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1. 发明申请

US20060147453A1 Methods and compositions for modulating and detecting WISP activity 有权
标题翻译：用于调节和检测WISP活性的方法和组合物
公开(公告)号：US20060147453A1
公开(公告)日：2006-07-06
申请号：US11105876
申请日：2005-04-14
申请人： Luc Desnoyer , Ellen Filvaroff
发明人： Luc Desnoyer , Ellen Filvaroff
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K14/475 , A01K2267/0331 , A61K2039/505 , C07K16/22 , C07K2317/76 , C07K2319/21 , C07K2319/30 , C12N2799/026
摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
摘要翻译：提供了用于调节WISP-1多肽活性的方法和组合物。 WISP-1拮抗剂包括通过天然人WISP-1多肽抑制或中和HAS2，HA，CD44或RHAMM的诱导或分泌的抗WISP-1抗体，WISP-1免疫粘附素和WISP-1变体（及其融合蛋白）至少一种哺乳动物细胞。本发明还提供了与天然WISP-1多肽相关的哺乳动物细胞或病理状态的体外，原位和/或体内诊断和/或治疗方法。

2. 发明申请

US20090148448A1 METHODS AND COMPOSITIONS FOR MODULATING AND DETECTING WISP ACTIVITY 有权
标题翻译：调查和检测WISP活动的方法和组合物
公开(公告)号：US20090148448A1
公开(公告)日：2009-06-11
申请号：US12254649
申请日：2008-10-20
申请人： Luc Desnoyer , Ellen Filvaroff
发明人： Luc Desnoyer , Ellen Filvaroff
IPC分类号： A61K39/395 , C12N5/00 , C07K14/00 , A61P35/00 , A61K38/16
CPC分类号： C07K14/475 , A01K2267/0331 , A61K2039/505 , C07K16/22 , C07K2317/76 , C07K2319/21 , C07K2319/30 , C12N2799/026
摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
摘要翻译：提供了用于调节WISP-1多肽活性的方法和组合物。 WISP-1拮抗剂包括通过天然人WISP-1多肽抑制或中和HAS2，HA，CD44或RHAMM的诱导或分泌的抗WISP-1抗体，WISP-1免疫粘附素和WISP-1变体（及其融合蛋白）至少一种哺乳动物细胞。本发明还提供了与天然WISP-1多肽相关的哺乳动物细胞或病理状态的体外，原位和/或体内诊断和/或治疗方法。

3. 发明授权

US07455834B2 Methods and compositions for modulating and detecting WISP activity 有权
标题翻译：用于调节和检测WISP活性的方法和组合物
公开(公告)号：US07455834B2
公开(公告)日：2008-11-25
申请号：US11105876
申请日：2005-04-14
申请人： Luc Desnoyer , Ellen Filvaroff
发明人： Luc Desnoyer , Ellen Filvaroff
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/32
CPC分类号： C07K14/475 , A01K2267/0331 , A61K2039/505 , C07K16/22 , C07K2317/76 , C07K2319/21 , C07K2319/30 , C12N2799/026
摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
摘要翻译：提供了用于调节WISP-1多肽活性的方法和组合物。 WISP-1拮抗剂包括通过天然人WISP-1多肽抑制或中和HAS2，HA，CD44或RHAMM的诱导或分泌的抗WISP-1抗体，WISP-1免疫粘附素和WISP-1变体（及其融合蛋白）至少一种哺乳动物细胞。本发明还提供了用于体外，原位和/或体内诊断和/或治疗与天然WISP-1多肽相关的哺乳动物细胞或病理状况的方法。

4. 发明申请

US20050054563A1 Methods of treatment using wisp polypeptides 失效
标题翻译：使用多肽的治疗方法
公开(公告)号：US20050054563A1
公开(公告)日：2005-03-10
申请号：US10399093
申请日：2001-10-12
申请人： Luc Desnoyer , Ellen Filvaroff , Diane Pennica
发明人： Luc Desnoyer , Ellen Filvaroff , Diane Pennica
IPC分类号： A61K38/00 , A61P19/02 , A61P29/00 , C07K14/47 , C07K14/475 , C12N15/12 , A61K38/17
CPC分类号： C07K14/475 , A61K38/00 , C07K14/47
摘要： A transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally replaces the disrupted first gene. In other embodiments, the genome comprises a disruption in a first endogenous gene in the MEP pathway and a second endogenous gene which is located downstream of the first gene in the MEP pathway. A transgene that functionally replaces the disrupted downstream gene is cloned into the host cell. A mini operon containing the essential genes for the MVA pathway may also be cloned into the host cell. The transgenic host cell may be used in a method for screening compounds for antibiotic and herbicidal properties. The agents determined by the screening method may be used to kill bacteria or plants.
摘要翻译：提供了可用作新型抗生素和除草剂筛选的转基因细菌宿主细胞。转基因细菌宿主细胞的基因组包括在MEP途径中的第一内源基因中的破坏）和在功能上替代被破坏的第一基因的转基因。在其他实施方案中，基因组包含MEP途径中的第一内源基因的破坏和位于MEP途径中第一个基因下游的第二内源基因。功能性替代被破坏的下游基因的转基因被克隆到宿主细胞中。含有MVA途径必需基因的迷你操纵子也可以克隆到宿主细胞中。转基因宿主细胞可用于筛选抗生素和除草性质的化合物的方法。通过筛选方法测定的试剂可用于杀死细菌或植物。

