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1. 发明授权

US06482588B1 Detection and identification of human papillomavirus by PCR and type-specific reverse hybridization 有权
标题翻译：通过PCR和类型特异性反向杂交检测和鉴定人乳头瘤病毒
公开(公告)号：US06482588B1
公开(公告)日：2002-11-19
申请号：US09527030
申请日：2000-03-16
申请人： Leen-Jan Van Doorn , Wim Quint , Berhnard Kleter , Jan TerSchegget
发明人： Leen-Jan Van Doorn , Wim Quint , Berhnard Kleter , Jan TerSchegget
IPC分类号： C12Q170
CPC分类号： C12Q1/708 , C12Q2531/113
摘要： The present invention relates to a method for detection and/or identification of HPV present on a biological sample, comprising the steps of amplification of HPV polynucleic acids and of hybridization of said amplified ploynucleic acids to a number of probes. By means of PCR, a short fragment of the L1 gene of HPV is amplified. The amplimers are then contacted with probes that specifically hybridize to said short fragment of the L1 gene of either one or more than one HPV type. A preferred format is the reverse hybridization technique, more particularly the LiPA technique. The invention also relates to primers and probes to be used in a method of detection and/or identification of HPV and to a diagnostic kit to perform said method.
摘要翻译：本发明涉及一种检测和/或鉴定存在于生物样品上的HPV的方法，其包括扩增HPV多核酸和将所述扩增的核酸与多个探针杂交的步骤。通过PCR，扩增HPV的L1基因的短片段。然后将扩增产物与与一种或多于一种HPV类型的L1基因的所述短片段特异性杂交的探针接触。优选的形式是反向杂交技术，更具体地说是LiPA技术。本发明还涉及用于检测和/或鉴定HPV的方法的引物和探针以及用于执行所述方法的诊断试剂盒。

2. 发明申请

US20120308594A1 HCV CLADE AND PROTOTYPE SEQUENCES THEREOF 审中-公开
标题翻译： HCV CLADE及其原型序列
公开(公告)号：US20120308594A1
公开(公告)日：2012-12-06
申请号：US13315569
申请日：2011-12-09
申请人： Erwin Sablon , Wim Quint , Leen-Jan Van Doorn
发明人： Erwin Sablon , Wim Quint , Leen-Jan Van Doorn
IPC分类号： C12N15/51 , C12Q1/70 , C12N5/10 , C12N1/21 , A61P31/14 , C12N1/15 , C07K14/18 , C07K7/06 , C07K7/08 , A61K39/29 , C12N15/63 , C12N1/19
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N2770/24222 , C12N2770/24251 , C12Q1/707 , C12Q2525/117
摘要： The current invention relates to a previously unrecognized clade of HCV genotypes as well as to diagnostic, prophylactic and therapeutic applications of nucleic acids, proteins, and antibodies to said protein, derived of or based on the newly characterized hepatitis C viruses.
摘要翻译：本发明涉及先前未被认可的HCV基因型进化枝，以及来源于或基于新表征的丙型肝炎病毒的所述蛋白质的核酸，蛋白质和抗体的诊断，预防和治疗应用。

3. 发明申请

US20050069870A1 HCV clade and prototype sequences thereof 有权
标题翻译： HCV进化枝及其原型序列
公开(公告)号：US20050069870A1
公开(公告)日：2005-03-31
申请号：US10927520
申请日：2004-08-27
申请人： Erwin Sablon , Wim Quint , Leen-Jan Van Doorn
发明人： Erwin Sablon , Wim Quint , Leen-Jan Van Doorn
IPC分类号： A61K38/00 , C07H21/04 , C07K14/18 , C12N7/02 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N2770/24222 , C12N2770/24251 , C12Q1/707 , C12Q2525/117
摘要： The current invention relates to a previously unrecognized clade of HCV genotypes as well as to diagnostic, prophylactic and therapeutic applications of nucleic acids, proteins, and antibodies to said protein, derived of or based on the newly characterized hepatitis C viruses.
摘要翻译：本发明涉及先前未被认可的HCV基因型进化枝，以及来源于或基于新表征的丙型肝炎病毒的所述蛋白质的核酸，蛋白质和抗体的诊断，预防和治疗应用。

4. 发明申请

US20070031828A1 Assay 审中-公开
标题翻译：测定
公开(公告)号：US20070031828A1
公开(公告)日：2007-02-08
申请号：US11581251
申请日：2006-10-12
申请人： Brigitte Desiree Colau , Gary Dubin , Marie-Therese Martin , Wim Quint , Leen-Jan Van Doorn
发明人： Brigitte Desiree Colau , Gary Dubin , Marie-Therese Martin , Wim Quint , Leen-Jan Van Doorn
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/708
摘要： A process for identification of type-specific polynucleotide sequences in a sample, the process comprising the steps of (1) contacting polynucleotides from the sample, or derived from the sample, with a plurality of type-specific probes in the context of a solid support, and detection of any type-specific hybridisation; and (2) contacting polynucleotides in the sample, or derived from the sample, with type-specific primers for those types capable of being detected by the hybridisation step in step 1, but not so detected, in a type-specific amplification reaction.
摘要翻译：用于鉴定样品中特定类型的多核苷酸序列的方法，所述方法包括以下步骤：（1）在固体支持物的上下文中将来自样品或衍生自样品的多核苷酸与多种类型特异性探针接触，以及任何类型特异性杂交的检测; 和（2）将样品中或衍生自样品的多核苷酸与类型特异性引物接触，用于在特异性扩增反应中能够通过步骤1中的杂交步骤检测到的那些类型的引物。

