专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110243914A1 SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3 EXPRESSING TUMORS 有权
标题翻译： SHIGA TOXIN B-SUBUNIT作为肿瘤诊断和药物递送给GB3表达肿瘤的载体
公开(公告)号：US20110243914A1
公开(公告)日：2011-10-06
申请号：US13159124
申请日：2011-06-13
申请人： Ludger JOHANNES , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
发明人： Ludger JOHANNES , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
IPC分类号： A61K38/45 , A61K38/00 , A61K38/48 , A61K38/46 , A61K38/47 , A61K38/14 , A61K31/704 , A61K31/351 , A61K31/522 , A61K31/517 , A61K31/513 , A61K33/24 , A61K31/407 , A61P43/00
CPC分类号： A61K49/085 , A61K38/00 , A61K41/0071 , A61K47/6415 , A61K47/67 , A61K49/0008 , A61K49/14 , B82Y5/00 , C07K14/25 , C07K14/36
摘要： The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z(n) whrein n is 0 or 1 and when n is 1, Z is an amino-acid residue devoidof sulfydryl group, or is a polypeptide, Cys is the amino-acid residue for Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, selected in a group comprising: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between T and Cys, said linker being either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into said cells.
摘要翻译：本发明涉及用于癌症治疗或诊断的新化合物，更具体地涉及使用志贺毒素突变体的无毒性B亚基作为过表达Gb3受体细胞的诊断产物或药物的载体，具有下式：STxB-Z（n）-Cys-Y（m）-T其中STxB是滋贺毒素B亚基或其功能等同物，Z（n）n为0或1，当n为1时，Z为氨基 - 不含巯基的酸性残基，或是多肽，Cys是半胱氨酸的氨基酸残基，T是通过与Sys的S部分的共价结合连接的分子，选自以下的组：包括用于体内诊断的试剂， Y（m），其中m为0或1，当m为1时，Y为T和Cys之间的接头，所述接头是可切割的或不可切割的用于在混合化合物内化至所述细胞后释放T。

2. 发明申请

US20060008475A1 Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to Gb3 expressing tumors 有权
标题翻译：志贺毒素B亚基作为肿瘤诊断和药物递送至Gb3表达肿瘤的载体
公开(公告)号：US20060008475A1
公开(公告)日：2006-01-12
申请号：US11046786
申请日：2005-02-01
申请人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
发明人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
IPC分类号： A61K39/095
CPC分类号： A61K49/085 , A61K38/00 , A61K41/0071 , A61K47/6415 , A61K47/67 , A61K49/0008 , A61K49/14 , B82Y5/00 , C07K14/25 , C07K14/36
摘要： The invention relates to new compounds for cancer therapy or diagnosis and to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein—STxB is the Shiga Toxin B subunit or a functional equivalent thereof, —Z(n) wherein n is 0 or 1, Z is an amino-acid residue devoid of sulfydryl groups, or is a polypeptide, —T is a molecule linked by a covalent bound to the S part of Cys, selected from: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, —Y(m) wherein m is 0 or 1, Y is a linker between T and Cys, which is either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into cells.
摘要翻译：本发明涉及用于癌症治疗或诊断的新化合物，以及使用志贺毒素突变体的无毒性B亚基作为过表达Gb3受体细胞的诊断产品或药物的载体，具有下式：STxB -Z（n）-Cys-Y（m）-T其中-STxB是志贺毒素B亚基或其功能等同物，-Z（n）其中n为0或1，Z为不含或者是多肽，-T是通过与Sys的S部分的共价结合连接的分子，其选自：用于体内诊断的试剂，细胞毒性剂，前药或用于将前药转化为药物的酶 -Y（m）其中m是0或1，Y是T和Cys之间的连接体，其在将杂化化合物内化为细胞后可以切割或不可切割以释放T。

3. 发明授权

US08313731B2 Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to GB3 expressing tumors 有权
标题翻译：志贺毒素B亚基作为肿瘤诊断和药物递送到GB3表达肿瘤的载体
公开(公告)号：US08313731B2
公开(公告)日：2012-11-20
申请号：US13159124
申请日：2011-06-13
申请人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
发明人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
IPC分类号： A61K49/00 , C07K14/00
CPC分类号： A61K49/085 , A61K38/00 , A61K41/0071 , A61K47/6415 , A61K47/67 , A61K49/0008 , A61K49/14 , B82Y5/00 , C07K14/25 , C07K14/36
摘要： The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z(n) wherein n is 0 or 1 and when n is 1, Z is an amino-acid residue devoid of sulfydryl group, or is a polypeptide, Cys is the amino-acid residue for Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, selected in a group comprising: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between T and Cys, said linker being either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into said cells.
摘要翻译：本发明涉及用于癌症治疗或诊断的新化合物，更具体地涉及使用志贺毒素突变体的无毒性B亚基作为过表达Gb3受体细胞的诊断产物或药物的载体，具有下式：STxB-Z（n）-Cys-Y（m）-T其中STxB是滋贺毒素B亚基或其功能等同物，Z（n）其中n为0或1，当n为1时，Z为氨基 - 不含巯基的酸性残基，或是多肽，Cys是半胱氨酸的氨基酸残基，T是通过与Sys的S部分共价结合连接的分子，选自以下组中：包括用于体内诊断的试剂，前药或前药转化为药物的Y（m），其中m为0或1，当m为1时，Y为T和Cys之间的接头，所述接头可切割或不切割在将杂化化合物内化至所述细胞后，可以切割T释放T。

