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1. 发明申请

US20060036210A1 Modular electroporation device with disposable electrode and drug delivery components 审中-公开
标题翻译：具有一次性电极和药物输送组件的模块化电穿孔装置
公开(公告)号：US20060036210A1
公开(公告)日：2006-02-16
申请号：US11173176
申请日：2005-06-30
申请人： Lei Zhang , Andre Gamelin , Dietmar Rabussay
发明人： Lei Zhang , Andre Gamelin , Dietmar Rabussay
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61N1/0412
摘要： The invention comprises a modular electroporation device for use in clinical settings. The device includes components which may be varied or adapted for application of electroporation-based delivery of therapeutic agents to cells of a subject in a variety of electroporation formats such as intratissue electroporation or transsurface electroporation. The device components include a hand-manipulable handle with activation switch and a disposable head comprising electrodes, injection port, electrode directional and depth guide, and a slideably engaged electrode safety shield
摘要翻译：本发明包括用于临床设置的模块化电穿孔装置。该装置包括可以变化或适于以多种电穿孔形式（例如组织间电穿孔或经表面电穿孔）将治疗剂施用于受试者细胞的电穿孔为基础的组分。装置部件包括具有致动开关的手动操纵手柄和包括电极，注射端口，电极定向和深度引导件以及可滑动接合的电极安全屏蔽件

2. 发明申请

US20080058706A1 Modular electroporation device with disposable electrode and drug delivery components 审中-公开
标题翻译：具有一次性电极和药物输送组件的模块化电穿孔装置
公开(公告)号：US20080058706A1
公开(公告)日：2008-03-06
申请号：US11784892
申请日：2007-04-10
申请人： Lei Zhang , Andre Gamelin , Dietmar Rabussay
发明人： Lei Zhang , Andre Gamelin , Dietmar Rabussay
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61N1/0412
摘要： The invention comprises a modular electroporation device for use in clinical settings. The device includes components which may be varied or adapted for application of electroporation-based delivery of therapeutic agents to cells of a subject in a variety of electroporation formats such as intratissue electroporation or transsurface electroporation. The device components include a hand-manipulable handle with activation switch and a disposable head comprising electrodes, injection port, electrode directional and depth guide, and a slideably engaged electrode safety shield.
摘要翻译：本发明包括用于临床设置的模块化电穿孔装置。该装置包括可以变化或适于以多种电穿孔形式（例如组织间电穿孔或经表面电穿孔）将治疗剂施用于受试者细胞的电穿孔为基础的组分。装置部件包括具有致动开关的可手动手柄和包括电极，注射端口，电极定向和深度引导件以及可滑动接合的电极安全屏蔽件的一次性头部。

3. 发明申请

US20050054594A1 Methods for particle-assisted polynucleotide immunization using a pulsed electric field 审中-公开
标题翻译：使用脉冲电场进行颗粒辅助多核苷酸免疫的方法
公开(公告)号：US20050054594A1
公开(公告)日：2005-03-10
申请号：US10498923
申请日：2002-12-16
申请人： Lei Zhang , Georg Widera , Dietmar Rabussay
发明人： Lei Zhang , Georg Widera , Dietmar Rabussay
IPC分类号： A61N1/10 , A61B17/20 , A61K9/127 , A61K31/7088 , A61K35/76 , A61K39/00 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/02 , A61K47/04 , A61K47/24 , A61K47/30 , A61K48/00 , A61P31/04 , A61P31/12 , A61P31/20 , A61P35/00 , A61P37/04 , C12N15/87 , A61N1/30
CPC分类号： A61K39/292 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C12N15/87 , C12N2730/10134 , A61K2300/00
摘要： Methods are provided for enhancing an immune response induced by administration of a DNA vaccine. In the invention methods a DNA vaccine encoding an antigen and non-chemically associated adjuvant particles are injected into muscle, dermal or mucosal tissue of a subject at substantially the same time and the tissue is subjected to a pulsed electric field of sufficient strength to result in the DNA vaccine entering cells of the target tissue. The immune response to the antigen is enhanced as compared to when the DNA vaccine is administered alone or in combination with either of the electric pulses or the adjuvant particles without the other.
摘要翻译：提供了用于增强通过施用DNA疫苗诱导的免疫应答的方法。在本发明方法中，将编码抗原和非化学相关佐剂颗粒的DNA疫苗基本上同时注射到受试者的肌肉，皮肤或粘膜组织中，组织经受足够强度的脉冲电场，导致 DNA疫苗进入目标组织的细胞。与单独施用DNA疫苗或与任意一种电脉冲或佐剂颗粒组合施用时，对抗原的免疫应答增强。

