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    • 1. 发明授权
    • Benzoxazinedione derivatives, method of producing them and uses thereof
    • 苯并恶嗪二酮衍生物,其制备方法和用途
    • US6013647A
    • 2000-01-11
    • US35344
    • 1998-03-05
    • Lothar HeinischSteffen WittmannUte MoellmannRolf Reissbrodt
    • Lothar HeinischSteffen WittmannUte MoellmannRolf Reissbrodt
    • C07D499/70A61K31/535A61K31/536A61K31/538A61K38/00A61K47/48A61P3/00A61P31/04A61P43/00C07D265/24C07D265/26C07D413/06C07D413/12C07D499/00C07D499/68C07D501/20C07K5/02C07K5/06C07K5/103C07K7/06
    • C07K7/06C07D265/26C07D499/00C07K5/02C07K5/06026C07K5/1008A61K38/00
    • This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R.sup.1 =H or carboxyalkyl, R.sup.2 =H, alkyl or phenyl, and R.sup.3 represents different acid groups derived from amino acids, dipeptides and hydrazones or conjugates thereof with active ingredients, e.g. antibiotics. The compounds may be present as free acids, in the form of their salts or as readily cleavable esters. The compounds according to the invention constitute heterocyclically protected catechol derivatives and are effective as siderophores against gram-negative bacterial strains, particularly against Pseudomonads and strains of E. coli and Salmonella. In the form of their conjugates with active ingredients, e.g. antibiotics (as "siderophore-antibiotic conjugates"), they can transport the latter into bacterial cells and can improve or extend the antibacterial effect thereof, sometimes even in relation to bacterial strains which are resistant to other .beta.-lactams. In addition, said compounds, as potential prodrug forms for iron chelating agents, are suitable for use against diseases which are caused by a disorder of the iron metabolism. The invention can be employed in pharmaceutical research and in the pharmaceutical industry, and in agriculture.
    • 本发明涉及对应于式I的新的苯并恶嗪二酮衍生物:其中R1 = H或羧基烷基,R2 = H,烷基或苯基,R3代表衍生自氨基酸,二肽和腙的不同酸基或​​其与活性成分例如 抗生素。 化合物可以其盐形式或易裂解的酯的形式存在为游离酸。 根据本发明的化合物构成了杂环保护的邻苯二酚衍生物,并且作为抗革兰氏阴性细菌菌株的铁载体是有效的,特别是对假单胞菌和大肠杆菌和沙门氏菌菌株有效。 以它们与活性成分的缀合物的形式,例如 抗生素(作为“铁载体 - 抗生素共轭物”),它们可以将后者转运到细菌细胞中,并且可以改善或延长其抗菌作用,有时甚至与对其它β-内酰胺酶有抗性的细菌菌株有关。 此外,作为铁螯合剂的潜在前体药物形式的所述化合物适用于针对由铁代谢紊乱引起的疾病。 本发明可用于制药研究,制药工业和农业领域。
    • 3. 发明申请
    • IMAGE CODING METHOD, IMAGE DECODING METHOD, AND APPARATUSES THEREFOR
    • 图像编码方法,图像解码方法及其设备
    • US20120082242A1
    • 2012-04-05
    • US13377160
    • 2010-06-10
    • Matthias NarroschkeSteffen Wittmann
    • Matthias NarroschkeSteffen Wittmann
    • H04N7/26
    • H04N19/117H04N19/174H04N19/176H04N19/423H04N19/46H04N19/50H04N19/61H04N19/70H04N19/86H04N19/94
    • The image coding method for improving the filtering quality and suppressing increase in the transmission bandwidth includes: selecting filter data elements of the first and second component filters from a filter memory (1330), and obtaining indexes stored in association with the selected filter data elements in the filter memory (1330) (S10, S11); coding a macroblock using the two filter data elements (S12); adding the two indexes to a coded video signal (S13); calculating the filter data elements of the first and second component filters based on a slice, and assigning indexes to the filter data elements (S20, S21); storing, in the filter memory (1330), a corresponding one of the calculated filter data elements and the index in association with each other for each of the component filters (S22); and adding the two calculated filter data elements to the coded video signal (S23).
