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1. 发明授权

US5514720A Stable emulsions of highly fluorinated organic compounds 失效
标题翻译：高度氟化有机化合物的稳定乳液
公开(公告)号：US5514720A
公开(公告)日：1996-05-07
申请号：US178860
申请日：1988-04-07
申请人： Leland C. Clark, Jr. , Robert F. Shaw
发明人： Leland C. Clark, Jr. , Robert F. Shaw
IPC分类号： A61K9/00 , A61K31/02 , A61K31/025 , A61K31/435 , A61K31/47 , A61K31/03
CPC分类号： A61K9/0026 , A61K31/02 , A61K31/025 , A61K31/435 , A61K31/47
摘要： Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly soluble in water, a surfactant and water.
摘要翻译：用作氧气运输剂的高度氟化的有机化合物的稳定乳液，“人造血液”或红细胞替代物以及用于生物成像的造影剂。乳液包含高度氟化的有机化合物，基本上不具有表面活性并且不能很好地溶于水，表面活性剂和水的油。

2. 发明授权

US5635539A Stable emulsions of highly fluorinated organic compounds 失效
公开(公告)号：US5635539A
公开(公告)日：1997-06-03
申请号：US652158
申请日：1996-05-23
申请人： Leland C. Clark, Jr. , Robert F. Shaw
发明人： Leland C. Clark, Jr. , Robert F. Shaw
IPC分类号： A61K9/00 , A61K31/02 , A61K31/025 , A61K31/435 , A61K31/47 , A61K31/03
CPC分类号： A61K9/0026 , A61K31/02 , A61K31/025 , A61K31/435 , A61K31/47
摘要： Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly soluble in water, a surfactant and water.

3. 发明授权

US06726683B1 Electrically heated surgical cutting instrument 失效
标题翻译：电加热手术切割仪
公开(公告)号：US06726683B1
公开(公告)日：2004-04-27
申请号：US05730221
申请日：1977-10-06
申请人： Robert F. Shaw
发明人： Robert F. Shaw
IPC分类号： A61B1738
CPC分类号： G05D23/2401 , A61B17/32 , A61B18/00 , A61B18/08 , A61B18/082 , A61B18/28 , A61B2018/00005 , A61B2018/00107 , A61B2018/00666 , A61B2090/0813
摘要： Surgical cutting instrument includes an electrically heated cutting edge and an automatic control system for maintaining the cutting edge at a constant high temperature for sterilizing the blade, cutting tissue, and cauterizing the incised tissue to reduce hemorrhage from the cut surfaces of the tissues (hemostasis).
摘要翻译：手术切割仪器包括电加热切割边缘和用于将切割刃保持在恒定高温的自动控制系统，用于对刀片进行消毒，切割组织和烧灼切割的组织以减少组织切割表面的出血（止血）。

4. 发明授权

US4295470A Optical catheters and method for making same 失效
标题翻译：光学导管及其制造方法
公开(公告)号：US4295470A
公开(公告)日：1981-10-20
申请号：US964612
申请日：1978-11-29
申请人： Robert F. Shaw , John Sperinde
发明人： Robert F. Shaw , John Sperinde
IPC分类号： A61B5/00 , G01N21/85 , A61B5/02
CPC分类号： A61B5/1459 , G01N21/8507
摘要： Catheter apparatus having transmitting and receiving optical fibers for photometric analysis of a fluid eliminates the need for individually calibrating each catheter within a population of catheters by making substantially uniform the center-to-center spacing between the outlet aperture of each and every transmitting fiber and the inlet aperture of each and every receiving fiber of an individual catheter for all catheters within a population of catheters; and by making the size and shape of all the outlet apertures of all transmitting fibers generally uniform and the size and shape of the inlet apertures of all receiving fibers generally uniform in each catheter and from catheter to catheter and that the orientation of all transmitting fibers relative to all receiving fibers be similar.
摘要翻译：具有用于流体光度分析的发送和接收光纤的导管装置消除了通过使每个发射光纤的出口孔与每个发射光纤的出口孔之间的中心到中心间隔基本上均匀的方式来消除对多个导管群内的每个导管进行单独校准的需要每个导管的每个接收纤维的入口孔，用于导管群体内的所有导管; 并且通过使所有传输纤维的所有出口孔的尺寸和形状大致均匀，并且所有接收纤维的入口孔的尺寸和形状在每个导管中以及从导管到导管大致均匀，并且所有发射纤维相对的取向所有接收光纤都相似。

