专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5925671A Antitumor isocoumarins 失效
标题翻译：抗肿瘤异香豆素
公开(公告)号：US5925671A
公开(公告)日：1999-07-20
申请号：US913099
申请日：1997-11-06
申请人： Librada Canedo Hernandez , Cristina Acebal Sarabia , Dolores Garcia Gravalos
发明人： Librada Canedo Hernandez , Cristina Acebal Sarabia , Dolores Garcia Gravalos
IPC分类号： A61K31/365 , A61K31/37 , A61P35/02 , C07D311/76 , C12P17/06 , C12R1/07 , A61K31/35 , C07D311/04
CPC分类号： C12R1/07 , A61K31/37 , C07D311/76 , C12P17/06
摘要： Antitumor isocoumarins are of general formula (III) where R is --CONH.sub.2 or --CH(CH.sub.3).sub.2, or a pharmaceutically acceptable addition salt thereof. The compound wherein R is --CONH.sub.2 is the known compound amicoumacin A. The compound wherein is --CH(CH.sub.3).sub.2 is a new compound which can be obtained from fermentation of the new marine bacterium Bacillus sp. strain M-00-PHD-090, CECT 4546. ##STR1##
摘要翻译： PCT No.PCT / GB96 / 00537 371日期：1997年11月6日 102（e）日期1997年11月6日PCT提交1996年3月8日PCT公布。公开号WO96 / 27594 日本1996年9月12日抗肿瘤异香豆素具有通式（III），其中R是-CONH 2或-CH（CH 3）2，或其药学上可接受的加成盐。其中R是-CONH 2的化合物是已知的化合物微乳糖素A.其中-CH（CH 3）2的化合物是可以从新型海洋细菌芽孢杆菌属的发酵获得的新化合物。菌株M-00-PHD-090，CECT4546。

2. 发明授权

US06391900B1 Cytotoxic tris(oxazole)-containing macrolides 失效
标题翻译：含有细菌毒性的三（恶唑）大环内酯类
公开(公告)号：US06391900B1
公开(公告)日：2002-05-21
申请号：US09601146
申请日：2001-01-12
申请人： Tatsuo Higa , Dolores Garcia Gravalos , Jose Luis Fernandez Puentes
发明人： Tatsuo Higa , Dolores Garcia Gravalos , Jose Luis Fernandez Puentes
IPC分类号： A61P3500
CPC分类号： C07D498/22
摘要： The present invention discloses new cytotoxic tris(oxazole)-containing macrolides having the formula: wherein X represents a lower alkyl; R1 and R2 represent hydrogen or lower alkyl; R3a represents hydrogen, and R3b represents or R3a and R3b together represent oxygen; R4 represents hydrogen, lower alkoxy or lower alkyl; R5 represents hydrogen, carbamoyl, or lower alkanoyl; R6a represents hydrogen, and R6b represents hydroxy, or R6a and R6b together represent oxygen; R7 represents hydrogen, lower alkyl, or hydroxymethyl; R8 represents lower alkoxy or lower alkyl; Y1 represents hydrogen or methyl, and y2 represents hydrogen, or Y1 and Y2 together represent a double bond. Also disclose are methods for treating mammals using the macrolides and pharmaceutical preparations including the macrolides.
摘要翻译：本发明公开了具有下式的新的具有细胞毒性的三（恶唑）的大环内酯类：其中X代表低级烷基; R1和R2表示氢或低级烷基; R3a表示氢，R3b表示R3a和R3b表示氧; R4代表氢，低级烷氧基或低级烷基; R5表示氢，氨基甲酰基或低级烷酰基; R6a表示氢，R6b表示羟基，R6a和R6b表示氧; R7表示氢，低级烷基或羟甲基; R8表示低级烷氧基或低级烷基; Y1表示氢或甲基，y2表示氢，Y1或Y2表示双键。还公开了使用大环内酯类和包括大环内酯类药物制剂治疗哺乳动物的方法。

3. 发明授权

US06350743B1 Cytotoxic pyridoacridine alkaloids 失效
标题翻译：细胞毒性吡啶并吖啶生物碱
公开(公告)号：US06350743B1
公开(公告)日：2002-02-26
申请号：US09554181
申请日：2001-02-22
申请人： Yoel Kashman , Ganit Koren-Goldshlager , Maurice Aknin , Dolores Garcia Gravalos
发明人： Yoel Kashman , Ganit Koren-Goldshlager , Maurice Aknin , Dolores Garcia Gravalos
IPC分类号： A61K31545
CPC分类号： C07D513/16
摘要： Shermilamine D, a novel cytotoxic pyridoacridine alkaloid of Formula 1, has been isolated from the tunicate Cystodytes violatinctus. The structure of the compound has been established on the basis of 1-D and 2-D NMR data.
摘要翻译：已经从隐孢子虫隐孢子虫（Cystodytes violatinctus）中分离出了具有式1的新型细胞毒性吡啶并吖啶生物碱的Shermilamine D。该化合物的结构是基于1-D和2-D NMR数据建立的。

