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1. 发明授权

US06593474B1 Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的芳基取代哌嗪
公开(公告)号：US06593474B1
公开(公告)日：2003-07-15
申请号：US09591814
申请日：2000-06-12
申请人： Linda Jolliffe , William Murray , Virginia Pulito , Linda Mulcahy , Xiaobing Li , Allen Reitz , Cynthia Maryanoff , Frank Villani
发明人： Linda Jolliffe , William Murray , Virginia Pulito , Linda Mulcahy , Xiaobing Li , Allen Reitz , Cynthia Maryanoff , Frank Villani
IPC分类号： C07D29514
CPC分类号： C07D207/27 , C07D207/28 , C07D209/48 , C07D211/76 , C07D223/10 , C07D295/13
摘要： This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
摘要翻译：本发明涉及一系列芳基取代的哌嗪，含有它们的式I药物组合物和用于其制备的中间体。本发明的化合物选择性地抑制与α-1a肾上腺素能受体的结合，α受体是与良性前列腺增生有关的受体。因此，这些化合物在治疗这种疾病和其他疾病中潜在有用。

2. 发明授权

US06071915A Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia 失效
标题翻译：用于治疗良性前列腺增生的芳基取代哌嗪
公开(公告)号：US06071915A
公开(公告)日：2000-06-06
申请号：US74789
申请日：1998-05-08
申请人： Linda Jolliffe , William Murray , Virginia Pulito , Allen Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
发明人： Linda Jolliffe , William Murray , Virginia Pulito , Allen Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
IPC分类号： C07D295/12 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/445 , A61K31/496 , A61K31/55 , A61P13/08 , C07D205/08 , C07D207/12 , C07D207/26 , C07D207/27 , C07D207/28 , C07D209/44 , C07D209/48 , C07D211/40 , C07D211/76 , C07D221/20 , C07D223/10 , C07D225/02 , C07D225/08 , C07D241/04 , C07D295/08 , C07D295/13 , C07D401/12 , C07D403/12 , C07D401/06 , C07D403/06
CPC分类号： C07D207/27 , C07D207/28 , C07D209/48 , C07D211/76 , C07D223/10 , C07D295/13
摘要： This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
摘要翻译：本发明涉及一系列含有它们的式I药物组合物和其制备中使用的中间体的芳基取代哌嗪。本发明的化合物选择性地抑制与α-1肾上腺素能受体的结合，所述α-1肾上腺素能受体是与前列腺增生有关的受体。因此，这些化合物在治疗这种疾病和其他疾病中潜在有用。

3. 发明授权

US06890921B1 Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的芳基取代哌嗪
公开(公告)号：US06890921B1
公开(公告)日：2005-05-10
申请号：US09526224
申请日：2000-03-15
申请人： Linda Jolliffe , William Murray , Virginia Pulito , Allen Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
发明人： Linda Jolliffe , William Murray , Virginia Pulito , Allen Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
IPC分类号： C07D295/12 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/445 , A61K31/496 , A61K31/55 , A61P13/08 , C07D205/08 , C07D207/12 , C07D207/26 , C07D207/27 , C07D207/28 , C07D209/44 , C07D209/48 , C07D211/40 , C07D211/76 , C07D221/20 , C07D223/10 , C07D225/02 , C07D225/08 , C07D241/04 , C07D295/08 , C07D295/13 , C07D401/12 , C07D403/12
CPC分类号： C07D207/27 , C07D207/28 , C07D209/48 , C07D211/76 , C07D223/10 , C07D295/13
摘要： This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
摘要翻译：本发明涉及一系列含有它们的式I药物组合物和其制备中使用的中间体的芳基取代哌嗪。本发明的化合物选择性地抑制与α-1a肾上腺素能受体的结合，α受体是与良性前列腺增生有关的受体。因此，这些化合物在治疗这种疾病和其他疾病中潜在有用。

4. 发明授权

US06303594B1 Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia 有权
公开(公告)号：US06303594B1
公开(公告)日：2001-10-16
申请号：US09526224
申请日：2000-03-15
申请人： Linda Jolliffe , William Murray , Virginia Pulito , Allan Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
发明人： Linda Jolliffe , William Murray , Virginia Pulito , Allan Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
IPC分类号： A61K3155
摘要： This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.

