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1. 发明授权

US5236412A Rehydratable product and method of preparation thereof 失效
标题翻译：可水化产品及其制备方法
公开(公告)号：US5236412A
公开(公告)日：1993-08-17
申请号：US627714
申请日：1990-12-14
申请人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Stephen C. Jacobsen
发明人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Stephen C. Jacobsen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044 , A61N1/0444 , A61N1/0468
摘要： A hydratable iontophoretic bioelectrode includes a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. Adjacent layers are maintained at least partially out of contact from one another by disposition between the layers of spacing elements such as sugar or other dissolvable particles or cellulose. The edges of the layers may be crimped to maintain the layers in a stack for assembly with an electrode sheet; such a sheet would be provided for receiving an electrical current to thereby produce an electric field and cause a migration of ions of the ionized fluid away from the electrode sheet and into the skin or tissue of a person or animal against which the bioelectrode is placed.
摘要翻译：可水合的离子电渗生物电极包括多个能够在与流体接触放置时吸收和保持电离流体的材料层。相邻的层通过在诸如糖或其它可溶性颗粒或纤维素之间的间隔元件层之间的配置而至少部分地彼此不接触。层的边缘可以被压接以将层保持在堆叠中以与电极片组装; 这样的片材将被提供用于接收电流从而产生电场并使离子化流体的离子迁移离开电极片并进入放置生物电极的人或动物的皮肤或组织。

2. 发明授权

US5281287A Method of making a hydratable bioelectrode 失效
标题翻译：制造可水合生物电极的方法
公开(公告)号：US5281287A
公开(公告)日：1994-01-25
申请号：US31260
申请日：1993-03-12
申请人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Stephen C. Jacobsen
发明人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Stephen C. Jacobsen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0436 , A61N1/0468 , Y10T156/1052
摘要： A hydratable iontophoretic bioelectrode includes a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. Adjacent layers are maintained at least partially out of contact from one another by disposition between the layers of spacing elements such as sugar or other dissolvable particles or cellulose. The edges of the layers may be crimped to maintain the layers in a stack for assembly with an electrode sheet; such a sheet would be provided for receiving an electrical current to thereby produce an electric field and cause a migration of ions of the ionized fluid away from the electrode sheet and into the skin or tissue of a person or animal against which the bioelectrode is placed.
摘要翻译：可水合的离子电渗生物电极包括多个能够在与流体接触放置时吸收和保持电离流体的材料层。相邻的层通过在诸如糖或其它可溶性颗粒或纤维素之间的间隔元件层之间的配置而至少部分地彼此不接触。层的边缘可以被压接以将层保持在堆叠中以与电极片组装; 这样的片材将被提供用于接收电流从而产生电场并使离子化流体的离子迁移离开电极片并进入放置生物电极的人或动物的皮肤或组织。

3. 发明授权

US5558632A Electrodes for iontophoresis 失效
标题翻译：离子电渗电极
公开(公告)号：US5558632A
公开(公告)日：1996-09-24
申请号：US333844
申请日：1994-11-03
申请人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Clay H. Holt , William F. Felman
发明人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Clay H. Holt , William F. Felman
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448
摘要： An improved electrode is disclosed for use in administering drug by means of iontophoresis, comprising a conductive element for receiving an electric current from a current source; a reticulated element having a plurality of reticulum for receiving an ionic drug solution for iontophoretic delivery, the reticulum being loaded or having applied thereto a hydrophilic polymer which is viscous when hydrated; and means for securing the reticulated element to the conductive element so that electric current will be distributed substantially uniformly through the reticulated element when hydrated and when current is delivered to the conductive element. The presently preferred embodiment utilizes open cell polyurethane foam as the reticulated element and high molecular weight polyethylene oxide as the hydrophilic polymer. The reticulum is further loaded with Tween 20, a surfactant, which serves to improve the rate of hydration. A reticulated element formed in accordance with the present invention is pliable and conformable both when in wet or dry state, making an electrode formed in accordance with the present invention susceptible of a wide variety of shapes and sizes and relatively easy to manufacture at reasonably low cost.
摘要翻译：公开了一种用于通过离子电渗法施用药物的改进的电极，其包括用于从电流源接收电流的导电元件; 具有多个网状物的网状元件，用于接收用于离子电渗疗法输送的离子药物溶液，所述网状物被加载或已经施加到其上，当水合时粘稠的亲水性聚合物; 以及用于将网状元件固定到导电元件的装置，使得当水合时和当电流被传送到导电元件时，电流将基本上均匀地分布通过网状元件。目前优选的实施方案使用开孔聚氨酯泡沫作为网状元素和高分子量聚环氧乙烷作为亲水性聚合物。网状物进一步装载有用于提高水合速率的表面活性剂吐温20。根据本发明形成的网状元件在湿或干态下既柔韧又顺应，使得根据本发明形成的电极易于形成多种形状和尺寸，并且以相当低的成本相对容易制造。

