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1. 发明授权

US08205930B1 Vehicle door with an irregular-circular frame for a recreational vehicle 有权
标题翻译：车门用于休闲车辆的不规则圆形框架
公开(公告)号：US08205930B1
公开(公告)日：2012-06-26
申请号：US13151474
申请日：2011-06-02
申请人： Liufeng Zhang , Jianshe Chen , Zhaoyu Li , Zaili Liu , Rui He , Wenwen Liu
发明人： Liufeng Zhang , Jianshe Chen , Zhaoyu Li , Zaili Liu , Rui He , Wenwen Liu
IPC分类号： B60J10/02
CPC分类号： B60J5/0487 , B60J1/14
摘要： Disclosed herein is a vehicle door with an irregular-circular frame for a recreational vehicle. A door window glass of the vehicle door includes a fixed glass (2) and a movable glass (1). The fixed glass (2) is fixedly installed in a portion of the door window surrounded by a lower door body (6), an outer frame (5) and a movable glass guide rail (9). The movable glass guild rail (9) has an arc rail. The movable glass (1) is installed on the lower door body (6) at the center of the arc of the movable glass guide rail (9) via a shaft sleeve and a shaft (4). A lock member (3) with a lock pin is installed on the upper part of the portion where the movable glass (1) engages with the movable glass guide rail (9). A stop block for adjusting the opening degree of the movable glass and stopping the lock pin of the lock member (3) is provided on the movable glass guide rail (9). Compared with the prior art, the vehicle door according to the present invention can solve the difficulty of opening and closing the widow glass of the vehicle door with the irregular-circular frame.
摘要翻译：本文公开了一种具有休闲车辆的不规则圆形框架的车门。车门的门窗玻璃包括固定玻璃（2）和活动玻璃（1）。固定玻璃（2）固定地安装在由下门体（6），外框架（5）和可动玻璃导轨（9）围绕的门窗的一部分中。活动玻璃导轨（9）具有弧轨。可移动玻璃（1）通过轴套和轴（4）安装在可动玻璃导轨（9）的圆弧中心的下门体（6）上。在可动玻璃（1）与可动玻璃导轨（9）接合的部分的上部安装有具有锁定销的锁定构件（3）。在可动玻璃导轨（9）上设置有用于调节可动玻璃的开度并使锁定构件（3）的锁定销停止的止动块。与现有技术相比，根据本发明的车门能够解决用不规则圆形框架打开和关闭车门的寡妇玻璃的困难。

2. 发明授权

US5763216A Gene encoding a human reduced folate carrier (RFC) 失效
标题翻译：基因编码人体叶酸载体（RFC）
公开(公告)号：US5763216A
公开(公告)日：1998-06-09
申请号：US483094
申请日：1995-06-07
申请人： Jeffrey A. Moscow , Kenneth H. Cowan , Kathy Dixon , Rui He
发明人： Jeffrey A. Moscow , Kenneth H. Cowan , Kathy Dixon , Rui He
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68 , C12N15/09 , C12N15/12 , C12P21/00
CPC分类号： C07K14/47 , A61K48/00
摘要： One shortcoming of methotrexate chemotherapy is that previously responsive tumors can become refractory to methotrexate after continued exposure. Such methotrexate resistance may be due to underexpression of reduced folate carrier (RFC) protein. The present invention provides DNA molecules encoding human RFC. The present invention also relates to expression vectors comprising RFC-encoding DNA molecules, and to the use of such vectors to restore methotrexate sensitivity in mammalian cells. The present invention further relates to antibodies that bind with human RFC protein, and to methods of detecting human RFC protein using such antibodies.
摘要翻译：甲氨蝶呤化疗的一个缺点是先前响应性的肿瘤可能在持续暴露后可能变得难治甲氨蝶呤。这种甲氨蝶呤的抗性可能是由于降低的叶酸载体（RFC）蛋白质的低表达。本发明提供编码人类RFC的DNA分子。本发明还涉及包含RFC编码DNA分子的表达载体，以及这些载体在哺乳动物细胞中恢复甲氨蝶呤敏感性的用途。本发明还涉及与人RFC蛋白质结合的抗体，以及使用这种抗体检测人类抗体的蛋白质的方法。

3. 发明授权

US5716788A Antibodies to human reduced folate carrier protein 失效
标题翻译：抗人类降低叶酸载体蛋白的抗体
公开(公告)号：US5716788A
公开(公告)日：1998-02-10
申请号：US484840
申请日：1995-06-07
申请人： Jeffrey A. Moscow , Kenneth H. Cowan , Kathy Dixon , Rui He
发明人： Jeffrey A. Moscow , Kenneth H. Cowan , Kathy Dixon , Rui He
IPC分类号： A61K48/00 , C07K14/47 , C07K16/00 , G01N33/53 , G01N33/567 , G01N33/573
CPC分类号： C07K14/47 , A61K48/00
摘要： One shortcoming of methotrexate chemotherapy is that previously responsive tumors can become refractory to methotrexate after continued exposure. Such methotrexate resistance may be due to underexpression of reduced folate carrier (RFC) protein. The present invention provides DNA molecules encoding human RFC. The present invention also relates to expression vectors comprising RFC-encoding DNA molecules, and to the use of such vectors to restore methotrexate sensitivity in mammalian cells. The present invention further relates to antibodies that bind with human RFC protein, and to methods of detecting human RFC protein using such antibodies.
摘要翻译：甲氨蝶呤化疗的一个缺点是先前响应性的肿瘤可能在持续暴露后可能变得难治甲氨蝶呤。这种甲氨蝶呤的抗性可能是由于降低的叶酸载体（RFC）蛋白质的低表达。本发明提供编码人类RFC的DNA分子。本发明还涉及包含RFC编码DNA分子的表达载体，以及这些载体在哺乳动物细胞中恢复甲氨蝶呤敏感性的用途。本发明还涉及与人RFC蛋白质结合的抗体，以及使用这种抗体检测人类抗体的蛋白质的方法。

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