4. 发明授权

US07718601B2 Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to Gb3 expressing tumors 有权
标题翻译：志贺毒素B亚基作为肿瘤诊断和药物递送至Gb3表达肿瘤的载体
公开(公告)号：US07718601B2
公开(公告)日：2010-05-18
申请号：US11046786
申请日：2005-02-01
申请人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
发明人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： A61K49/085 , A61K38/00 , A61K41/0071 , A61K47/6415 , A61K47/67 , A61K49/0008 , A61K49/14 , B82Y5/00 , C07K14/25 , C07K14/36
摘要： The invention relates to new compounds for cancer therapy or diagnosis and to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein-STxB is the Shiga Toxin B subunit or a functional equivalent thereof, -Z(n) wherein n is 0 or 1, Z is an amino-acid residue devoid of sulfydryl groups, or is a polypeptide, -T is a molecule linked by a covalent bound to the S part of Cys, selected from: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, - Y(m) wherein m is 0 or 1, Y is a linker between T and Cys, which is either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into cells.
摘要翻译：本发明涉及用于癌症治疗或诊断的新化合物，以及使用志贺毒素突变体的无毒性B亚基作为过表达Gb3受体细胞的诊断产品或药物的载体，具有下式：STxB -Z（n）-Cys-Y（m）-T其中-STxB是志贺毒素B亚基或其功能等同物，-Z（n）其中n为0或1，Z为不含或者是多肽，-T是通过与Sys的S部分的共价结合连接的分子，其选自：用于体内诊断的试剂，细胞毒性剂，前药或用于将前药转化成药物的酶， - Y（m）其中m是0或1，Y是T和Cys之间的连接体，在混合化合物内化到细胞中之后，它们是可切割的或不可裂解的用于释放T。

5. 发明授权

US07981400B2 Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to GB3 expressing tumors 有权
标题翻译：志贺毒素B亚基作为肿瘤诊断和药物递送到GB3表达肿瘤的载体
公开(公告)号：US07981400B2
公开(公告)日：2011-07-19
申请号：US12723361
申请日：2010-03-12
申请人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
发明人： Ludger Johannes , David Grierson , Sylvie Robine , Jean-Claude Florent , Philipe Maillard , Jacky Roger
IPC分类号： A61K49/00 , C07K14/00
CPC分类号： A61K49/085 , A61K38/00 , A61K41/0071 , A61K47/6415 , A61K47/67 , A61K49/0008 , A61K49/14 , B82Y5/00 , C07K14/25 , C07K14/36
摘要： The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)-T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z(n) wherein n is 0 or 1 and when n is 1, Z is an amino-acid residue devoid of sulfhydryl group, or is a polypeptide, Cys is the amino-acid residue for Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, selected in a group comprising: agents for in vivo diagnosis, cytotoxic agents, prodrugs, or enzymes for the conversion of a prodrug to a drug, Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between T and Cys, said linker being either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into said cells.
摘要翻译：本发明涉及用于癌症治疗或诊断的新化合物，更具体地涉及使用志贺毒素突变体的无毒性B亚基作为过表达Gb3受体细胞的诊断产物或药物的载体，具有下式：STxB-Z（n）-Cys-Y（m）-T其中STxB是滋贺毒素B亚基或其功能等同物，Z（n）其中n为0或1，当n为1时，Z为氨基 - 没有巯基的酸性残基，或是多肽，Cys是半胱氨酸的氨基酸残基，T是通过共价结合到Cys的S部分的分子连接的分子，所述组分选自：用于体内诊断的试剂，前药或前药转化为药物的Y（m），其中m为0或1，当m为1时，Y为T和Cys之间的接头，所述接头可切割或不切割在将杂化化合物内化至所述细胞后，可以切割T释放T。