4. 发明授权

US06266560B1 Electrically assisted transdermal method and apparatus for the treatment of erectile dysfunction 失效
标题翻译：用于治疗勃起功能障碍的电辅助透皮方法和仪器
公开(公告)号：US06266560B1
公开(公告)日：2001-07-24
申请号：US09336400
申请日：1999-06-18
申请人： Lei Zhang , Gunter A. Hofmann , Dietmar Rabussay
发明人： Lei Zhang , Gunter A. Hofmann , Dietmar Rabussay
IPC分类号： A61N144
CPC分类号： A61N1/36007 , Y10S977/906
摘要： A non-invasive method is provided for treating erectile dysfunction using electroporation enhanced with delivery of a vasoactive or androgenic composition applied to the penis which affords an alternative treatment for patients afflicted with erectile dysfunction (ED). Sufficient electric pulses temporarily create new pathways in the penile skin thereby driving a composition, such as a vasoactive or androgenic medication, into the corporal cavernosum.
摘要翻译：提供一种非侵入性方法，用于使用通过递送施用于阴茎的血管活性或雄激素成分增强的电穿孔来治疗勃起功能障碍，其为患有勃起功能障碍（ED）的患者提供替代治疗。足够的电脉冲暂时在阴茎皮肤中产生新的途径，从而将组合物（例如血管活性或雄激素药物）驱动到体外海绵体中。

5. 发明申请

US20060084938A1 Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation 有权
标题翻译：通过非侵入性体内电穿孔增强裸DNA的表达
公开(公告)号：US20060084938A1
公开(公告)日：2006-04-20
申请号：US11291459
申请日：2005-11-30
申请人： Lei Zhang , Dietmar Rabussay
发明人： Lei Zhang , Dietmar Rabussay
IPC分类号： A61M31/00
CPC分类号： A61N1/327 , A61N1/306
摘要： In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
摘要翻译：提供体内方法，通过将非侵入性的，用户友好的电极施加到皮肤表面，使用电场来传递对受试者的治疗或免疫治疗。因此，治疗或免疫剂可以递送到皮肤细胞中用于局部和全身治疗或用最佳基因表达和最小组织损伤进行免疫。特别地，治疗剂包括裸体或配制的核酸，多肽和化学治疗剂。

6. 发明授权

US09037230B2 Method and device for treating microscopic tumors remaining in tissues following surgical resection 有权
标题翻译：用于治疗手术切除后组织中剩余的微观肿瘤的方法和装置
公开(公告)号：US09037230B2
公开(公告)日：2015-05-19
申请号：US11713181
申请日：2007-03-02
申请人： Paul Goldfarb , Dietmar Rabussay
发明人： Paul Goldfarb , Dietmar Rabussay
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/327 , A61K9/0009 , A61K38/14 , A61M5/19 , A61M5/20
摘要： This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
摘要翻译：本发明涉及治疗癌性肿瘤周围部位的正常正常组织，以减少在癌组织的位点附近或其附近的癌症复发的可能性，并减少通常切除的明显健康组织的量肿瘤，从而通过消除或延迟肿瘤复发和保持正常组织的功能并避免不必要的损伤，为癌症患者提供实质性益处。

