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1. 发明授权

US06576422B1 Method for identifying products employing gene expression 有权
标题翻译：用于鉴定使用基因表达的产物的方法
公开(公告)号：US06576422B1
公开(公告)日：2003-06-10
申请号：US09690391
申请日：2000-10-17
申请人： Barry Weinstein , Lorraine Holowach Keller , Subba Reddy Palli
发明人： Barry Weinstein , Lorraine Holowach Keller , Subba Reddy Palli
IPC分类号： C12Q168
CPC分类号： C12Q1/6897
摘要： A method for identifying a product involves the steps of: (1) associating with the product a marker ligand; and (2) detecting the marker ligand in the product at a later point in time as a means of identifying the product by contacting the product with a detector composition. The detector composition comprises one or more first nucleotide sequences encoding one or more natural or synthetic ligand-dependent transcription factors, wherein said factors comprise at least one ligand binding domain, at least one DNA binding domain and at least one transactivation domain; and a second nucleotide sequence encoding a reporter gene under the regulatory control of a receptor response element or a modified or synthetic response element, and a second promoter. The method may also employ a corepressor or coactivator or a nucleotide sequence encoding the corepressor or activator Interaction between the marker ligand and ligand binding domain is highly specific and induces a change in the expression of the reporter gene, the change producing a detectable signal identifying the presence of the marker ligand in the product. The detector composition, a cell line containing the first and second nucleotide sequences, kits using them and products marked with specific marker ligands are useful in this method.
摘要翻译：用于鉴定产物的方法包括以下步骤：（1）与产物相关联的标记配体; 和（2）在稍后的时间点检测产品中的标记配体，作为通过使产物与检测器组合物接触来鉴定产物的手段。检测器组合物包含编码一种或多种天然或合成配体依赖性转录因子的一种或多种第一核苷酸序列，其中所述因子包含至少一个配体结合结构域，至少一个DNA结合结构域和至少一个反式激活结构域; 以及在受体应答元件或修饰或合成应答元件的调节控制下编码报告基因的第二核苷酸序列和第二启动子。该方法还可以使用共抑制因子或共激活物或编码共抑制因子或激活物的核苷酸序列。标记物配体和配体结合结构域之间的相互作用是高度特异性的并且引起报告基因表达的变化，该变化产生识别可检测信号标记配体在产物中的存在。检测器组合物，含有第一和第二核苷酸序列的细胞系，使用它们的试剂盒和标记有特异标记配体的产物在该方法中是有用的。

2. 发明授权

US06197522B1 Method for identifying and quantifying polymers utilizing immunoassay techniques 失效
标题翻译：利用免疫测定技术鉴定和定量聚合物的方法
公开(公告)号：US06197522B1
公开(公告)日：2001-03-06
申请号：US08783727
申请日：1997-01-16
申请人： Lorraine Holowach Keller , Barry Weinstein
发明人： Lorraine Holowach Keller , Barry Weinstein
IPC分类号： G01N3353
CPC分类号： G01N33/5308
摘要： Disclosed is a method for quantitatively identifying polymers in an aqueous system using immunoassay techniques, wherein at least a portion of the polymers contain a detectable terminus. This is particularly useful in water treatment systems. Also disclosed are new hybridoma cell lines which express MAbs which specifically recognize such a detectable terminus.
摘要翻译：公开了一种使用免疫测定技术定量鉴定含水体系中的聚合物的方法，其中至少一部分聚合物含有可检测的末端。这在水处理系统中特别有用。还公开了表达特异性识别这种可检测末端的MAb的新的杂交瘤细胞系。

