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1. 发明申请

US20070203111A1 Cycloalkylamines as monoamine reuptake inhibitors 审中-公开
标题翻译：环烷基胺作为单胺再摄取抑制剂
公开(公告)号：US20070203111A1
公开(公告)日：2007-08-30
申请号：US11649927
申请日：2007-01-05
申请人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Jianguo Ma , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , John Campbell
发明人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Jianguo Ma , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , John Campbell
IPC分类号： A61K31/55 , A61K31/445 , A61K31/40 , A61K31/397 , A61K31/396 , C07D211/06 , C07D203/04 , C07D207/04
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）障碍如抑郁，焦虑，精神分裂症和睡眠障碍中的用途及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。

2. 发明申请

US20070197588A1 Tetralone-based monoamine reuptake inhibitors 有权
标题翻译：基于四氢萘酮的单胺再摄取抑制剂
公开(公告)号：US20070197588A1
公开(公告)日：2007-08-23
申请号：US11643190
申请日：2006-12-21
申请人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , Jianguo Ma
发明人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , Jianguo Ma
IPC分类号： A61K31/4706 , A61K31/137 , A61K31/135
CPC分类号： C07C211/40 , C07C17/16 , C07C17/35 , C07C45/38 , C07C45/52 , C07C45/63 , C07C45/67 , C07C45/68 , C07C45/74 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/44 , C07C217/74 , C07C2601/14 , C07C2602/10 , C07D215/12 , C07C25/22 , C07C22/04 , C07C47/453 , C07C49/67 , C07C49/697 , C07C49/255 , C07C49/755 , C07C49/683
摘要： The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的四氢萘酮类胺及其用于治疗中枢神经系统（CNS）障碍，例如抑郁症，注意缺陷多动障碍（ADHD）和帕金森病。本发明还涉及含有本发明化合物和组合物的药物组合物以及抑制一种或多种单胺（例如多巴胺和去甲肾上腺素）从突触裂缝再摄取的方法，以及调节一种或多种单胺转运蛋白的方法。

3. 发明申请

US20080016739A1 Easy loader card insertion device 审中-公开
标题翻译：轻松装载卡插入装置
公开(公告)号：US20080016739A1
公开(公告)日：2008-01-24
申请号：US11474264
申请日：2006-06-26
申请人： Scott Malcolm
发明人： Scott Malcolm
IPC分类号： G09F3/18
CPC分类号： G09F3/20
摘要： An insertion device is described which enables an operator to easily insert flat cards into the pockets provided in display devices. The device has the general shape of a miniature dust pan having a flat floor and which has a tapered nose for insertion into said pockets. The device includes shallow vertical sides which slope upwardly from the floor of the device adjacent said nose so as to lift the upper surface of the pocket when inserted therein. A card is then laid on the device, the dimensions of the card, insertion device, and the pocket having been previously decided, and the card is now slid along the floor of the insertion device into the pocket.
摘要翻译：描述了插入装置，其使得操作者能够容易地将平板卡插入设置在显示装置中的口袋中。该装置具有具有平坦地板的微型防尘盘的一般形状，并且具有用于插入所述袋中的锥形鼻。该装置包括从邻近所述鼻部的装置的地板向上倾斜的浅的垂直侧，以便在插入其中时提升袋的上表面。然后将卡放置在设备上，卡，插入装置和口袋的尺寸已经被预先确定，并且卡现在沿着插入装置的底部滑动到口袋中。

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