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1. 发明授权

US12070458B2 Therapeutic agent composition and method of use, for treatment of mild congnitive impairment, depression, and psychological disorders 有权
公开(公告)号：US12070458B2
公开(公告)日：2024-08-27
申请号：US18315910
申请日：2023-05-11
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K31/4985 , A61K9/00 , A61K38/12 , A61K38/30 , A61K45/06 , A61P25/24 , A61P25/28
CPC分类号： A61K31/4985 , A61K9/0019 , A61K9/0053 , A61K38/12 , A61K38/30 , A61K45/06 , A61P25/24 , A61P25/28
摘要： The present invention generally relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogues and mimetics thereof, as neuroprotective agents for the treatment and or prevention of cognitive impairment and neurological disorders including but not limited to cerebral ischemia or cerebral infarction, status epilepticus, perinatal asphyxia, anoxia, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Dementia with Lewy Bodies. The present invention also generally provides manufacturing methods to prepare dosage forms. The present invention further generally relates to the use of cyclic Prolyl Glycine and analogues and mimetics thereof, as neuroprotective and neuro-regenerating agents for the treatment and or prevention of depression and other psychological disorders.

2. 发明授权

US11090303B2 Therapeutic agent composition and method of use, for treatment of mild congnitive impairment, depression, and psychological disorders 有权
公开(公告)号：US11090303B2
公开(公告)日：2021-08-17
申请号：US16412759
申请日：2019-05-15
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K31/4985 , A61P25/28 , A61P25/24 , A61K9/00 , A61K38/12 , A61K38/30 , A61K45/06
摘要： The present invention generally relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogues and mimetics thereof, as neuroprotective agents for the treatment and or prevention of cognitive impairment and neurological disorders including but not limited to cerebral ischemic or cerebral infarction, status epilepticus, perinatal asphyxia, anoxia, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants. The present invention also generally provides manufacturing methods to prepare of dosage forms. The present invention further generally relates to the use of cyclic Prolyl Glycine and analogues and mimetics thereof, as neuroprotective and neuro-regenerating agents for the treatment and or prevention of depression and other psychological disorders.

3. 发明公开

US20230172902A1 METHODS FOR THE PROPHYLAXIS AND TREATMENT OF COVID AND COVID-19 审中-公开
公开(公告)号：US20230172902A1
公开(公告)日：2023-06-08
申请号：US18047432
申请日：2022-10-18
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K31/357 , A61P31/14 , A61K31/4706 , A61K38/05 , A61K31/536 , A61K31/4725 , A61K31/675 , A61K31/4985 , A61K31/445 , A61K31/41 , A61K31/27 , A61K9/51 , A61K31/573 , A61K39/13
CPC分类号： A61K31/357 , A61K9/5161 , A61K31/27 , A61K31/41 , A61K31/445 , A61K31/536 , A61K31/573 , A61K31/675 , A61K31/4706 , A61K31/4725 , A61K31/4985 , A61K38/05 , A61K39/13 , A61P31/14 , A61K2039/545
摘要： The present invention recognizes that there is a need for the prophylaxis or treatment of COVID and COVID-19. A first aspect of the present invention generally relates to methods of prophylaxis or treatment of COVID or COVID-19 using various pharmaceutical compositions. A second aspect of the present invention generally relates to methods of prophylaxis or treatment of COVID or COVID-19 using combinations of antimalarial drugs and antiviral drugs. A third aspect of the present invention generally relates to methods of prophylaxis or treatment of COVID or COVID-19 using nanoparticle formulations that include pharmaceutical compositions. A fourth aspect of the present invention generally relates to methods of prophylaxis or treatment of COVID or COVID-19 using combinations of various pharmaceutical compositions. A fifth aspect of the present invention generally relates to methods of prophylaxis or treatment of COVID or COVID-19 using a polio vaccine and pharmaceutical compositions.

4. 发明申请

US20220000866A1 THERAPEUTIC AGENT COMPOSITION AND METHOD OF USE, FOR TREATMENT OF MILD CONGNITIVE IMPAIRMENT, DEPRESSION, AND PSYCHOLOGICAL DISORDERS 有权
公开(公告)号：US20220000866A1
公开(公告)日：2022-01-06
申请号：US17359515
申请日：2021-06-26
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K31/4985 , A61P25/28 , A61P25/24 , A61K9/00 , A61K38/12 , A61K38/30 , A61K45/06
摘要： The present invention generally relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogues and mimetics thereof, as neuroprotective agents for the treatment and or prevention of cognitive impairment and neurological disorders including but not limited to cerebral ischemia or cerebral infarction, status epilepticus, perinatal asphyxia, anoxia, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Dementia with Lewy Bodies. The present invention also generally provides manufacturing methods to prepare of dosage forms. The present invention further generally relates to the use of cyclic Prolyl Glycine and analogues and mimetics thereof, as neuroprotective and neuro-regenerating agents for the treatment and or prevention of depression and other psychological disorders.

