专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06387906B1 2,4,4-trisubstituted-1,3-dioxolane antifungals 有权
标题翻译： 2,4,4-三取代-1,3-二氧戊环抗真菌剂
公开(公告)号：US06387906B1
公开(公告)日：2002-05-14
申请号：US09462588
申请日：2000-01-07
申请人： Lieven Meerpoel , Jan Heeres , Frank Christopher Odds , Hugo Florent Adolf Vanden Bossche , Louis Jozef Elisabeth Van der Veken
发明人： Lieven Meerpoel , Jan Heeres , Frank Christopher Odds , Hugo Florent Adolf Vanden Bossche , Louis Jozef Elisabeth Van der Veken
IPC分类号： C07D40514
CPC分类号： C07D249/08 , A61K31/496 , A61K31/506 , A61K31/53 , C07D231/12 , C07D233/56
摘要： The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or 3; X is N or CH; each R1 independently is halo, nitro, cyano, amino, hydroxy, C1-4alkyl, C1-4alkyloxy or trifluoromethyl; R2 is hydrogen; C3-7alkenyl; C3-7alkynyl, aryl; C3-7cycloalkyl; optionally substituted C1-6alkyl R3 and R4 each independently are hydrogen, C1-6alkyl, C3-7cycloalkyl or aryl; or R3 and R4 taken together form a bivalent radical —R3—R4— of formula: wherein R5a, R5b, R5c, R5d each independently are hydrogen, C1-6alkyl or aryl; and aryl is optionally substituted phenyl; as antifungals; their preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及式N-氧化物形式的新型化合物，其药学上可接受的酸加成盐或其立体化学异构形式，其中n为0,1,2或3; X是N或CH;每个R 1独立地是卤素，硝基，氰基，氨基，羟基，C 1-4烷基，C 1-4烷氧基或三氟甲基; R2是氢; C3-7烯基; C 3-7炔基，芳基; C 3-7环烷基; 任选取代的C 1-6烷基R 3和R 4各自独立地为氢，C 1-6烷基，C 3-7环烷基或芳基; 或R 3和R 4一起形成下式的二价基团-R 3 -R 4 - 其中R 5a，R 5b，R 5c，R 5d各自独立地是氢，C 1-6烷基或芳基; 芳基是任选取代的苯基; 作为抗真菌剂; 其制剂，含有它们的组合物及其作为药物的用途。

2. 发明授权

US06384030B1 Water soluble azoles as broad-spectrum antifungals 有权
标题翻译：水溶性唑类作为广谱抗真菌剂
公开(公告)号：US06384030B1
公开(公告)日：2002-05-07
申请号：US09700251
申请日：2000-11-09
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Jan Heeres , Frank Christopher Odds
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Jan Heeres , Frank Christopher Odds
IPC分类号： C07D40514
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/12
摘要： The present invention concerns novel compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein L represent a radical of formula wherein each Alk independently represents an optionally substituted C1-6alkanediyl; is 1, 2 or 3; Y is O, S or NR2; R1 represents hydrogen, aryl, Het1, or an optionally substituted C1-6alkyl; each R2 independently represents hydrogen or C1-6alkyl; or in case R1 and R2 are attached to the same nitrogen atom, they may be taken together to form a heterocyclic radical; or they may be taken together to form an azido radical; each R3 independently represents hydrogen, hydroxy or C1-4alkyloxy; aryl represents phenyl, naphthalenyl, 1,2,3,4-tetrahydro-naphthalenyl, indenyl or indanyl; each of said aryl groups may optionally be substituted; Het1 represents an optionally substituted monocyclic or bicyclic heterocyclic radical; Het2 is the same as Het1 and may also be piperazinyl, homopiperazinyl, 1,4-dioxanyl, morpholinyl, thiomorpholinyl; R6 represents hydrogen or C1-4alkyl; R7 represents hydrogen or C1-4alkyl; or R6 and R7 taken together form a bivalent radical of formula —N═CH— (i), —CH═N— (ii), —CH═CH— (iii), —CH2—CH2 (iv), wherein one hydrogen atom in the radicals (i) and (ii) may be replaced with a C1-4alkyl radical and one or more hydrogen atoms in radicals (iii) and (iv) may be replaced by a C1-4alkyl radical; D represents a trisubstituted 1,3-dioxolane derivative; as antifungals; their processes for preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及配制N-氧化物形式的新化合物，其药学上可接受的加成盐和立体化学异构形式，其中L代表甲酰基的基团，每个Alk独立地表示任选取代的C 1-6烷二基; 是1，2或3; Y是O，S或NR2; R 1表示氢，芳基，Het1或任选取代的C 1-6烷基; 每个R 2独立地表示氢或C 1-6烷基; 或者在R1和R2连接到相同的氮原子的情况下，它们可以一起形成杂环基; 或者它们可以一起形成叠氮基; 每个R 3独立地表示氢，羟基或C 1-4烷氧基; 芳基表示苯基，萘基，1,2,3,4-四氢 - 萘基，茚基或茚满基; 每个所述芳基可任选被取代; Het1表示任选取代的单环或双环杂环基; Het2与Het1相同，也可以是哌嗪基，高哌嗪基，1,4-二氧杂环己基，吗啉基，硫代吗啉基; R6代表氢或C1-4烷基; R7代表氢或C1-4烷基; 或者R 6和R 7一起形成式-N = CH-（ⅰ），-CH = N-（ⅱ），-CH = CH-（ⅲ），-CH 2 -CH 2（ⅳ）的二价基团，其中一个氢基团（i）和（ii）中的原子可以被C 1-4烷基取代，并且基团（iii）和（iv）中的一个或多个氢原子可被C 1-4烷基取代; D表示三取代的1,3-二氧戊环衍生物; 作为抗真菌剂; 其制备方法，含有它们的组合物及其作为药物的用途。

