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1. 发明授权

US06566075B1 Methods for detecting human platelet-derived growth factor receptor agonists and antagonists 失效
标题翻译：用于检测人血小板衍生生长因子受体激动剂和拮抗剂的方法
公开(公告)号：US06566075B1
公开(公告)日：2003-05-20
申请号：US09628188
申请日：2000-07-28
申请人： Jaime A. Escobedo , Lewis T. Williams
发明人： Jaime A. Escobedo , Lewis T. Williams
IPC分类号： G01N102
CPC分类号： C07K14/71
摘要： A DNA sequence encoding human platelet-derived growth factor receptor (hPDGF-R) has now been isolated and sequenced. An expression construct comprising the sequence encodes a receptor that can be secreted or incorporated into the membrane of a mammalian cell. The incorporated receptor is functionally equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor. The construct can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列现已被分离并测序。包含该序列的表达构建体编码可分泌或并入哺乳动物细胞膜的受体。所掺入的受体在功能上等同于野生型受体，赋予对缺乏受体的细胞的PDGF敏感的促有丝分裂反应。该构建体可以用于增强细胞的PDGF应答，确定响应于PDGF结合参与转导信号的区域，提供突变的类似物并评价药物的生理活性。

2. 发明授权

US6110737A Human platelet-derived growth factor receptor, type A 失效
标题翻译：人类血小板衍生生长因子受体A型
公开(公告)号：US6110737A
公开(公告)日：2000-08-29
申请号：US240294
申请日：1994-05-09
申请人： Jaime A. Escobedo , Lewis T. Williams
发明人： Jaime A. Escobedo , Lewis T. Williams
IPC分类号： C07K14/435 , C07K14/71 , C07K14/715 , C12N1/19 , C12N5/10 , C12N5/16 , C12N15/63 , C12N15/81 , C12N15/85 , C12Q1/14 , G01N1/02 , G01N33/53 , G01N33/567
CPC分类号： C07K14/71
摘要： A DNA sequence encoding human platelet-derived growth factor receptor (hPDGF-R) has now been isolated and sequenced. An expression construct comprising the sequence encodes a receptor that can be secreted or incorporated into the membrane of a mammalian cell. The incorporated receptor is functionally equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor. The construct can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列现已被分离并测序。包含该序列的表达构建体编码可分泌或并入哺乳动物细胞膜的受体。所掺入的受体在功能上等同于野生型受体，赋予对缺乏受体的细胞的PDGF敏感的促有丝分裂反应。该构建体可以用于增强细胞的PDGF应答，确定响应于PDGF结合参与转导信号的区域，提供突变的类似物并评价药物的生理活性。

3. 发明授权

US07105305B2 Human platelet-derived growth factor receptors 失效
公开(公告)号：US07105305B2
公开(公告)日：2006-09-12
申请号：US10027400
申请日：2001-12-19
申请人： Lewis T. Williams , Jaime A. Escobedo
发明人： Lewis T. Williams , Jaime A. Escobedo
IPC分类号： G01N33/53 , C07K14/49
CPC分类号： C07K14/71 , G01N33/74 , G01N2333/49
摘要： DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.

4. 发明授权

US06475782B1 Human platelet-derived growth factor receptor 失效
标题翻译：人血小板衍生生长因子受体
公开(公告)号：US06475782B1
公开(公告)日：2002-11-05
申请号：US08451693
申请日：1995-05-26
申请人： Jaime A. Escobedo , Lewis T. Williams
发明人： Jaime A. Escobedo , Lewis T. Williams
IPC分类号： C12N510
CPC分类号： C07K14/71
摘要： A DNA sequence encoding human platelet-derived growth factor receptor (hPDGF-R) has now been isolated and sequenced. An expression construct comprising the sequence encodes a receptor that can be secreted or incorporated into the membrane of a mammalian cell. The incorporated receptor is functionally equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor. The construct can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列现已被分离并测序。包含该序列的表达构建体编码可分泌或并入哺乳动物细胞膜的受体。所掺入的受体在功能上等同于野生型受体，赋予对缺乏受体的细胞的PDGF敏感的促有丝分裂反应。该构建体可以用于增强细胞的PDGF应答，确定响应于PDGF结合参与转导信号的区域，提供突变的类似物并评价药物的生理活性。

5. 发明授权

US5891652A Methods of using domains of extracellular region of human platelet-derived growth factor receptor polypeptides 失效
标题翻译：使用人血小板衍生生长因子受体多肽细胞外区域的方法
公开(公告)号：US5891652A
公开(公告)日：1999-04-06
申请号：US460490
申请日：1995-06-02
申请人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
发明人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
IPC分类号： A61K39/395 , A61K38/00 , C07K7/04 , C07K14/00 , C07K14/705 , C07K14/71 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/566 , G01N33/50
CPC分类号： C07K16/2863 , C07K14/71 , A61K38/00 , C07K2319/00
摘要： Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.
摘要翻译：提供修饰的人血小板衍生生长因子受体多肽的定义构建体。鉴定细胞外区域结构，并提供受体区段的修饰和组合重排。修饰片段的细胞结合和可溶形式均可获得，使用它们的测定方法也可用，允许筛选配体类似物。

