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1. 发明申请

US20050107390A1 Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
标题翻译： β-氨基杂环二肽基肽酶抑制剂，用于治疗或预防糖尿病
公开(公告)号：US20050107390A1
公开(公告)日：2005-05-19
申请号：US10508898
申请日：2003-03-21
申请人： Linda Brockunier , Joseph Duffy , Dooseop Kim , Emma Parmee , Ann Weber
发明人： Linda Brockunier , Joseph Duffy , Dooseop Kim , Emma Parmee , Ann Weber
IPC分类号： A61K31/498 , A61K31/4985 , A61P1/00 , A61P1/12 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/28 , A61P5/50 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

2. 发明申请

US20060052382A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 审中-公开
公开(公告)号：US20060052382A1
公开(公告)日：2006-03-09
申请号：US10540283
申请日：2003-12-16
申请人： Joseph Duffy , Scott Edmondson , Dooseop Kim , Brian Kirk , Liping Wang , Ann Weber
发明人： Joseph Duffy , Scott Edmondson , Dooseop Kim , Brian Kirk , Liping Wang , Ann Weber
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

3. 发明申请

US20060111336A1 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
标题翻译：苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病
公开(公告)号：US20060111336A1
公开(公告)日：2006-05-25
申请号：US10537476
申请日：2003-11-26
申请人： Joseph Duffy , Robert Mathvink , Ann Weber , Jinyou Xu
发明人： Joseph Duffy , Robert Mathvink , Ann Weber , Jinyou Xu
IPC分类号： A61K31/426 , A61K31/401 , A61K31/397 , C07D277/56
CPC分类号： C07D295/185 , A61K31/40 , C07D207/10 , C07D207/16 , C07D277/04
摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

4. 发明申请

US20080027093A1 Cyclohexylalanine Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权
标题翻译：环己基丙氨酸衍生物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
公开(公告)号：US20080027093A1
公开(公告)日：2008-01-31
申请号：US11579265
申请日：2005-05-13
申请人： Joseph Duffy , David Kaelin , Ann Weber , Brian Kirk
发明人： Joseph Duffy , David Kaelin , Ann Weber , Brian Kirk
IPC分类号： A61K31/4025 , A61K31/4015 , A61K31/437 , A61K31/4439 , A61P3/10 , C07D207/16 , C07D401/02 , C07D403/02 , C07D471/04
CPC分类号： C07D207/27 , C07D207/10 , C07D211/38 , C07D401/08 , C07D401/12 , C07D413/08 , C07D471/04
摘要： The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新型环己基丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如作为糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

5. 发明申请

US20060074087A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
公开(公告)号：US20060074087A1
公开(公告)日：2006-04-06
申请号：US10542694
申请日：2004-01-27
申请人： Wallace Ashton , Charles Caldwell , Joseph Duffy , Robert Mathvink , Liping Wang , Ann Weber
发明人： Wallace Ashton , Charles Caldwell , Joseph Duffy , Robert Mathvink , Liping Wang , Ann Weber
IPC分类号： A61K31/519 , A61K31/503 , A61K31/498 , C07D487/02
CPC分类号： C07D471/04 , C07D217/06 , C07D217/26
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

6. 发明申请

US20070213853A1 System and method for implementing safety instrumented systems in a fieldbus architecture 失效
标题翻译：在现场总线架构中实施安全仪表系统的系统和方法
公开(公告)号：US20070213853A1
公开(公告)日：2007-09-13
申请号：US11656883
申请日：2007-01-22
申请人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Carl Gabler , L. Jonas Berge
发明人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Carl Gabler , L. Jonas Berge
IPC分类号： G05B9/02
CPC分类号： G05B9/02 , G05B11/01 , G05B15/02 , G05B19/042 , G05B2219/13127 , G05B2219/15068 , G05B2219/23256 , G05B2219/25085 , G05B2219/25428 , G05B2219/31118 , H04L67/125 , H04L67/325 , H04L69/08
摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, an extended safety-related protocol provides for authenticating communications between safety-related components over an existing black channel, such as one using a fieldbus Architecture.
摘要翻译：提供了一种装置，系统和过程，用于通过开放系统从发送器传送安全相关数据到接收器。提供与安全相关的组件，包括功能块，灵活功能块，资源块和传感器块，以及与安全相关的对象。此外，扩展的安全相关协议提供了通过现有黑色通道（例如使用现场总线架构）的安全相关组件之间的通信认证。

7. 发明申请

US20070142939A1 System and method for implementing time synchronization monitoring and detection in a safety instrumented system 失效
标题翻译：在安全仪表化系统中实现时间同步监测和检测的系统和方法
公开(公告)号：US20070142939A1
公开(公告)日：2007-06-21
申请号：US11642498
申请日：2006-12-19
申请人： Joseph Duffy , Ram Ramachandran , John Gabler
发明人： Joseph Duffy , Ram Ramachandran , John Gabler
IPC分类号： G05B11/01
CPC分类号： G06F1/12
摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, a time synchronization monitor is provided for monitoring timing distributions and determining when such distributions have drifted beyond an acceptable limit.
摘要翻译：提供了一种装置，系统和过程，用于通过开放系统从发送器传送安全相关数据到接收器。提供与安全相关的组件，包括功能块，灵活功能块，资源块和传感器块，以及与安全相关的对象。此外，提供时间同步监视器用于监视定时分布，并确定这些分布何时漂移超过可接受的极限。

