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1. 发明授权

US06646005B1 Method of treating hair loss using sulfonyl thyromimetic compounds 失效
标题翻译：使用磺酰甲状腺素化合物治疗脱发的方法
公开(公告)号：US06646005B1
公开(公告)日：2003-11-11
申请号：US09980351
申请日：2002-02-21
申请人： Lixin Lilly Zhang , Robert Scott Youngquist
发明人： Lixin Lilly Zhang , Robert Scott Youngquist
IPC分类号： A61K3150
CPC分类号： A61Q7/00 , A61K8/46 , A61K8/4953
摘要： Methods for treating hair loss using a composition including a compound having the following structure and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof are provided. R1 is —(CH2)n(CHNR7R8)mC(O)R9, wherein n is an integer from 1 to 3, and m is an integer from 0 to 1. R3 and R5each, independently, is chlorine, bromine, iodine and —CH3. R7 and R8 each, independently, is hydrogen or C1 to C4 alkyl. R9 is hydroxy, C1 to C4 alkoxy and —NR7R8. R31 is a hydrogen, chlorine, bromine, iodine, C1 to C4 alkyl, C4 to C6 cycloalklyl, C1 to C4 haloalkyl, C4 to C6 halocycloalkyl, or CH(R10)Ar. Ar is 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methioxypyridazin-3-yl N-oxide or 6-hydroxypyridazin-3-yl N-oxide. R10 is hydrogen or C1 to C4 alkyl. R41 is hydroxy or C1 to C4 alkoxy.
摘要翻译：提供了使用包含具有以下结构的化合物和药学上可接受的盐，水合物和生物可水解的酰胺，酯和酰亚胺的组合物来治疗脱发的方法。 R 1为 - （CH 2）n（CHNR 7 R 8）m C（O）R 9，其中n为1至3的整数，m为0至1的整数。R 3和R 5各自独立地为氯，溴，碘和 - CH3。 R 7和R 8各自独立地是氢或C 1至C 4烷基。 R9是羟基，C1-C4烷氧基和-NR7R8。 R31是氢，氯，溴，碘，C1至C4烷基，C4至C6环烷基，C1至C4卤代烷基，C4至C6卤代环烷基或CH（R10）Ar。 Ar是5-羟基吡啶-2-基，6-羟基吡啶-3-基，6-羟基哒嗪-3-基，6-甲氧基哒嗪-3-基N-氧化物或6-羟基哒嗪-3-基N-氧化物。 R 10是氢或C 1至C 4烷基。 R41是羟基或C1-C4烷氧基。

2. 发明授权

US06525094B1 Method of treating hair loss using diphenylether derivatives 失效
标题翻译：使用二苯醚衍生物治疗脱发的方法
公开(公告)号：US06525094B1
公开(公告)日：2003-02-25
申请号：US09980408
申请日：2000-12-08
申请人： Lixin Lilly Zhang , Robert Scott Youngquist
发明人： Lixin Lilly Zhang , Robert Scott Youngquist
IPC分类号： A61K3124
CPC分类号： A61K8/44 , A61Q7/00
摘要： The present invention describes methods for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The methods comprise administering a cardiac-sparing compound which is a derivative of diphenylether and pharmaceutically-acceptable carrier.
摘要翻译：本发明描述了治疗哺乳动物脱发的方法，包括阻止和/或逆转脱发并促进毛发生长。所述方法包括施用作为二苯醚衍生物的心脏保留化合物和药学上可接受的载体。

