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1. 发明授权

US07833581B2 Method for making a highly stable diamond film on a substrate 有权
标题翻译：在基材上制备高度稳定的金刚石膜的方法
公开(公告)号：US07833581B2
公开(公告)日：2010-11-16
申请号：US11898112
申请日：2007-09-10
申请人： Liang Guo , Guohua Chen
发明人： Liang Guo , Guohua Chen
IPC分类号： C23C16/00
CPC分类号： C23C16/0272 , C02F2001/46147 , C23C16/27 , C23C16/272 , C23C16/278 , C23C16/279 , C25B11/0478 , Y10T428/31678
摘要： A method of depositing a stable diamond film on a metal substrate includes pretreating a surface of the substrate and depositing a diamond film on the substrate by way of a multi-stage chemical vapor deposition, in which each subsequent stage is performed at progressively higher temperature. The deposited diamond may be doped with boron. The substrate may be titanium, a titanium alloy, iron, an iron alloy, or any other valve metal. The diamond deposition may be a high temperature chemical vapor deposition. The first deposition stage may optionally create a carbide of diamond and substrate, and an optional mixture of diamond and amorphous carbon may be deposited to bond this carbide layer to a subsequently applied layer. The resulting product may be used as an electrode, as a tooth or blade in a cutting tool, or may have many other uses.
摘要翻译：在金属基底上沉积稳定的金刚石薄膜的方法包括预处理基片的表面，并通过多级化学气相沉积在基片上沉积金刚石薄膜，其中每个后续阶段都在逐渐升高的温度下进行。沉积的金刚石可以掺杂硼。基底可以是钛，钛合金，铁，铁合金或任何其它阀金属。金刚石沉积可以是高温化学气相沉积。第一沉积阶段可以任选地产生金刚石和衬底的碳化物，并且可以沉积金刚石和无定形碳的任选混合物以将该碳化物层结合到随后施加的层。所得到的产品可以用作切割工具中的电极，作为牙齿或刀片，或者可以具有许多其它用途。

2. 发明申请

US20080070049A1 Method for making a highly stable diamond film on a subtrate 有权
标题翻译：制备高度稳定的金刚石薄膜的方法
公开(公告)号：US20080070049A1
公开(公告)日：2008-03-20
申请号：US11898112
申请日：2007-09-10
申请人： Liang Guo , Guohua Chen
发明人： Liang Guo , Guohua Chen
IPC分类号： B32B15/04 , C23C16/00
CPC分类号： C23C16/0272 , C02F2001/46147 , C23C16/27 , C23C16/272 , C23C16/278 , C23C16/279 , C25B11/0478 , Y10T428/31678
摘要： A method of depositing a stable diamond film on a metal substrate includes pretreating a surface of the substrate and depositing a diamond film on the substrate by way of a multi-stage chemical vapor deposition, in which each subsequent stage is performed at progressively higher temperature. The deposited diamond may be doped with boron. The substrate may be titanium, a titanium alloy, iron, an iron alloy, or any other valve metal. The diamond deposition may be a high temperature chemical vapor deposition. The first deposition stage may optionally create a carbide of diamond and substrate, and an optional mixture of diamond and amorphous carbon may be deposited to bond this carbide layer to a subsequently applied layer. The resulting product may be used as an electrode, as a tooth or blade in a cutting tool, or may have many other uses.
摘要翻译：在金属基底上沉积稳定的金刚石薄膜的方法包括预处理基片的表面，并通过多级化学气相沉积在基片上沉积金刚石薄膜，其中每个后续阶段都在逐渐升高的温度下进行。沉积的金刚石可以掺杂硼。基底可以是钛，钛合金，铁，铁合金或任何其它阀金属。金刚石沉积可以是高温化学气相沉积。第一沉积阶段可以任选地产生金刚石和衬底的碳化物，并且可以沉积金刚石和无定形碳的任选混合物以将该碳化物层结合到随后施加的层。所得到的产品可以用作切割工具中的电极，作为牙齿或刀片，或者可以具有许多其它用途。

