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1. 发明授权

US06414143B1 Extraction and recovery of nitramines from propellants, explosives, and pyrotechnics 失效
标题翻译：从推进剂，爆炸物和烟火中萃取和回收硝胺
公开(公告)号：US06414143B1
公开(公告)日：2002-07-02
申请号：US09505872
申请日：2000-02-17
申请人： Louis Cannizzo , Lew Huntsmann
发明人： Louis Cannizzo , Lew Huntsmann
IPC分类号： C07D25502
CPC分类号： A62D3/35 , A62D2101/06 , C06B21/0091 , Y10S149/124
摘要： Nitramine oxidizers are recovered from propellant, explosive, and pyrotechnic materials with a concentrated mineral acid bath, preferably comprising 70 to 90 wt. % nitric acid, that serves to dissolve the nitramine oxidizers into solution and permit filtration of the binder therefrom. The recovery process is conducted in the absence of organic solvents.
摘要翻译：使用浓缩的无机酸浴从推进剂，爆炸物和烟火材料中回收硝胺氧化剂，优选包含70至90wt。硝酸，用于将硝胺氧化剂溶解在溶液中，并允许过滤粘合剂。回收过程在没有有机溶剂的情况下进行。

2. 发明授权

US08664247B2 Acyclic organonitro compounds for use in treating cancer 有权
标题翻译：用于治疗癌症的无环有机硝基化合物
公开(公告)号：US08664247B2
公开(公告)日：2014-03-04
申请号：US13593737
申请日：2012-08-24
申请人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
发明人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
IPC分类号： A61K31/08 , A61K31/27 , A61K31/17 , A61K31/16 , A61K31/18 , C07D401/12 , A61K31/225 , A61K31/444 , A61K31/265 , A61K31/22 , A61P35/00 , C07C205/29
CPC分类号： C07D213/79 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/225 , C07C205/15 , C07C205/29 , C07C205/40 , C07C233/36 , C07C2601/02 , C07D307/68
摘要： The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
摘要翻译：本发明提供无环，偕二硝基有机化合物，合成化合物的方法，药物组合物，治疗方法和用于使用这些化合物和药物组合物治疗各种病症的医疗试剂盒。化合物和组合物可用于治疗癌症。

3. 发明申请

US20120237615A1 PHARMACEUTICAL COMPOSITIONS OF O-NITRO COMPOUNDS 有权
标题翻译： O-硝基化合物的药物组合物
公开(公告)号：US20120237615A1
公开(公告)日：2012-09-20
申请号：US13484138
申请日：2012-05-30
申请人： Mark D. Bednarski , Lynn M. Oehler , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
发明人： Mark D. Bednarski , Lynn M. Oehler , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/336 , A61K31/08 , A61K33/24 , A61P35/00 , A61K31/397 , A61K31/337 , A61K31/381 , A61K31/38 , A61K31/40 , A61K31/04 , A61K31/341
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫性疾病。

4. 发明申请

US20130053418A1 ACYCLIC ORGANONITRO COMPOUNDS FOR USE IN TREATING CANCER 有权
标题翻译： ACYCLIC ORGANONITRO化合物用于治疗癌症
公开(公告)号：US20130053418A1
公开(公告)日：2013-02-28
申请号：US13593737
申请日：2012-08-24
申请人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
发明人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
IPC分类号： A61K31/08 , A61K31/27 , A61K31/17 , A61K31/16 , A61K31/18 , C07D401/12 , A61K31/225 , A61K31/444 , A61P35/00 , C07C205/29 , C07C205/49 , A61K31/265 , A61K31/22
CPC分类号： C07D213/79 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/225 , C07C205/15 , C07C205/29 , C07C205/40 , C07C233/36 , C07C2601/02 , C07D307/68
摘要： The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
摘要翻译：本发明提供无环，偕二硝基有机化合物，合成化合物的方法，药物组合物，治疗方法和用于使用这些化合物和药物组合物治疗各种病症的医疗试剂盒。化合物和组合物可用于治疗癌症。

5. 发明授权

US08299053B2 Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof 有权
标题翻译：环状硝基化合物，其药物组合物及其用途
公开(公告)号：US08299053B2
公开(公告)日：2012-10-30
申请号：US12397651
申请日：2009-03-04
申请人： Mark D. Bednarski , Lynn M. Oehler, legal representative , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
发明人： Mark D. Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物和/或其药物组合物的方法，以治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