6. 发明授权

US06372438B1 Human platelet-derived growth factor receptors 失效
标题翻译：人血小板衍生生长因子受体
公开(公告)号：US06372438B1
公开(公告)日：2002-04-16
申请号：US08461917
申请日：1995-06-05
申请人： Lewis Thomas Williams , Jaime A. Escobedo
发明人： Lewis Thomas Williams , Jaime A. Escobedo
IPC分类号： G01N3353
CPC分类号： C07K14/71 , G01N33/74 , G01N2333/49
摘要： DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列和包含编码可以分泌或并入哺乳动物细胞膜的受体的序列的表达构建体。提供了功能相当于野生型受体的肽片段，赋予缺乏受体的细胞对PDGF敏感的促有丝分裂反应。该构建体可用于增强细胞的PDGF应答，确定与PDGF结合相关的转导信号所涉及的区域，提供突变的类似物并评估药物的生理活性。还提供了包含PDGF受体序列的可溶性片段，包括与细胞内蛋白质相互作用的重要细胞内激酶插入序列。

7. 发明授权

US5686572A Domains of extracellular region of human platelet derived growth factor receptor polypeptides 失效
标题翻译：人类血小板衍生生长因子受体多肽细胞外区域
公开(公告)号：US5686572A
公开(公告)日：1997-11-11
申请号：US168917
申请日：1993-12-15
申请人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
发明人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
IPC分类号： A61K39/395 , A61K38/00 , C07K7/04 , C07K14/00 , C07K14/705 , C07K14/71 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/566 , C07K19/00
CPC分类号： C07K16/2863 , C07K14/71 , A61K38/00 , C07K2319/00
摘要： Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.
摘要翻译：提供修饰的人血小板衍生生长因子受体多肽的定义构建体。鉴定细胞外区域结构，并提供受体区段的修饰和组合重排。修饰片段的细胞结合和可溶形式均可获得，使用它们的测定方法也可用，允许筛选配体类似物。

8. 发明授权

US06642022B1 Platelet-derived growth factor receptors 失效
标题翻译：血小板衍生生长因子受体
公开(公告)号：US06642022B1
公开(公告)日：2003-11-04
申请号：US08464436
申请日：1995-06-05
申请人： Lewis Thomas Williams , Jaime A. Escobedo
发明人： Lewis Thomas Williams , Jaime A. Escobedo
IPC分类号： C12N1500
CPC分类号： C07K14/71 , G01N33/74 , G01N2333/49
摘要： DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列和包含编码可以分泌或并入哺乳动物细胞膜的受体的序列的表达构建体。提供了功能相当于野生型受体的肽片段，赋予缺乏受体的细胞对PDGF敏感的促有丝分裂反应。该构建体可用于增强细胞的PDGF应答，确定与PDGF结合相关的转导信号所涉及的区域，提供突变的类似物并评估药物的生理活性。还提供了包含PDGF受体序列的可溶性片段，包括与细胞内蛋白质相互作用的重要细胞内激酶插入序列。

9. 发明授权

US06043211A Method for inhibiting the activity of a platelet-derived growth factor receptor binding protein 失效
标题翻译：抑制血小板衍生生长因子受体结合蛋白活性的方法
公开(公告)号：US06043211A
公开(公告)日：2000-03-28
申请号：US462728
申请日：1995-06-05
申请人： Lewis Thomas Williams , Jaime A. Escobedo
发明人： Lewis Thomas Williams , Jaime A. Escobedo
IPC分类号： A61K38/17 , C07H21/04 , C07K14/705 , C07K14/71 , C12N5/06 , C12N9/24 , C12N15/00 , C12P21/02 , G01N33/53
CPC分类号： C07K14/71 , G01N33/74 , G01N2333/49
摘要： DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列和包含编码可以分泌或并入哺乳动物细胞膜的受体的序列的表达构建体。提供了功能相当于野生型受体的肽片段，赋予缺乏受体的细胞对PDGF敏感的促有丝分裂反应。该构建体可用于增强细胞的PDGF应答，确定与PDGF结合相关的转导信号所涉及的区域，提供突变的类似物并评估药物的生理活性。还提供了包含PDGF受体序列的可溶性片段，包括与细胞内蛋白质相互作用的重要细胞内激酶插入序列。

10. 发明授权

US5872218A Human platelet-derived growth factor receptor extracellular domain antibodies 失效
标题翻译：人血小板衍生生长因子受体细胞外结构域抗体
公开(公告)号：US5872218A
公开(公告)日：1999-02-16
申请号：US460510
申请日：1995-06-02
申请人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
发明人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
IPC分类号： A61K39/395 , A61K38/00 , C07K7/04 , C07K14/00 , C07K14/705 , C07K14/71 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/566
CPC分类号： C07K16/2863 , C07K14/71 , A61K38/00 , C07K2319/00
摘要： This invention provides antibodies that bind to epitopes of human platelet-derived growth factor receptor (hPDGF-R) fragments, wherein the fragments comprise one or more platelet-derived growth factor (PDGF) ligand binding regions from extracellular domains D1, D2, and D3. Also provided are antibodies specific for domain D3, such as monoclonal antibodies directed to the intra-cysteine portion of domain D3.
摘要翻译：本发明提供与人血小板衍生生长因子受体（hPDGF-R）片段的表位结合的抗体，其中所述片段包含来自胞外域D1，D2和D3的一个或多个血小板衍生生长因子（PDGF）配体结合区。还提供了针对结构域D3特异性的抗体，例如针对结构域D3的半胱氨酸部分的单克隆抗体。

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