6. 发明申请

US20110152252A1 SHIGA TOXIN B-SUBUNIT/CHEMOTHERAPEUTICS CONJUGATES 审中-公开
标题翻译： SHIGA毒素B亚纲/化疗合并
公开(公告)号：US20110152252A1
公开(公告)日：2011-06-23
申请号：US11958576
申请日：2007-12-18
申请人： Ludger Johannes , Abdessamed El Alaoui , Didier Decaudin , Sylvie Robine , Frederic Schmidt , Jean-Claude Florent
发明人： Ludger Johannes , Abdessamed El Alaoui , Didier Decaudin , Sylvie Robine , Frederic Schmidt , Jean-Claude Florent
IPC分类号： A61K31/5513 , C07D491/14 , C07D243/14 , A61K31/437 , A61P35/00
CPC分类号： C07D243/14 , A61K31/437 , A61K31/5513 , A61K45/06 , A61K47/6415 , A61K47/66 , B82Y5/00 , C07D491/14 , A61K2300/00
摘要： The present invention relates to the use of a Shiga toxin B-subunit moiety as carrier for therapeutic agents, for example, anti-cancer agents such as anti-cancer agents that require intracellular uptake to exert their anti-cancer effects. In particular, the present invention provides conjugates comprising a Shiga toxin moiety covalently linked to an anti-cancer agent through a self-immolative spacer, and methods of using such conjugates to increase cellular uptake and/or specificity for cancer cells of the anti-cancer drug. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment.
摘要翻译：本发明涉及志贺毒素B亚基部分作为治疗剂的载体的用途，例如抗癌剂，例如需要细胞内摄取以发挥其抗癌作用的抗癌剂。特别地，本发明提供了包含通过自身免疫隔离物与抗癌剂共价连接的志贺毒素部分的缀合物，以及使用这种缀合物增加抗癌癌细胞的细胞吸收和/或特异性的方法药物。还提供了涉及施用这种缀合物的治疗方法，以及可用于实施这些治疗方法的药物组合物和试剂盒。

7. 发明授权

US5830729A I Sce I-induced gene replacement and gene conversion in embryonic stem cells 失效
标题翻译： I Sce I诱导的胚胎干细胞中的基因替换和基因转化
公开(公告)号：US5830729A
公开(公告)日：1998-11-03
申请号：US693948
申请日：1996-08-07
申请人： Frederic Jaisser , Michel Cohen-Tannoudji , Sylvie Robine , Andre Choulika , Daniel Louvard , Charles Babinet
发明人： Frederic Jaisser , Michel Cohen-Tannoudji , Sylvie Robine , Andre Choulika , Daniel Louvard , Charles Babinet
IPC分类号： C07K14/47 , C12N15/36 , C12N15/00
CPC分类号： C07K14/4735
摘要： This invention relates to a method of constructing a villin gene hybrid by inserting an I-Sce I restriction site next to or within a gene or cDNA encoding a villin protein. The insertion site of the I-Sce I restriction site is chosen as to provide a first downstream part and a second upstream part from the site, containing at least twelve nucleotides of the gene or cDNA encoding the villin protein. Furthermore, the insertion of the restriction permits a high frequency of homologous recombination events. The villin gene hybrid may be used to transfect eukaryotic cells, and particularly, embryonic stem cells.
摘要翻译：本发明涉及一种通过在编码绒毛蛋白的基因或cDNA之前或之内插入I-Sce I限制性位点来构建绒毛蛋白基因杂交体的方法。选择I-Sce I限制性位点的插入位点，从该位点提供第一个下游部分和第二个上游部分，其中含有至少12个核苷酸的基因或编码绒毛蛋白的cDNA。此外，插入限制允许高频率的同源重组事件。绒毛蛋白基因杂交体可用于转染真核细胞，特别是胚胎干细胞。

8. 发明授权

US5888722A Stable cell lines expressing the CFTR protein or a mutant of this protein, tool for selecting molecules having an effect on the intracellular transport of these proteins 失效
标题翻译：表达CFTR蛋白的稳定细胞系或该蛋白质的突变体，用于选择对这些蛋白质的细胞内转运具有影响的分子的工具
公开(公告)号：US5888722A
公开(公告)日：1999-03-30
申请号：US874040
申请日：1997-06-12
申请人： Marie-Alyette Costa De Beauregard , Daniel Louvard , Sylvie Robine , Alexandre Edelman , Dominique Chesnoy-Marchais , Ming Chen , Manuel Buchwald
发明人： Marie-Alyette Costa De Beauregard , Daniel Louvard , Sylvie Robine , Alexandre Edelman , Dominique Chesnoy-Marchais , Ming Chen , Manuel Buchwald
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/00 , C07H17/00 , C12N15/00 , C12P21/06
CPC分类号： C07K14/4712 , C07K2319/00 , G01N2800/382
摘要： The invention relates to a recombinant nucleic acid, characterized in that it comprises:a nucleotide sequence encoding (coding sequence) the normal CFTR protein,an epitope sequence located at the 3' end of the abovementioned coding sequence,a strong promoter sequence capable of controlling the expression of the abovementioned coding sequence and epitope sequence, when they are integrated into a determined cell.
摘要翻译：本发明涉及重组核酸，其特征在于其包含：编码（编码序列）正常CFTR蛋白的核苷酸序列，位于上述编码序列3'端的表位序列，能够控制的强启动子序列当将它们整合到确定的细胞中时，上述编码序列和表位序列的表达。