4. 发明授权

US5374241A Electrodes for iontophoresis 失效
标题翻译：离子电渗电极
公开(公告)号：US5374241A
公开(公告)日：1994-12-20
申请号：US45040
申请日：1993-04-07
申请人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Clay H. Holt , William F. Felman
发明人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Clay H. Holt , William F. Felman
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448
摘要： An improved electrode is disclosed for use in administering drug by means of iontophoresis, comprising a conductive element for receiving an electric current from a current source; a reticulated element having a plurality of reticulum for receiving an ionic drug solution for iontophoretic delivery, the reticulum being loaded or having applied thereto a hydrophilic polymer which is viscous when hydrated; and means for securing the reticulated element to the conductive element so that electric current will be distributed substantially uniformly through the reticulated element when hydrated and when current is delivered to the conductive element. The presently preferred embodiment utilizes open cell polyurethane foam as the reticulated element and high molecular weight polyethylene oxide as the hydrophilic polymer. The reticulum is further loaded with Tween 20, a surfactant, which serves to improve the rate of hydration. A reticulated element formed in accordance with the present invention is pliable and conformable both when in wet or dry state, making an electrode formed in accordance with the present invention susceptible of a wide variety of shapes and sizes and relatively easy to manufacture at reasonably low cost.
摘要翻译：公开了一种用于通过离子电渗法施用药物的改进的电极，其包括用于从电流源接收电流的导电元件; 具有多个网状物的网状元件，用于接收用于离子电渗疗法输送的离子药物溶液，所述网状物被加载或已经施加到其上，当水合时粘稠的亲水性聚合物; 以及用于将网状元件固定到导电元件的装置，使得当水合时和当电流被传送到导电元件时，电流将基本上均匀地分布通过网状元件。目前优选的实施方案使用开孔聚氨酯泡沫作为网状元素和高分子量聚环氧乙烷作为亲水性聚合物。网状物进一步装载有用于提高水合速率的表面活性剂吐温20。根据本发明形成的网状元件在湿或干态下既柔韧又顺应，使得根据本发明形成的电极易于形成多种形状和尺寸，并且以相当低的成本相对容易制造。

5. 发明授权

US06223075B1 Iontophoretic delivery device with integral hydrating means 失效
标题翻译：具有整体保湿手段的离子电渗输送装置
公开(公告)号：US06223075B1
公开(公告)日：2001-04-24
申请号：US08762051
申请日：1996-12-09
申请人： Jon E. Beck , Lindsay B. Lloyd , Tomasz J. Petelenz
发明人： Jon E. Beck , Lindsay B. Lloyd , Tomasz J. Petelenz
IPC分类号： A61N130
CPC分类号： A61N1/0448 , A61N1/0444
摘要： The present invention provides methods and apparatus permitting rapid and thorough hydration of an initially dry hydratable matrix element contained within an iontophoretic bioelectrode. The apparatus of the invention comprises a bioelectrode system for iontophoretic delivery of medicaments having at least one hydratable matrix element and associated removable hydration assembly. The preferred embodiment of the present invention comprises two hydratable matrix elements each having an associated removable hydration assembly and each being associated with an electrical current distribution element. The removable hydration assembly includes an initially sealed liquid-storage component which maintains the desired hydrating liquid in isolation from the hydratable matrix element until such time as hydration is desired. At that time, the removable hydration assembly can be activated by the user through application of force to an extending tab member attached to the sealed liquid-storage component thereby causing progressive unsealing of the sealed liquid-storage component and progressively depositing the hydrating liquid uniformly onto the entire surface of the hydratable matrix element. Following hydration of the matrix element, the spent hydration assembly can be withdrawn completely from within the bioelectrode system.
摘要翻译：本发明提供允许快速且彻底水化包含在离子电渗生物电极内的初始干燥的可水合的基质元素的方法和装置。本发明的装置包括用于离子电渗疗法输送具有至少一个可水合基质元件和相关的可移除水合组合物的生物电极系统。本发明的优选实施方案包括两个可水合的基质元素，每个具有相关的可移除的水合组合，并且每个与电流分布元件相关联。可移除水合组件包括初始密封的液体储存组分，其将期望的保湿液体与可水合的基质元件隔离，直到需要水合为止。此时，可拆卸水合组件可以由用户通过向连接到密封的液体储存部件的延伸片部件施加力来启动，从而引起密封的液体储存部件的逐渐开封，并逐渐将水合液体均匀地沉积到水合基质元素的整个表面。在水化基质元素之后，废水合组件可以从生物电极系统内完全取出。