3. 发明授权

US06251680B1 Detectable polymers and methods for detecting polymers in Aqueous systems 有权
标题翻译：可检测的聚合物和在水系统中检测聚合物的方法
公开(公告)号：US06251680B1
公开(公告)日：2001-06-26
申请号：US09245959
申请日：1999-02-05
申请人： Zhenwen Fu , Lorraine Holowach Keller , Barry Weinstein
发明人： Zhenwen Fu , Lorraine Holowach Keller , Barry Weinstein
IPC分类号： G01N3700
CPC分类号： C02F1/56 , C02F5/10 , C08F2/38 , C08F8/30 , C08F8/34 , C11D3/3769 , Y10T436/13
摘要： Polymers having amine-thiol terminal moieties are provided. The amine-thiol terminal moieties are imparted by using amine-thiols as chain transfer agents in aqueous addition polymerizations. The polymers are useful as mineral dispersants, as water-treatment additives for boiler waters, cooling towers, reverse osmosis applications, sugar refining, paper production, geothermal processes and oil wells, and as detergent additives acting as builders, anti-filming agents, dispersants, sequestering agents and encrustation inhibitors.
摘要翻译：提供具有胺 - 硫醇末端部分的聚合物。通过在水加成聚合中使用胺 - 硫醇作为链转移剂赋予胺 - 硫醇末端部分。这些聚合物可用作矿物分散剂，作为锅炉水，冷却塔，反渗透应用的水处理添加剂，糖精炼，造纸，地热过程和油井的水处理添加剂，以及用作助洗剂，抗蚀剂，分散剂，螯合剂和结壳抑制剂。

4. 发明授权

US06218491B1 Colorimetric or fluorometric-detectable polymers containing pendant amine groups 有权
标题翻译：含有侧基胺基的比色或荧光检测聚合物
公开(公告)号：US06218491B1
公开(公告)日：2001-04-17
申请号：US09246659
申请日：1999-02-05
申请人： Zhenwen Fu , Lorraine Holowach Keller , Barry Weinstein
发明人： Zhenwen Fu , Lorraine Holowach Keller , Barry Weinstein
IPC分类号： C08F2006
CPC分类号： G01N33/533 , C02F1/56 , C02F5/10 , C08F2/38 , C08F8/30 , C08F8/32 , C08F8/34 , C11D3/3769
摘要： Polymers having amine-thiol terminal moieties are provided. The amine-thiol terminal moieties are imparted by using amine-thiols as chain transfer agents in aqueous addition polymerizations. The polymers are useful as mineral dispersants, as water-treatment additives for boiler waters, cooling towers, reverse osmosis applications, sugar refining, paper production, geothermal processes and oil wells, and as detergent additives acting as builders, anti-filming agents, dispersants, sequestering agents and encrustation inhibitors.
摘要翻译：提供具有胺 - 硫醇末端部分的聚合物。胺 - 硫醇末端部分通过在水加成聚合中使用胺 - 硫醇作为链转移剂来赋予。聚合物可用作矿物分散剂，作为锅炉水，冷却塔，反渗透应用，糖精炼，纸的水处理添加剂生产，地热过程和油井，以及作为助洗剂，防腐剂，分散剂，螯合剂和结垢抑制剂的洗涤剂添加剂。

5. 发明授权

US5925716A Polymers from unsaturated acid monomers containing amine-sulfide moiety 失效
标题翻译：含有胺 - 硫化物部分的不饱和酸单体的聚合物
公开(公告)号：US5925716A
公开(公告)日：1999-07-20
申请号：US785640
申请日：1997-01-17
申请人： Zhenwen Fu , Lorraine Holowach Keller , Barry Weinstein
发明人： Zhenwen Fu , Lorraine Holowach Keller , Barry Weinstein
IPC分类号： G01N21/64 , C02F1/56 , C02F5/10 , C08F2/38 , C08F8/30 , C08F8/32 , C08F8/34 , C08F220/34 , C11D3/37 , G01N33/533
CPC分类号： G01N33/533 , C02F1/56 , C02F5/10 , C08F2/38 , C08F8/30 , C08F8/32 , C08F8/34 , C11D3/3769
摘要： Polymers having amine-thiol terminal moieties are provided. The amine-thiol terminal moieties are imparted by using amine-thiols as chain transfer agents in aqueous addition polymerizations.The polymers are useful as mineral dispersants, as water-treatment additives for boiler waters, cooling towers, reverse osmosis applications, sugar refining, paper production, geothermal processes and oil wells, and as detergent additives acting as builders, anti-filminig agents, dispersants, sequestering agents and encrustation inhibitors.
摘要翻译：提供具有胺 - 硫醇末端部分的聚合物。通过在水加成聚合中使用胺 - 硫醇作为链转移剂赋予胺 - 硫醇末端部分。这些聚合物可用作矿物分散剂，作为锅炉水，冷却塔，反渗透应用的水处理添加剂，糖精炼，造纸，地热过程和油井的水处理添加剂，以及作为助洗剂，抗电影剂，分散剂，螯合剂和结壳抑制剂。

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