9. 发明授权

US06879394B2 Multi-photon imaging installation 失效
标题翻译：多光子成像安装
公开(公告)号：US06879394B2
公开(公告)日：2005-04-12
申请号：US10441027
申请日：2003-05-20
申请人： François Amblard , Xavier Sastre-Garau , Sylvie Robine
发明人： François Amblard , Xavier Sastre-Garau , Sylvie Robine
IPC分类号： A61B1/00 , A61B3/10 , A61B3/12 , A61N5/06 , G01N21/64 , G01N21/65 , G02B21/00 , G02B23/24
CPC分类号： G01N21/6486 , G01N21/6458 , G02B21/0024 , G02B21/0076 , G02B21/0084
摘要： An installation is provided for multi-dimensional non-linear imaging of a material comprising intrinsic chromophores, using laser scanning. This installation comprises i) at least one source (115) of time stamp pulses of synchronized photons, ii) means (12-14) for locally focusing the pulses on a material to cause its intrinsic chromophores to absorb groups of at least two synchronized photons to produce response photons, iii) means (22, 40, 53) for directing the response photons to at leat one collecting zone, iv) means (30-34) for collecting the response photons in the collecting zone(s) whatever their energy, v) processing means for converting the collected photons into data at least representative of their number and storing them in correspondence with at least the time stamp pulses that cause the material to produce the response photons, vi) means for scanning (11, 20) the pulses through a chosen area of the material, and vii) means for delivering from said data stored an image representative of said material chosen area, with a sub-millimeter resolution, and in function of the respective time stamp pulses of data.
摘要翻译：提供了一种用于使用激光扫描对包括内在发色团的材料进行多维非线性成像的装置。该装置包括i）同步光子的时间戳脉冲的至少一个源（115），ii）用于将材料上的脉冲局部聚焦以使其内在发色团吸收至少两个同步光子的组的装置（12-14）以产生响应光子，iii）用于将响应光子引导到一个收集区的装置（22,40,53），iv）用于收集收集区中的响应光子的装置（30-34），无论其能量如何 v）处理装置，用于将所收集的光子转换成至少代表其数量的数据，并且至少存储它们与至少引起材料产生响应光子的时间戳脉冲相对应; vi）扫描装置（11,20）脉冲通过材料的选定区域，以及vii）用于从所述数据传送的装置，用于存储表示所述材料选择区域的图像，具有亚毫米分辨率，并且具有数据的相应时间戳脉冲的功能。

10. 发明授权

US06566579B1 I-Sce I induced gene replacement and gene conversion in embryonic stem cells 失效
标题翻译： I-Sce I诱导胚胎干细胞中的基因替换和基因转化
公开(公告)号：US06566579B1
公开(公告)日：2003-05-20
申请号：US09116834
申请日：1998-07-17
申请人： Frederic Jaisser , Michel Cohen-Tannoudji , Sylvie Robine , Andre Choulika , Daniel Louvard , Charles Babinet
发明人： Frederic Jaisser , Michel Cohen-Tannoudji , Sylvie Robine , Andre Choulika , Daniel Louvard , Charles Babinet
IPC分类号： G01N3300
CPC分类号： C07K14/4735
摘要： The invention relates to methods of introducing a heterologous DNA sequence into a mouse embryonic stem cell wherein the DNA sequence is inserted by homologous recombination into a villin gene/I-SceI hybrid by creating a double strand break with I-SceI meganuclease. Subsequently, the mouse embryonic stem cells can be used to generate a transgenic mouse comprising the heterologous DNA sequence. Additionally, the methods can be used for gene replacement in ovo where a mouse oocyte containing a villin gene/I-SceI hybrid within its genome exists or is first generated. More generally, the methods can be used for the targeted insertion of a heterologous DNA sequence into any cell containing a villin gene/I-SceI hybrid sequence within its genome.
摘要翻译：本发明涉及将异源DNA序列引入小鼠胚胎干细胞的方法，其中通过与I-SceI大范围核酸酶产生双链断裂，将DNA序列通过同源重组插入到绒毛蛋白基因/ I-SceI杂交体中。随后，小鼠胚胎干细胞可用于产生包含异源DNA序列的转基因小鼠。此外，该方法可用于卵巢中的基因替换，其中在其基因组内含有绒毛蛋白基因/ I-SceI杂交体的小鼠卵母细胞存在或首先产生。更一般地，该方法可用于将异源DNA序列靶向插入到其基因组内含有绒毛蛋白基因/ I-SceI杂交序列的任何细胞中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式