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1. 发明申请

US20110229451A2 TEMPERATURE SENSITIVE MUTANTS OF MATRIX METALLOPROTEASES AND USES THEREOF 审中-公开
标题翻译：基质金属的温度敏感性及其用途
公开(公告)号：US20110229451A2
公开(公告)日：2011-09-22
申请号：US12660894
申请日：2010-03-05
申请人： Louis Bookbinder , Gregory Frost , Gilbert Keller , Gerhard Frey , Hwai Chang , Jay Short
发明人： Louis Bookbinder , Gregory Frost , Gilbert Keller , Gerhard Frey , Hwai Chang , Jay Short
IPC分类号： A61K38/48 , A61K38/47 , A61P17/02 , A61P19/00 , A61P17/00 , C12N9/50 , C12N9/96 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C12N9/6491 , A61K38/4886 , C12Y304/24007
摘要： Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
摘要翻译：提供了显示温度依赖性活性及其用途的修饰的基质金属蛋白酶（MMP）酶。 MMP可用于例如治疗ECM介导的疾病或特征在于增加一种或多种ECM组分的沉积或积累的疾病。

2. 发明申请

US20050260186A1 Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases 有权
标题翻译：可溶性糖胺聚糖酶和制备和使用可溶性糖胺聚糖酶的方法
公开(公告)号：US20050260186A1
公开(公告)日：2005-11-24
申请号：US11065716
申请日：2005-02-23
申请人： Louis Bookbinder , Anirban Kundu , Gregory Frost , Michael Haller , Gilbert Keller , Tyler Dylan
发明人： Louis Bookbinder , Anirban Kundu , Gregory Frost , Michael Haller , Gilbert Keller , Tyler Dylan
IPC分类号： A01K67/027 , A61K38/17 , A61K38/47 , C07H21/04 , C12N9/24 , C12P21/06
CPC分类号： A61K38/47 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C12N9/2408 , C12Y302/01035 , A61K2300/00
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
摘要翻译：本发明涉及新型可溶性中性活性透明质酸酶糖蛋白（sHASEGPs）的发现，其制备方法及其用于促进其它分子的施用或减轻糖胺聚糖相关病理学的用途。描述了可溶性中性活性sHASEGP结构域的微活性多肽结构域，其包括功能性中性活性透明质酸酶结构域所需的天冬酰胺连接的糖部分。包括改进的氨基末端前导肽，其增强sHASEGP的分泌。本发明还包含重组sHASEGP的唾液酸化和聚乙二醇化形式，以增强天然存在的屠宰酶的稳定性和血清药代动力学。进一步描述了衍生自真核细胞的基本上纯化的重组sHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。

3. 发明申请

US20060104968A1 Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases 审中-公开
标题翻译：可溶性糖胺聚糖酶及其制备和使用可溶性糖胺聚糖的方法
公开(公告)号：US20060104968A1
公开(公告)日：2006-05-18
申请号：US11238171
申请日：2005-09-27
申请人： Louis Bookbinder , Anirban Kundu , Gregory Frost , Michael Haller , Gilbert Keller , Tyler Dylan
发明人： Louis Bookbinder , Anirban Kundu , Gregory Frost , Michael Haller , Gilbert Keller , Tyler Dylan
IPC分类号： A61K38/47 , C12N9/24
CPC分类号： A61K47/6811 , A61K35/768 , A61K38/465 , A61K38/47 , A61K39/395 , A61K39/3955 , A61K47/60 , A61K2039/505 , C12N7/00 , C12N9/2408 , C12N9/2474 , Y02A50/466 , A61K2300/00
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
摘要翻译：本发明涉及新型可溶性中性活性透明质酸酶糖蛋白（sHASEGPs）的发现，其制备方法及其用于促进其它分子的施用或减轻糖胺聚糖相关病理学的用途。描述了可溶性中性活性sHASEGP结构域的微活性多肽结构域，其包括功能性中性活性透明质酸酶结构域所需的天冬酰胺连接的糖部分。包括改进的氨基末端前导肽，其增强sHASEGP的分泌。本发明还包含重组sHASEGP的唾液酸化和聚乙二醇化形式，以增强天然存在的屠宰酶的稳定性和血清药代动力学。进一步描述了衍生自真核细胞的基本上纯化的重组sHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。

4. 发明申请

US20100284995A1 Temperature sensitive mutants of matrix metalloproteases and uses thereof 审中-公开
标题翻译：基质金属蛋白酶的温度敏感突变体及其用途
公开(公告)号：US20100284995A1
公开(公告)日：2010-11-11
申请号：US12660894
申请日：2010-03-05
申请人： Louis Bookbinder , Gregory I. Frost , Gilbert Keller , Gerhard Johann Frey , Hwai Wen Chang , Jay Milton Short
发明人： Louis Bookbinder , Gregory I. Frost , Gilbert Keller , Gerhard Johann Frey , Hwai Wen Chang , Jay Milton Short
IPC分类号： A61K38/48 , A61K38/47 , A61P17/02 , A61P19/00 , A61P17/00 , C12N9/50 , C12N9/96 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C12N9/6491 , A61K38/4886 , C12Y304/24007
摘要： Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
摘要翻译：提供了显示温度依赖性活性及其用途的修饰的基质金属蛋白酶（MMP）酶。 MMP可用于例如治疗ECM介导的疾病或特征在于增加一种或多种ECM组分的沉积或积累的疾病。

