专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070054884A1 4-SUBSTITUTED 2-ARYLOXYPHENOL DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译： 4-取代的2-芳基苯酚衍生物作为抗菌剂
公开(公告)号：US20070054884A1
公开(公告)日：2007-03-08
申请号：US11469291
申请日：2006-08-31
申请人： Liren Huang , Joanna Clancy , Alenka Tomazic , Weitong Wang , Christopher Taylor , W. Jackson , Yufa Liu
发明人： Liren Huang , Joanna Clancy , Alenka Tomazic , Weitong Wang , Christopher Taylor , W. Jackson , Yufa Liu
IPC分类号： A61K31/69 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/433 , A61K31/427 , A61K31/4245 , A61K31/4196 , A61K31/4192 , A61K31/4178
CPC分类号： C07C259/18 , C07C65/24 , C07C235/46 , C07C275/36 , C07C335/18 , C07C335/28 , C07C2601/14 , C07D207/325 , C07D207/333 , C07D231/14 , C07D233/90 , C07D257/04 , C07D261/18 , C07D271/06 , C07D277/46 , C07D285/06 , C07D295/096 , C07D307/33 , C07D307/36 , C07D307/42 , C07D307/68 , C07D333/16 , C07D333/38 , C07F5/025
摘要： Antimicrobial compounds, compositions and methods of treatment administering same, of 2-aryloxyphenol derivatives having heterocyclic groups or highly polar functional groups substituted at position 4 of the phenolic ring, as well as methods for their preparation and formation, wherein the compounds are generally of Formula 1.
摘要翻译：具有杂环基或在酚环的第4位取代的高极性官能团的2-芳氧基苯酚衍生物及其制备和形成方法的抗微生物化合物，其组合物和施用方法，其中化合物通常为式 1。

2. 发明授权

US08097762B2 Process for the preparation of β- and α-cryptoxanthin 有权
公开(公告)号：US08097762B2
公开(公告)日：2012-01-17
申请号：US12834460
申请日：2010-07-12
申请人： Frederick Khachik , Yufa Liu , Holly Showalter
发明人： Frederick Khachik , Yufa Liu , Holly Showalter
IPC分类号： C07C35/18 , C07C35/21
CPC分类号： A23L33/10
摘要： The present invention relates to a process for converting lutein and/or lutein esters to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-β-Cryptoxanthin and (3R,6′R)-α-cryptoxanthin are two rare food carotenoids that are not commercially available and the former exhibits vitamin A activity. In the first synthetic step, commercially available lutein and/or lutein esters are transformed into a mixture of dehydration products of lutein (anhydroluteins) in the presence of a catalytic amount of an acid. The resulting anhydroluteins are then converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by heterogeneous catalytic hydrogenation employing transition elements of group VIII (Pt, Pd, Rh supported on alumina or carbon) in a variety of organic solvents under atmospheric pressure of hydrogen and at temperatures ranging from −15° C. to 40° C. Among these catalysts, Pt supported on alumina at 40° C. in ethyl acetate provides the best yield of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin. Several homogeneous catalysts can also promote the regioselective hydrogenation of anhydroluteins to a mixture of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in low to moderate yields. The catalysts may be transition metal complexes such as palladium acetylacetonate, Rh(Ph3P)3Cl (Wilkinson's catalyst), [(C6H11)3P[C8H12][C5H5N]Ir+PF6− (Crabtree catalyst), or [C8H12][(MePh2P)2]Ir+PF6−. Among these, Wilkinson catalyst converts anhydroluteins to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in nearly quantitative yield. A novel feature of this invention is the regioselective hydrogenation of anhydroluteins while the highly conjugated polyene chain of these carotenoids remains intact.

3. 发明申请

US20100280286A1 Process For The Preparation of Beta and Alpha Cryptoxanthin 有权
公开(公告)号：US20100280286A1
公开(公告)日：2010-11-04
申请号：US12834460
申请日：2010-07-12
申请人： Frederick KHACHIK , Yufa Liu , Holly Showalter
发明人： Frederick KHACHIK , Yufa Liu , Holly Showalter
IPC分类号： C07C35/21
CPC分类号： A23L33/10
摘要： The present invention relates to a process for converting lutein and/or lutein esters to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-β-Cryptoxanthin and (3R,6′R)-α-cryptoxanthin are two rare food carotenoids that are not commercially available and the former exhibits vitamin A activity. In the first synthetic step, commercially available lutein and/or lutein esters are transformed into a mixture of dehydration products of lutein (anhydroluteins) in the presence of a catalytic amount of an acid. The resulting anhydroluteins are then converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by heterogeneous catalytic hydrogenation employing transition elements of group VIII (Pt, Pd, Rh supported on alumina or carbon) in a variety of organic solvents under atmospheric pressure of hydrogen and at temperatures ranging from −15° C. to 40° C. Among these catalysts, Pt supported on alumina at 40° C. in ethyl acetate provides the best yield of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin. Several homogeneous catalysts can also promote the regioselective hydrogenation of anhydroluteins to a mixture of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in low to moderate yields. The catalysts may be transition metal complexes such as palladium acetylacetonate, Rh(Ph3P)3Cl (Wilkinson's catalyst), [(C6H11)3P[C8H12][C5H5N] Ir+PF6− (Crabtree catalyst), or [C8H12][(MePh2P)2]Ir+PF6−. Among these, Wilkinson catalyst converts anhydroluteins to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in nearly quantitative yield. A novel feature of this invention is the regioselective hydrogenation of anhydroluteins while the highly conjugated polyene chain of these carotenoids remains intact.

4. 发明申请

US20060088631A1 Process for the preparation of alpha- and beta-cryptoxanthin 审中-公开
公开(公告)号：US20060088631A1
公开(公告)日：2006-04-27
申请号：US10973204
申请日：2004-10-26
申请人： Frederick Khachik , Yufa Liu , Holly Showalter
发明人： Frederick Khachik , Yufa Liu , Holly Showalter
IPC分类号： A23L1/27
CPC分类号： A23L33/10
摘要： The present invention relates to a process for converting lutein and/or lutein esters to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-β-Cryptoxanthin and (3R,6′R)-α-cryptoxanthin are two rare food carotenoids that are not commercially available and the former exhibits vitamin A activity. In the first synthetic step, commercially available lutein and/or lutein esters are transformed into a mixture of dehydration products of lutein (anhydroluteins) in the presence of a catalytic amount of an acid. The resulting anhydroluteins are then converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by heterogeneous catalytic hydrogenation employing transition elements of group VIII (Pt, Pd, Rh supported on alumina or carbon) in a variety of organic solvents under atmospheric pressure of hydrogen and at temperatures ranging from −15° C. to 40° C. Among these catalysts, Pt supported on alumina at 40° C. in ethyl acetate provides the best yield of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin. Several homogeneous catalysts can also promote the regioselective hydrogenation of anhydroluteins to a mixture of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in low to moderate yields. The catalysts may be transition metal complexes such as palladium acetylacetonate, Rh(Ph3P)3Cl (Wilkinson's catalyst), [(C6H11)3P[C8H12][C5H5N]Ir+PF6− (Crabtree catalyst), or [C8H12][(MePh2P)2]Ir+PF6−. Among these, Wilkinson catalyst converts anhydroluteins to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in nearly quantitative yield. A novel feature of this invention is the regioselective hydrogenation of anhydroluteins while the highly conjugated polyene chain of these carotenoids remains intact.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式