4. 发明授权

US5849540A Thiodepsipeptide isolated from a marine actinomycete 失效
标题翻译：从海洋放线菌分离的硫代三肽
公开(公告)号：US5849540A
公开(公告)日：1998-12-15
申请号：US936460
申请日：1997-09-24
申请人： Julia Perez Baz , Francisco Romero Millan , Teresa Garcia De Quesada , Dolores Garcia Gravalos
发明人： Julia Perez Baz , Francisco Romero Millan , Teresa Garcia De Quesada , Dolores Garcia Gravalos
IPC分类号： C12N1/20 , A61K38/00 , C07K7/06 , C12R1/29 , C12P21/00
CPC分类号： C12R1/29 , C07K7/06 , A61K38/00
摘要： The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
摘要翻译：本发明涉及从属于小单孢菌科的新型海洋菌株L-13-ACM2-092中分离出新的脱脂肽。本文描述了在菌株的受控条件下通过需氧发酵的生产以及PM-93135的分离和纯化。化合物和发酵液显示出对几种癌细胞系的显着活性。该化合物还显示针对几种革兰氏阳性菌的活性。

5. 发明授权

US06812245B2 Polycylic xanthones and their use 失效
标题翻译：多晶呫吨酮及其用途
公开(公告)号：US06812245B2
公开(公告)日：2004-11-02
申请号：US10312343
申请日：2003-06-09
申请人： Librada Maria Cañedo , Dolores Garcia Gravalos , Francisco Romero , Fernando Espliego , Julia Perez-Baz
发明人： Librada Maria Cañedo , Dolores Garcia Gravalos , Francisco Romero , Fernando Espliego , Julia Perez-Baz
IPC分类号： A61K3135
CPC分类号： C07D493/04 , C07H17/08 , C12P17/181 , C12R1/03
摘要： A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.
摘要翻译：基于与名为IB-00208的化合物的新型海洋微生物属于Actinomadura属植物菌株PO13-046的分离，已经认识到一类新的抗肿瘤化合物。式（I）或（II）的类别，其中R 1可以是氢，酰基，烷基，烯基，芳基，苄基，碱金属和/或糖，R 2和R 3可以是氢，烷基或一起R 2和R 3形成不饱和键。这些化合物表现出一些有趣的活性，一些取消细胞系和革兰氏阳性菌。

6. 发明授权

US06800661B1 Spisulosine compounds 失效
标题翻译： Spisulosine化合物
公开(公告)号：US06800661B1
公开(公告)日：2004-10-05
申请号：US09386724
申请日：1999-08-31
申请人： Kenneth L. Rinehart , Robert A. Warwick , Jesus Avila , Nancy L. Fregeau Gallagher , Dolores Garcia Gravalos , Glynn T. Faircloth
发明人： Kenneth L. Rinehart , Robert A. Warwick , Jesus Avila , Nancy L. Fregeau Gallagher , Dolores Garcia Gravalos , Glynn T. Faircloth
IPC分类号： A61V3113
CPC分类号： C07C215/08 , A61K35/618 , C07B2200/07
摘要： Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.
摘要翻译：对蛤蜊提取物的活性的研究Spisula polynyma已经导致具有2-氨基和3-羟基的抗肿瘤长链，直链烷烃或烯烃化合物。

7. 发明授权

US06214793B1 Method of treating tumors with thiodepsipeptide isolated from a marine actinomycete 失效
标题翻译：使用从海洋放线菌分离的硫代前列腺素治疗肿瘤的方法
公开(公告)号：US06214793B1
公开(公告)日：2001-04-10
申请号：US08936678
申请日：1997-09-24
申请人： Julia Perez Baz , Francisco Romero Millan , Teresa Garcia De Quesada , Dolores Garcia Gravalos
发明人： Julia Perez Baz , Francisco Romero Millan , Teresa Garcia De Quesada , Dolores Garcia Gravalos
IPC分类号： A61K3800
CPC分类号： C12R1/29 , A61K38/00 , C07K7/06
摘要： The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
摘要翻译：本发明涉及从属于小单孢菌科的新型海洋菌株L-13-ACM2-092中分离出新的脱脂肽。本文描述了在菌株的受控条件下通过需氧发酵的生产以及PM-93135的分离和纯化。化合物和发酵液显示出对几种癌细胞系的显着活性。该化合物还显示针对几种革兰氏阳性菌的活性。

