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1. 发明授权

US4473696A Synthesis of 2-substituted-5-methyl-pyridines 失效
标题翻译： 2-取代-5-甲基 - 吡啶的合成
公开(公告)号：US4473696A
公开(公告)日：1984-09-25
申请号：US433273
申请日：1982-10-07
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D295/14 , C07C69/67 , C07D211/26 , C07D211/86 , C07D213/61 , C07D213/64 , C07D295/02 , C07D295/03 , C07D295/155 , C07D211/70 , C07D223/04
CPC分类号： C07D213/64 , C07C255/00 , C07D211/86 , C07D213/61 , C07D295/03 , C07D295/155
摘要： A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.
摘要翻译：用于合成作为吡啶氧基苯氧基除草剂的已知中间体的化合物的方法以及该方法中使用的中间体。将丙醛和丙烯酸化合物（两种容易获得的原料）反应以形成2-甲酰基戊酸化合物，将其环化成二氢吡啶酮，然后将其氧化成2-羟基吡啶。羟基吡啶可以被卤化成2-卤代吡啶。

2. 发明授权

US5053516A Synthesis of 2-substituted-5-methylpyridines from methylcyclobutanecarbonitrile, valeronitrile and pentenonitrile intermediates 失效
标题翻译：从甲基环丁腈，戊腈和戊烯腈中间体合成2-取代-5-甲基吡啶
公开(公告)号：US5053516A
公开(公告)日：1991-10-01
申请号：US492004
申请日：1990-03-12
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D213/08 , C07D213/09 , C07D213/61 , C07D213/64
CPC分类号： C07D213/64 , C07C255/00 , C07D213/61
摘要： 3-Methyl-2-alkylamino-1-halo-1-cyano cyclobutanes are cleaved under acid conditions to form 2-halo-4-formylvaleronitrile and 4-formyl-2-pentenonitrile which can be cyclized to form 2-substituted-5-methylpyridine derivatives. These pyridine derivatives are useful as starting materials in the manufacture of herbicides such as fluazifop-butyl.
摘要翻译： 3-甲基-2-烷基氨基-1-卤代-1-氰基环丁烷在酸性条件下裂解形成2-卤代-4-甲酰基戊腈和4-甲酰基-2-戊烯腈，其可以环化形成2-取代-5- 甲基吡啶衍生物。这些吡啶衍生物可用作制造除草剂例如氟吡菊酯的原料。

3. 发明授权

US4866185A Difunctional polyfluoroaromatic derivatives and a process of preparing the same 失效
标题翻译：二官能多氟芳族衍生物及其制备方法
公开(公告)号：US4866185A
公开(公告)日：1989-09-12
申请号：US223464
申请日：1988-09-06
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D207/452
CPC分类号： C07C255/00
摘要： The difunctional polyfluoroaromatic compounds represented by the formula ##STR1## wherein X and Y are identical and are selected from the class consisting of --COOR.sup.1, --CH.sub.2 NH.sub.2, --CH.sub.2 NCO and ##STR2## wherein R.sup.1 is --H, alkyl and R.sup.2 and R.sup.3 independently are either --H, X or alkyl and n is either 0 or 1 are disclosed. These compounds are derived from those wherein X and Y are --CN which are produced in a solvent specific reaction. The process comprises reacting pentafluorobenzonitrile with a Grignard reagent of the formula CH.sub.3 MgHal, wherein Hal is --Cl or --Br, in the presence of either tetrahydrofuran, 1,3-dioxolane, dimethoxyethane or diglyme. When the solvent employed is tetrahydrofuran, the cyano compound wherein n is 1 is obtained. When the solvent is 1,3-dioxolane, the cyano compound wherein n is 0 is obtained.
摘要翻译：由式＆lt; IMAGE＆gt;表示的双官能多氟芳族化合物，其中X和Y相同并且选自-COOR1，-CH2NH2，-CH2NCO和＆lt; IMAGE＆gt;其中R1是-H，烷基和R2和R3独立地是 -H，X或烷基，n是0或1。这些化合物衍生自其中X和Y是在溶剂特异性反应中产生的-CN的那些。该方法包括在四氢呋喃，1,3-二氧戊环，二甲氧基乙烷或二甘醇二甲醚的存在下使五氟苄腈与式CH 3 M g Hal的格氏试剂反应，其中Hal为-Cl或-Br。当所用溶剂是四氢呋喃时，得到n为1的氰基化合物。当溶剂为1,3-二氧戊环时，得到n为0的氰基化合物。