3. 发明授权

US06440440B1 Biocidal benzylbiphenyl derivatives 失效
标题翻译：杀生物苄基联苯衍生物
公开(公告)号：US06440440B1
公开(公告)日：2002-08-27
申请号：US09647015
申请日：2000-09-22
申请人： Lieven Meerpoel , Mark Arthur Josepha Van der Flaas , Louis Jozef Elisabeth Van Der Veken , Jan Heeres
发明人： Lieven Meerpoel , Mark Arthur Josepha Van der Flaas , Louis Jozef Elisabeth Van Der Veken , Jan Heeres
IPC分类号： A01N4340
CPC分类号： C07D211/58 , A01N33/04 , A01N33/12 , A01N43/40 , C07C211/27 , C07C211/28 , C07D211/26 , C07D211/70
摘要： This invention concerns compounds of formula. stereochemically isomeric forms thereof, acid or base addition salts thereof, N-oxides thereof, or quaternary ammonium derivatives thereof, wherein the dotted line is an optional bond; X is a direct bond when the dotted line represents a bond, or X is hydrogen or hydroxy, when the dotted line does not represent a bond; R1, R2, R5 and R6 are each independently selected from hydrogen, halo, hydroxy, C1-4alkyl, C1-4alkyloxy, —SO3H, and the like; R3 and R4 are each independently selected from hydrogen, halo, hydroxy, C1-4alkyl, C1-4alkyloxy, nitro, amino, cyano, trifluoromethyl, or trifluoromethoxy; L is a radical of formula wherein A1 is a direct bond or C1-6alkanediyl; A2 is C2-6alkanediyl; and R7 to R11 are hydrogen, C1-6alkyl, aminoC1-6alkyl and the like; having biocidal properties; their preparation, compositions containing them and their use as a biocide.
摘要翻译：本发明涉及其化学式为其立体化学异构形式，其酸或碱加成盐，其N-氧化物或其季铵衍生物，其中虚线为任选的键; 当虚线不表示键时，X是直链键，当虚线表示键时，X表示氢或羟基; R 1，R 2，R 5和R 6各自独立地选自氢，卤素，羟基，C 1-4烷基，C 1-4烷氧基，-SO 3 H等; R 3和R 4各自独立地选自氢，卤素，羟基，C 1-4烷基，C 1-4烷氧基，硝基，氨基，氰基，三氟甲基或三氟甲氧基; L是公式的基数A1 直接键或C1-6烷二基; A2是C2-6烷二基; 并且R 7至R 11为氢，C 1-6烷基，氨基C 1-6烷基等; 具有杀生物性; 它们的制备方法，含有它们的组合物以及它们作为杀生物剂的用途。

