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1. 发明授权

US08815291B2 Particles comprising a releasable dopant therein 有权
标题翻译：其中包含可释放掺杂剂的颗粒
公开(公告)号：US08815291B2
公开(公告)日：2014-08-26
申请号：US11917662
申请日：2006-06-19
申请人： Kim Suzanne Finnie , Christophe Jean Alexandre Barbe , Linggen Kong
发明人： Kim Suzanne Finnie , Christophe Jean Alexandre Barbe , Linggen Kong
IPC分类号： A61K9/14
CPC分类号： A01N25/08 , A01N25/28 , A23V2002/00 , A61K8/0279 , A61K8/585 , A61K9/1641 , A61K9/1682 , A61K9/5026 , A61K9/5115 , A61K9/70 , A61K31/07 , A61K31/17 , A61K47/24 , A61K49/0004 , A61Q13/00 , B01J13/185 , B01J35/026 , B82Y30/00 , C01B33/163 , C09B67/0005 , C09B67/0013 , C09K11/025 , C12N11/04 , Y10T428/2982 , A01N2300/00
摘要： A process for making particles comprising a hydrophobic dopant for subsequent release therefrom is disclosed. The process comprises providing an emulsion comprising a hydrophilic phase and a hydrophobic phase dispersed in the hydrophilic phase, and reacting the precursor material to form the particles comprising the dopant therein. The hydrophobic phase comprises a precursor material and the dopant.
摘要翻译：公开了一种制备包含疏水掺杂剂的颗粒以便随后从其中释放的方法。该方法包括提供包含分散在亲水相中的亲水相和疏水相的乳液，并使前体材料反应以形成其中包含掺杂剂的颗粒。疏水相包含前体材料和掺杂剂。

2. 发明授权

US08992986B2 Controlled release of biological entities 有权
标题翻译：生物实体的控制释放
公开(公告)号：US08992986B2
公开(公告)日：2015-03-31
申请号：US11721728
申请日：2005-12-20
申请人： Kim Suzanne Finnie , David Jacques , Christophe Jean Alexandre Barbe , Linggen Kong
发明人： Kim Suzanne Finnie , David Jacques , Christophe Jean Alexandre Barbe , Linggen Kong
IPC分类号： A61K9/16 , A61K9/14 , A61K9/00 , A61K9/50 , A61K38/00 , A61K38/48 , B01J2/08 , B01J13/02 , A61K38/17 , A61K38/46 , A61K38/50
CPC分类号： A61K9/14 , A61K9/1611 , A61K9/1694 , A61K9/501 , A61K38/1709 , A61K38/465 , A61K38/482 , A61K38/4826 , A61K38/50 , B01J2/08 , B01J13/02 , C12Y304/21001 , C12Y304/21062 , C12Y305/01005 , A61K2300/00
摘要： A process is provided for releasably encapsulating a biological entity. The process comprise combining a solution of a surfactant in a non-polar solvent with a precursor material and the biological entity to form an emulsion. The emulsion comprises a polar phase dispersed in a non-polar phase, wherein the polar phase comprises the biological entity. The particles comprising the biological entity are then formed from the polar phase.
摘要翻译：提供了用于可释放地包封生物实体的方法。该方法包括将表面活性剂在非极性溶剂中的溶液与前体材料和生物实体组合以形成乳液。乳液包含分散在非极性相中的极性相，其中极性相包含生物实体。然后由极性相形成包含生物实体的颗粒。