6. 发明授权

US5730716A Iontophoretic delivery device with integral hydrating means 失效
标题翻译：具有整体保湿手段的离子电渗输送装置
公开(公告)号：US5730716A
公开(公告)日：1998-03-24
申请号：US711816
申请日：1996-09-10
申请人： Jon E. Beck , Lindsay B. Lloyd , Tomasz J. Petelenz
发明人： Jon E. Beck , Lindsay B. Lloyd , Tomasz J. Petelenz
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0444
摘要： The present invention provides methods and apparatus permitting rapid and thorough hydration of an initially dry hydratable matrix element contained within an iontophoretic bioelectrode. The apparatus of the invention comprises a bioelectrode system for iontophoretic delivery of medicaments having at least one hydratable matrix element and associated removable hydration assembly. The preferred embodiment of the present invention comprises two hydratable matrix elements each having an associated removable hydration assembly and each being associated with an electrical current distribution element. The removable hydration assembly includes an initially sealed liquid-storage component which maintains the desired hydrating liquid in isolation from the hydratable matrix element until such time as hydration is desired. At that time, the removable hydration assembly can be activated by the user through application of force to an extending tab member attached to the sealed liquid-storage component thereby causing progressive unsealing of the sealed liquid-storage component and progressively depositing the hydrating liquid uniformly onto the entire surface of the hydratable matrix element. Following hydration of the matrix element, the spent hydration assembly can be withdrawn completely from within the bioelectrode system.
摘要翻译：本发明提供允许快速且彻底水化包含在离子电渗生物电极内的初始干燥的可水合的基质元素的方法和装置。本发明的装置包括用于离子电渗疗法输送具有至少一个可水合基质元件和相关的可移除水合组合物的生物电极系统。本发明的优选实施方案包括两个可水合的基质元素，每个具有相关的可移除的水合组合，并且每个与电流分布元件相关联。可移除水合组件包括初始密封的液体储存组分，其将期望的保湿液体与可水合的基质元件隔离，直到需要水合为止。此时，可拆卸水合组件可以由用户通过向连接到密封的液体储存部件的延伸片部件施加力来启动，从而引起密封的液体储存部件的逐渐开封，并逐渐将水合液体均匀地沉积到水合基质元素的整个表面。在水化基质元素之后，废水合组件可以从生物电极系统内完全取出。