8. 发明申请

US20060025872A1 System and method for implementing safety instrumented systems in a fieldbus architecture 有权
公开(公告)号：US20060025872A1
公开(公告)日：2006-02-02
申请号：US11240939
申请日：2005-09-30
申请人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Gabler , L. Berge
发明人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Gabler , L. Berge
IPC分类号： G05B11/01 , G05B9/02
CPC分类号： G05B9/02 , G05B11/01 , G05B15/02 , G05B19/042 , G05B2219/13127 , G05B2219/15068 , G05B2219/23256 , G05B2219/25085 , G05B2219/25428 , G05B2219/31118 , H04L67/125 , H04L67/325 , H04L69/08
摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, an extended safety-related protocol provides for authenticating communications between safety-related components over an existing black channel, such as one using a fieldbus Architecture.

9. 发明授权

US06518519B1 Method and apparatus for determining a weight of a payload 失效
标题翻译：用于确定有效载荷的重量的方法和装置
公开(公告)号：US06518519B1
公开(公告)日：2003-02-11
申请号：US09651173
申请日：2000-08-30
申请人： Carl D. Crane, III , Joseph Duffy
发明人： Carl D. Crane, III , Joseph Duffy
IPC分类号： G01G1908
CPC分类号： E02F9/264
摘要： Methods and apparatuses for determining a mass of a payload in a work machine. The work machine has a chassis, a cab coupled with the chassis, and a boom coupled with the cab. A first actuator is coupled with the boom and the cab and moves the boom relative to the cab. The work machine has a stick coupled with the boom, and a second actuator coupled with the stick and the boom that moves the stick relative to the boom. The work machine also has a bucket operable to receive the payload. The bucket is coupled with the stick, and a third actuator is coupled with the bucket and the stick and moves the bucket relative to the stick. A first joint angle of the boom relative to the cab is determined at at least two instances in time. A second joint angle of the stick relative to the boom is determined at at least two instances in time. A third joint angle of the bucket relative to the stick is determined at at least two instances in time. A first actuator force exerted on the first actuator is determined at at least two instances in time. A second actuator force exerted on the second actuator is determined at at least two instances in time. A third actuator force exerted on the third actuator is determined at at least two instances in time. A plurality of physical characteristics of the work machine is determined. The mass of the bucket and payload is determined as a function of the first joint angles, the second joint angles, the third joint angles, the first actuator forces, the second actuator forces, the third actuator forces, and the plurality of predetermined physical characteristics.
摘要翻译：用于确定作业机器中的有效载荷的质量的方法和装置。工作机具有底盘，与底盘连接的驾驶室以及与驾驶室联动的动臂。第一致动器与动臂和驾驶室联接，并使悬臂相对于驾驶室移动。工作机具有与吊杆结合的杆，以及与杆和悬臂相耦合的第二致动器，其相对于悬臂移动杆。工作机器还具有可操作以接收有效载荷的铲斗。铲斗与杆联接，第三执行器与铲斗和棍子联接，并相对于棒移动铲斗。在至少两个时间上确定起重臂相对于驾驶室的第一关节角度。在至少两个时间的情况下确定棒相对于吊杆的第二关节角度。在至少两个时间上确定桶相对于棒的第三关节角度。在至少两个时间上确定施加在第一致动器上的第一致动器力。在至少两个时间的情况下确定施加在第二致动器上的第二致动器力。在至少两个时间上确定施加在第三致动器上的第三致动器力。确定作业机器的多个物理特性。铲斗和有效载荷的质量根据第一关节角度，第二关节角度，第三关节角度，第一致动器力，第二致动器力，第三致动器力和多个预定物理特性来确定。

10. 发明申请

US20060035958A1 Method of treating diabetes and related conditions 审中-公开
标题翻译：治疗糖尿病及相关病症的方法
公开(公告)号：US20060035958A1
公开(公告)日：2006-02-16
申请号：US10527652
申请日：2003-09-08
申请人： Joseph Duffy , Elizabeth Campbell , Sajjad Qureshi , Bei Zhang , James Tata , Zenon Konteatis , Rui Liang
发明人： Joseph Duffy , Elizabeth Campbell , Sajjad Qureshi , Bei Zhang , James Tata , Zenon Konteatis , Rui Liang
IPC分类号： A61K31/381
CPC分类号： A61K31/381
摘要： The present invention addresses the use of substituted thiophene derivatives, as well as compositions containing such compounds for treating type 2 diabetes mellitus. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
摘要翻译：本发明涉及取代的噻吩衍生物的用途，以及含有这些化合物用于治疗2型糖尿病的组合物。本发明中的化合物是胰高血糖素拮抗剂。该化合物阻断胰高血糖素在其受体上的作用，从而降低提供糖尿病治疗的血浆葡萄糖水平。

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