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1. 发明申请

US20110207751A1 HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 审中-公开
标题翻译：杂环化合物和作为反应剂的用途
公开(公告)号：US20110207751A1
公开(公告)日：2011-08-25
申请号：US13031134
申请日：2011-02-18
申请人： Long Mao , Xiaobo Wang , Xiao Xu , Li Zhao , Jia Liu
发明人： Long Mao , Xiaobo Wang , Xiao Xu , Li Zhao , Jia Liu
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00 , A61P35/02 , A61K31/429 , C07D513/04 , A61K31/4439
CPC分类号： C07D471/04 , C07D513/04
摘要： Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有被噻唑环取代的稠合双环杂芳环体系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

2. 发明授权

US10215748B2 Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways 有权
公开(公告)号：US10215748B2
公开(公告)日：2019-02-26
申请号：US13403976
申请日：2012-02-23
申请人： Yama A. Abassi , Li Zhao , Ning Ke , Xiaobo Wang , Xiao Xu
发明人： Yama A. Abassi , Li Zhao , Ning Ke , Xiaobo Wang , Xiao Xu
IPC分类号： C40B30/04 , G01N33/50 , C12Q1/00 , G01N33/543
摘要： Use of impedance devices in methods of generating a time dependent cellular profiles (TCRP) for the modulation of oncogene addicted cells and comparing the impedance-based TCRP to controls or knowns to identify signature time dependent cellular profiles.

3. 发明授权

US09612234B2 Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments 有权
公开(公告)号：US09612234B2
公开(公告)日：2017-04-04
申请号：US13109809
申请日：2011-05-17
申请人： Nan Li , Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
发明人： Nan Li , Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
IPC分类号： C40B30/06 , G01N7/00 , C12Q1/00 , G01N33/50 , G01N33/483
CPC分类号： G01N33/48728 , G01N33/4836 , G01N33/5008 , G01N33/5014 , G01N33/5061 , G01N33/5073 , G01N2800/326 , G01N2800/52
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.

4. 发明授权

US08921041B2 Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses 有权
标题翻译：分子进入细胞的基于电穿孔的装置和方法以及细胞反应的动态监测
公开(公告)号：US08921041B2
公开(公告)日：2014-12-30
申请号：US13474355
申请日：2012-05-17
申请人： Xiaobo Wang , Yama A. Abassi , Josephine Atienza , Xiao Xu , Junquan Xu
发明人： Xiaobo Wang , Yama A. Abassi , Josephine Atienza , Xiao Xu , Junquan Xu
IPC分类号： C12Q1/68 , C12M1/42 , C12N15/87
CPC分类号： C12N15/87 , C12M35/02 , G01N15/12 , G01N33/48728
摘要： The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms.
摘要翻译：本发明包括用于转染细胞或细胞群的装置和方法以及细胞事件的动态监测。提供了多种微电子器件，其包括诸如电穿孔，跨膜电位的调节和细胞功能和机制的动态监测的功能。

5. 发明授权

US08344742B2 Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays 有权
标题翻译：实时电子细胞感测系统和细胞毒性分析和化合物分析的应用
公开(公告)号：US08344742B2
公开(公告)日：2013-01-01
申请号：US13011725
申请日：2011-01-21
申请人： Yama A. Abassi , Xiaobo Wang , Xiao Xu
发明人： Yama A. Abassi , Xiaobo Wang , Xiao Xu
IPC分类号： G01R27/08
CPC分类号： C12Q1/025 , C12Q1/002 , G01N27/02 , G01N33/4836 , G01N33/5014 , G01N33/5438
摘要： The invention provides methods of investigating a mechanism of action of a compound, which includes providing a device for monitoring cell-substrate impedance; attaching the device to an impedance analyzer; adding cells to two or more wells; adding a test compound to at least one of the wells and providing at least one control well; monitoring impedance of the wells to obtain a series of impedance measurements; plotting impedance measurements to obtain impedance curves and comparing the impedance curves to determine a time frame at which the test compound has a significant effect on cell growth or behavior. Determining the time frame provides information on changes in cell status in response to the test compound, including cell attachment or adhesion status, cell growth or proliferation status, the number of viable or dead cells, cytoskeletal organization or structure, and the number of cells going through apoptosis or necrosis.
摘要翻译：本发明提供了研究化合物作用机理的方法，其包括提供用于监测细胞 - 基底阻抗的装置; 将设备连接到阻抗分析仪; 将细胞添加到两个或更多个孔中; 向至少一个孔中加入测试化合物并提供至少一个对照孔; 监测井的阻抗以获得一系列阻抗测量; 绘制阻抗测量以获得阻抗曲线并比较阻抗曲线以确定测试化合物对细胞生长或行为具有显着影响的时间范围。确定时间框架提供了响应于测试化合物的细胞状态变化的信息，包括细胞附着或粘附状态，细胞生长或增殖状态，活细胞或死细胞的数量，细胞骨架组织或结构以及细胞数目通过凋亡或坏死。