4. 发明授权

US4584380A Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor 失效
标题翻译： 2-取代-5-甲基吡啶的合成及其中间体
公开(公告)号：US4584380A
公开(公告)日：1986-04-22
申请号：US649423
申请日：1984-09-11
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D213/61 , C07D213/64 , C07D295/02 , C07D295/03 , C07D295/155 , C07D213/09
CPC分类号： C07D213/64 , C07C255/00 , C07D213/61 , C07D295/03 , C07D295/155
摘要： A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.
摘要翻译：用于合成作为吡啶氧基苯氧基除草剂的已知中间体的化合物的方法以及该方法中使用的中间体。将丙醛和丙烯酸化合物（两种容易获得的原料）反应以形成2-甲酰基戊酸化合物，将其环化成二氢吡啶酮，然后将其氧化成2-羟基吡啶。羟基吡啶可以被卤化成2-卤代吡啶。

5. 发明授权

US4783547A Polyfluoroaromatic nitriles 失效
标题翻译：多氟芳香腈
公开(公告)号：US4783547A
公开(公告)日：1988-11-08
申请号：US853448
申请日：1986-04-18
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07C255/51 , C07C121/52 , C07C121/60
CPC分类号： C07C255/00
摘要： The difunctional polyfluoroaromatic compounds represented by the formula ##STR1## wherein X and Y are identical and are selected from the class consisting of --COOR.sup.1, --CH.sub.2 NH.sub.2, --CH.sub.2 NCO and ##STR2## wherein R.sup.1 is --H, alkyl and R.sup.2 and R.sup.3 independently are either --H, X or alkyl and n is either 0 or 1 are disclosed. These compounds are derived from those wherein X and Y are --CN which are produced in a solvent specific reaction. The process comprises reacting pentafluorobenzonitrile with a Grignard reagent of the formula CH.sub.3 MgHal, wherein Hal is --Cl or --Br, in the presence of either tetrahydrofuran, 1,3-dioxolane, dimethoxyethane or diglyme. When the solvent employed is tetrahydrofuran, the cyano compound wherein n is 1 is obtained. When the solvent is 1,3-dioxolane, the cyano compound wherein n is 0 is obtained.
摘要翻译：由式＆lt; IMAGE＆gt;表示的双官能多氟芳族化合物，其中X和Y相同并且选自-COOR1，-CH2NH2，-CH2NCO和＆lt; IMAGE＆gt;其中R1是-H，烷基和R2和R3独立地是 -H，X或烷基，n是0或1。这些化合物衍生自其中X和Y是在溶剂特异性反应中产生的-CN的那些。该方法包括在四氢呋喃，1,3-二氧戊环，二甲氧基乙烷或二甘醇二甲醚的存在下使五氟苄腈与式CH 3 M g Hal的格氏试剂反应，其中Hal为-Cl或-Br。当所用溶剂是四氢呋喃时，得到n为1的氰基化合物。当溶剂为1,3-二氧戊环时，得到n为0的氰基化合物。

6. 发明授权

US4965394A Difunctional polyfluoroaromatic derivatives and a process of preparing the same 失效
标题翻译：二官能多氟芳族衍生物及其制备方法
公开(公告)号：US4965394A
公开(公告)日：1990-10-23
申请号：US355517
申请日：1989-05-23
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07C63/14 , C07C211/09 , C07C211/52 , C07C255/49 , C07C255/50
CPC分类号： C07C255/00
摘要： The difunctional polyfluoroaromatic compounds represented by the formula ##STR1## wherein X and Y are identical and are selected from the class consisting of --COOR.sup.1, --CH.sub.2 NH.sub.2, --CH.sub.2 NCO and ##STR2## wherein R.sup.1 is --H, alkyl and R.sup.2 and R.sup.3 independently are either --H, X or alkyl and n is either 0 or 1 are disclosed. These compounds are derived from those wherein X and Y are --CN which are produced in a solvent specific reaction. The process comprises reacting pentafluorobenzonitrile with a Grignard reagent of the formula CH.sub.3 MgHal, wherein Hal is --Cl or --Br, in the presence of either tetrahydrofuran, 1,3-dioxolane, dimethoxyethane or diglyme. When the solvent employed is tetrahydrofuran, the cyano compound wherein n is 1 is obtained. When the solvent is 1,3-dioxolane, the cyano compound wherein n is 0 is obtained.
摘要翻译：由式＆lt; IMAGE＆gt;表示的双官能多氟芳族化合物，其中X和Y相同并且选自-COOR1，-CH2NH2，-CH2NCO和＆lt; IMAGE＆gt;其中R1是-H，烷基和R2和R3独立地是 -H，X或烷基，n是0或1。这些化合物衍生自其中X和Y是在溶剂特异性反应中产生的-CN的那些。该方法包括在四氢呋喃，1,3-二氧戊环，二甲氧基乙烷或二甘醇二甲醚的存在下使五氟苄腈与式CH 3 M g Hal的格氏试剂反应，其中Hal为-Cl或-Br。当所用溶剂是四氢呋喃时，得到n为1的氰基化合物。当溶剂为1,3-二氧戊环时，得到n为0的氰基化合物。