4. 发明授权

US5728700A Sulfonamide compounds of azolones anti-helicobacter agents 失效
标题翻译：磺酰胺化合物的唑类抗幽门螺杆菌药物
公开(公告)号：US5728700A
公开(公告)日：1998-03-17
申请号：US776003
申请日：1997-01-09
申请人： Jan Heeres , Raymond Antoine Stokbroekx , Joseph Hector Mostmans , Louis Jozef Elisabeth Van der Veken
发明人： Jan Heeres , Raymond Antoine Stokbroekx , Joseph Hector Mostmans , Louis Jozef Elisabeth Van der Veken
IPC分类号： A61K31/41 , A61K31/415 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61P1/00 , A61P1/04 , A61P31/04 , C07D233/70 , C07D249/12 , C07D401/04
CPC分类号： C07D401/04 , C07D249/12
摘要： The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-4 alkyl; or phenyl optionally substituted with halo, C.sub.1-4 alkylcarbonylamino, C.sub.1-4 alkyloxy, C.sub.1-4 alkyl or nitro; Z is C.dbd.O or CHOH; and ##STR2## is a radical of formula ##STR3## Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
摘要翻译： PCT No.PCT / EP95 / 02619 Sec。 371日期1997年1月9日 102（e）1997年1月9日PCT PCT 1995年7月5日PCT公布。出版物WO96 / 01818 日本1996年1月25日本发明涉及具有下式的化合物：其药学上可接受的加成盐及其立体化学异构形式，其中Y为CH或N; R1，R2和R3各自独立地为氢或C1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R6是C1-4烷基; 或任选被卤素，C 1-4烷基羰基氨基，C 1-4烷氧基，C 1-4烷基或硝基取代的苯基; Z是C = O或CHOH; （a-4）（a-5）（a-3）（a-6）（a-7）包含所述化合物的组合物，其制备方法以及这些化合物作为药物的用途。

5. 发明授权

US5710156A Ester and carbamate derivatives of azolones 失效
标题翻译：唑类的酯和氨基甲酸酯衍生物
公开(公告)号：US5710156A
公开(公告)日：1998-01-20
申请号：US716397
申请日：1996-09-20
申请人： Jan Heeres , Joseph Hector Mostmans , Robert Jozef Maria Hendrickx , Louis Jozef Elisabeth Van der Veken , Raymond Antoine Stokbroekx , Marcel Jozef Maria Van de Aa
发明人： Jan Heeres , Joseph Hector Mostmans , Robert Jozef Maria Hendrickx , Louis Jozef Elisabeth Van der Veken , Raymond Antoine Stokbroekx , Marcel Jozef Maria Van de Aa
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4427 , A61K31/445 , A61K31/495 , A61P31/04 , C07D233/70 , C07D249/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D407/14
CPC分类号： C07D401/04 , C07D233/70 , C07D249/12 , C07D401/10
摘要： The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric form thereof, wherein X and Y are CH or N; R.sup.1, R.sup.2 and R.sup.3 are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.1-4 alkyloxyC.sub.1-6 alkyl, phenyl or phenylC.sub.1-4 alkyl; Z is C.dbd.O or CHOH; and ##STR2## compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating Helicobacter related diseases.
摘要翻译： PCT No.PCT / EP95 / 01184第 371日期：1996年9月20日 102（e）1996年9月20日PCT 1995年3月29日PCT公布。出版物WO95 / 27704 日期：1995年10月19日本发明涉及具有式（I）的化合物：其药学上可接受的酸加成盐及其立体化学异构形式，其中X和Y是CH或N; R1，R2和R3是氢或C1-4烷基; R 4和R 5是氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R 6是C 1-6烷基，羟基C 1-6烷基，C 1-4烷氧基C 1-6烷基，苯基或苯基C 1-4烷基; Z是C = O或CHOH; （a-3）（a-4）（a-5）（a-5）（a-6）（a-7）包含所述化合物的组合物，以及这些化合物用于治疗幽门螺杆菌相关疾病的用途。

