专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070072256A1 OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY 审中-公开
公开(公告)号：US20070072256A1
公开(公告)日：2007-03-29
申请号：US11531136
申请日：2006-09-12
申请人： Lewis MAKINGS , Gregor ZLOKARNIK
发明人： Lewis MAKINGS , Gregor ZLOKARNIK
IPC分类号： C12Q1/26
CPC分类号： C07D493/10 , C07D265/38 , C07D311/16 , C07D311/82 , C12Q1/26 , G01N2333/90245 , G01N2500/02
摘要： The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Y is selected from the group consisting of Q as herein defined, saturated C1-C20 alkyl, unsaturated C1-C20 alkenyl, unsaturated C1-C20 alkynyl, substituted saturated C1-C20 alkyl, substituted unsaturated C1-C20 alkenyl, substituted unsaturated C1-C20 alkynyl, C1-C20 cycloalkyl, C1-C20 cycloalkenyl, substituted saturated C1-C20 cycloalkyl, substituted unsaturated C1-C20 cycloalkenyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; L is selected from the group of (—OCR2H)p—, wherein for each p, all R2 are separately selected from the group consisting of a hydrogen atom, saturated C1-C20 alkyl, unsaturated C1-C20 alkenyl, unsaturated C1-C20 alkynyl, substituted saturated C1-C20 alkyl, substituted unsaturated C1-C20 alkenyl, substituted unsaturated C1-C20 alkynyl, C1-C20 cycloalkyl, C1-C20 cycloalkenyl, substituted saturated C1-C20 cycloalkyl, substituted unsaturated C1-C20 cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and p is a positive integer no greater than twelve; and Q is a chemical moiety that gives rise to optical properties in its hydroxy or hydroxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form. Most preferably, p is one, R2 is hydrogen, and Q is the ether form of a phenoxide fluorophore.

IPRDB

热门服务

关于我们

友情链接

联系方式