3. 发明授权

US06680344B1 Method of treating hair loss using diphenylmethane derivatives 失效
标题翻译：使用二苯基甲烷衍生物治疗脱发的方法
公开(公告)号：US06680344B1
公开(公告)日：2004-01-20
申请号：US09980407
申请日：2002-03-29
申请人： Lixin Lilly Zhang , Robert Scott Youngquist
发明人： Lixin Lilly Zhang , Robert Scott Youngquist
IPC分类号： A61K31192
CPC分类号： A61K31/192 , A61K8/365 , A61Q7/00
摘要： The present invention relates to a method of treating hair loss comprising administering a composition having a cardiac-sparing compound characterized by the structure: and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof. In this compound, n may be an integer from 1 to 3; R1 and R2 may each, independently, be a hydrogen or lower alkyl; R4 may be hydrogen, lower alkyl or cycloalkyl; R6 and R9 may each, independently, be hydrogen or lower alkyl; R7 and R8 may each, independently, be hydrogen, lower alkyl, substituted phenyl, or substituted benzyl; R10 may be hydrogen, lower alkyl, cycloalkyl, or acyl; and R11 may be hydrogen, lower alkyl, or cycloalkyl.
摘要翻译：本发明涉及治疗脱发的方法，其包括给予具有以下结构为特征的心脏保留化合物的组合物：及其药学上可接受的盐，水合物和可生物水解的酰胺，酯和酰亚胺。在该化合物中，n可以是1至3的整数; R 1和R 2可各自独立地为氢或低级烷基; R4可以是氢，低级烷基或环烷基; R6和R9各自独立地为氢或低级烷基; R 7和R 8各自独立地为氢，低级烷基，取代的苯基或取代的苄基; R 10可以是氢，低级烷基，环烷基或酰基; R 11可以是氢，低级烷基或环烷基。

4. 发明授权

US10072293B2 Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis 有权
公开(公告)号：US10072293B2
公开(公告)日：2018-09-11
申请号：US13437072
申请日：2012-04-02
申请人： Kevin John Mills , Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Ping Hu , Makio Tamura
发明人： Kevin John Mills , Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Ping Hu , Makio Tamura
IPC分类号： G01N33/48 , C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158
摘要： Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

5. 发明授权

US08618086B2 Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins 有权
公开(公告)号：US08618086B2
公开(公告)日：2013-12-31
申请号：US12138733
申请日：2008-06-13
申请人： Mitchell Anthony deLong , John McMillan McIver , Robert Scott Youngquist
发明人： Mitchell Anthony deLong , John McMillan McIver , Robert Scott Youngquist
IPC分类号： A61K31/165 , A61K31/21 , A61K31/33 , A61K31/425 , A61K31/54 , A61K8/00 , A61K8/18
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

6. 发明申请

US20080241078A1 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING C16-C20 AROMATIC TETRAHYDRO PROSTAGLANDINS 有权
标题翻译：使用C16-C20芳族四氢叶酸治疗头发损失的组合物和方法
公开(公告)号：US20080241078A1
公开(公告)日：2008-10-02
申请号：US12138733
申请日：2008-06-13
申请人： Mitchell Anthony DeLong , John McMillan McIver , Robert Scott Youngquist
发明人： Mitchell Anthony DeLong , John McMillan McIver , Robert Scott Youngquist
IPC分类号： A61K9/12 , A61K31/192 , A61P17/14
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
摘要翻译：用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。组合物可以局部施用于皮肤。组合物可以阻止脱发，逆转脱发，并促进毛发生长。

7. 发明申请

US20120157478A1 Hair Care Compositions and Methods to Improve Hair Appearance 审中-公开
标题翻译：护发组合和改善头发外观的方法
公开(公告)号：US20120157478A1
公开(公告)日：2012-06-21
申请号：US13328176
申请日：2011-12-16
申请人： Thomas Larry DAWSON, JR. , Robert Scott Youngquist , Jeanette Anthea Richards , Sancai Xie , Mary Jane Combs
发明人： Thomas Larry DAWSON, JR. , Robert Scott Youngquist , Jeanette Anthea Richards , Sancai Xie , Mary Jane Combs
IPC分类号： A61K8/49 , A61Q5/00
CPC分类号： A61Q7/00 , A61K8/42 , A61K8/4953 , A61K8/498 , A61K8/675 , A61Q5/002
摘要： Hair care compositions and methods that can increase the appearance of healthier hair by increasing the appearance of thicker and fuller hair, longer hair, and/or delayed emergence of gray hair. Such compositions can be applied to any areas where healthier hair appearance is desired, such as the scalp or face.
摘要翻译：护发组合物和方法可以通过增加更厚和更丰满的头发，更长的头发和/或延迟出现灰白色头发的外观来增加更健康的头发的外观。这样的组合物可以应用于需要更健康的头发外观的任何区域，例如头皮或脸部。