3. 发明申请

US20080199523A1 Particles Comprising A Releasable Dopant Therein 有权
标题翻译：颗粒包含可释放的掺杂剂
公开(公告)号：US20080199523A1
公开(公告)日：2008-08-21
申请号：US11917662
申请日：2006-06-19
申请人： Kim Suzanne Finnie , Christophe Jean Alexandre Barbe , Linggen Kong
发明人： Kim Suzanne Finnie , Christophe Jean Alexandre Barbe , Linggen Kong
IPC分类号： A61K9/14 , B05D7/00 , A61P35/00 , B32B5/16
CPC分类号： A01N25/08 , A01N25/28 , A23V2002/00 , A61K8/0279 , A61K8/585 , A61K9/1641 , A61K9/1682 , A61K9/5026 , A61K9/5115 , A61K9/70 , A61K31/07 , A61K31/17 , A61K47/24 , A61K49/0004 , A61Q13/00 , B01J13/185 , B01J35/026 , B82Y30/00 , C01B33/163 , C09B67/0005 , C09B67/0013 , C09K11/025 , C12N11/04 , Y10T428/2982 , A01N2300/00
摘要： A process for making particles comprising a hydrophobic dopant for subsequent release therefrom is disclosed. The process comprises providing an emulsion comprising a hydrophilic phase and a hydrophobic phase dispersed in the hydrophilic phase, and reacting the precursor material to form the particles comprising the dopant therein. The hydrophobic phase comprises a precursor material and the dopant.
摘要翻译：公开了一种制备包含疏水掺杂剂的颗粒以便随后从其中释放的方法。该方法包括提供包含分散在亲水相中的亲水相和疏水相的乳液，并使前体材料反应以形成其中包含掺杂剂的颗粒。疏水相包含前体材料和掺杂剂。

4. 发明授权

US09345667B2 Particles having hydrophobic material therein 有权
标题翻译：其中具有疏水性材料的颗粒
公开(公告)号：US09345667B2
公开(公告)日：2016-05-24
申请号：US11917432
申请日：2006-06-19
申请人： Linggen Kong , Christophe Jean Alexandre Barbe , Kim Suzanne Finnie
发明人： Linggen Kong , Christophe Jean Alexandre Barbe , Kim Suzanne Finnie
IPC分类号： A61K9/10 , A61K9/16 , C01G1/02 , C09C1/30 , C09C3/08 , C09C3/12
CPC分类号： A61K9/1611 , C01G1/02 , C01P2002/88 , C01P2004/03 , C09C1/3063 , C09C1/3072 , C09C3/08 , C09C3/12
摘要： A process for preparing particles having a hydrophobic material therein is disclosed. The process comprises providing a multiple emulsion comprising a first emulsion dispersed in a hydrophobic medium, said first emulsion comprising a hydrophobic phase dispersed in a hydrophilic phase, wherein the hydrophobic phase comprises the hydrophobic material and the hydrophilic phase comprises a precursor which is capable of reacting to form a non-fluid matrix and reacting the precursor in the multiple emulsion to form the matrix in the form of the particles having the hydrophobic material therein wherein the precursor is added prior to formation of the multiple emulsion. Also disclosed are particles having a hydrophobic material therein, which may be releasable, as well as particles having a hydrophobic material therein, which may be releasable, made by the process and methods of using the particles.
摘要翻译：公开了一种制备其中具有疏水性材料的颗粒的方法。该方法包括提供包含分散在疏水介质中的第一乳液的多重乳液，所述第一乳液包含分散在亲水相中的疏水相，其中疏水相包含疏水性材料，亲水相包含能够使以形成非流体基质并使多元乳液中的前体反应形成其中具有疏水性材料的颗粒形式的基质，其中在形成多重乳液之前加入前体。还公开了在其中具有疏水性材料的颗粒，其可以是可释放的，以及其中具有疏水性材料的颗粒，其可以是可释放的，通过使用颗粒的方法和方法制备。

5. 发明申请

US20090252808A1 CONTROLLED RELEASE OF BIOLOGICAL ENTITIES 有权
标题翻译：控制性释放生物实体
公开(公告)号：US20090252808A1
公开(公告)日：2009-10-08
申请号：US11721728
申请日：2005-12-20
申请人： Kim Suzanne Finnie , David Jacques , Christophe Jean Alexandre Barbe , Linggen Kong
发明人： Kim Suzanne Finnie , David Jacques , Christophe Jean Alexandre Barbe , Linggen Kong
IPC分类号： A61K9/14 , A61K38/00 , A61K38/43
CPC分类号： A61K9/14 , A61K9/1611 , A61K9/1694 , A61K9/501 , A61K38/1709 , A61K38/465 , A61K38/482 , A61K38/4826 , A61K38/50 , B01J2/08 , B01J13/02 , C12Y304/21001 , C12Y304/21062 , C12Y305/01005 , A61K2300/00
摘要： A process is provided for releasably encapsulating a biological entity. The process comprise combining a solution of a surfactant in a non-polar solvent with a precursor material and the biological entity to form an emulsion. The emulsion comprises a polar phase dispersed in a non-polar phase, wherein the polar phase comprises the biological entity. The particles comprising the biological entity are then formed from the polar phase.
摘要翻译：提供了用于可释放地包封生物实体的方法。该方法包括将表面活性剂在非极性溶剂中的溶液与前体材料和生物实体组合以形成乳液。乳液包含分散在非极性相中的极性相，其中极性相包含生物实体。然后由极性相形成包含生物实体的颗粒。