6. 发明授权

US06512116B2 Amino acid ester containing azole antifungals 有权
标题翻译：氨基酸酯含唑类抗真菌剂
公开(公告)号：US06512116B2
公开(公告)日：2003-01-28
申请号：US09848989
申请日：2001-05-04
申请人： Lieven Meerpoel , Jan Heeres , Robert Jozef Maria Hendrickx
发明人： Lieven Meerpoel , Jan Heeres , Robert Jozef Maria Hendrickx
IPC分类号： C07D40514
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： The present invention concerns novel compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts thereof and stereochemically isomeric forms thereof, wherein —A—B— forms a bivalent radical of formula —N═CH— (a), —CH═N— (b), —CH═CH— (c), L represents the acyl moiety of an amino acid; D is an azole containing 1,3- or 1,4-dioxolane derivative as broad-spectrum antifungals; their preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及N-氧化物形式的新化合物，其药学上可接受的加成盐和其立体化学异构形式，其中-AB-形成式-N = CH-（a），-CH = N-（ b），-CH = CH-（c），L表示氨基酸的酰基部分; D是含有1,3-或1,4-二氧戊环衍生物作为广谱抗真菌剂的唑类; 其制剂，含有它们的组合物及其作为药物的用途。

7. 发明授权

US06262052B1 Amino acid ester containing azole antifungals 有权
标题翻译：氨基酸酯含唑类抗真菌剂
公开(公告)号：US06262052B1
公开(公告)日：2001-07-17
申请号：US09355369
申请日：1999-07-26
申请人： Lieven Meerpoel , Jan Heeres , Robert Jozef Maria Hendrickx
发明人： Lieven Meerpoel , Jan Heeres , Robert Jozef Maria Hendrickx
IPC分类号： A61K31496
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： The present invention concerns novel compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts thereof and stereochemically isomeric forms thereof, wherein —A—B— forms a bivalent radical of formula —N═CH— (a), —CH═N— (b), —CH═CH— (c), L represents the acyl moiety of an amino acid; D is an azole containing 1,3- or 1,4-dioxolane derivative as broad-spectrum antifungals; their preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及N-氧化物形式的新化合物，其药学上可接受的加成盐和其立体化学异构形式，其中-AB-形成式-N = CH-（a），-CH = N-（ b），-CH = CH-（c），L表示氨基酸的酰基部分; D是含有1,3-或1,4-二氧戊环衍生物作为广谱抗真菌剂的唑类; 其制剂，含有它们的组合物及其作为药物的用途。

8. 发明授权

US5707977A Watersoluble azole antifungals 失效
标题翻译：水溶性唑类抗真菌剂
公开(公告)号：US5707977A
公开(公告)日：1998-01-13
申请号：US666270
申请日：1996-06-20
申请人： Jan Heeres , Leo Jacobus Jozef Backx , Luc Alfons Leo Van der Eycken , Frank Christopher Odds , Jean Louis Mesens
发明人： Jan Heeres , Leo Jacobus Jozef Backx , Luc Alfons Leo Van der Eycken , Frank Christopher Odds , Jean Louis Mesens
IPC分类号： C07D405/14 , A01N43/653 , A01N57/16 , A61K31/34 , A61K31/36 , A61K31/41 , A61K31/415 , A61K31/495 , A61K31/535 , A61K31/675 , A61P31/04 , A61P31/10 , C07D403/12 , C07D407/14 , C07D413/14 , C07D521/00 , C07F9/6558
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07F9/65586
摘要： A compound of formula (I), ##STR1## an acid or base addition salt thereof or a stereochemically isomeric form thereof, wherein A and B taken together form --N.dbd.CH--, --CH.dbd.N--, --CH.sub.2 --CH.sub.2, CH.dbd.CH--, --C(.dbd.O)--CH.sub.2 --, --CH.sub.2 --C(.dbd.O); D is a radical of formula ##STR2## L is a radical of formula ##STR3## Alk is a C.sub.1-4 alkanediyl radical; R.sup.1 is halo; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl or halophenyl; R.sup.4 is hydrogen, C.sub.1-6 alkyl, phenyl or halophenyl; R.sup.5 is hydrogen or C.sub.1-6 alkyl; R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxycarbonyl, or R.sup.5 and R.sup.6 taken together with the nitrogen atom to which they are attached form a heterocyclic ring. Active intermediates, compositions and methods of preparing compounds, compositions are described.
摘要翻译： PCT No.PCT / EP95 / 00174 Sec。 371日期：1996年6月20日 102（e）1996年6月20日PCT 1995年1月17日PCT PCT。公开号WO95 / 19983 日期：1995年7月27日一种式（I）化合物，其中A和B一起形成-N = CH-，-CH = N-，-CH 2 -CH 2， CH = CH - ， - C（= O）-CH 2 - ， - CH 2 -C（= O）; （D1）（D1）图像（D1）图像（D1）图像（L2）Alk是C1-4烷二基; R1是卤素; R2是氢或卤素; R3是氢，C1-6烷基，苯基或卤代苯基; R4是氢，C1-6烷基，苯基或卤代苯基; R5是氢或C1-6烷基; R6是氢，C1-6烷基，C1-6烷氧基羰基或R5和R6与它们所连接的氮原子一起形成杂环。描述了制备化合物的活性中间体，组合物和方法，组合物。

