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    • 1. 发明授权
    • Responsive microgel and methods related thereto
    • 响应性微凝胶及其相关方法
    • US07204997B2
    • 2007-04-17
    • US10298808
    • 2002-11-18
    • Lev E. BrombergMarina Temchenko
    • Lev E. BrombergMarina Temchenko
    • A61K9/14
    • A61K8/042A61K8/90A61K9/1641A61K47/34A61Q19/00
    • A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.
    • 提供了响应性微凝胶,其响应于体积和可逆地响应于一种或多种选自由共价交联的均聚可离子化单体的可电离网络组成的组(温度,pH和离子条件)中的变化,其中可电离的 网络共价连接到两亲共聚物以形成多个“悬挂链”,并且其中两亲性共聚物的“悬挂链”在水溶液中形成固定的胶束状聚集体。 进一步提供响应性微凝胶,其包含至少一种治疗实体并且在生理条件下递送治疗实体的基本线性和持续释放。