaccinal vehicle of the present invention shows advantages over others disclosed by the previous art due to the robustness and functionality of the induced immune response as well as its immunomodulating properties.
摘要翻译：本发明涉及应用于人类健康的生物技术领域。这里描述了一种疫苗载体，其中来自真核生物的毒素被包封在通过脱水 - 再水化过程获得的多层囊泡中，其脂质组成是二棕榈酰磷脂酰胆碱：用于皮下或肌内给药的1:1摩尔比的胆固醇。这些组合物不需要使用其它佐剂。所公开的组合物允许调节针对共同包封到含毒素脂质体中的一种或几种抗原的CTL特异性免疫应答。由于诱导的免疫应答的鲁棒性和功能性以及其免疫调节特性，本发明的疫苗载体显示出优于先前技术公开的其他优点。

5. 发明授权

US07776342B2 Preparations that potentiate immunogenicity in low immunogenic antigens 有权
标题翻译：在低免疫原性抗原中增强免疫原性的制剂
公开(公告)号：US07776342B2
公开(公告)日：2010-08-17
申请号：US10003463
申请日：2001-12-06
申请人： Luis Enrique Fernandez Molina , Belinda Sanchez Ramirez , Eduardo Raul Suarez Pestana , Anabel de la Barrera Aira , Circe Mesa Pardillo , Joel de Leon Delgado , Yildian Diaz Rodriguez , Rolando Perez Rodriguez
发明人： Luis Enrique Fernandez Molina , Belinda Sanchez Ramirez , Eduardo Raul Suarez Pestana , Anabel de la Barrera Aira , Circe Mesa Pardillo , Joel de Leon Delgado , Yildian Diaz Rodriguez , Rolando Perez Rodriguez
IPC分类号： A61K39/095 , A61K39/00
CPC分类号： A61K39/0011 , A61K2039/55555 , A61K2039/55594 , A61K2039/6081
摘要： This invention discloses means for obtaining immunogenic peptides, polypeptides, proteins, and their corresponding nucleic acid sequences, target cells with vaccine interest, or lysates thereof, without making structural changes in said antigens, through their association with Very Small Size Proteoliposomes.The object of the invention is to provide immunogenic compositions containing peptides, polypeptides, proteins, their corresponding DNA sequences, cells or their lysates and Very Small Size Proteoliposomes (VSSP), which are formed by binding the Outer Membrane Protein Complex (OMPC) of Neisseria meningitidis with gangliosides, by means of hydrophobic links. Additionally, it is stated that these compositions can be formulated alone or in the form of emulsions with the Incomplete Freund's Adjuvant (IFA), and may also be lyophilized.The essence of the invention consists in describing compositions that triggers immunogenicity in low immunogenic antigens, such as growth factor receptors, without imparting structural changes therein. Particularly, this invention refers to preparation of immuno-stimulating compositions capable of generating antigen-specific immune responses, even in immuno-compromised hosts, such as those suffering form cancer or viral or bacterial chronic infections. In said patients, the administration of the vaccine compositions described in this invention has lead to the reestablishment of the functionality of the immune system. Vaccine compositions of this invention can be used to protect or treat infectious, or auto-immune diseases.
摘要翻译：本发明公开了通过与非常小尺寸蛋白脂质体的结合，获得免疫原性肽，多肽，蛋白质及其相应的核酸序列，具有疫苗意义的靶细胞或其裂解物，而不会在所述抗原中进行结构变化的方法。本发明的目的是提供含有肽，多肽，蛋白质，它们相应的DNA序列，细胞或其裂解物和非常小尺寸蛋白质脂质体（VSSP）的免疫原性组合物，其通过结合奈瑟氏球菌的外膜蛋白复合物（OMPC）而形成神经节苷脂通过疏水性连接起到脑膜炎。此外，据说这些组合物可以单独配制或以不完全弗氏佐剂（IFA）的乳液形式配制，也可以冻干。本发明的实质在于描述在低免疫原性抗原如生长因子受体中触发免疫原性的组合物，而不会在其中引起结构变化。特别地，本发明涉及能够产生抗原特异性免疫应答的免疫刺激组合物的制备，甚至在免疫受损的宿主例如患有癌症或病毒或细菌性慢性感染的宿主中。在所述患者中，本发明描述的疫苗组合物的施用导致免疫系统功能的重新建立。本发明的疫苗组合物可用于保护或治疗感染性或自身免疫性疾病。

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