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1. 发明申请

US20090142797A1 BLOOD DILUENT AND METHOD OF USE THEREOF 审中-公开
标题翻译：血液稀释液及其使用方法
公开(公告)号：US20090142797A1
公开(公告)日：2009-06-04
申请号：US11966713
申请日：2007-12-28
申请人： Lina Zhang , Dan Liu , Wenjuan Xu , Mulong Liu
发明人： Lina Zhang , Dan Liu , Wenjuan Xu , Mulong Liu
IPC分类号： C07D487/04 , C12Q1/00
CPC分类号： G01N33/5002 , G01N1/38 , G01N33/5094
摘要： Blood diluent for use in the analysis of blood components may include at least one purine compound or salt thereof. The blood diluent may also include at least one of alkali metal salt and/or at least one organic buffers and/or inorganic buffer. The blood diluent may be utilized to stabilize blood cells during storage and facilitate the analysis thereof.
摘要翻译：用于分析血液成分的血液稀释剂可以包括至少一种嘌呤化合物或其盐。血液稀释剂还可以包括碱金属盐和/或至少一种有机缓冲剂和/或无机缓冲剂中的至少一种。血液稀释剂可用于在储存期间稳定血细胞并促进其分析。

2. 发明授权

US08163559B2 White blood cell differentiation reagent and method 有权
标题翻译：白细胞分化试剂及方法
公开(公告)号：US08163559B2
公开(公告)日：2012-04-24
申请号：US13016571
申请日：2011-01-28
申请人： Yanmei Qiao , Bing Liu , Xiangping Meng , Wenjuan Xu , Mulong Liu
发明人： Yanmei Qiao , Bing Liu , Xiangping Meng , Wenjuan Xu , Mulong Liu
IPC分类号： G01N33/48 , C12N5/078
CPC分类号： G01N33/5094 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331 , Y10T436/25
摘要： A reagent for four-part differentiation of white blood cells is provided. In one embodiment the reagent has an osmolality below 50 mOsm/kg H2O. A method for differentiating white blood cells using the reagent is also provided. The disclosure provides for a rapid lysis of red blood cells and four-part differentiation of white blood cells. The reagent may be simple in components and a surfactant is not necessary, but optional. A wide range of pH values may be suitable for the reagent.
摘要翻译：提供了白细胞四部分分化试剂。在一个实施方案中，试剂的重量摩尔渗透压浓度低于50mOsm / kg H 2 O。还提供了使用该试剂来分化白细胞的方法。本公开提供红细胞的快速溶解和白细胞的四部分分化。试剂可以是简单的组分，并且表面活性剂不是必需的，但是是任选的。大范围的pH值可能适用于试剂。

3. 发明授权

US08003586B2 Cleaning solution for an automatic biochemical analyzer 有权
标题翻译：自动生化分析仪清洗液
公开(公告)号：US08003586B2
公开(公告)日：2011-08-23
申请号：US12255455
申请日：2008-10-21
申请人： Yuping Zhang , Mulong Liu , Wenjuan Xu , Jun Cheng
发明人： Yuping Zhang , Mulong Liu , Wenjuan Xu , Jun Cheng
IPC分类号： C11D3/20 , C03C23/20 , B08B9/00 , B08B3/00 , B08B3/14
CPC分类号： G01N35/1004 , B01L99/00 , C11D1/83 , C11D3/044 , C11D3/2086 , C11D11/0041
摘要： A cleaning solution for automatic biochemical analyzers includes: at least one anionic surfactant, at least one nonionic surfactant, an alkali metal hydroxide, an alkali metal citrate, and a buffering agent stabilizing the pH value above 13.0. In some embodiments, the cleaning solution provides low residual rate of proteins, low residual rate of lipids, desirable within-batch repeatability in clinical testing, low level of cross-contamination, and low level of reactant deposit after cleaning, without affecting test results of the biochemical analyzer. In some embodiments, the cleaning solution has no corrosive effects on the liquid path and reaction cup of the analyzer. The ingredients of the cleaning solution may also be biodegradable.
摘要翻译：用于自动生化分析仪的清洁溶液包括：至少一种阴离子表面活性剂，至少一种非离子表面活性剂，碱金属氢氧化物，碱金属柠檬酸盐和将pH值稳定在13.0以上的缓冲剂。在一些实施方案中，清洁溶液提供了低残留率的蛋白质，低残留脂肪率，临床测试中期望的批次内重复性，交叉污染水平低，清洁后反应物沉积量低，而不影响测试结果生化分析仪。在一些实施方案中，清洁溶液对分析仪的液体路径和反应杯没有腐蚀作用。清洁溶液的成分也可以是可生物降解的。