5. 发明申请

US20050272784A1 Inhibitors of bacterial Type III protein secretion systems 审中-公开
标题翻译：细菌III型蛋白分泌系统的抑制剂
公开(公告)号：US20050272784A1
公开(公告)日：2005-12-08
申请号：US11123977
申请日：2005-05-06
申请人： Xiaobing Li , William Murray , Mark Macielag , Qunying Guan
发明人： Xiaobing Li , William Murray , Mark Macielag , Qunying Guan
IPC分类号： A61K31/421 , A61K31/4245 , A61P31/04 , C07D231/14 , C07D233/90 , C07D249/10 , C07D263/34 , C07D277/56 , C07D413/02 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D263/34 , C07D231/14 , C07D233/90 , C07D249/10 , C07D277/56 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10
摘要： In accordance with the present invention, compounds that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein secretion and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.
摘要翻译：根据本发明，已经鉴定了抑制III型蛋白质分泌的化合物，并提供了它们的使用方法。在本发明的一个方面，提供了可用于抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的化合物。在本发明的另一方面，提供了使用本发明化合物抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的方法。

6. 发明申请

US20050070534A1 Non-peptidic NPY Y2 receptor inhibitors 有权
标题翻译：非肽NPY Y2受体抑制剂
公开(公告)号：US20050070534A1
公开(公告)日：2005-03-31
申请号：US10949055
申请日：2004-09-24
申请人： Nicholas Carruthers , Wenying Chai , Scott Dax , Jill Jablonowski , Xiaobing Li , Timothy Lovenberg , William Murray , Dale Rudolph , Mark Seierstad , Mark Youngman
发明人： Nicholas Carruthers , Wenying Chai , Scott Dax , Jill Jablonowski , Xiaobing Li , Timothy Lovenberg , William Murray , Dale Rudolph , Mark Seierstad , Mark Youngman
IPC分类号： A61K31/404 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P15/08 , A61P25/22 , A61P25/24 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/02 , C07D417/02 , C07D473/02 , C07D43/02
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译：本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松物质相关疾病; 肥胖; 或肥胖相关疾病。本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防排卵和不育症。

7. 发明授权

US09334691B2 Apparatus and method for controlling or limiting rotor orbit in moving cavity motors and pumps 有权
标题翻译：用于控制或限制移动腔马达和泵中的转子轨道的装置和方法
公开(公告)号：US09334691B2
公开(公告)日：2016-05-10
申请号：US13300446
申请日：2011-11-18
申请人： Brian P. Jarvis , Nigel Wilcox , Brian Williams , Lance Underwood , William Murray , Peter Thomas Cariveau
发明人： Brian P. Jarvis , Nigel Wilcox , Brian Williams , Lance Underwood , William Murray , Peter Thomas Cariveau
IPC分类号： F03C2/08 , F04C2/107 , F04C13/00 , E21B4/02
CPC分类号： E21B4/02 , F03C2/08 , F04C2/1071 , F04C2/1075 , F04C13/008 , F04C2240/80 , Y10T29/49242
摘要： A moving cavity motor or pump, such as a mud motor, comprising: a rotor, a stator, and one or more apparatus for constraining (i.e., controlling or limiting) the movement of the rotor relative to the stator.
摘要翻译：诸如泥浆马达的运动腔马达或泵包括：转子，定子以及用于约束（即控制或限制）转子相对于定子运动的一个或多个装置。

8. 发明申请

US20110136092A1 EDUCATIONAL SYSTEMS, METHODS AND APPARATUS 审中-公开
标题翻译：教育系统，方法和设备
公开(公告)号：US20110136092A1
公开(公告)日：2011-06-09
申请号：US13056763
申请日：2008-07-30
申请人： William Murray
发明人： William Murray
IPC分类号： G09B7/00
CPC分类号： G09B19/00 , G06Q10/10 , G06Q50/20 , G06Q50/205 , G09B5/00 , G09B7/00 , G09B7/02 , Y10S706/926
摘要： Systems, methods and apparatus for organising and monitoring education of one or more students are disclosed. The apparatus comprises a topic planner for the student comprising at least one topic category to be studied by the student and a student tracker linked to the topic planner for tracking progress by the student in studying the at least one topic category. Embodiments include a master sheet linked to the topic planner for each student, the master sheet identifying each student, a subject and one or more subject topics, and a class tracker linked to one or more of the topic planner, the master sheet and/or the student tracker for tracking progress by each student in studying each topic and each topic category.
摘要翻译：披露了一个或多个学生组织和监督教育的系统，方法和设备。该装置包括用于学生的主题规划器，其包括由学生研究的至少一个主题类别和与主题计划者相关联的学生跟踪器，用于跟踪学生在研究至少一个主题类别时的进度。实施例包括链接到每个学生的主题规划器的母版，标识每个学生的主表，主题和一个或多个主题，以及链接到主题计划者，主表和/或其中的一个或多个的课堂跟踪器学生跟踪器，用于跟踪每个学生在学习每个主题和每个主题类别时的进度。