8. 发明授权

US07407987B2 Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins 有权
标题翻译：使用C16-C20芳族四氢前列腺素治疗脱发的组合物和方法
公开(公告)号：US07407987B2
公开(公告)日：2008-08-05
申请号：US11565297
申请日：2006-11-30
申请人： Mitchell Anthony deLong , John McMillan McIver , Robert Scott Youngquist
发明人： Mitchell Anthony deLong , John McMillan McIver , Robert Scott Youngquist
IPC分类号： A61K31/215 , A61K31/33 , A61K31/38 , A61K31/41
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
摘要翻译：用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。组合物可以局部施用于皮肤。组合物可以阻止脱发，逆转脱发，并促进毛发生长。

9. 发明申请

US20120283112A1 Systems and Methods for Identifying Cosmetic Agents for Skin Care Compositions 审中-公开
标题翻译：用于鉴定护肤组合物的化妆品的系统和方法
公开(公告)号：US20120283112A1
公开(公告)日：2012-11-08
申请号：US13402102
申请日：2012-02-22
申请人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
IPC分类号： C40B30/04 , C40B30/02 , C40B60/12
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B50/00
摘要： Provided are methods and systems for determining functional relationships between a cosmetic agent and a skin tissue condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a skin aging tissue condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
摘要翻译：提供了用于确定化妆品和感兴趣的皮肤组织状况之间的功能关系的方法和系统。还提供了用于鉴定影响皮肤老化组织状况的化妆品的方法和系统，以及用于制备化妆品组合物，个人护理产品或这两者的这些方法和系统鉴定的药剂的使用。

10. 发明申请

US20120093752A1 Use of Monoamine Oxidase Inhibitors to Improve Epithelial Biology 有权
标题翻译：使用单胺氧化酶抑制剂改善上皮生物学
公开(公告)号：US20120093752A1
公开(公告)日：2012-04-19
申请号：US13272255
申请日：2011-10-13
申请人： Teresa DiColandrea , Robert Scott Youngquist , Sancai Xie , Robert Lloyd Binder , Gary Richard Fuentes , Deborah Lade
发明人： Teresa DiColandrea , Robert Scott Youngquist , Sancai Xie , Robert Lloyd Binder , Gary Richard Fuentes , Deborah Lade
IPC分类号： A61K8/49 , A61K31/138 , A61K31/137 , A61K31/44 , A61K8/58 , A61K8/60 , A61K8/36 , A61K8/63 , A61K8/362 , A61K8/64 , A61K8/41 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61Q19/08 , A61K31/506
CPC分类号： A61K31/435 , A61K8/40 , A61K8/4926 , A61K8/4953 , A61K9/0014 , A61K31/137 , A61K31/138 , A61K31/495 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61Q19/08 , A61K2300/00
摘要： The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.
摘要翻译：本发明提供了一种改善毛发生物学的方法，例如毛发生长。该方法包括向受试者施用单胺氧化酶抑制剂和血管扩张剂，羧酸锌盐，黄嘌呤化合物，吡啶硫酮或其盐，皂角苷，三苯甲酸，山梨醇酸，celastrol，积雪草酸，5- α-还原酶，1,4-甲基-4-氮灰石，雄激素受体拮抗剂，壬二酸或其衍生物，环孢菌素，三碘甲状腺原氨酸，二氮嗪，视黄酸，前列腺素类似物，胺氧化物，酒石酸肉碱，芹菜素，前肽或腺苷，有效地达到期望效果的量。本发明还提供减少或延迟与年龄相关的皮肤缺陷的外观的方法。该方法包括向受试者施用包含MAO抑制剂的组合物。还提供了一种用于改善毛发生长的试剂盒。

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