6. 发明授权

US08041515B2 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents 有权
标题翻译：使用基于阻抗的细胞学分析来分类暴露于生物活性剂时的细胞反应谱
公开(公告)号：US08041515B2
公开(公告)日：2011-10-18
申请号：US11903454
申请日：2007-09-20
申请人： Xiaobo Wang , Yama A. Abassi , Wen fu Zhang , Xiao Xu
发明人： Xiaobo Wang , Yama A. Abassi , Wen fu Zhang , Xiao Xu
IPC分类号： G06F19/00 , C12Q1/02 , C12M1/42
CPC分类号： G01N33/502
摘要： The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
摘要翻译：本发明提供生物活性剂的多维轮廓化方法，并确定其对生物系统的影响。本发明的方法包括对生物活性剂的细胞反应的实时阻抗监测和细胞动力学特征分类到机制特异性细胞应答谱组中。类似的细胞反应谱的分组允许试剂和机制之间的相关性，从而允许鉴定试剂的潜在治疗应用或进一步研究细胞应答或机制。

7. 发明授权

US07732127B2 Dynamic monitoring of cell adhesion and spreading using the RT-CES system 有权
标题翻译：使用RT-CES系统动态监测细胞粘附和扩散
公开(公告)号：US07732127B2
公开(公告)日：2010-06-08
申请号：US11235938
申请日：2005-09-27
申请人： Xiaobo Wang , Yama Abassi , Josephine Atienza , Xiao Xu
发明人： Xiaobo Wang , Yama Abassi , Josephine Atienza , Xiao Xu
IPC分类号： C12Q1/00 , C12N5/00
CPC分类号： G01N29/036 , G01N2291/0257
摘要： The present invention includes devices and methods for dynamically monitoring cell adhesion and cell spreading. Cells are added to a microelectronic cell sensor array operably connected to an impedance analyzer. The device also includes a coating including biological molecule or organic compound capable of interacting with the cell. Cell adhesion and cell mobility is determined by detecting changes in impedance and comparing impedance or cell index values between samples.
摘要翻译：本发明包括用于动态监测细胞粘附和细胞扩散的装置和方法。将细胞添加到可操作地连接到阻抗分析器的微电子单元传感器阵列。该装置还包括包含能够与细胞相互作用的生物分子或有机化合物的涂层。通过检测阻抗变化并比较样品之间的阻抗或细胞指数值来确定细胞粘附和细胞迁移率。

8. 发明申请

US20090309618A1 Real Time Electronic Cell Sensing System and Applications For Cytotoxicity Profiling and Compound Assays 有权
标题翻译：实时电子细胞感应系统及其用于细胞毒性分析和化合物分析的应用
公开(公告)号：US20090309618A1
公开(公告)日：2009-12-17
申请号：US12480592
申请日：2009-06-08
申请人： Xiao Xu , Yama A. Abassi , Xiaobo Wang
发明人： Xiao Xu , Yama A. Abassi , Xiaobo Wang
IPC分类号： G01R27/08
CPC分类号： C12Q1/025 , C12Q1/002 , G01N27/02 , G01N33/4836 , G01N33/5014 , G01N33/5438
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. The methods can be used to test the effects of compounds on cells, such as in cytotoxicity assays. Methods of cytotoxicity profiling of compounds are also provided.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。该方法可用于测试化合物对细胞的影响，例如细胞毒性测定。还提供了化合物的细胞毒性分析方法。

9. 发明授权

US07192752B2 Real time electronic cell sensing systems and applications for cell-based assays 有权
标题翻译：实时电子传感系统和基于细胞的测定的应用
公开(公告)号：US07192752B2
公开(公告)日：2007-03-20
申请号：US10987732
申请日：2004-11-12
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： C12N13/00
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。在其它优选方面，设计这些测定法来研究影响细胞对抗原的IgE介导的反应的化合物。

10. 发明申请

US20060121446A1 Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses 有权
标题翻译：分子进入细胞的基于电穿孔的装置和方法以及细胞反应的动态监测
公开(公告)号：US20060121446A1
公开(公告)日：2006-06-08
申请号：US11286882
申请日：2005-11-23
申请人： Yama Abassi , Xiaobo Wang , Josephine Atienza , Xiao Xu , Junquan Xu
发明人： Yama Abassi , Xiaobo Wang , Josephine Atienza , Xiao Xu , Junquan Xu
IPC分类号： C12Q1/00 , C12N15/86
CPC分类号： C12N15/87 , C12M35/02 , G01N15/12 , G01N33/48728
摘要： The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms.
摘要翻译：本发明包括用于转染细胞或细胞群的装置和方法以及细胞事件的动态监测。提供了多种微电子器件，其包括诸如电穿孔，跨膜电位的调节和细胞功能和机制的动态监测的功能。

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