7. 发明授权

US4687854A Bispiperidone precursor of 2-substituted-5-methyl-pyridines 失效
标题翻译： 2-取代-5-甲基 - 吡啶的双哌啶酮前体
公开(公告)号：US4687854A
公开(公告)日：1987-08-18
申请号：US937383
申请日：1986-12-03
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D211/76 , C07D211/86 , C07D213/61 , C07D213/64 , C07D295/02 , C07D295/03 , C07D295/155
CPC分类号： C07D213/64 , C07C255/00 , C07D211/86 , C07D213/61 , C07D295/03 , C07D295/155
摘要： A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two radily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.
摘要翻译：用于合成作为吡啶氧基苯氧基除草剂的已知中间体的化合物的方法以及该方法中使用的中间体。使丙醛和丙烯酸化合物（两种可用的原料）反应形成2-甲酰基戊酸化合物，将其环化成二氢吡啶酮，然后氧化成2-羟基吡啶。羟基吡啶可以被卤化成2-卤代吡啶。

8. 发明授权

US4658031A Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor 失效
标题翻译： 2-取代-5-甲基吡啶的合成及其中间体
公开(公告)号：US4658031A
公开(公告)日：1987-04-14
申请号：US807850
申请日：1985-12-11
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D211/86 , C07D213/12 , C07D213/61 , C07D213/64 , C07D295/02 , C07D295/03 , C07D295/155 , C07D401/12
CPC分类号： C07D213/64 , C07C255/00 , C07D211/86 , C07D213/61 , C07D295/03 , C07D295/155
摘要： A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicies as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.
摘要翻译：用于合成化合物的方法，其为已知的吡啶氧基苯氧基草本中间体以及该方法中使用的中间体。将丙醛和丙烯酸化合物（两种容易获得的原料）反应以形成2-甲酰基戊酸化合物，将其环化成二氢吡啶酮，然后将其氧化成2-羟基吡啶。羟基吡啶可以被卤化成2-卤代吡啶。

9. 发明授权

US4709063A Preparation of 2-halo-5-methylpyridines from 4-methyl-4-pentene derivatives 失效
标题翻译：由4-甲基-4-戊烯衍生物制备2-卤代-5-甲基吡啶
公开(公告)号：US4709063A
公开(公告)日：1987-11-24
申请号：US894615
申请日：1986-08-08
申请人： Richard V. Nelson , John F. Stephen
发明人： Richard V. Nelson , John F. Stephen
IPC分类号： C07D211/94 , C07D213/61 , C07D303/40
CPC分类号： C07D213/61 , C07D211/94
摘要： A method of preparing certain 2-halo-5-methylpyridines, useful as herbicide intermediates, is presented starting from acyclic pentenes. The pentene is difunctionalized, e.g., by making the epoxide, and is then reacted with a nitrogen source to close the ring. The nitrogen-containing 6-membered heterocycle may then be aromatized readily to produce the 2-halo-5-methylpyridine desired. Also part of the invention are novel acyclic and cyclic intermediates used in the process.
摘要翻译：从无环戊烯开始制备一些可用作除草剂中间体的2-卤代-5-甲基吡啶的方法。戊烯是双官能的，例如通过制备环氧化物，然后与氮源反应以封闭环。然后可以容易地将含氮的6元杂环芳族化以产生所需的2-卤代-5-甲基吡啶。本发明的一部分是在该方法中使用的新型无环和中间体。

10. 发明授权

US4690963A Tartrate-based light stabilizers for plastics 失效
标题翻译：基于酒石酸盐的塑料光稳定剂
公开(公告)号：US4690963A
公开(公告)日：1987-09-01
申请号：US902781
申请日：1986-09-02
申请人： Richard V. Nelson , John F. Stephen
发明人： Richard V. Nelson , John F. Stephen
IPC分类号： C08L23/00 , C07D491/10 , C07D491/113 , C07D519/00 , C08G63/685 , C08G69/26 , C08K5/3412 , C08K5/3435 , C08K5/3437 , C08L1/00 , C08L7/00 , C08L21/00 , C08L27/00 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L67/00 , C08L77/00 , C08L101/00 , C07D401/12 , C07D401/14 , C08K5/34
CPC分类号： C07D491/10 , C08G63/6856 , C08G69/26 , C08K5/3435
摘要： Monomeric and oligomeric derivatives of the diethyl ester of polyalkyl 1,4-dioxa-8-azaspiro-[4.5]-decane-2,3-dicarboxylic acid are useful light stabilizers for synthetic polymer resins such as polyolefins, and in particular, polypropylene.
摘要翻译：聚烷基1,4-二氧杂-8-氮杂螺[4.5]癸烷-2,3-二羧酸的二酯的单体和低聚衍生物是合成聚合物树脂如聚烯烃，特别是聚丙烯的光稳定剂。

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