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1. 发明授权

US5731255A Catalytic systems and methods for carbonylation 失效
标题翻译：催化体系和羰基化方法
公开(公告)号：US5731255A
公开(公告)日：1998-03-24
申请号：US504547
申请日：1995-07-20
申请人： Li Rui Pan , Tomohide Ina , Kazuyuki Matsuoka
发明人： Li Rui Pan , Tomohide Ina , Kazuyuki Matsuoka
IPC分类号： B01J31/16 , B01J31/18 , B01J31/24 , C07C67/38 , C07C37/36 , B01J31/00
CPC分类号： B01J31/1616 , B01J31/24 , B01J31/2404 , C07C67/38 , B01J2231/321 , B01J2531/80 , B01J2531/822 , B01J2531/824 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J31/1895
摘要： A carbonylation catalytic system comprises (A) a combination of (A1) a Group VIII metal source of Periodic Table of the Elements (e.g., palladium, palladium chloride) supported on a carrier, (A2) a ligand such as triphenylphosphine and (A3) an acid such as an alkyl-sulfonic acid, or (B) a combination of (B1) the Group VIII metal source except for palladium (e.g., a platinum compound), (B2) a ligand such as triphenylphosphine and (B3) an electron donative compound having an electron donability .DELTA..nu.D of not less than 2 (for instance, an amine such as a heterocyclic tertiary amine). The catalytic system (B) may further comprise (B4) an acid such as methanesulfonic acid. In the presence of the catalytic system (A) or (B), an acetylenic or olefinic unsaturated compound is allowed to react with carbon monoxide and a nucleophilic compound having an active hydrogen such as water, an alcohol and a carboxylic acid in a liquid phase to give an unsaturated or saturated carboxylic acid or an ester thereof with high transformation rate and selectivity.
摘要翻译：羰基化催化体系包括（A）负载在载体上的（A1）元素周期表第Ⅷ族金属源（例如钯，氯化钯），（A2）配体如三苯基膦和（A3）一种酸如烷基磺酸，或（B）除了钯（例如铂化合物）之外的（B1）第Ⅷ族金属源，（B2）配体如三苯基膦和（B3）电子的组合具有不小于2的电子偶联性DELTA nu D的助孕化合物（例如，胺如杂环叔胺）。催化体系（B）还可以包含（B4）酸，例如甲磺酸。在催化体系（A）或（B）的存在下，允许炔属或烯属不饱和化合物与一氧化碳和具有活性氢的亲核化合物如水，醇和羧酸在液相中反应得到具有高转化率和选择性的不饱和或饱和羧酸或其酯。

2. 发明授权

US5869738A Catalytic systems and methods for carbonylation 失效
标题翻译：催化体系和羰基化方法
公开(公告)号：US5869738A
公开(公告)日：1999-02-09
申请号：US965487
申请日：1997-11-06
申请人： Li Rui Pan , Tomohide Ina , Kazuyuki Matsuoka
发明人： Li Rui Pan , Tomohide Ina , Kazuyuki Matsuoka
IPC分类号： B01J31/16 , B01J31/18 , B01J31/24 , C07C67/38 , C07C67/36
CPC分类号： B01J31/1616 , B01J31/24 , B01J31/2404 , C07C67/38 , B01J2231/321 , B01J2531/80 , B01J2531/822 , B01J2531/824 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J31/1895
摘要： A carbonylation catalytic system comprises (A) a combination of (A1) a Group VIII metal source of Periodic Table of the Elements (e.g., palladium, palladium chloride) supported on a carrier, (A2) a ligand such as triphenylphosphine and (A3) an acid such as an alkylsulfonic acid, or (B) a combination of (B1) the Group VIII metal source except for palladium (e.g., a platinum compound), (B2) a ligand such as triphenylphosphine and (B3) an electron donative compound having an electron donability .DELTA..nu.D of not less than 2 (for instance, an amine such as a heterocyclic tertiary amine). The catalytic system (B) may further comprise (B4) an acid such as methanesulfonic acid. In the presence of the catalytic system (A) or (B), an acetylenic or olefinic unsaturated compound is allowed to react with carbon monoxide and a nucleophilic compound having an active hydrogen such as water, an alcohol and a carboxylic acid in a liquid phase to give an unsaturated or saturated carboxylic acid or an ester thereof with high transformation rate and selectivity.
摘要翻译：羰基化催化体系包括（A）负载在载体上的（A1）元素周期表第Ⅷ族金属源（例如钯，氯化钯），（A2）配体如三苯基膦和（A3）一种酸如烷基磺酸，或（B）除了钯（例如铂化合物）之外的（B1）第Ⅷ族金属源，（B2）三苯基膦等配体和（B3）给电子化合物具有不小于2的电子供体DELTA nu D（例如胺如杂环叔胺）。催化体系（B）还可以包含（B4）酸，例如甲磺酸。在催化体系（A）或（B）的存在下，允许炔属或烯属不饱和化合物与一氧化碳和具有活性氢的亲核化合物如水，醇和羧酸在液相中反应得到具有高转化率和选择性的不饱和或饱和羧酸或其酯。