5. 发明授权

US4111191A Apparatus and method for examining blood vessels of interest by tracking position with respect to time of particles introduced therein 失效
标题翻译：通过跟踪位置检测血液中血小板的时间与引入时间相关的装置和方法
公开(公告)号：US4111191A
公开(公告)日：1978-09-05
申请号：US487425
申请日：1974-07-10
申请人： Robert F. Shaw
发明人： Robert F. Shaw
IPC分类号： A61B6/00 , G01T1/164 , G06F19/00 , A61B5/02
CPC分类号： G01T1/1647 , A61B6/4057 , A61B6/4258 , A61B6/507 , G06F19/3487
摘要： The extent, location, and severity of stenotic atherosclerotic lesions in the coronary arteries are determined by intravenous injection into the circulating blood of a number of small, discrete positron-emitting particles and by tracking the particles in three dimensions in the region of the heart using suitable gamma detectors disposed external to the patient's chest. The resolution and counting rates of the gamma detectors permit the sequence of positions of each particle to be recorded as a function of time as each particle flows through a coronary vessel. Data analysis of these recordings of particle position provide information about the velocity of blood flow through the course of each coronary artery. This velocity information is used to determine the extent, severity, and location of stenotic lesions of the coronary arteries.

6. 发明授权

US4848337A Abherent surgical instrument and method 失效
标题翻译：外科手术器械及方法
公开(公告)号：US4848337A
公开(公告)日：1989-07-18
申请号：US874814
申请日：1986-06-13
申请人： Robert F. Shaw , Philip E. Eggers
发明人： Robert F. Shaw , Philip E. Eggers
IPC分类号： A61B18/00 , A61B18/08 , A61B18/14
CPC分类号： A61B18/082 , A61B18/085 , A61B2018/00107 , A61B2018/0097
摘要： Method and means are disclosed for preventing tissue from adhering to surgical apparatus while operating at tissue temperatures at which hemostasis with minimal tissue damage occurs, and include interposing between the surgical apparatus and the tissue being heated thereby an abherent coating which exhibits electrical insulation and thermal impedance, thickness and thermal drop thereacross within specified limits.
摘要翻译：公开了用于防止组织粘附到外科手术器械上的方法和装置，同时在发生具有最小组织损伤的止血的组织温度下操作，并且包括插入手术装置和被加热的组织之间，从而形成具有电绝缘和热阻抗，厚度和热滴在规定的限度内。

7. 发明授权

US4785823A Methods and apparatus for performing in vivo blood thermodilution procedures 失效
标题翻译：用于进行体内血液热稀释程序的方法和装置
公开(公告)号：US4785823A
公开(公告)日：1988-11-22
申请号：US75945
申请日：1987-07-21
申请人： Philip E. Eggers , Robert F. Shaw
发明人： Philip E. Eggers , Robert F. Shaw
IPC分类号： A61B5/028 , A61B5/02
CPC分类号： A61B5/028
摘要： A thermodilution catheter has electrodes in electrical contact with the blood flowing adjacent to the catheter. A potential difference applied to the electrodes causes electrical current to flow in the volume of blood in the region of the electrodes, thereby creating a bolus of blood at elevated temperature suitable for measurement of blood flow by the thermodilution principle.
摘要翻译：热稀释导管具有与邻近导管流动的血液电接触的电极。施加到电极的电位差导致电流在电极区域中的血液体积中流动，从而在适于通过热稀释原理测量血流量的高温下产生大量血液。