5. 发明申请

US20050037352A1 Assay 审中-公开
标题翻译：测定
公开(公告)号：US20050037352A1
公开(公告)日：2005-02-17
申请号：US10485838
申请日：2002-08-06
申请人： Brigitte Colau , Gary Dubin , Marie-Therese Martin , Wim Quint , Leen-Jan Van Doorn
发明人： Brigitte Colau , Gary Dubin , Marie-Therese Martin , Wim Quint , Leen-Jan Van Doorn
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34
CPC分类号： C12Q1/708
摘要： A process for identification of type-specific polynucleotide sequences in a sample, the process comprising the steps of (1) contacting polynucleotides from the sample, or derived from the sample, with a plurality of type-specific probes in the context of a solid support, and detection of any type-specific hybridisation; and (2) contacting polynucleotides in the sample, or derived from the sample, with type-specific primers for those types capable of being detected by the hybridisation step in step 1, but not so detected, in a type-specific amplification reaction.
摘要翻译：用于鉴定样品中特定类型的多核苷酸序列的方法，该方法包括以下步骤：（1）在固体支持物的上下文中将来自样品或衍生自样品的多核苷酸与多种类型特异性探针接触，以及任何类型特异性杂交的检测; 和（2）将样品中或衍生自样品的多核苷酸与类型特异性引物接触，用于在特异性扩增反应中能够通过步骤1中的杂交步骤检测到的那些类型的引物。

6. 发明授权

US08124747B2 HCV clade and prototype sequences thereof 有权
标题翻译： HCV进化枝及其原型序列
公开(公告)号：US08124747B2
公开(公告)日：2012-02-28
申请号：US10927520
申请日：2004-08-27
申请人： Erwin Sablon , Wim Quint , Leen-Jan Van Doorn
发明人： Erwin Sablon , Wim Quint , Leen-Jan Van Doorn
IPC分类号： C07H23/00
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N2770/24222 , C12N2770/24251 , C12Q1/707 , C12Q2525/117
摘要： The current invention relates to a previously unrecognized clade of HCV genotypes as well as to diagnostic, prophylactic and therapeutic applications of nucleic acids, proteins, and antibodies to said protein, derived of or based on the newly characterized hepatitis C viruses.
摘要翻译：本发明涉及先前未被认可的HCV基因型进化枝，以及来源于或基于新表征的丙型肝炎病毒的所述蛋白质的核酸，蛋白质和抗体的诊断，预防和治疗应用。

7. 发明授权

US07196183B2 Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent 有权
标题翻译：丙型肝炎病毒基因型，其用作预防，治疗和诊断剂
公开(公告)号：US07196183B2
公开(公告)日：2007-03-27
申请号：US10230381
申请日：2002-08-29
申请人： Erwin Sablon , Leen-Jan Van Doorn , Wim Quint
发明人： Erwin Sablon , Leen-Jan Van Doorn , Wim Quint
IPC分类号： C07H21/04 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/707
摘要： The present invention relates to genomic nucleotide sequences and amino acid sequences corresponding to the non-coding and coding region of a new type of HCV. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes sequences. Particularly, the present invention relates to said new HCV type sequences; a process for preparing them, and their use for diagnosis, prophylaxis and therapy. More particularly, the present invention provides new type-specific sequences of the 5′ NCR, Core, the E1 and the NS5 regions of the new HCV type. These new HCV sequences are useful to diagnose the presence of HCV type genotypes or serotypes in a biological sample. Moreover, the availability of these new type-specific sequences can increase the overall sensitivity of HCV detection and should also prove to be useful for prophylactic and therapeutic purposes.
摘要翻译：本发明涉及对应于新型HCV的非编码区和编码区的基因组核苷酸序列和氨基酸序列。本发明涉及与已知的HCV类型和亚型序列不同的新的HCV类型和亚型序列。特别地，本发明涉及所述新型HCV型序列; 它们的制备过程及其在诊断，预防和治疗中的应用。更具体地说，本发明提供新HCV型5'NCR，核心，E1和NS5区域的新型特异性序列。这些新的HCV序列可用于诊断生物样品中HCV型基因型或血清型的存在。此外，这些新型特异性序列的可用性可以提高HCV检测的总体灵敏度，并且还应证明可用于预防和治疗目的。

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