6. 发明申请

US20090246279A1 PARTICLES HAVING HYDROPHOBIC MATERIAL THEREIN 有权
标题翻译：具有疏水性物质的颗粒
公开(公告)号：US20090246279A1
公开(公告)日：2009-10-01
申请号：US11917432
申请日：2006-06-19
申请人： Linggen Kong , Christophe Jean Alexandre Barbe , Kim Suzanne Finnie
发明人： Linggen Kong , Christophe Jean Alexandre Barbe , Kim Suzanne Finnie
IPC分类号： A61K9/10
CPC分类号： A61K9/1611 , C01G1/02 , C01P2002/88 , C01P2004/03 , C09C1/3063 , C09C1/3072 , C09C3/08 , C09C3/12
摘要： A process for preparing particles having a hydrophobic material therein is disclosed. The process comprises providing a multiple emulsion comprising a first emulsion dispersed in a hydrophobic medium, said first emulsion comprising a hydrophobic phase dispersed in a hydrophilic phase, wherein the hydrophobic phase comprises the hydrophobic material and the hydrophilic phase comprises a precursor which is capable of reacting to form a non-fluid matrix and reacting the precursor in the multiple emulsion to form the matrix in the form of the particles having the hydrophobic material therein wherein the precursor is added prior to formation of the multiple emulsion. Also disclosed are particles having a hydrophobic material therein, which may be releasable, as well as particles having a hydrophobic material therein, which may be releasable, made by the process and methods of using the particles.
摘要翻译：公开了一种制备其中具有疏水性材料的颗粒的方法。该方法包括提供包含分散在疏水介质中的第一乳液的多重乳液，所述第一乳液包含分散在亲水相中的疏水相，其中疏水相包含疏水性材料，亲水相包含能够使以形成非流体基质并使多元乳液中的前体反应形成其中具有疏水性材料的颗粒形式的基质，其中在形成多重乳液之前加入前体。还公开了在其中具有疏水性材料的颗粒，其可以是可释放的，以及其中具有疏水性材料的颗粒，其可以是可释放的，通过使用颗粒的方法和方法制备。

7. 发明申请

US20130259942A1 PARTICULATE SUBSTANCES COMPRISING CERAMIC PARTICLES FOR DELIVERY OF BIOMOLECULES 审中-公开
标题翻译：包含用于输送生物分子的陶瓷颗粒的颗粒物质
公开(公告)号：US20130259942A1
公开(公告)日：2013-10-03
申请号：US13817159
申请日：2011-08-15
申请人： Christophe Jean Alexandre Barbe , Kim Suzanne Finnie , Samuel Knight , Toby Johnston Passioura
发明人： Christophe Jean Alexandre Barbe , Kim Suzanne Finnie , Samuel Knight , Toby Johnston Passioura
IPC分类号： A61K47/02 , A61K47/18 , A61K9/14
CPC分类号： A61K47/02 , A61K9/5115 , A61K9/5192 , A61K31/70 , A61K47/60 , A61K47/6923 , A61K47/6929 , A61L27/10 , A61L27/427 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , C01B33/18 , C12N15/87 , Y02A50/411
摘要： A particulate substance comprising particles of a ceramic matrix bearing a functional group, the functional group being capable of promoting penetration of the particles into cells, and a biomolecule disposed within pores of the particles, the biomolecule being releasable from the particles by dissolution of the ceramic matrix.
摘要翻译：一种颗粒物质，其包含具有官能团的陶瓷基质颗粒，所述官能团能够促进颗粒渗入细胞，以及设置在颗粒孔中的生物分子，所述生物分子可通过溶解陶瓷而从颗粒中释放矩阵。