8. 发明授权

US4364390A Surgical instrument having self-regulating dielectric heating of its cutting edge and method of using the same 失效
标题翻译：具有切割边缘自调节电介质加热的手术器械及其使用方法
公开(公告)号：US4364390A
公开(公告)日：1982-12-21
申请号：US72359
申请日：1979-09-05
申请人： Robert F. Shaw
发明人： Robert F. Shaw
IPC分类号： A61B18/08 , A61B18/14 , A61B17/32 , A61N3/00
CPC分类号： A61B18/08 , A61B18/082 , A61B2018/00107
摘要： The cutting edge of a scalpel blade is heated to an elevated preselected constant operating temperature for cutting tissue with simultaneous hemostasis by dielectric heating of the internal structure of the blade in the region along the cutting edge. Selective heating of regions of the cutting edge that are locally cooled by contact with tissues during surgical cutting is provided for by constructing the heating elements of the blade of ferroelectric materials that have a Curie point in the operating temperature range and that provide large increases in loss factor (the product of relative dielectric constant times the ratio of loss current to charging current) for temperature decrements below the Curie point.
摘要翻译：手术刀刀片的切割刃被加热到升高的预选的恒定操作温度，以通过沿着切割边缘的区域中的刀片的内部结构的介电加热来同时止血来切割组织。通过构建在工作温度范围内具有居里点的铁电材料刀片的加热元件并提供大的损耗增加来提供通过在外科切割期间与组织接触而局部冷却的切削刃区域的选择性加热因子（相对介电常数的乘积乘以损耗电流与充电电流的比值）低于居里点的温度降低。

9. 再颁专利

USRE29088E Surgical cutting instrument having electrically heated cutting edge 失效
标题翻译：手术切割仪具有电加热切割刃
公开(公告)号：USRE29088E
公开(公告)日：1976-12-28
申请号：US625845
申请日：1975-10-28
申请人： Robert F. Shaw
发明人： Robert F. Shaw
IPC分类号： A61B18/08 , A61B18/14
CPC分类号： A61B18/082 , A61B18/1402 , A61B2018/00119
摘要： A surgical cutting instrument includes an electrically heated cutting edge and a power supply system for maintaining the cutting edge at a constant high temperature for sterilizing the blade, cutting tissue, and cauterizing the incised tissue to reduce hemorrhage from the cut surfaces of the tissues (hemostasis). .Iadd.

10. 发明授权

US5308311A Electrically heated surgical blade and methods of making 失效
标题翻译：电加热手术刀片及其制作方法
公开(公告)号：US5308311A
公开(公告)日：1994-05-03
申请号：US877698
申请日：1992-05-01
申请人： Philip E. Eggers , Robert F. Shaw
发明人： Philip E. Eggers , Robert F. Shaw
IPC分类号： A61B17/3211 , A61B17/32 , A61B18/04 , A61B18/08 , A61B18/14 , A61B17/38
CPC分类号： A61B17/3211 , A61B18/082 , A61B2018/00107 , A61B2018/1412 , Y10T83/293
摘要： A hemostatic surgical blade and methods of manufacturing such blades are provided, wherein the blade comprises a laminate region having a hardenable center layer and highly thermally conductive outer layers, joined to a second region of a low thermal conductivity material. A heating element is secured to the laminate region and in thermal communication therewith to thermally reform the collagen of tissue as it is incised. The heat generated by the heating element is conducted to the cutting edge of the blade to maintain the cutting edge temperature within 20.degree. C. to 70.degree. C. of a user-selected operating temperature. The second region reduces the conduction of heat to the handle of the instrument. The heating element comprises a thermally conductive dielectric layer attached to an outer surface of the laminate region, resistive conductive elements deposited on the dielectric, a second dielectric layer covering the resistive conductor elements, and an abherent coating disposed thereon to reduce coagulum buildup on the blade.
摘要翻译：提供止血外科刀片和制造这种刀片的方法，其中刀片包括具有可硬化中心层和高度导热的外层的层压区域，其连接到低热导率材料的第二区域。加热元件被固定到层压区域并与其热连通以便在切割时对组织的胶原进行热改性。由加热元件产生的热量被传导到叶片的切割边缘，以将刀刃温度保持在用户选择的工作温度的20℃至70℃。第二区域减少热量传递到仪器的手柄。加热元件包括附着到层压区域的外表面的导热介电层，沉积在电介质上的电阻导电元件，覆盖电阻导体元件的第二电介质层，以及设置在其上的减阻凝结物。

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