7. 发明申请

US20070239099A1 Method and device for treating microscopic tumors remaining in tissues following surgical resection 有权
标题翻译：用于治疗手术切除后组织中剩余的微观肿瘤的方法和装置
公开(公告)号：US20070239099A1
公开(公告)日：2007-10-11
申请号：US11713181
申请日：2007-03-02
申请人： Paul Goldfarb , Dietmar Rabussay
发明人： Paul Goldfarb , Dietmar Rabussay
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61K9/0009 , A61K38/14 , A61M5/19 , A61M5/20
摘要： This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
摘要翻译：本发明涉及治疗癌性肿瘤周围部位的正常正常组织，以减少在癌组织的位点附近或其附近的癌症复发的可能性，并减少通常切除的明显健康组织的量肿瘤，从而通过消除或延迟肿瘤复发和保持正常组织的功能并避免不必要的损伤，为癌症患者提供实质性益处。

8. 发明授权

US06192270B1 Apparatus and method for the delivery of drugs and genes into tissue 失效
标题翻译：用于将药物和基因递送到组织中的装置和方法
公开(公告)号：US06192270B1
公开(公告)日：2001-02-20
申请号：US09134245
申请日：1998-08-14
申请人： Gunter A. Hofmann , Dietmar Rabussay , Arnt Tonnessen
发明人： Gunter A. Hofmann , Dietmar Rabussay , Arnt Tonnessen
IPC分类号： A61N130
CPC分类号： A61N1/0424 , A61N1/042 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/325
摘要： An electrode assembly for an apparatus for and a method of trans-surface molecular delivery, including a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a first electrode disposed on at least a portion of the distal surface and extending through at least a portion of the plurality of through holes and onto at least a portion of the proximal surface, a second electrode disposed on at least a portion of the proximal surface and in closely spaced relation with the first electrode for engaging a tissue surface through which to apply an electric field, and an insulating barrier that is disposed on at least a portion of the proximal surface of the carrier between the first electrode and the second electrode.
摘要翻译：一种用于反式表面分子传递的装置和方法的电极组件，包括具有近端表面，远端表面和从近端表面到远端表面的多个通孔的非导电载体，第一电极设置在所述远端表面的至少一部分上并且延伸穿过所述多个通孔的至少一部分并且延伸到所述近端表面的至少一部分上，第二电极，设置在所述近端表面的至少一部分上并且紧密地与用于接合施加电场的组织表面的第一电极间隔开的关系;以及设置在第一电极和第二电极之间的载体近端表面的至少一部分上的绝缘屏障。

9. 发明授权

US10610684B2 Variable current density single needle electroporation system and method 有权
公开(公告)号：US10610684B2
公开(公告)日：2020-04-07
申请号：US12836163
申请日：2010-07-14
申请人： Rune Kjeken , Stephen Vincent Kemmerrer , Feng Lin , Dietmar Rabussay , Thomas Joseph Kardos
发明人： Rune Kjeken , Stephen Vincent Kemmerrer , Feng Lin , Dietmar Rabussay , Thomas Joseph Kardos
IPC分类号： A61N1/30 , A61N1/32 , C12N15/87 , C12M1/42 , C12N13/00
CPC分类号： A61N1/327 , C12M35/02 , C12N13/00 , C12N15/87 , A61N1/325
摘要： This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.

10. 发明授权

US06746441B1 Flow-through electroporation system for ex vivo gene therapy 失效
标题翻译：用于离体基因治疗的流通电穿孔系统
公开(公告)号：US06746441B1
公开(公告)日：2004-06-08
申请号：US09470567
申请日：1999-12-22
申请人： Gunter A. Hofmann , Dietmar Rabussay
发明人： Gunter A. Hofmann , Dietmar Rabussay
IPC分类号： A61M3100
CPC分类号： A61N1/327 , A61N1/306 , A61N1/325 , C12M35/02
摘要： A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.
摘要翻译：一种通过使细胞与预选分子接触并向细胞施加多系列电脉冲将预选分子引入活细胞的方法和装置。该方法可以离体使用。多个电脉冲产生旋转电场，其在活细胞中引入瞬时孔而不杀死细胞。旋转电场设置在具有多于两个电极的流通室装置中。三步脉冲处理，例如收集，电穿孔，电泳，用于将预选分子引入细胞。还提供了在连续脉冲之间重新定位电池的机械装置。该装置还可以提供在不同温度下脉冲细胞的手段，然后在脉冲之后，让细胞在另一个温度恢复指定的停留时间。

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