会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明授权
    • Ergolines exhibiting protactin secretion inhibition activity
    • Ergolines表现出protactin分泌抑制活性
    • US4690929A
    • 1987-09-01
    • US604041
    • 1984-04-26
    • Luigi BernardiLaura ChiodiniSergio ManteganiDaniela RuggieriAldemio TemperilliPatricia Salvati
    • Luigi BernardiLaura ChiodiniSergio ManteganiDaniela RuggieriAldemio TemperilliPatricia Salvati
    • C07D457/02C07D457/12A61K31/48C07D457/04
    • C07D457/02C07D457/12
    • Compounds of formula I: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group; R.sub.2 represents a hydrogen or halogen atom or a methyl, cyano, C.sub.1 -C.sub.4 alkylthio or phenylthio group; R.sub.7 and R.sub.8 represent hydrogen atoms and R.sub.3 represents a hydrogen atom or a methoxy group, or R.sub.7 represents a hydrogen atom and R.sub.3 and R.sub.8 taken together represent a bond, or R.sub.3 represents a hydrogen atom or a methoxy group and R.sub.7 and R.sub.8 taken together represent a bond; R.sub.4 represents a hydrocarbon group having from 1 to 4 carbon atoms; R.sub.5 represents a hydrogen atom or a hydrocarbon group having from 1 to 4 carbon atoms or a phenyl group; X represents an oxygen or sulphur atom or an imino group, R.sub.9 represents a hydrogen atom and B represents a cyano, a C.sub.2 -C.sub.5 alkoxycarbonyl or carbamoyl group, or R.sub.9 and B taken together represent a ##STR2## group wherein W represents an oxygen atom or an imino group; A represents a group of the formula CHR.sub.6, CH.sub.2 --CHR.sub.6 or CH.dbd.CR.sub.6 group wherein R.sub.6 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; and n is 0, 1 or 2; and their pharmaceutically acceptable salts are disclosed, along with the use of these compounds as antiprolactinic and antihypertensive agents. The preparation of these compounds and pharmaceutical compositions containing them are also described.
    • 式I的化合物:其中R 1表示氢原子或甲基; R 2表示氢或卤素原子或甲基,氰基,C 1 -C 4烷硫基或苯硫基; R7和R8表示氢原子,R3表示氢原子或甲氧基,或R7表示氢原子,R3和R8表示一个键,或R3表示氢原子或甲氧基,R7和R8表示 一个债券 R4表示具有1至4个碳原子的烃基; R5表示氢原子或碳原子数1〜4的烃基或苯基; X表示氧或硫原子或亚氨基,R9表示氢原子,B表示氰基,C2-C5烷氧基羰基或氨基甲酰基,或R9和B表示“IMA”基团,其中W表示氧原子 或亚氨基; A表示式CHR 6,CH 2 -CHR 6或CH = CR 6基团的基团,其中R 6表示氢原子或C 1 -C 4烷基; 且n为0,1或2; 以及它们的药学上可接受的盐以及这些化合物作为抗孕激素和抗高血压药的用途。 还描述了这些化合物的制备和含有它们的药物组合物。