5. 发明申请

US20070148156A1 Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof 有权
标题翻译：人类软骨素酶糖蛋白（chasegp），其制备方法和由其组成的药物组合物
公开(公告)号：US20070148156A1
公开(公告)日：2007-06-28
申请号：US10539110
申请日：2003-12-15
申请人： Gregory Frost , Anirban Kundu , Louis Bookbinder
发明人： Gregory Frost , Anirban Kundu , Louis Bookbinder
IPC分类号： A61K38/47 , C12N9/24
CPC分类号： C12N9/88 , A61K38/47 , C12Y402/02004
摘要： The invention relates to the discovery of a novel Chondroitinase Glycoproteins (CHASEGP's), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase activity. The invention also includes carboxy-terminal deletion variants of CHASEGP that result in secreted variants of the protein to facilitate manufacture of a recombinant CHASEGP. Further described are suitable formulations of a substantially purified recombinant CHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. CHASEGP is useful for the degradation of glycosaminoglycans and chondroitin sulfate proteoglycans under clinical conditions where their removal is of therapeutic value.
摘要翻译：本发明涉及新型软骨素酶糖蛋白（CHASEGP）的发现，其制备方法和潜在用途，其中去除硫酸软骨素可具有治疗益处。软骨素酶糖蛋白需要CHASEGP多肽的大部分催化结构域和天冬酰胺连接的糖基化以获得最佳的软骨素酶活性。本发明还包括CHASEGP的羧基末端缺失变体，其导致蛋白质的分泌型变体以促进重组CHASEGP的制备。进一步描述了衍生自真核细胞的基本上纯化的重组CHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。 CHASEGP可用于在其去除具有治疗价值的临床条件下降解糖胺聚糖和硫酸软骨素蛋白聚糖。

6. 发明授权

US09284543B2 Neutral active soluble truncated PH20 polypeptides and uses thereof 有权
标题翻译：中性活性可溶性截短的PH20多肽及其用途
公开(公告)号：US09284543B2
公开(公告)日：2016-03-15
申请号：US13385527
申请日：2012-02-21
申请人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
发明人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
IPC分类号： C12N9/26 , A61K47/48 , A61K38/00
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译：提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。

7. 发明授权

US08431380B2 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof 有权
公开(公告)号：US08431380B2
公开(公告)日：2013-04-30
申请号：US12378984
申请日：2009-02-20
申请人： Louis Bookbinder , Anirban Kundu , Gregory I. Frost
发明人： Louis Bookbinder , Anirban Kundu , Gregory I. Frost
IPC分类号： C12N9/26 , A61K38/47 , C12P21/02 , C07K14/435
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

8. 发明申请

US20130058893A1 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof 有权
公开(公告)号：US20130058893A1
公开(公告)日：2013-03-07
申请号：US13694005
申请日：2012-10-18
申请人： Louis Bookbinder , Anirban Kundu , Gregory I. Frost
发明人： Louis Bookbinder , Anirban Kundu , Gregory I. Frost
IPC分类号： C12N9/26 , A61K38/47 , A61K38/19 , A61K39/395 , A61P29/00 , A61P33/04 , A61P25/16 , A61P33/06 , A61P25/24 , A61P19/02 , A61P31/10 , A61P9/12 , A61P33/00 , A61P31/00 , A61P31/04 , A61P31/12 , C12N9/96
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.

9. 发明授权

US08927249B2 Extended soluble PH20 polypeptides and uses thereof 有权
标题翻译：可扩展的可溶性PH20多肽及其用途
公开(公告)号：US08927249B2
公开(公告)日：2015-01-06
申请号：US12653245
申请日：2009-12-09
申请人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
发明人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
IPC分类号： C12N9/26 , A61K38/47 , A61K47/48 , A61K38/00
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译：提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。

10. 发明申请

US20130101577A9 Extended Soluble PH20 Polypeptides and uses thereof 有权
标题翻译：扩增的可溶性PH20多肽及其用途
公开(公告)号：US20130101577A9
公开(公告)日：2013-04-25
申请号：US13385527
申请日：2012-02-21
申请人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
发明人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
IPC分类号： A61K38/47 , C12N9/96 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12N1/15 , C12N15/56 , A61P25/00 , A61P35/00 , A61P27/02 , A61P9/00 , A61P29/00 , A61P9/12 , A61P31/10 , A61P33/04 , A61P31/00 , A61P25/16 , A61K39/395 , A61P33/06 , C12N9/26
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译：提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。

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