4. 发明申请

US20090155764A1 WHITE BLOOD CELL DIFFERENTIATION REAGENT AND METHOD 审中-公开
标题翻译：白血球细胞分化试剂和方法
公开(公告)号：US20090155764A1
公开(公告)日：2009-06-18
申请号：US12337381
申请日：2008-12-17
申请人： Yanmei Qiao , Bing Liu , Xiangping Meng , Wenjuan Xu , Mulong Liu
发明人： Yanmei Qiao , Bing Liu , Xiangping Meng , Wenjuan Xu , Mulong Liu
IPC分类号： A01N1/02
CPC分类号： G01N33/5094 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331 , Y10T436/25
摘要： A reagent for four-part differentiation of white blood cells is provided. In one embodiment the reagent has an osmolarity below 50 mOsm/kg H2O. A method for differentiating white blood cells using the reagent is also provided. The disclosure provides for a rapid lysis of red blood cells and four-part differentiation of white blood cells. The reagent may be simple in components and a surfactant is not necessary, but optional. A wide range of pH values may be suitable for the reagent.
摘要翻译：提供了白细胞四部分分化试剂。在一个实施方案中，试剂的渗透压低于50mOsm / kg H 2 O。还提供了使用该试剂来分化白细胞的方法。本公开提供红细胞的快速溶解和白细胞的四部分分化。试剂可以是简单的组分，并且表面活性剂不是必需的，但是是任选的。大范围的pH值可能适用于试剂。

5. 发明申请

US20070269896A1 Reagent and method for classifying leucocytes 有权
标题翻译：用于白细胞分类的试剂和方法
公开(公告)号：US20070269896A1
公开(公告)日：2007-11-22
申请号：US11516900
申请日：2006-09-07
申请人： Wenjuan Xu , Mulong Liu
发明人： Wenjuan Xu , Mulong Liu
IPC分类号： G01N33/48
CPC分类号： G01N33/5002 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331
摘要： A reagent for classifying leucocytes including: a) at least one of surfactant selected from a cationic surfactant, an amphoteric surfactant, and the combination thereof; b) an organic compound having phenyl or heterocyclic group, wherein when the surfactant is a cationic surfactant, the organic compound is an organic compound having an anionic group; when the surfactant is an amphoteric surfactant or a combination of amphotheric and cationic surfactant, the organic compound is an organic compound having an anionic or cationic group; c) a buffer for adjusting pH.
摘要翻译： 1.一种用于白细胞分类的试剂，包括：a）选自阳离子表面活性剂，两性表面活性剂及其组合中的至少一种表面活性剂; b）具有苯基或杂环基的有机化合物，其中当表面活性剂是阳离子表面活性剂时，有机化合物是具有阴离子基团的有机化合物; 当表面活性剂是两性表面活性剂或两性表面活性剂和阳离子表面活性剂的组合时，有机化合物是具有阴离子或阳离子基团的有机化合物; c）调节pH的缓冲液。

6. 发明授权

US08304243B2 Reagents and methods for classifying leukocytes 有权
标题翻译：用于白细胞分类的试剂和方法
公开(公告)号：US08304243B2
公开(公告)日：2012-11-06
申请号：US13429189
申请日：2012-03-23
申请人： Bing Liu , Wenjuan Xu , Xiangping Meng , Yanmei Qiao , Mulong Liu
发明人： Bing Liu , Wenjuan Xu , Xiangping Meng , Yanmei Qiao , Mulong Liu
IPC分类号： G01N33/48
CPC分类号： G01N33/5094 , G01N33/52 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent. With the reagent and method, erythrocytes are lysed rapidly and classification of leukocytes into five groups is achieved in the same channel. The reaction may be carried out at approximately between 10-40° C. and scattered light signals may be detected at two angles for measuring the classification of leukocytes into five groups.
摘要翻译：用于白细胞分类的试剂包括（a）至少两种阳离子表面活性剂; （b）至少一种带有疏水基团和阴离子基团的有机化合物; （c）用于将pH调节到约2-8范围内的缓冲液。还公开了一种用于将白细胞与该试剂进行分类的方法。利用试剂和方法，红细胞迅速裂解，白细胞在同一通道中分为5组。反应可以在大约10-40℃进行，并且可以以两个角度检测散射光信号，以测量白细胞分为五组。

7. 发明授权

US07416891B2 Reagent and method for classifying leucocytes 有权
标题翻译：用于白细胞分类的试剂和方法
公开(公告)号：US07416891B2
公开(公告)日：2008-08-26
申请号：US11516900
申请日：2006-09-07
申请人： Wenjuan Xu , Mulong Liu
发明人： Wenjuan Xu , Mulong Liu
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N33/5002 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331
摘要： A reagent for classifying leucocytes, including: a) at least one of surfactant selected from a cationic surfactant, an amphoteric surfactant, and the combination thereof; b) an organic compound having phenyl or heterocyclic group, wherein when the surfactant is a cationic surfactant, the organic compound is an organic compound having an anionic group; when the surfactant is an amphoteric surfactant or a combination of amphotheric and cationic surfactant, the organic compound is an organic compound having an anionic or cationic group; c) a buffer for adjusting pH.
摘要翻译： 1.一种用于白细胞分类的试剂，包括：a）选自阳离子表面活性剂，两性表面活性剂及其组合中的至少一种表面活性剂; b）具有苯基或杂环基的有机化合物，其中当表面活性剂是阳离子表面活性剂时，有机化合物是具有阴离子基团的有机化合物; 当表面活性剂是两性表面活性剂或两性表面活性剂和阳离子表面活性剂的组合时，有机化合物是具有阴离子或阳离子基团的有机化合物; c）调节pH的缓冲液。