8. 发明申请

US20120021964A1 TRIGGERED RELEASE 有权
标题翻译：触发释放
公开(公告)号：US20120021964A1
公开(公告)日：2012-01-26
申请号：US13260653
申请日：2009-12-22
申请人： Christophe Jean Alexandre Barbe , Kim Suzanne Finnie
发明人： Christophe Jean Alexandre Barbe , Kim Suzanne Finnie
IPC分类号： C11D17/00
CPC分类号： C11D3/124 , C11D3/38 , C11D3/386 , C11D3/38672 , C11D17/0039 , C11D17/06
摘要： A method is described for delivering a species to a liquid, whereby porous particles are exposed to a condition such that the species is rapidly released into the liquid. Each of the porous particles comprises an agglomeration of primary particles so that outer surfaces of said primary particles define pores of said porous particles. The primary particles comprise silica and the species is disposed in the pores of the porous particles.
摘要翻译：描述了用于将物质输送到液体的方法，由此多孔颗粒暴露于使物质快速释放到液体中的状态。每个多孔颗粒包括初级颗粒的聚集，使得所述一次颗粒的外表面限定所述多孔颗粒的孔。主要颗粒包括二氧化硅，并且该物质设置在多孔颗粒的孔中。

9. 发明授权

US08871272B2 Layered nanoparticles 有权
标题翻译：层状纳米粒子
公开(公告)号：US08871272B2
公开(公告)日：2014-10-28
申请号：US11816052
申请日：2006-02-14
申请人： Linggen Kong , Christophe Jean Alexandre Barbe
发明人： Linggen Kong , Christophe Jean Alexandre Barbe
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50 , A61K9/00 , C01B33/149 , A61K9/51 , A61K47/02 , C01B33/142
CPC分类号： A61K9/5115 , A61K9/5192 , A61K47/02 , A61K49/0093 , A61K51/1244 , C01B33/142 , C01B33/149 , Y10T428/2991
摘要： A process for forming a layered nanoparticle includes providing a suspension including a core particle in a first liquid, adding a second liquid to the suspension, and adding a reagent or a precursor for the reagent, to the suspension. The second liquid is immiscible with the first liquid. If the reagent is added to the suspension, the reagent reacts to form a layer on the core particle to form the layered nanoparticle. If a precursor for the reagent is added to the suspension, the precursor is converted to the reagent, and the reagent reacts to form a layer on the core particle to form the layered nanoparticle.
摘要翻译：形成层状纳米颗粒的方法包括提供包含第一液体中的核心颗粒的悬浮液，向悬浮液中加入第二液体，并向试剂添加试剂或前体。第二液体与第一液体不混溶。如果将试剂加入到悬浮液中，则试剂在核心颗粒上反应形成层，形成层状纳米颗粒。如果将试剂的前体加入悬浮液中，则将前体转化为试剂，并且试剂在核心颗粒上反应形成层以形成层状纳米颗粒。

10. 发明申请

US20090098044A1 SOLID PARTICLES FROM CONTROLLED DESTABILISATION OF MICROEMULSIONS 审中-公开
标题翻译：来自微乳液的控制性去除的固体颗粒
公开(公告)号：US20090098044A1
公开(公告)日：2009-04-16
申请号：US11719176
申请日：2005-11-15
申请人： Linggen Kong , Christophe Jean Alexandre Barbe
发明人： Linggen Kong , Christophe Jean Alexandre Barbe
IPC分类号： A61K51/12 , A61K9/12
CPC分类号： A61K49/0093 , A61K9/107 , A61K9/1075 , A61K9/1682 , A61K9/1694 , A61K9/5115 , A61K9/5192 , A61K47/24
摘要： The present invention relates to a process for making a particulate substance. The process comprises providing an emulsion, optionally a microemulsion, comprising droplets dispersed in a continuous liquid phase. At least some of the droplets of the emulsion comprise nuclei. The droplets are then at least partially destabilised to form the particulate substance.
摘要翻译：本发明涉及一种制备颗粒物质的方法。该方法包括提供乳液，任选的微乳液，其包含分散在连续液相中的液滴。乳液的至少一些液滴包含核。然后液滴至少部分地不稳定以形成颗粒物质。

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