5. 发明申请

US20200054629A1 THERAPEUTIC AGENT COMPOSITION AND METHOD OF USE, FOR TREATMENT OF MILD CONGNITIVE IMPAIRMENT, DEPRESSION, AND PSYCHOLOGICAL DISORDERS 审中-公开
公开(公告)号：US20200054629A1
公开(公告)日：2020-02-20
申请号：US16412759
申请日：2019-05-15
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K31/4985 , A61K38/12 , A61K9/00 , A61K38/30 , A61P25/24 , A61P25/28 , A61K45/06
摘要： The present invention generally relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogues and mimetics thereof, as neuroprotective agents for the treatment and or prevention of cognitive impairment and neurological disorders including but not limited to cerebral ischemic or cerebral infarction, status epilepticus, perinatal asphyxia, anoxia, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants. The present invention also generally provides manufacturing methods to prepare of dosage forms. The present invention further generally relates to the use of cyclic Prolyl Glycine and analogues and mimetics thereof, as neuroprotective and neuro-regenerating agents for the treatment and or prevention of depression and other psychological disorders.

6. 发明公开

US20230381175A1 THERAPEUTIC AGENT COMPOSITION AND METHOD OF USE, FOR TREATMENT OF MILD CONGNITIVE IMPAIRMENT, DEPRESSION, AND PSYCHOLOGICAL DISORDERS 审中-公开
公开(公告)号：US20230381175A1
公开(公告)日：2023-11-30
申请号：US18315910
申请日：2023-05-11
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K31/4985 , A61P25/28 , A61P25/24 , A61K9/00 , A61K38/12 , A61K38/30 , A61K45/06
CPC分类号： A61K31/4985 , A61P25/28 , A61P25/24 , A61K9/0019 , A61K9/0053 , A61K38/12 , A61K38/30 , A61K45/06
摘要： The present invention generally relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogues and mimetics thereof, as neuroprotective agents for the treatment and or prevention of cognitive impairment and neurological disorders including but not limited to cerebral ischemia or cerebral infarction, status epilepticus, perinatal asphyxia, anoxia, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Dementia with Lewy Bodies. The present invention also generally provides manufacturing methods to prepare dosage forms. The present invention further generally relates to the use of cyclic Prolyl Glycine and analogues and mimetics thereof, as neuroprotective and neuro-regenerating agents for the treatment and or prevention of depression and other psychological disorders.

7. 发明申请

US20150306171A1 THERAPEUTIC AGENT COMPOSITION AND METHOD OF USE 审中-公开
标题翻译：治疗药物组合物和使用方法
公开(公告)号：US20150306171A1
公开(公告)日：2015-10-29
申请号：US14791317
申请日：2015-07-03
申请人： Lloyd Hung Loi Tran
发明人： Lloyd Hung Loi Tran
IPC分类号： A61K38/12 , A61K45/06 , A61K38/30
CPC分类号： A61K38/12 , A61K38/00 , A61K38/30 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogs and mimetics thereof, as neuroprotective agents for the treatment and or prevention of neurological disorders including but not limited to cerebral ischemia or cerebral infarction resulting from a range of phenomena, such as thromboembolic or hemorrhagic stroke, cerebral basospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia such as from drowning, pulmonary surgery, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants.
摘要翻译：本发明涉及使用环状脯氨酸甘氨酸（“环状PG”或“cPG”）及其类似物和模拟物作为神经保护剂，用于治疗和/或预防神经障碍，包括但不限于由脑缺血或脑梗死引起的脑梗死一系列现象，如血栓栓塞或出血性中风，脑基底血症，低血糖症，心脏骤停，癫痫持续状态，围产期窒息，溺水，肺外科手术和脑创伤等缺氧症，以及治疗和预防慢性神经变性诸如阿尔茨海默氏病，帕金森病和亨廷顿病的疾病，以及抗惊厥药。

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