3. 发明授权

US06710210B2 N-substituted-aminomethyl cyclopropyl ketone derivatives or salts thereof and production process therefor 失效
标题翻译： N-取代氨基甲基环丙基酮衍生物或其盐及其制备方法
公开(公告)号：US06710210B2
公开(公告)日：2004-03-23
申请号：US10117233
申请日：2002-04-08
申请人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
发明人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
IPC分类号： C07C22510
CPC分类号： C07C225/10 , C07C213/00 , C07C2601/02 , C07C215/20
摘要： Novel N-substituted-aminomethyl cyclopropyl ketone derivatives are represented by following Formula (1): wherein R1, R2 and R3 are each a hydrogen atom or an aliphatic hydrocarbon group; and R4 and R5 are each a hydrogen atom or an arylmethyl group which may have a substituent, where at least one hydrogen atom or aryl group as a substituent is combined with a carbon atom in the methyl moiety of the arylmethyl group, and at least one of R4 and R5 is an arylmethyl group which may have a substituent. These compounds are useful for the preparation of aminomethyl cyclopropyl ketone derivatives and 2-amino-1-cyclopropylethanol derivatives or salts thereof.
摘要翻译：新的N-取代的氨基甲基环丙基酮衍生物由下式（1）表示：其中R 1，R 2和R 3各自为氢原子或脂族烃基; R 4和R 5各自为氢原子或可具有取代基的芳基甲基，其中至少一个氢原子或芳基作为取代基与芳基甲基的甲基部分中的碳原子结合并且R 4和R 5中的至少一个是可以具有取代基的芳基甲基。这些化合物可用于制备氨基甲基环丙基酮衍生物和2-氨基-1-环丙基乙醇衍生物或其盐。

4. 发明授权

US06906197B2 Process for the preparation of optically active amines or salts thereof 失效
标题翻译：制备光学活性胺或其盐的方法
公开(公告)号：US06906197B2
公开(公告)日：2005-06-14
申请号：US10310805
申请日：2002-12-06
申请人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
发明人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
IPC分类号： C07B53/00 , C07B61/00 , C07C209/00 , C07C209/52 , C07C209/68 , C07C211/03 , C07C221/00 , C07C249/02 , C07C251/16 , C07D209/54
CPC分类号： C07C209/68 , C07B2200/07 , C07C221/00 , C07D209/54
摘要： A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): wherein R3 is an unsubstituted or substituted aryl group; R4 is an unsubstituted or substituted lower alkyl group; and C1 is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
摘要翻译：一种方法产生光学活性胺或其盐，并且包括以下步骤：使式（1a）的酮其中R 1通常为未取代或取代的烃基; 和R 2a通常是具有至少一个氧代基并任选具有其它取代基的烃基与式（2）的光学活性胺：其中R 3是未取代或取代的芳基; R 4是未取代或取代的低级烷基; 在有机酸存在下，C 1是不对称碳原子，从而得到相应的光学活性亚胺，在催化剂存在下氢化亚胺，得到相应的胺，使胺或其盐在催化剂存在下进行氢解，并用还原剂还原氢解产物。