8. 发明授权

US5571927A Areno [E]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity 失效
标题翻译：竞争性[E]吲哚，制备方法和应用作为合成具有抗肿瘤活性的产品的中间体
公开(公告)号：US5571927A
公开(公告)日：1996-11-05
申请号：US252658
申请日：1994-05-19
申请人： Koen Alexander , Jose Delamano Garcia , Benedikt Sas , Gabriel Tojo Suarez , Dolores Garcia Gravalos
发明人： Koen Alexander , Jose Delamano Garcia , Benedikt Sas , Gabriel Tojo Suarez , Dolores Garcia Gravalos
IPC分类号： C07D209/58 , C07D207/34 , C07D209/00 , C07D209/60 , C07D487/04 , C07D491/048 , C07D495/04 , C07D487/02 , C07D209/56
CPC分类号： C07D487/04 , C07D209/60
摘要： The areno[e]indols have the formula (I). The methods comprises: (a) reacting (VI) with an aldehyde Ar"--CHO to obtain (VII); (b) oxidizing (VII) to yield the cetone (VIII); (c) reating (VIII) with a strong base and thereafter with an acycle chloride ClCOR, to produce (IX); (d) subjecting to a photochemical cyclization (IX) to produce (I). In said formulas Ar is phenyl or substituted phenyl; Ar' is radical (i) or (ii); R is an acyle group, Ar" is a phenyl, pyrolyl, furanyl or thiophenyl group substituted up to three times by any of the radials R, R.sup.1, R.sup.2, or R.sup.3. The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.
摘要翻译：异烟肼[e]吲哚具有式（I）。所述方法包括：（a）使（VI）与醛Ar“ - CHO反应得到（VII）; （b）氧化（VII）以产生该酮（VIII）; （c）用强碱反应（VIII），然后用氯化碳氯化物ClCOR反应生成（IX）; （d）进行光化学环化（IX）以制备（I）。在所述式中Ar是苯基或取代的苯基; Ar'是激进的（i）或（ii）; R是芳基，Ar“是通过任何径向R，R 1，R 2或R 3取代三次以上的苯基，焦油基，呋喃基或噻吩基。化合物（I）可用作合成具有抗肿瘤活性的六氢异环（e）环丙烷（c）吲哚-4-酮的中间体。

9. 发明授权

US07153885B2 Stolonoxides 失效
公开(公告)号：US07153885B2
公开(公告)日：2006-12-26
申请号：US10275377
申请日：2001-05-04
申请人： Rosario Duran , Eva Zubia , Maria J. Ortega , Javier Salva , Jose Luis Fernandez Puentes , Dolores Garcia Gravalos , Santiago Naranjo Lozano
发明人： Rosario Duran , Eva Zubia , Maria J. Ortega , Javier Salva , Jose Luis Fernandez Puentes , Dolores Garcia Gravalos , Santiago Naranjo Lozano
IPC分类号： A61K31/335 , C07D407/04
CPC分类号： C07D407/04 , A61K31/341 , A61K31/357
摘要： Naturally occurring stolonoxide compounds, and derivatives thereof, have antitumor activity. Typical compounds are of the formula (I) or a derivative thereof
摘要翻译：天然存在的泛素化合物及其衍生物具有抗肿瘤活性。典型的化合物是式（I）化合物或其衍生物

10. 发明授权

US06852715B1 Indolocarbazole alkaloids from a marine actinomycete 失效
标题翻译：来自海洋放线菌的吲哚咔唑生物碱
公开(公告)号：US06852715B1
公开(公告)日：2005-02-08
申请号：US10019388
申请日：2000-06-28
申请人： Dolores Garcia Gravalos , Julia Perez , Librada Maria Cañedo , Francisco Romero , Fernando Espliego
发明人： Dolores Garcia Gravalos , Julia Perez , Librada Maria Cañedo , Francisco Romero , Fernando Espliego
IPC分类号： C12P17/18 , A61K31/7052 , A61K35/74 , A61P35/00 , C07D498/22 , C07H19/04 , C12R1/01 , A61K31/353
CPC分类号： C07D498/22
摘要： The invention provides compounds of formula (1) wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and R2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.
摘要翻译：本发明提供式（1）化合物，其中R 1为氢原子，具有1至6个碳原子的烷基或具有1至6个碳原子的烷氧基; R 2为氢原子，碳原子数1〜6的烷基或碳原子数1〜6的烷氧基。及其药学上可接受的盐。本发明还涉及获得化合物的方法，含有它们的组合物及其治疗用途。该化合物对哺乳动物癌细胞系表现出优异的活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式