9. 发明申请

US20070249590A1 Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders 审中-公开
标题翻译：用于治疗激酶障碍的取代吲哚并[2,3-a]吡咯并[3,4-c]咔唑化合物
公开(公告)号：US20070249590A1
公开(公告)日：2007-10-25
申请号：US11586817
申请日：2006-10-26
申请人： Lawrence Wilson , William Murray , Shyh-Ming Yang , Cangming Yang , Bingbing Wang
发明人： Lawrence Wilson , William Murray , Shyh-Ming Yang , Cangming Yang , Bingbing Wang
IPC分类号： A61K31/551 , A61P11/06 , A61P17/06 , A61P19/00 , A61P19/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D243/10 , C07D487/22
CPC分类号： C07D487/22 , C07D491/22 , C07D498/22
摘要： The present invention is directed to substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds of formula (I): and forms thereof and their synthesis and use as protein kinase inhibitors and interactions thereof.
摘要翻译：本发明涉及式（I）的取代吲哚并[2,3-a]吡咯并[3,4-c]咔唑化合物及其形式及其作为蛋白激酶抑制剂及其相互作用的合成和用途。

10. 发明申请

US20050150263A1 Computer physical security device 有权
标题翻译：计算机物理安全设备
公开(公告)号：US20050150263A1
公开(公告)日：2005-07-14
申请号：US11009813
申请日：2004-12-09
申请人： William Murray , Stewart Carl , Arthur Zarnowitz
发明人： William Murray , Stewart Carl , Arthur Zarnowitz
IPC分类号： E05B73/00
CPC分类号： E05B73/0005 , E05B67/383 , E05B73/0082 , Y10T70/40 , Y10T70/5009 , Y10T70/5973
摘要： An apparatus which inhibits the theft of equipment such as personal computers is disclosed. The equipment must have an external wall provided with a specially designed, approximately rectangular slot having preselected dimensions. An attachment mechanism includes a housing for a spindle having a first portion rotatable within the housing, a shaft extending outwardly from the housing, and a crossmember at the end of the shaft having peripheral dimensions closely conforming to the internal dimensions of the slot. An abutment mechanism also emanates from the housing, and is located on opposite sides of the shaft intermediate the housing and the crossmember. The peripheral cross-sectional dimensions of the abutment mechanism and the shaft in combination closely conform to the dimensions of the slot. The length of the shaft from the housing to the crossmember is approximately equal to the thickness of the external wall of equipment. The crossmember is aligned with the abutment mechanism so that the crossmember can be inserted through the slot with the shaft and the abutment mechanism occupying the slot. The spindle is then rotated 90° to misalign the crossmember with the slot, thereby attaching the attachment mechanism rigidly to the external wall. A cable is secured to the housing and to an immovable object so that the equipment cannot be stolen.
摘要翻译：公开了一种抑制个人计算机等设备的盗窃的装置。设备必须有一个外墙，设有一个特别设计的，具有预选尺寸的大致矩形的槽。附接机构包括用于主轴的壳体，其具有可在壳体内旋转的第一部分，从壳体向外延伸的轴，以及在轴端部处的横向构件，其外周尺寸与槽的内部尺寸紧密相符。邻接机构也从壳体发出，并且位于轴的相对侧，位于壳体和横梁之间。邻接机构和轴的周边横截面尺寸组合紧密地符合槽的尺寸。轴从外壳到横梁的长度近似等于设备外壁的厚度。交叉构件与邻接机构对准，使得横梁可以穿过狭槽插入，轴和邻接机构占据槽。然后将心轴旋转90°以使横梁与槽错位，从而将附接机构刚性地附接到外壁。电缆固定到外壳和不可移动的物体上，使设备不能被盗。

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