5. 发明授权

US07109350B2 Process for the preparation of optically active amines or salts thereof 失效
标题翻译：制备光学活性胺或其盐的方法
公开(公告)号：US07109350B2
公开(公告)日：2006-09-19
申请号：US10878118
申请日：2004-06-29
申请人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
发明人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
IPC分类号： C07D209/54
CPC分类号： C07C209/68 , C07B2200/07 , C07C221/00 , C07D209/54
摘要： A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): wherein R3 is an unsubstituted or substituted aryl group; R4 is an unsubstituted or substituted lower alkyl group; and C1 is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
摘要翻译：一种方法产生光学活性胺或其盐，并且包括使式（1a）的酮反应的步骤：其中R 1通常是未取代或取代的烃基; 和R 2a通常是具有至少一个氧代基并任选具有其它取代基的烃基与式（2）的光学活性胺：其中R 3是未取代或取代的芳基; R 4是未取代或取代的低级烷基; 在有机酸存在下，C 1是不对称碳原子，从而得到相应的光学活性亚胺，在催化剂存在下氢化亚胺，得到相应的胺，使胺或其盐在催化剂存在下进行氢解，并用还原剂还原氢解产物。

6. 发明授权

US06613935B2 Process for producing 1-acyl-1-cyclopropanecarboxylate derivatives 失效
标题翻译： 1-酰基-1-环丙烷羧酸酯衍生物的制备方法
公开(公告)号：US06613935B2
公开(公告)日：2003-09-02
申请号：US10241592
申请日：2002-09-12
申请人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
发明人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
IPC分类号： C07C6974
CPC分类号： C07C67/343 , C07C2601/02 , C07C69/757
摘要： A process includes allowing a &bgr;-ketoester derivative represented by following Formula (1): wherein R1 is a hydrogen atom or a hydrocarbon group; and R2 is a hydrocarbon group, to react with 1,2-dichloroethane and there by produces a 1-acyl-1-cyclopropanecarboxylate derivative represented by following Formula (2): wherein R1 and R2 have the same meanings as defined above.
摘要翻译：一种方法包括使下式（1）表示的β-酮酯衍生物：其中R1是氢原子或烃基; R2为烃基，与1,2-二氯乙烷反应，生成由下式（2）表示的1-酰基-1-环丙烷羧酸酯衍生物：其中R1和R2具有与上述相同的含义。

7. 发明授权

US06498258B2 3-acetyl-N-substituted-3-aminomethyltetrahydrofuran-2-one derivative and production process therefor 失效
标题翻译： 3-乙酰基-N-取代-3-氨基甲基四氢呋喃-2-酮衍生物及其制备方法
公开(公告)号：US06498258B2
公开(公告)日：2002-12-24
申请号：US10115949
申请日：2002-04-05
申请人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
发明人： Hiroki Tanaka , Li Rui Pan , Kiyoshi Ikura
IPC分类号： C07D30756
CPC分类号： C07D307/33
摘要： A novel 3-acetyl-N-substituted-3-aminomethyltetrahydrofuran-2-one derivative is represented by following Formula (1): wherein R1, R2 and R3 are the same or different and are each a hydrogen atom or an aliphatic hydrocarbon group; and R4 and R5 are the same or different and are each a hydrogen atom or an arylmethyl group which may have a substituent, where at least one of R4 and R5 is an arylmethyl group which may have a substituent. This compound can be prepared by aminomethylating an 3-acetyltetrahydrofuran-2-one derivative represented by following Formula (2): wherein R1, R2 and R3 have the same meanings as above, by a reaction with formaldehyde or a polymer thereof and a primary or secondary amine represented by following Formula (3): wherein R4 and R5 have the same meanings as above.
摘要翻译：新型3-乙酰基-N-取代-3-氨基甲基四氢呋喃-2-酮衍生物由下式（1）表示：其中R1，R2和R3相同或不同，各自为氢原子或脂族烃基; R 4和R 5相同或不同，各自为氢原子或可具有取代基的芳基甲基，其中R 4和R 5中的至少一个为可具有取代基的芳基甲基。该化合物可以通过与下列通式（2）表示的3-乙酰基四氢呋喃-2-酮衍生物氨基甲基化来制备：其中R1，R2和R3具有与上述相同的含义，通过与甲醛或其聚合物和伯或由下式（3）表示的仲胺：其中R4和R5具有与上述相同的含义。

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