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    • 5. 发明申请
    • BILAYERS
    • US20120220481A1
    • 2012-08-30
    • US13389197
    • 2010-08-04
    • Mark Ian WallaceSebastian LeptihnJames Russell Thompson
    • Mark Ian WallaceSebastian LeptihnJames Russell Thompson
    • C40B30/04C40B50/18C40B40/02
    • G01N33/543G01N33/5432G01N33/6842
    • A method for producing a bilayer, the method comprising: (a) providing a hydrated support and a hydrophilic body immersed in a hydrophobic medium; wherein a first monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrophilic body and a second monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrated support; and (b) bringing the first monolayer into contact with the second monolayer to form a bilayer of amphipathic molecules, wherein at least part of a cell membrane, comprising cell membrane constituents, is provided in or on the hydrated support and/or in the hydrophilic body, and such that constituents of the cell membrane incorporate into the bilayer during or after the bilayer formation. A bilayer produced by the method of the invention, and uses of the bilayer.
    • 一种制备双层的方法,该方法包括:(a)提供浸入疏水介质中的水合载体和亲水体; 其中在所述疏水介质和所述亲水体之间的界面上形成第一单层的两亲性分子,并且在所述疏水介质和所述水合载体之间的界面上形成第二单层的两亲分子; 和(b)使第一单层与第二单层接触以形成两亲性分子的双层,其中至少部分包含细胞膜组分的细胞膜提供在水合载体中和/或在亲水性 并且使得细胞膜的成分在双层形成期间或之后并入双层。 通过本发明的方法生产的双层以及双层的用途。