    • 用于提高滤波质量并抑制传输带宽增加的图像编码方法包括:从滤波器存储器(1330)中选择第一和第二分量滤波器的滤波器数据元素,并且获得与所选择的滤波数据元素相关联地存储的索引 滤波器存储器(1330)(S10,S11); 使用两个滤波器数据元素编码宏块(S12); 将两个索引添加到编码视频信号(S13); 基于切片计算第一和第二分量滤波器的滤波器数据元素,并向滤波器数据元素分配索引(S20,S21); 在所述滤波器存储器(1330)中,针对每个所述分量滤波器,将所计算的滤波数据元素和所述索引中的相应一个相关联地存储在所述滤波器存储器中(S22); 并将两个计算的滤波器数据元素相加到编码视频信号(S23)。
    • 4. 发明申请
    • INTERPOLATION FILTERING METHOD, IMAGE CODING METHOD, IMAGE DECODING METHOD, INTERPOLATION FILTERING APPARATUS, PROGRAM, AND INTEGRATED CIRCUIT
    • 插值滤波方法,图像编码方法,图像解码方法,插值滤波器,程序和集成电路
    • US20100226432A1
    • 2010-09-09
    • US12682944
    • 2009-08-13
    • Steffen WittmannMatthias Narroschke
    • Steffen WittmannMatthias Narroschke
    • H04N7/32H04N7/26
    • H04N19/523
    • An interpolation filtering method includes selecting (S33), from an image, pixels to be used to interpolate a pixel to be interpolated; determining (S34) weight coefficients, each for a corresponding one of the pixels selected in the selecting of pixels; and calculating (S35) a pixel value of the pixel to be interpolated, by performing a weighted sum of pixel values of the pixels using the weight coefficients determined in the determining (S34) of weight coefficients. In the determining (S34) of weight coefficients, each of the weight coefficients is determined for the corresponding one of the pixels such that a smaller weight coefficient is assigned to a pixel when the pixel is included in a neighboring block than when the pixel is included in a current block in which the pixel to be interpolated is included and which is different from the neighboring block.
    • 内插滤波方法包括:从图像中选择(S33)作为内插用于内插的像素的像素; 确定(S34)权重系数,每个权重系数用于在所述像素选择中选择的所述像素中的相应一个像素; 以及通过使用在权重系数的确定(S34)中确定的权重系数来执行像素的像素值的加权和来计算(S35)要插值的像素的像素值。 在权重系数的确定(S34)中,对于相应的一个像素确定每个权重系数,使得当像素包括在相邻块中时,将较小的权重系数分配给像素,而不是包括像素 在其中包含要内插的像素并且与相邻块不同的当前块中。
    • 7. 发明授权
    • Image coding apparatus and image decoding apparatus
    • 图像编码装置和图像解码装置
    • US08712171B2
    • 2014-04-29
    • US13437315
    • 2012-04-02
    • Steffen WittmannThomas Wedi
    • Steffen WittmannThomas Wedi
    • G06K9/36
    • H04N19/117H04N19/14H04N19/154H04N19/172H04N19/174H04N19/176H04N19/177H04N19/46H04N19/50H04N19/61H04N19/82H04N19/86
    • Provide is an image decoding apparatus which reliably prevents deterioration of the image quality of decoded images which have been previously coded. An image decoding apparatus (200) includes: an inverse quantization and inverse orthogonal transform unit (220) and an adder (230) which decode a coded image included in a coded stream (Str) to generate a decoded image (Rc); an entropy decoding unit (210) which extracts cross-correlation data (p) which indicates a cross-correlation between the decoded image (Rc) and an image which corresponds to the decoded image and has not yet been coded; and an adaptive filter (240) which computes a filter parameter (w) based on the extracted cross-correlation data (p), and performs a filtering operation on the decoded image (Rc) according to the filter parameter (w).
    • 提供一种可靠地防止已经被编码的解码图像的图像质量劣化的图像解码装置。 一种图像解码装置(200)包括:对包含在编码流(Str)中的编码图像进行解码以产生解码图像(Rc)的逆量化和逆正交变换单元(220)和加法器(230) 提取表示解码图像(Rc)与对应于解码图像并且尚未被编码的图像之间的互相关的互相关数据(p)的熵解码单元(210) 以及基于所提取的互相关数据(p)来计算滤波器参数(w)的自适应滤波器(240),并根据滤波器参数(w)对解码图像(Rc)进行滤波处理。