8. 发明授权

US08647443B2 Methods for cleaning an automatic biochemical analyzer 有权
标题翻译：清洁自动生化分析仪的方法
公开(公告)号：US08647443B2
公开(公告)日：2014-02-11
申请号：US13112812
申请日：2011-05-20
申请人： Yuping Zhang , Mulong Liu , Wenjuan Xu , Jun Cheng
发明人： Yuping Zhang , Mulong Liu , Wenjuan Xu , Jun Cheng
IPC分类号： B08B7/04 , B08B9/00 , B08B3/00 , C11D3/20
CPC分类号： G01N35/1004 , B01L99/00 , C11D1/83 , C11D3/044 , C11D3/2086 , C11D11/0041
摘要： A method of cleaning an automatic biochemical analyzer, wherein the cleaning solution includes: at least one anionic surfactant, at least one nonionic surfactant, an alkali metal hydroxide, an alkali metal citrate, and a buffering agent stabilizing the pH value above 13.0. In some embodiments, the cleaning solution provides low residual rate of proteins, low residual rate of lipids, desirable within-batch repeatability in clinical testing, low level of cross-contamination, and low level of reactant deposit after cleaning, without affecting test results of the biochemical analyzer. In some embodiments, the cleaning solution has no corrosive effects on the liquid path and reaction cup of the analyzer. The ingredients of the cleaning solution may also be biodegradable.
摘要翻译：一种清洁自动生化分析仪的方法，其中所述清洁溶液包括：至少一种阴离子表面活性剂，至少一种非离子表面活性剂，碱金属氢氧化物，碱金属柠檬酸盐和将pH值稳定在13.0以上的缓冲剂。在一些实施方案中，清洁溶液提供了低残留率的蛋白质，低残留脂肪率，临床测试中期望的批次内重复性，交叉污染水平低，清洁后反应物沉积量低，而不影响测试结果生化分析仪。在一些实施方案中，清洁溶液对分析仪的液体路径和反应杯没有腐蚀作用。清洁溶液的成分也可以是可生物降解的。

9. 发明申请

US20120183992A1 Reagents and Methods for Classifying Leukocytes 有权
标题翻译：用于分类白细胞的试剂和方法
公开(公告)号：US20120183992A1
公开(公告)日：2012-07-19
申请号：US13429189
申请日：2012-03-23
申请人： Bing LIU , Wenjuan Xu , Xiangping Meng , Yanmei Qiao , Mulong Liu
发明人： Bing LIU , Wenjuan Xu , Xiangping Meng , Yanmei Qiao , Mulong Liu
IPC分类号： C12Q1/04
CPC分类号： G01N33/5094 , G01N33/52 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent. With the reagent and method, erythrocytes are lysed rapidly and classification of leukocytes into five groups is achieved in the same channel. The reaction may be carried out at approximately between 10-40° C. and scattered light signals may be detected at two angles for measuring the classification of leukocytes into five groups.
摘要翻译：用于白细胞分类的试剂包括（a）至少两种阳离子表面活性剂; （b）至少一种带有疏水基团和阴离子基团的有机化合物; （c）用于将pH调节到约2-8范围内的缓冲液。还公开了一种用于将白细胞与该试剂进行分类的方法。利用试剂和方法，红细胞迅速裂解，白细胞在同一通道中分为5组。反应可以在大约10-40℃进行，并且可以以两个角度检测散射光信号，以测量白细胞分为五组。

10. 发明授权

US08143064B2 Reagents and methods for classifying leukocytes 有权
公开(公告)号：US08143064B2
公开(公告)日：2012-03-27
申请号：US12265588
申请日：2008-11-05
申请人： Bing Liu , Wenjuan Xu , Xiangping Meng , Yanmei Qiao , Mulong Liu
发明人： Bing Liu , Wenjuan Xu , Xiangping Meng , Yanmei Qiao , Mulong Liu
IPC分类号： G01N33/48
CPC分类号： G01N33/5094 , G01N33/52 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent. With the reagent and method, erythrocytes are lysed rapidly and classification of leukocytes into five groups is achieved in the same channel. The reaction may be carried out at approximately between 10-40° C. and scattered light signals may be detected at two angles for measuring the classification of leukocytes into five groups.

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