7. 发明授权

US06546283B1 High current density iontophoretic device and method of use thereof 失效
标题翻译：高电流密度离子电渗装置及其使用方法
公开(公告)号：US06546283B1
公开(公告)日：2003-04-08
申请号：US09691411
申请日：2000-10-18
申请人： Jon E. Beck , Lindsay B. Lloyd
发明人： Jon E. Beck , Lindsay B. Lloyd
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： A high current density iontophoretic device, comprising a reservoir, an applicator, an orientation maintaining member and an iontophoretic medicament administering member. The reservoir is capable of retaining medicament. The applicator is positionable upon a surface of an eye and includes at least one punctation therethrough. The at least one punctation is capable of being placed in fluid communication with each of the reservoir and at least one treatment area of an eye upon operative positioning of same. The orientation member substantially maintains the orientation of the applicator in the desired orientation upon operative positioning of same. The iontophoretic administering member serves to administer a medicament from the reservoir to the at least one punctation and, in turn, to a specific region of an eye of a patient.
摘要翻译：一种高电流密度离子电渗疗法装置，包括储存器，施用器，取向保持构件和离子电渗疗法施用构件。储存器能够保留药物。施用器可定位在眼睛的表面上并且包括穿过其中的至少一个刺孔。至少一个点状物能够在其相应的操作定位时与每个储存器和眼睛的至少一个治疗区域流体连通。定位构件在其操作定位时基本上将敷贴器的取向保持在期望的取向。离子电渗疗法施用组件用于将药物从储存器施用至至少一个刺孔，并且依次进入患者眼睛的特定区域。

8. 发明授权

US06697668B2 Ocular iontophoretic device and method for using the same 失效
标题翻译：眼部离子电渗疗法及其使用方法
公开(公告)号：US06697668B2
公开(公告)日：2004-02-24
申请号：US09769658
申请日：2001-01-25
申请人： Thomas M. Parkinson , Malgorzata Szlek , Lindsay B. Lloyd
发明人： Thomas M. Parkinson , Malgorzata Szlek , Lindsay B. Lloyd
IPC分类号： A61N500
CPC分类号： A61N1/0448 , A61F9/0008
摘要： An ocular iontophoretic device for delivering an interferon to an affected area of a living being's eye comprising an active electrode assembly associated with a matrix, wherein the matrix includes an interferon capable of treating viral, immunoregulatory, and/or neovascularization conditions. A method for treating an affected area of a living being's eye comprising the steps of: associating an interferon with an ocular iontophoretic device; positioning at least a portion of the ocular iontophoretic device on the eye of a living being; and iontophoretically delivering the interferon to an affected area of the living being's eye.
摘要翻译：一种用于将干扰素递送至活体眼睛的受影响区域的眼部离子电渗疗法装置，包括与基质相关的活性电极组件，其中所述基质包括能够治疗病毒，免疫调节和/或新生血管形成条件的干扰素。影响生命的眼睛的区域包括以下步骤：将干扰素与眼部离子电渗疗法装置相关联; 将眼部离子电渗装置的至少一部分定位在生命的眼睛上; 并将干扰素离子电渗输送到生命眼睛的受影响区域。

9. 发明授权

US06579276B2 Ocular iontophoretic device and method for inhibiting vascular endothelial growth factor (VEGF) using the same 失效
标题翻译：眼部离子电渗疗法及使用该方法抑制血管内皮生长因子（VEGF）
公开(公告)号：US06579276B2
公开(公告)日：2003-06-17
申请号：US09767032
申请日：2001-01-22
申请人： Lindsay B. Lloyd , Thomas M. Parkinson , Malgorzata Szlek
发明人： Lindsay B. Lloyd , Thomas M. Parkinson , Malgorzata Szlek
IPC分类号： A61N130
CPC分类号： A61N1/30 , A61F9/0008
摘要： An ocular iontophoretic device for delivering an aptamer to an affected area of a living being's eye for inhibiting VEGF function therein, the device comprising an active electrode assembly associated with a matrix and/or reservoir, wherein the matrix and/or reservoir includes an aptamer capable of inhibiting VEGF function. A method for treating an affected area of a living being's eye, comprising the steps of: associating an aptamer with an ocular iontophoretic device; positioning at least a portion of an ocular iontophoretic device on the eye of the living being; and iontophoretically delivering the aptamer to an affected area of the living being's eye.
摘要翻译：一种眼部离子电渗疗法装置，用于将适体递送至生命眼睛的受影响区域以抑制其中的VEGF功能，所述装置包括与基质和/或储库相关联的活性电极组件，其中所述基质和/或储器包括适配体一种治疗眼睛的受影响区域的方法，包括以下步骤：将适体与眼部离子电渗疗法相关联; 将眼部离子电渗设备的至少一部分定位在生命的眼睛上; 并将适配体离子电渗输送到生命眼睛的受影响区域。

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