6. 发明申请

US20070135384A1 Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof 有权
标题翻译：环状硝基化合物，其药物组合物及其用途
公开(公告)号：US20070135384A1
公开(公告)日：2007-06-14
申请号：US11502810
申请日：2006-08-11
申请人： Mark Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning , Lynn Oehler
发明人： Mark Bednarski , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning , Lynn Oehler
IPC分类号： A61K31/675 , C07D205/02 , A61K31/397
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物和/或其药物组合物的方法，以治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

7. 发明申请

US20090163466A1 CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF 有权
标题翻译：环己烷化合物，其药物组合物及其用途
公开(公告)号：US20090163466A1
公开(公告)日：2009-06-25
申请号：US12397651
申请日：2009-03-04
申请人： Mark D. Bednarski , Lynn M. Oehler , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
发明人： Mark D. Bednarski , Lynn M. Oehler , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物和/或其药物组合物的方法，以治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

8. 发明申请

US20070135380A1 O-nitro compounds, pharmaceutical compositions thereof and uses thereof 审中-公开
标题翻译： O-硝基化合物，其药物组合物及其用途
公开(公告)号：US20070135380A1
公开(公告)日：2007-06-14
申请号：US11502974
申请日：2006-08-11
申请人： Mark Bednarski , Lynn Oehler , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
发明人： Mark Bednarski , Lynn Oehler , Susan Knox , Louis Cannizzo , Kirstin Warner , Robert Wardle , Stephen Velarde , Shoucheng Ning
IPC分类号： A61K31/69 , C07D331/02 , A61K31/21
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compound, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫性疾病。

9. 发明申请

US20060157173A1 Synthesis of energetic thermoplastic elastomers containing both polyoxirane and polyoxetane blocks 审中-公开
标题翻译：合成含有聚氧化乙烯和聚氧乙烯嵌段的高能热塑性弹性体
公开(公告)号：US20060157173A1
公开(公告)日：2006-07-20
申请号：US11354191
申请日：2006-02-14
申请人： Andrew Sanderson , Wayne Edwards , Louis Cannizzo , Robert Wardle
发明人： Andrew Sanderson , Wayne Edwards , Louis Cannizzo , Robert Wardle
IPC分类号： C06B45/20
CPC分类号： C08G18/3206 , C06B45/105 , C08G18/48 , C08G18/4833 , C08G18/5021 , C08G18/7621 , C08G65/18 , C08G65/22
摘要： This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75° C. and B blocks which are amorphous at temperatures above about −20° C. The A blocks are derived from oxetane derivatives and the B blocks are derived from oxiranes and derivatives thereof. The A blocks and B-blocks are end-capped with a diisocyanate having a first isocyanate moiety that is substantially more reactive with the terminal groups of the blocks than the second isocyanate moiety, whereby the more reactive first isocyanate moiety is capable of reacting with the terminal groups of the blocks, leaving the less reactive second isocyanate moiety free and unreacted. The end-capped A blocks and the end-capped B blocks are linked together with a linking compound having two isocyanate-reactive groups which are sufficiently unhindered to react with the free and unreacted isocyanate moieties of the end-capped polymers.
摘要翻译：该热塑性弹性体以基本固态的形式存在，适合用作补充约束系统的推进剂，爆炸物和/或气体发生剂的粘合剂。热塑性弹性体由包括在低于约75℃的温度下结晶的A嵌段的组合物形成，以及在高于约-20℃的温度下是无定形的B嵌段.A嵌段衍生自氧杂环丁烷衍生物，B嵌段是衍生自环氧乙烷及其衍生物。 A嵌段和B嵌段用具有第一异氰酸酯部分的二异氰酸酯封端，所述第一异氰酸酯部分与第二异氰酸酯部分的嵌段端基基本上更具反应性，由此反应性较高的第一异氰酸酯部分能够与这些嵌段的末端基团，使较少反应性的第二异氰酸酯部分游离并未反应。封端的A嵌段和封端的B嵌段与具有两个异氰酸酯反应性基团的连接化合物连接在一起，这两个异氰酸酯反应性基团充分地不受阻碍地与封端的聚合物的游离的和未反应的异氰酸酯部分反应。

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