3. 发明授权

US09687641B2 Method and device for transdermal delivery of parathyroid hormone using a microprojection array 有权
公开(公告)号：US09687641B2
公开(公告)日：2017-06-27
申请号：US13101071
申请日：2011-05-04
申请人： Parminder Singh , Danir Bairamov , Guohua Chen , Robert Wade Worsham
发明人： Parminder Singh , Danir Bairamov , Guohua Chen , Robert Wade Worsham
IPC分类号： A61M37/00 , A61K9/00
CPC分类号： A61K9/0021 , A61K38/29 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/36 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

4. 发明申请

US20130108681A1 Injectable Depot Compositions and Uses Thereof 审中-公开
标题翻译：可注射仓库组合物及其用途
公开(公告)号：US20130108681A1
公开(公告)日：2013-05-02
申请号：US13593371
申请日：2012-08-23
申请人： Guohua Chen , Paul R. Houston , Lothar Walter Kleiner , John J. Spaltro
发明人： Guohua Chen , Paul R. Houston , Lothar Walter Kleiner , John J. Spaltro
IPC分类号： A61K9/00
CPC分类号： A61K38/1858 , A61K9/0002 , A61K9/0024 , A61K9/1617 , A61K31/445 , A61K38/27 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patients body surface by injection.
摘要翻译：提供了可注射的储库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中的混溶性小于或等于7wt。％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。组合物已经显着改善了剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

5. 发明申请

US20120259318A1 SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES 有权
标题翻译：溶剂/聚合物溶液作为悬浮液
公开(公告)号：US20120259318A1
公开(公告)日：2012-10-11
申请号：US13526375
申请日：2012-06-18
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61K47/32 , B23P17/04 , A61M37/00 , A61K38/21 , G01N23/00
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译：能够悬浮活性剂的非水性单相载体。非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯，不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

6. 发明授权

US08114437B2 Solvent/polymer solutions as suspension vehicles 有权
标题翻译：溶剂/聚合物溶液作为悬浮载体
公开(公告)号：US08114437B2
公开(公告)日：2012-02-14
申请号：US11347562
申请日：2006-02-03
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61K9/14 , A61K45/00 , A61K38/47 , A61K38/00 , A61F2/00
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译：能够悬浮活性剂的非水性单相载体。非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯，不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

7. 发明申请

US20110104111A1 Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles 有权
标题翻译：渗透性药物递送装置含有包含具有活性剂和非水性单相载体的颗粒的悬浮液制剂
公开(公告)号：US20110104111A1
公开(公告)日：2011-05-05
申请号：US12925864
申请日：2010-11-01
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61K38/21 , A61K47/30 , A61K47/32
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译：能够悬浮活性剂的非水性单相载体。非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯，不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

8. 发明授权

US07829109B2 Catheter injectable depot compositions and uses thereof 失效
标题翻译：导管可注射药剂组合物及其用途
公开(公告)号：US07829109B2
公开(公告)日：2010-11-09
申请号：US10295603
申请日：2002-11-14
申请人： Guohua Chen , Paul R. Houston , Lothar Kleiner , John Spaltro
发明人： Guohua Chen , Paul R. Houston , Lothar Kleiner , John Spaltro
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
摘要翻译：提供导管可注射贮库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中具有小于或等于7重量％的混溶性的溶剂。％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

9. 发明申请

US20080269685A1 Solvent-cast microneedle arrays containing active 有权
标题翻译：含有活性的溶剂型微针阵列
公开(公告)号：US20080269685A1
公开(公告)日：2008-10-30
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61M37/00 , B29C43/14
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译：在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。第一溶液优选含有活性成分。

10. 发明申请

US20060193918A1 Solvent/polymer solutions as suspension vehicles 有权
公开(公告)号：US20060193918A1
公开(公告)日：2006-08-31
申请号：US11347562
申请日：2006-02-03
申请人： Catherine Rohloff , Guohua Chen , Andrew Luk , Rupal Ayer , Paul Houston , Michael Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine Rohloff , Guohua Chen , Andrew Luk , Rupal Ayer , Paul Houston , Michael Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61K38/19 , A61K38/22 , A61K38/48 , A61K9/14
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

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