9. 发明授权

US5650411A Substituted azolone derivatives 失效
标题翻译：取代的唑啉衍生物
公开(公告)号：US5650411A
公开(公告)日：1997-07-22
申请号：US491960
申请日：1995-07-18
申请人： Jan Heeres , Joseph Hector Mostmans , Luc Alfons Leo Van Der Eycken , Frank Christopher Odds , Raymond Antoine Stokbroekx , Marcel Jozef Maria Van der Aa
发明人： Jan Heeres , Joseph Hector Mostmans , Luc Alfons Leo Van Der Eycken , Frank Christopher Odds , Raymond Antoine Stokbroekx , Marcel Jozef Maria Van der Aa
IPC分类号： A61K31/41 , A61K31/445 , A61K31/4523 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/695 , A61P31/04 , C07D233/70 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07F7/18
CPC分类号： C07D401/04 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , C07D233/70 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07F7/1856
摘要： The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula ##STR1## a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, whereinX and Y each independently are CH or N;R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl;R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy;Z is C.dbd.O or CHOH; andAr is phenyl optionally substituted with up to three substituents selected from hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, halo, trifluoromethyl, triC.sub.1-4 alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C.sub.1-4 alkyloxy; and--A-- is a radical of formula ##STR2##
摘要翻译： PCT No.PCT / EP94 / 00380 Sec。 371 1995年7月18日第 102（e）日期1995年7月18日PCT 1994年2月9日PCT PCT。公开号WO94 / 18978 1994年9月1日生产用于治疗下列化合物的幽门螺杆菌相关疾病的药物的用途：（I）药学上可接受的酸加成盐或其立体化学异构形式，其中X和Y各自独立地为 CH或N; R1，R2和R3各自独立地为氢或C1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; Z是C = O或CHOH; Ar是任选被至多三个选自羟基，C 1-4烷基，C 1-4烷氧基，卤素，三氟甲基，三C 1-4烷基甲硅烷氧基，硝基，氨基和氰基的取代基取代的苯基或被羟基或C 1-4烷氧基取代的吡啶基; （a-4）（a-5）（a-2）（a-6）或（a-7）

10. 发明授权

US06703506B2 Amino acid ester containing azole antifungals 有权
标题翻译：氨基酸酯含唑类抗真菌剂
公开(公告)号：US06703506B2
公开(公告)日：2004-03-09
申请号：US10298038
申请日：2002-11-15
申请人： Lieven Meerpoel , Jan Heeres , Robert Jozef Maria Hendrickx
发明人： Lieven Meerpoel , Jan Heeres , Robert Jozef Maria Hendrickx
IPC分类号： C07D40514
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： The present invention concerns novel compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts thereof and stereochemically isomeric forms thereof, wherein —A—B— forms a bivalent radical of formula —N═CH— (a), —CH═N— (b), —CH═CH— (c), L represents the acyl moiety of an amino acid; D is an azole containing 1,3- or 1,4-dioxolane derivative as broad-spectrum antifungals; their preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及N-氧化物形式的新化合物，其药学上可接受的加成盐和其立体化学异构形式，其中-AB-形成式-N = CH-（a），-CH = N-（ b），-CH = CH-（c），L表示氨基酸的酰基部分; D是含有1,3-或1,4-二氧戊环衍生物作为广谱抗真菌剂的唑类; 其制剂，含有它们的组合物及其作为药物的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式