5. 发明授权

US08110548B2 Method for treating cartilage disorders 有权
标题翻译：软骨疾病治疗方法
公开(公告)号：US08110548B2
公开(公告)日：2012-02-07
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译：本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。

6. 发明申请

US20100233153A1 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND THE METHODS RELATING THERETO 审中-公开
标题翻译：新基因破坏，组合物及其相关方法
公开(公告)号：US20100233153A1
公开(公告)日：2010-09-16
申请号：US12375662
申请日：2007-10-01
申请人： Mark Dominic Borromeo , Jaime-Jo Cunningham , Frederick Desauvage , Ellen Filvaroff , Mark Alan Klamer , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Peter Vogel
发明人： Mark Dominic Borromeo , Jaime-Jo Cunningham , Frederick Desauvage , Ellen Filvaroff , Mark Alan Klamer , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Peter Vogel
IPC分类号： A61K39/395 , C12N5/10 , C07K16/00 , A61K49/00 , A61P37/02 , A61P27/02 , A61P25/00 , A61P19/00 , A61P17/00 , A61P1/16 , A61P35/00 , A61P9/10 , A61P9/00 , A61P5/18 , C12Q1/02 , A01K67/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO1105, PRO1279 or PRO1783 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供包含PRO1105，PRO1279或PRO1783基因中断的转基因小鼠。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

7. 发明授权

US07732567B2 Methods and compositions for modulating and detecting wisp activity 有权
标题翻译：用于调节和检测小鼠活动的方法和组合物
公开(公告)号：US07732567B2
公开(公告)日：2010-06-08
申请号：US12254649
申请日：2008-10-20
申请人： Luc Desnoyers , Ellen Filvaroff
发明人： Luc Desnoyers , Ellen Filvaroff
IPC分类号： C07K4/12 , A61K38/00 , A61K39/00
CPC分类号： C07K14/475 , A01K2267/0331 , A61K2039/505 , C07K16/22 , C07K2317/76 , C07K2319/21 , C07K2319/30 , C12N2799/026
摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
摘要翻译：提供了用于调节WISP-1多肽活性的方法和组合物。 WISP-1拮抗剂包括通过天然人WISP-1多肽抑制或中和HAS2，HA，CD44或RHAMM的诱导或分泌的抗WISP-1抗体，WISP-1免疫粘附素和WISP-1变体（及其融合蛋白）至少一种哺乳动物细胞。本发明还提供了与天然WISP-1多肽相关的哺乳动物细胞或病理状态的体外，原位和/或体内诊断和/或治疗方法。

8. 发明申请

US20090297512A1 COMPOSITIONS AND METHODS FOR MODULATING VASCULAR DEVELOPMENT 审中-公开
标题翻译：用于调节血管发育的组合物和方法
公开(公告)号：US20090297512A1
公开(公告)日：2009-12-03
申请号：US12357819
申请日：2009-01-22
申请人： Ellen Filvaroff , Weilan Ye , Leon H. Parker, IV , Jo-Anne S. Hongo , Maike Schmidt
发明人： Ellen Filvaroff , Weilan Ye , Leon H. Parker, IV , Jo-Anne S. Hongo , Maike Schmidt
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K31/7088 , A61K2039/505 , C07K16/22
摘要： The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
摘要翻译：本发明提供使用EGFL7拮抗剂调节血管发育的方法。本文还提供筛选EGFL7活性调节剂的方法。此外，提供了使用EGFL7拮抗剂的治疗方法。

9. 发明授权

US07619062B2 PRO214 polypeptides 有权
标题翻译： PRO214多肽
公开(公告)号：US07619062B2
公开(公告)日：2009-11-17
申请号：US11080062
申请日：2005-03-14
申请人： Luc Desnoyers , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , William I. Wood , Ellen Filvaroff
发明人： Luc Desnoyers , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , William I. Wood , Ellen Filvaroff
IPC分类号： C07K14/435 , C07K19/00 , C07K14/515
CPC分类号： C07K14/47 , C07K14/50 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

10. 发明授权

US07557192B2 Anti-PRO335 antibodies 有权
标题翻译：抗PRO335抗体
公开(公告)号：US07557192B2
公开(公告)日：2009-07-07
申请号：US09904786
申请日：2001-07-12
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , G01N33/68 , G01N2333/485
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

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